Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2021 9
2022 11
2023 4
2024 8
2025 14
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

44 results

Results by year

Filters applied: . Clear all
Page 1
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Lin F, Li X, Wang X, Sun H, Wang Z, Wang X. Lin F, et al. J Exp Clin Cancer Res. 2022 Apr 7;41(1):129. doi: 10.1186/s13046-022-02315-3. J Exp Clin Cancer Res. 2022. PMID: 35392966 Free PMC article.
Moreover, STC1 was directly regulated by Forkhead box C2 (FOXC2) in OC. Notably, targeting STC1 and the FOXC2/ITGB6 signaling axis was related to DDP chemoresistance in vitro. CONCLUSIONS: Overall, these findings revealed that STC1 promoted meta …
Moreover, STC1 was directly regulated by Forkhead box C2 (FOXC2) in OC. Notably, targeting STC1 and the FOXC2 …
Vasculogenic skin reprogramming requires TET-mediated gene demethylation in fibroblasts for rescuing impaired perfusion in diabetes.
Mohanty SK, Singh K, Kumar M, Verma SS, Srivastava R, Gnyawali SC, Palakurti R, Sahi AK, El Masry MS, Banerjee P, Kacar S, Rustagi Y, Verma P, Ghatak S, Hernandez E, Rubin JP, Khanna S, Roy S, Yoder MC, Sen CK. Mohanty SK, et al. Nat Commun. 2024 Nov 27;15(1):10277. doi: 10.1038/s41467-024-54385-w. Nat Commun. 2024. PMID: 39604331 Free PMC article.
Tissue nanotransfection (TNT) topically delivers Etv2, Foxc2, and Fli1 (EFF) plasmids increasing vasculogenic fibroblasts (VF) and promoting vascularization in ischemic murine skin. ...
Tissue nanotransfection (TNT) topically delivers Etv2, Foxc2, and Fli1 (EFF) plasmids increasing vasculogenic fibroblasts (VF) and pr …
Oncogenic functions of the FOXC2 transcription factor: a hallmarks of cancer perspective.
Hargadon KM, Goodloe TB 3rd, Lloyd ND. Hargadon KM, et al. Cancer Metastasis Rev. 2022 Dec;41(4):833-852. doi: 10.1007/s10555-022-10045-3. Epub 2022 Jun 14. Cancer Metastasis Rev. 2022. PMID: 35701636 Review.
In addition to highlighting the clinical impact of aberrant FOXC2 activity in cancer, we discuss mechanisms by which this transcription factor becomes dysregulated in both tumor and tumor-associated cells, placing particular emphasis on the ways in which FOXC2 promo …
In addition to highlighting the clinical impact of aberrant FOXC2 activity in cancer, we discuss mechanisms by which this transcripti …
Molecular Mechanisms Regulating Epithelial Mesenchymal Transition (EMT) to Promote Cancer Progression.
Ghafoor S, Garcia E, Jay DJ, Persad S. Ghafoor S, et al. Int J Mol Sci. 2025 May 3;26(9):4364. doi: 10.3390/ijms26094364. Int J Mol Sci. 2025. PMID: 40362600 Free PMC article. Review.
This reprogramming is initiated and controlled by various signaling pathways and governed by several key transcription factors, including Snail 1, Snail 2 (Slug), TWIST 1, TWIST2, ZEB1, ZEB2, PRRX1, GOOSECOID, E47, FOXC2, SOX4, SOX9, HAND1, and HAND2. The intracellular sig …
This reprogramming is initiated and controlled by various signaling pathways and governed by several key transcription factors, including Sn …
Identification of quiescent FOXC2(+) spermatogonial stem cells in adult mammals.
Wang Z, Jin C, Li P, Li Y, Tang J, Yu Z, Jiao T, Ou J, Wang H, Zou D, Li M, Mang X, Liu J, Lu Y, Li K, Zhang N, Yu J, Miao S, Wang L, Song W. Wang Z, et al. Elife. 2023 Aug 23;12:RP85380. doi: 10.7554/eLife.85380. Elife. 2023. PMID: 37610429 Free PMC article.
Using single-cell analysis and lineage tracing, we discovered both in mice and humans the quiescent adult SSC subpopulation marked specifically by forkhead box protein C2 (FOXC2). All spermatogenic progenies can be derived from FOXC2(+) SSCs and the ablation of F …
