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2024 29
2025 5

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32 results

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Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing's sarcoma.
Kim YR, Joo J, Lee HJ, Kim C, Park JC, Yu YS, Kim CR, Lee DH, Cha J, Kwon H, Hanssen KM, Grünewald TGP, Choi M, Han I, Bae S, Jung I, Shin Y, Baek SH. Kim YR, et al. Nat Commun. 2024 Aug 3;15(1):6569. doi: 10.1038/s41467-024-51050-0. Nat Commun. 2024. PMID: 39095374 Free PMC article.
Through genome-wide chromatin structure and transcription profiling, we identify that the ARID1A condensate localizes to EWS/FLI1 target enhancers and induces long-range chromatin architectural changes by forming functional chromatin remodeling hubs at oncogenic target gen …
Through genome-wide chromatin structure and transcription profiling, we identify that the ARID1A condensate localizes to EWS/FLI1 tar …
EWSR1: the promiscuous king of mesenchymal neoplasia.
Towery EA, Papke DJ. Towery EA, et al. J Clin Pathol. 2024 Oct 20;77(11):721-725. doi: 10.1136/jcp-2023-208867. J Clin Pathol. 2024. PMID: 39209444 Review.
We also discuss recent data demonstrating the imperfect specificity of EWSR1::WT1 and, possibly, EWSR1::FLI1 fusions....
We also discuss recent data demonstrating the imperfect specificity of EWSR1::WT1 and, possibly, EWSR1::FLI1 fusions....
FLI1 promotes IFN-gamma-induced kynurenine production to impair anti-tumor immunity.
Chen E, Wu J, Huang J, Zhu W, Sun H, Wang X, Lin D, Li X, Shi D, Liu Z, Huang J, Chen M, Xie F, Deng W. Chen E, et al. Nat Commun. 2024 May 30;15(1):4590. doi: 10.1038/s41467-024-48397-9. Nat Commun. 2024. PMID: 38816360 Free PMC article.
In this study, we identify tumor-intrinsic FLI1 as a critical mediator in impairing T cell anti-tumor immunity. A mechanistic inquiry reveals that FLI1 orchestrates the expression of CBP and STAT1, facilitating chromatin accessibility and transcriptional activation …
In this study, we identify tumor-intrinsic FLI1 as a critical mediator in impairing T cell anti-tumor immunity. A mechanistic inquiry …
Oncogenic ETS fusions promote DNA damage and proinflammatory responses via pericentromeric RNAs in extracellular vesicles.
Ruzanov P, Evdokimova V, Pachva MC, Minkovich A, Zhang Z, Langman S, Gassmann H, Thiel U, Orlic-Milacic M, Zaidi SH, Peltekova V, Heisler LE, Sharma M, Cox ME, McKee TD, Zaidi M, Lapouble E, McPherson JD, Delattre O, Radvanyi L, Burdach SE, Stein LD, Sorensen PH. Ruzanov P, et al. J Clin Invest. 2024 Mar 26;134(9):e169470. doi: 10.1172/JCI169470. J Clin Invest. 2024. PMID: 38530366 Free PMC article.
We report here that both EWS:FLI1 and ERG bind and transcriptionally activate GGAA-rich pericentromeric heterochromatin. ...High human satellite 2 and 3 (HSAT2,3) levels in EWS:FLI1- or ERG-expressing cells and tumors were associated with induction of G2/M checkpoin …
We report here that both EWS:FLI1 and ERG bind and transcriptionally activate GGAA-rich pericentromeric heterochromatin. ...High huma …
Oncofusions - shaping cancer care.
Dashi G, Varjosalo M. Dashi G, et al. Oncologist. 2025 Jan 17;30(1):oyae126. doi: 10.1093/oncolo/oyae126. Oncologist. 2025. PMID: 38833619 Free PMC article. Review.
Notable examples such as BCR::ABL and EWS::FLI1 underscore their clinical significance. Several case studies exemplify the role of identifying and targeting oncofusions in guiding treatment decisions and improving patient outcomes. ...
Notable examples such as BCR::ABL and EWS::FLI1 underscore their clinical significance. Several case studies exemplify the role of id …
The potential crosstalk genes and molecular mechanisms between glioblastoma and periodontitis.
Huang JH, Chen Y, Kang YB, Yao ZJ, Song JH. Huang JH, et al. Sci Rep. 2024 Mar 12;14(1):5970. doi: 10.1038/s41598-024-56577-2. Sci Rep. 2024. PMID: 38472293 Free PMC article.
Additionally, immune cell landscape analysis revealed elevated expression levels of multiple immune cells in GBM and PD compared to controls, with the key crosstalk genes negatively associated with Macrophages M2. FLI1 was identified as a potential key transcription factor …
Additionally, immune cell landscape analysis revealed elevated expression levels of multiple immune cells in GBM and PD compared to controls …
Pharmacological targeting of P300/CBP reveals EWS::FLI1-mediated senescence evasion in Ewing sarcoma.
Wei E, Mitanoska A, O'Brien Q, Porter K, Molina M, Ahsan H, Jung U, Mills L, Kyba M, Bosnakovski D. Wei E, et al. Mol Cancer. 2024 Oct 5;23(1):222. doi: 10.1186/s12943-024-02115-7. Mol Cancer. 2024. PMID: 39367409 Free PMC article.
Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in targeting its main oncodriver, EWS::FLI1. We show that pharmacological targeting of the EWS::FLI1 transcriptional complex via inhibition of P300/CBP drives a global transcriptional …
Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in targeting its main oncodriver, EWS::FLI1. We sh …
Superficial Neurocristic EWSR1::FLI1 Fusion Tumor: A Distinctive, Clinically Indolent, S100 Protein/SOX10-Positive Neoplasm.
Folpe AL, Tetzlaff MT, Billings SD, Torres-Mora J, Borowsky AD, Santiago TC, Ameline B, Baumhoer D. Folpe AL, et al. Mod Pathol. 2024 Aug;37(8):100537. doi: 10.1016/j.modpat.2024.100537. Epub 2024 Jun 10. Mod Pathol. 2024. PMID: 38866368
We report a distinctive neoplasm of the skin and subcutis, harboring the Ewing sarcoma-associated EWSR1::FLI1 fusion but differing otherwise from Ewing sarcoma. Slides and blocks for 5 cutaneous neoplasms coded as other than Ewing sarcoma and harboring EWSR1::FLI1 w …
We report a distinctive neoplasm of the skin and subcutis, harboring the Ewing sarcoma-associated EWSR1::FLI1 fusion but differing ot …
EWS-FLI1 and Activator Protein-1 (AP-1) Reciprocally Regulate Extracellular-Matrix Proteins in Ewing sarcoma Cells.
Croushore EE, Stipp CS, Gordon DJ. Croushore EE, et al. Int J Mol Sci. 2024 Aug 6;25(16):8595. doi: 10.3390/ijms25168595. Int J Mol Sci. 2024. PMID: 39201282 Free PMC article.
AP-1 expression in Ewing sarcoma cells also drives, concurrent with these perturbations in gene and protein expression, changes in cell morphology and phenotype. We also identified that EWS-FLI1 dysregulates the expression of multiple AP-1 proteins, aligning with previous …
AP-1 expression in Ewing sarcoma cells also drives, concurrent with these perturbations in gene and protein expression, changes in cell morp …
32 results