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2020 1
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Page 1
Folic Acid and Autism: A Systematic Review of the Current State of Knowledge.
Hoxha B, Hoxha M, Domi E, Gervasoni J, Persichilli S, Malaj V, Zappacosta B. Hoxha B, et al. Cells. 2021 Aug 3;10(8):1976. doi: 10.3390/cells10081976. Cells. 2021. PMID: 34440744 Free PMC article.
Several authors report an increased frequency of serum auto-antibodies against folate receptor alpha (FRAA) in autism spectrum disorder children. Furthermore, methylene tetrahydrofolate reductase (MTHFR) polymorphisms showed a significant influence on ASD ris …
Several authors report an increased frequency of serum auto-antibodies against folate receptor alpha (FRAA) in autism s …
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression.
Schweizer L, Kenny HA, Krishnan R, Kelliher L, Bilecz AJ, Heide J, Donle L, Shimizu A, Metousis A, Mendoza R, Nordmann TM, Rauch S, Richter S, Li Y, Rosenberger FA, Strauss MT, Kurnit KC, Thielert M, Rodriguez E, Müller-Reif JB, Yamada SD, Theis FJ, Mund A, Lastra RR, Mann M, Lengyel E. Schweizer L, et al. Cancer Cell. 2025 Aug 11;43(8):1495-1511.e7. doi: 10.1016/j.ccell.2025.06.004. Epub 2025 Jun 26. Cancer Cell. 2025. PMID: 40578359
Combined treatment targeting CDK4/6 (milciclib) and FOLR1 (mirvetuximab) achieved significant tumor reduction in vivo, representing a promising therapeutic strategy for LGSC....
Combined treatment targeting CDK4/6 (milciclib) and FOLR1 (mirvetuximab) achieved significant tumor reduction in vivo, representing a …
Pilomatrix-like High-grade Endometrial Carcinoma: An Underdiagnosed Entity With Aggressive Clinicopathologic Features.
Zhou F, Qin L, Huang S, Lin W, Zhang H, Parkash V, Zheng W. Zhou F, et al. Am J Surg Pathol. 2025 Apr 9;49(8):818-829. doi: 10.1097/PAS.0000000000002402. Am J Surg Pathol. 2025. PMID: 40202384
PD-L1 expression in 4 tumors suggests potential responsiveness to immune checkpoint inhibitors, whereas low-level HER2 expression (1+ to 2+) in 5 tumors raises the possibility of HER2-targeted therapies. Folate receptor alpha was not expressed in any tumor. I …
PD-L1 expression in 4 tumors suggests potential responsiveness to immune checkpoint inhibitors, whereas low-level HER2 expression (1+ to 2+) …
Association of polymorphisms of FOLR1 gene and FOLR2 gene and maternal folic acid supplementation with risk of ventricular septal defect: a case-control study.
Song X, Wei J, Shu J, Liu Y, Sun M, Zhu P, Qin J. Song X, et al. Eur J Clin Nutr. 2022 Sep;76(9):1273-1280. doi: 10.1038/s41430-022-01110-9. Epub 2022 Mar 10. Eur J Clin Nutr. 2022. PMID: 35273364
We also observed genetic polymorphisms of FOLR1 gene at rs2071010 (GA vs. GG: aOR = 0.63, 95%CI: 0.45 to 0.88) and rs11235462 (AA vs. ...CONCLUSIONS: The maternal genetic polymorphisms of the FOLR1 gene and FOLR2 gene, as well as FAS and their interactions, were sho …
We also observed genetic polymorphisms of FOLR1 gene at rs2071010 (GA vs. GG: aOR = 0.63, 95%CI: 0.45 to 0.88) and rs11235462 (AA vs. …
Characterizing the genomic landscape through the lens of FOLR1 status in low and high grade serous ovarian carcinoma.
Rushton T, Krause HB, Samec T, Elliott A, Karnezis AN, Toboni MD, Thaker PH, Braxton DR, Oberley M, Gershenson DM, Armstrong DK. Rushton T, et al. Gynecol Oncol. 2024 Dec;191:80-85. doi: 10.1016/j.ygyno.2024.09.021. Epub 2024 Oct 3. Gynecol Oncol. 2024. PMID: 39366033
OBJECTIVE: Targeted therapy in folate receptor alpha (FOLR1)-positive high grade serous ovarian carcinoma (HGSOC) is now a mainstay for platinum-resistant disease. ...FOLR1- LGSOC and HGSOC had similar prevalences of T cell-inflamed tumors, thou …
OBJECTIVE: Targeted therapy in folate receptor alpha (FOLR1)-positive high grade serous ovarian carcinoma (HGSOC …
Tandem CAR-T cells targeting FOLR1 and MSLN enhance the antitumor effects in ovarian cancer.
