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2022 11
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Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family.
Li HZ, Zhang JL, Yuan DL, Xie WQ, Ladel CH, Mobasheri A, Li YS. Li HZ, et al. Mil Med Res. 2024 Jun 21;11(1):40. doi: 10.1186/s40779-024-00544-5. Mil Med Res. 2024. PMID: 38902808 Free PMC article. Review.
In OA and IVDD pathologies specifically, FGF1, FGF2, FGF8, FGF9, FGF18, FGF21, and FGF23 regulate the synthesis, catabolism, and ossification of cartilage tissue. ...
In OA and IVDD pathologies specifically, FGF1, FGF2, FGF8, FGF9, FGF18, FGF21, and FGF23 regulate the synthesis, catabolism, and ossi …
Unravelling the molecular landscape of endometrial cancer subtypes: insights from multiomics analysis.
Shen Y, Tian Y, Ding J, Chen Z, Zhao R, Lu Y, Li L, Zhang H, Wu H, Li X, Zhang Y. Shen Y, et al. Int J Surg. 2024 Sep 1;110(9):5385-5395. doi: 10.1097/JS9.0000000000001685. Int J Surg. 2024. PMID: 38775562 Free PMC article.
The authors identified seven overlapping proteins (RGMA, NRXN2, EVA1C, SLC14A1, SLC6A14, SCUBE1, FGF8) in endometrioid subtype and six overlapping proteins (IL32, GRB7, L1CAM, CCL25, GGT2, PSG5) in nonendometrioid subtype and conducted network analysis of above proteins an …
The authors identified seven overlapping proteins (RGMA, NRXN2, EVA1C, SLC14A1, SLC6A14, SCUBE1, FGF8) in endometrioid subtype and si …
Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis.
Ward JM, Ambatipudi M, O'Hanlon TP, Smith MA, de Los Reyes M, Schiffenbauer A, Rahman S, Zerrouki K, Miller FW, Sanjuan MA, Li JL, Casey KA, Rider LG. Ward JM, et al. Arthritis Rheumatol. 2023 Nov;75(11):2014-2026. doi: 10.1002/art.42615. Epub 2023 Aug 13. Arthritis Rheumatol. 2023. PMID: 37229703 Free PMC article.
Up-regulated components shared by DM and juvenile DM included cytokine:receptor pairs LGALS9:HAVCR2, LTF/NAMPT/S100A8/HSPA1A:TLR4, CSF2:CSF2RA, EPO:EPOR, FGF2/FGF8:FGFR, several Bcl-2 components, and numerous glycolytic enzymes. Pathways unique to DM included sirtuin signa …
Up-regulated components shared by DM and juvenile DM included cytokine:receptor pairs LGALS9:HAVCR2, LTF/NAMPT/S100A8/HSPA1A:TLR4, CSF2:CSF2 …
NMR resonance assignment of a fibroblast growth factor 8 splicing isoform b.
Hargittay B, Mineev KS, Richter C, Sreeramulu S, Jonker HRA, Saxena K, Schwalbe H. Hargittay B, et al. Biomol NMR Assign. 2023 Jun;17(1):135-142. doi: 10.1007/s12104-023-10132-8. Epub 2023 Apr 29. Biomol NMR Assign. 2023. PMID: 37118562 Free PMC article.
The splicing isoform b of human fibroblast growth factor 8 (FGF8b) is an important regulator of brain embryonic development. ...
The splicing isoform b of human fibroblast growth factor 8 (FGF8b) is an important regulator of brain embryonic …
Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response.
Nandakumar M, Moin ASM, Ramanjaneya M, Qaissi AA, Sathyapalan T, Atkin SL, Butler AE. Nandakumar M, et al. Diabetes Obes Metab. 2022 Aug;24(8):1483-1497. doi: 10.1111/dom.14716. Epub 2022 May 3. Diabetes Obes Metab. 2022. PMID: 35415885
No differences between T2D and controls were seen for FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF10, FGF21 or any of the FGF receptors. At 24 h post-hypoglycaemia, FGF20 (p = .01) differed between controls and T2D, while the levels for the other proteins measured returned to b …
No differences between T2D and controls were seen for FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF10, FGF21 or any of the FGF receptors. A …
Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation.