Using single-cell analysis and lineage tracing, we discovered both in mice and humans the quiescent adult SSC subpopulation marked specifica …
FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells.
Yan J, Liu J, Huang Z, Huang W, Lv J. Yan J, et al. Hum Cell. 2021 Nov;34(6):1755-1764. doi: 10.1007/s13577-021-00583-3. Epub 2021 Jul 29. Hum Cell. 2021. PMID: 34324140
Functionally, knockdown of FOXC2-AS1 attenuated the proliferation, migration and invasion of GC cells, whereas overexpression of FOXC2-AS1 showed the opposite effects. Further investigation revealed that FOXC2-AS1 interacted with FOXC2 mRNA and repress …
Functionally, knockdown of FOXC2-AS1 attenuated the proliferation, migration and invasion of GC cells, whereas overexpression of F …
Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations.
Missaglia S, Tavian D, Michelini S, Maltese PE, Bonanomi A, Bertelli M. Missaglia S, et al. Genes (Basel). 2021 Apr 27;12(5):650. doi: 10.3390/genes12050650. Genes (Basel). 2021. PMID: 33925370 Free PMC article.
Forkhead-box C2 (FOXC2) is a transcription factor involved in lymphatic system development. FOXC2 mutations cause Lymphedema-distichiasis syndrome (LD). Recently, a natural antisense was identified, called lncRNA FOXC2-AS1, which increase …
Forkhead-box C2 (FOXC2) is a transcription factor involved in lymphatic system development. FOXC2 mutatio …
The effects of FOXC2-gene-manipulated human periodontal ligament stem cells on bone regeneration of craniofacial bone defect.
Chen Y, Zhang X, Tang Y, Yang Y, Wu Z, Lai W, Long H. Chen Y, et al. Dent Mater. 2025 Jun;41(6):708-720. doi: 10.1016/j.dental.2025.03.009. Epub 2025 Apr 14. Dent Mater. 2025. PMID: 40234127
As one of the ideal seed cells, the induction of human periodontal ligament stem cells (hPDLSCs) into osteoblasts has become a focus in current research. Forkhead box C2 (FOXC2) may be a good candidate gene for bone regeneration. Therefore, the aim of …
As one of the ideal seed cells, the induction of human periodontal ligament stem cells (hPDLSCs) into osteoblasts has become a focus in curr …
Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival.
Ulanja MB, Moody AE, Beutler BD, Antwi-Amoabeng D, Rahman GA, Alese OB. Ulanja MB, et al. Oncotarget. 2022 Jun 15;13:828-841. doi: 10.18632/oncotarget.28242. eCollection 2022. Oncotarget. 2022. PMID: 35720978 Free PMC article. Review.
MATERIALS AND METHODS: Using PubMed and Medline, the following terms were searched and relevant citations assessed: "early onset pancreatic cancer," "late onset pancreatic cancer," "pancreatic cancer," "pancreatic cancer genes," and "pancreatic cancer targeted therapy." RESULTS: …
MATERIALS AND METHODS: Using PubMed and Medline, the following terms were searched and relevant citations assessed: "early onset pancreatic …
A role for pH dynamics regulating transcription factor DNA-binding selectivity.
Kisor KP, Ruiz DG, Jacobson MP, Barber DL. Kisor KP, et al. Nucleic Acids Res. 2025 May 22;53(10):gkaf474. doi: 10.1093/nar/gkaf474. Nucleic Acids Res. 2025. PMID: 40464693 Free PMC article.
For FOXC2, we also find that greater activity for an FkhP motif at lower pH is dependent on a conserved histidine (His122) in the DBD. ChIP-seq and RNA-seq with FOXC2 also reveal pH-dependent differences in enriched promoter motifs. Our findings identify pH-regulate …
For FOXC2, we also find that greater activity for an FkhP motif at lower pH is dependent on a conserved histidine (His122) in the DBD …
44 results