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2021 2
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miR-877-5p Inhibits Epithelial Mesenchymal Transformation of Breast Cancer Cells by Targeting FGB.
Liu H, Xiang L, Mei Y. Liu H, et al. Dis Markers. 2022 Nov 17;2022:4882375. doi: 10.1155/2022/4882375. eCollection 2022. Dis Markers. 2022. PMID: 36438895 Free PMC article.
RT-qPCR was utilized to evaluate the mRNA expression of FGB and miR-877-5p. Immunohistochemistry was applied to evaluate the protein expression of FGB. ...In addition, the Ki-67 expression was observably declined in the sh-FGB group. The protein expression of …
RT-qPCR was utilized to evaluate the mRNA expression of FGB and miR-877-5p. Immunohistochemistry was applied to evaluate the protein …
Congenital Fibrinogen Deficiencies: Not So Rare.
Couzens A, Neerman-Arbez M. Couzens A, et al. Hamostaseologie. 2025 Aug;45(4):286-296. doi: 10.1055/a-2511-3314. Epub 2025 Mar 12. Hamostaseologie. 2025. PMID: 40074015 Free article. Review.
Indeed, the symptoms manifested in CFD patients, such as bleeding and thrombosis, are likely to result from variation in several genes rather than solely driven by variants in one of the three fibrinogen genes, FGB, FGA, and FGG. This review highlights recent advances in u …
Indeed, the symptoms manifested in CFD patients, such as bleeding and thrombosis, are likely to result from variation in several genes rathe …
miR-139-5p Suppresses Proliferation and Angiogenesis of Intracranial Aneurysm via FGB.
Jin T, Chen G, An Q, Qin X, Hu Y, Yan Y, Hu J, Zhou B, Leng B. Jin T, et al. J Healthc Eng. 2022 Apr 16;2022:5824327. doi: 10.1155/2022/5824327. eCollection 2022. J Healthc Eng. 2022. PMID: 35469231 Free PMC article.
However, we found that FGB in intracranial aneurysm samples was remarkedly enhanced compared to normal tissues. Moreover, we found miR-139-5p overexpression and FGB silencing inhibit HBMEC proliferation and tube formation and suppressed alpha-SMA and CXCR4 levels in …
However, we found that FGB in intracranial aneurysm samples was remarkedly enhanced compared to normal tissues. Moreover, we found mi …
Globin phylogeny, evolution and function, the newest update.
Schuster CD, Salvatore F, Moens L, Martí MA. Schuster CD, et al. Proteins. 2024 Jun;92(6):720-734. doi: 10.1002/prot.26659. Epub 2024 Jan 9. Proteins. 2024. PMID: 38192262 Review.
M-family evolution also lead to distinctive major types (FHb and Fgb, Ngb, Adgb, GbX vertebrate Gbs), and shows the shift from high oxygen affinity controlled by TyrB10-Gln/AsnE11 likely related to RNOS chemistry in microorganisms, to a moderate oxygen affinity storage/tra …
M-family evolution also lead to distinctive major types (FHb and Fgb, Ngb, Adgb, GbX vertebrate Gbs), and shows the shift from high o …
Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.
Huffman JE, Nicholas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessler J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BAT, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gögele M, Greinacher A, Gao H, Howard T, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Paüls-Vergés F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van Rooij FJA, Wang H, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MPM, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris SE, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O'Connell JR, Orrù V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott DJ, van Hylckama Vlieg A, Watkins H, Willemsen G, Wilson PWF, Ben-Shlomo Y, Blangero J, Boomsma D, Cox SR, Dehghan A, Eriksson JG, Fiorillo E, Fornage M, Hansen T, Hayward C, Ikr… See abstract for full author list ➔ Huffman JE, et al. Blood. 2024 Nov 21;144(21):2248-2265. doi: 10.1182/blood.2023022596. Blood. 2024. PMID: 39226462 Free PMC article.
The gene region encoding the fibrinogen protein chain subunits (FGG;FGB;FGA) contains 7 distinct signals, including 1 novel signal driven by rs28577061, a variant common in African ancestry populations but extremely rare in Europeans (MAFAFR = 0.180; MAFEUR = 0.008). ...
The gene region encoding the fibrinogen protein chain subunits (FGG;FGB;FGA) contains 7 distinct signals, including 1 novel signal dr …
Mutations Accounting for Congenital Fibrinogen Disorders: An Update.