Mac TT, Fauquier T, Jullien N, Romanet P, Etchevers H, Barlier A, Castinetti F, Brue T. Mac TT, et al. Elife. 2024 Nov 28;12:RP90875. doi: 10.7554/eLife.90875. Elife. 2024. PMID: 39607428 Free PMC article.
NFKB2(D865G/D865G) mutation acted at different levels of development with mutant organoids displaying changes in the expression of genes involved on pituitary progenitor generation (HESX1, PITX1, LHX3), hypothalamic secreted factors (BMP4, FGF8, FGF10), epithelial-to-mesen …
NFKB2(D865G/D865G) mutation acted at different levels of development with mutant organoids displaying changes in the expression of genes inv …
Immunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressiveness.
Poli E, Barbon V, Lucchetta S, Cattelan M, Santoro L, Zin A, Milano GM, Zanetti I, Bisogno G, Bonvini P. Poli E, et al. Oncoimmunology. 2022 Jul 6;11(1):2096349. doi: 10.1080/2162402X.2022.2096349. eCollection 2022. Oncoimmunology. 2022. PMID: 35813575 Free PMC article.
Herein, we matched autoantibody profiling of alveolar RMS (ARMS) patients with genes under regulatory control of PAX3-FOXO1 transcription factor and revealed fibroblast growth factor 8 (FGF8) as a novel ARMS tumor antigen of diagnostic, prognost …
Herein, we matched autoantibody profiling of alveolar RMS (ARMS) patients with genes under regulatory control of PAX3-FOXO1 transcription fa …
Identification of genetic variants and phenotypic characterization of a large cohort of patients with congenital hypopituitarism and related disorders.
Gregory LC, Cionna C, Cerbone M, Dattani MT. Gregory LC, et al. Genet Med. 2023 Sep;25(9):100881. doi: 10.1016/j.gim.2023.100881. Epub 2023 May 8. Genet Med. 2023. PMID: 37165954 Free article.
RESULTS: We identified variants in 178 patients: GH1/GHRHR (51 patients of 414 screened), PROP1 (17 of 253), POU1F1 (15 of 139), SOX2 (13 of 59), GLI2 (7 of 106), LHX3/LHX4 (8 of 110), HESX1 (8 of 724), SOX3 (9 of 354), OTX2 (5 of 59), SHH (2 of 64), and TCF7L1, KAL1, FGFR1, and …
RESULTS: We identified variants in 178 patients: GH1/GHRHR (51 patients of 414 screened), PROP1 (17 of 253), POU1F1 (15 of 139), SOX2 (13 of …
Genetic spectrum of Kallmann syndrome: Single-center experience and systematic review.
Patil VA, Lila AR, Shah N, Arya S, Sarathi V, Shah R, Jadhav SS, Memon SS, Karlekar M, Bandgar T. Patil VA, et al. Clin Endocrinol (Oxf). 2022 Dec;97(6):804-813. doi: 10.1111/cen.14822. Epub 2022 Sep 30. Clin Endocrinol (Oxf). 2022. PMID: 36138264
The affected genes were FGFR1 (9.8%), ANOS1 (7.5%), PROKR2 (6.1%), CHD7 (5.4%), oligogenic (2.1%), and others <1% each (FGF8, SOX10, PROK2, SEMA3A, IL17RD, and GNRHR). FGFR1 and ANOS1 were the commonly affected genes globally, whereas PROKR2 was commonest in studies …
The affected genes were FGFR1 (9.8%), ANOS1 (7.5%), PROKR2 (6.1%), CHD7 (5.4%), oligogenic (2.1%), and others <1% each (FGF8, …
48 results