Liang Z, Dong J, Yang N, Li SD, Yang ZY, Huang R, Li FJ, Wang WT, Ren JK, Lei J, Xu C, Wang D, Wang YZ, Liang ZQ. Liang Z, et al. Int J Biol Sci. 2021 Oct 22;17(15):4365-4376. doi: 10.7150/ijbs.63181. eCollection 2021. Int J Biol Sci. 2021. PMID: 34803504 Free PMC article.
Twenty coexpressed upregulated genes were identified from the GEO database, and we found FOLR1 (folate receptor 1) and MSLN (mesothelin) were specifically and highly expressed in cancer tissues and only 11.25% of samples were negative for both antigens. ...Furthermore, the …
Twenty coexpressed upregulated genes were identified from the GEO database, and we found FOLR1 (folate receptor 1) and MSLN (mesothel …
Reinforcing one-carbon metabolism via folic acid/Folr1 promotes beta-cell differentiation.
Karampelias C, Rezanejad H, Rosko M, Duan L, Lu J, Pazzagli L, Bertolino P, Cesta CE, Liu X, Korbutt GS, Andersson O. Karampelias C, et al. Nat Commun. 2021 Jun 7;12(1):3362. doi: 10.1038/s41467-021-23673-0. Nat Commun. 2021. PMID: 34099692 Free PMC article.
Here, we performed a genetic screen in a zebrafish model of beta-cell loss to identify pathways promoting beta-cell regeneration. We found that both folate receptor 1 (folr1) overexpression and treatment with folinic acid, stimulated beta-cell differentiation in zebrafish. …
Here, we performed a genetic screen in a zebrafish model of beta-cell loss to identify pathways promoting beta-cell regeneration. We found t …
Quantitative proteomics identifies FOLR1 to drive sorafenib resistance via activating autophagy in hepatocellular carcinoma cells.
Chu H, Wu C, Zhao Q, Sun R, Yang K, Zhao B, Liu Y, Liang Z, Zhong S, Zhang L, Zhang Y. Chu H, et al. Carcinogenesis. 2021 May 28;42(5):753-761. doi: 10.1093/carcin/bgab019. Carcinogenesis. 2021. PMID: 33677528
Among them, 89 were differentially expressed and highly enriched in the processes of cell-cell adhesion, negative regulation of apoptosis, response to drug and metabolic processes involving in sorafenib resistance. Notably, folate receptor alpha (FOLR1 …
Among them, 89 were differentially expressed and highly enriched in the processes of cell-cell adhesion, negative regulation of apoptosis, r …
CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Le Q, Hadland B, Smith JL, Leonti A, Huang BJ, Ries R, Hylkema TA, Castro S, Tang TT, McKay CN, Perkins L, Pardo L, Sarthy J, Beckman AK, Williams R, Idemmili R, Furlan S, Ishida T, Call L, Srivastava S, Loeb AM, Milano F, Imren S, Morris SM, Pakiam F, Olson JM, Loken MR, Brodersen L, Riddell SR, Tarlock K, Bernstein ID, Loeb KR, Meshinchi S. Le Q, et al. J Clin Invest. 2022 Nov 15;132(22):e157101. doi: 10.1172/JCI157101. J Clin Invest. 2022. PMID: 36136600 Free PMC article.
We developed chimeric antigen receptor (CAR) T cells directed against one of the targets, folate receptor alpha (FOLR1), and demonstrated their preclinical efficacy against C/G AML using in vitro and xenograft models. FOLR1 is also expressed in …
We developed chimeric antigen receptor (CAR) T cells directed against one of the targets, folate receptor alpha (FOL …
Mutational analysis of FOLR1 and FOLR2 genes in children with Myelomeningocele.
Hussain N, Malik S, Faiz T, Shafqat F, Khan AA, Haq TU, Ali W, Aziz T, Alharbi M, Alshammari A, Alasmari AF. Hussain N, et al. Acta Biochim Pol. 2023 Oct 26;70(4):885-889. doi: 10.18388/abp.2020_6729. Acta Biochim Pol. 2023. PMID: 37883728 Free article.
This study focused on the mutational analysis of FOLR1 and FOLR2 genes in children suffering from MMC. Myelomeningocele is a rare disorder so twenty blood samples from the children were collected. ...Sanger sequencing method was performed to confirm mutation in FOLR1 …
This study focused on the mutational analysis of FOLR1 and FOLR2 genes in children suffering from MMC. Myelomeningocele is a rare dis …
44 results