Richard M, Celeny D, Neerman-Arbez M. Richard M, et al. Semin Thromb Hemost. 2022 Nov;48(8):889-903. doi: 10.1055/s-0041-1742170. Epub 2022 Jan 24. Semin Thromb Hemost. 2022. PMID: 35073585
It is a hexamer composed of two copies of three distinct chains: Aalpha, Bbeta, and gamma encoded by three genes, FGA, FGB, and FGG, clustered on the long arm of chromosome 4. Congenital fibrinogen disorders (CFDs) are divided into qualitative deficiencies (dysfibrinogenem …
It is a hexamer composed of two copies of three distinct chains: Aalpha, Bbeta, and gamma encoded by three genes, FGA, FGB, and FGG, …
Fibrinogen beta chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolism.
Klajmon A, Chmiel J, Ząbczyk M, Pociask E, Wypasek E, Malinowski KP, Undas A, Natorska J. Klajmon A, et al. Eur J Clin Invest. 2022 Apr;52(4):e13718. doi: 10.1111/eci.13718. Epub 2021 Nov 21. Eur J Clin Invest. 2022. PMID: 34783023
We investigated whether fibrinogen alpha-chain gene (FGA) c.991A>G (rs6050), fibrinogen beta chain gene (FGB) -455G>A (rs1800790) and factor XIII gene (F13) c.103G>T (rs5985) polymorphisms affect plasma fibrin clot properties in patients with …
We investigated whether fibrinogen alpha-chain gene (FGA) c.991A>G (rs6050), fibrinogen beta chain gene (FGB) …
Multiple sclerosis and genetic polymorphisms in fibrinogen-mediated hemostatic pathways: a case-control study.
Abbadessa G, Miele G, Di Pietro A, Sparaco M, Palladino R, Armetta I, D'Elia G, Trojsi F, Signoriello E, Lus G, Lavorgna L, Bonavita S. Abbadessa G, et al. Neurol Sci. 2022 Apr;43(4):2601-2609. doi: 10.1007/s10072-021-05608-1. Epub 2021 Sep 24. Neurol Sci. 2022. PMID: 34561786 Free PMC article.
Multivariate ordinal logistic regression and multivariate multinomial logistic regression were applied to evaluate the effect of CGRS on MS susceptibility. RESULTS: The FGB 455 G/A and Factor V H1299R variants might be associated with MS status, in the recessive and domina …
Multivariate ordinal logistic regression and multivariate multinomial logistic regression were applied to evaluate the effect of CGRS on MS …
Antiviral Intervention of COVID-19: Linkage of Disease Severity with Genetic Markers FGB (rs1800790), NOS3 (rs2070744) and TMPRSS2 (rs12329760).
Sokolenko M, Sydorchuk L, Sokolenko A, Sydorchuk R, Kamyshna I, Sydorchuk A, Sokolenko L, Sokolenko O, Oksenych V, Kamyshnyi O. Sokolenko M, et al. Viruses. 2025 May 30;17(6):792. doi: 10.3390/v17060792. Viruses. 2025. PMID: 40573382 Free PMC article.
The purpose of this study was to investigate polymorphic variants of the genes FGB (rs1800790), NOS3 (rs2070744) and TMPRSS2 (rs12329760) in patients with SARS-CoV-2 and to determine their role in the COVID-19 severity course against the background of antiviral therapy. .. …
The purpose of this study was to investigate polymorphic variants of the genes FGB (rs1800790), NOS3 (rs2070744) and TMPRSS2 (rs12329 …
Epigenetic role of LINE-1 methylation and key genes in pregnancy maintenance.
Tisato V, Silva JA, Scarpellini F, Capucci R, Marci R, Gallo I, Salvatori F, D'Aversa E, Secchiero P, Serino ML, Zauli G, Singh AV, Gemmati D. Tisato V, et al. Sci Rep. 2024 Feb 8;14(1):3275. doi: 10.1038/s41598-024-53737-2. Sci Rep. 2024. PMID: 38332006 Free PMC article.
Genotyping of the following SNPs accounted for different EPL/RPL risk odds ratio: F13A1 rs5985 (OR = 0.24; 0.06-0.90); F13B rs6003 (OR = 0.23; 0.047-1.1); FGA rs6050 (OR = 0.58; 0.33-1.0); CRP rs2808635/rs876538 (OR = 0.15; 0.014-0.81); ABO rs657152 (OR = 0.48; 0.22-1.08); TP53 r …
Genotyping of the following SNPs accounted for different EPL/RPL risk odds ratio: F13A1 rs5985 (OR = 0.24; 0.06-0.90); F13B rs6003 (OR = 0.2 …
40 results