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2016 2
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83 results

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Page 1
TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation.
Wei S, Huang X, Zhu Q, Chen T, Zhang Y, Tian J, Pan T, Zhang L, Xie T, Zhang Q, Kuang X, Lei E, Li Y. Wei S, et al. Cell Death Differ. 2024 Nov;31(11):1422-1438. doi: 10.1038/s41418-024-01336-z. Epub 2024 Jun 29. Cell Death Differ. 2024. PMID: 38951701 Free PMC article.
The degradation of NUDT21 subsequently altered the length and sequence content of the 3'UTR (3'UTR-APA) of several pro-fibrotic genes including Col1a1, Fn-1, Tgfbr1, Wnt5a, and Fzd2. Furthermore, reducing NUDT21 expression via hydrodynamic renal pelvis injection of adeno-a …
The degradation of NUDT21 subsequently altered the length and sequence content of the 3'UTR (3'UTR-APA) of several pro-fibrotic genes includ …
Histamine N-methyltransferase upregulation, cardiac hypertrophy, and heart failure.
Zhang J, Jiang H, Liu L, Li X, Hong W, Xu L, Dong Z, Xu Z, Gao J, Sun X, Luo W, Liu J, Song Y, Wang P, Zhang J, Cui Y, Huang L, Zhou X, Zhang Y, Hu K, Yang J, Ge J, Sun A. Zhang J, et al. Eur Heart J. 2026 May 18;47(19):2345-2363. doi: 10.1093/eurheartj/ehaf1065. Eur Heart J. 2026. PMID: 41568626 Free PMC article.
Mechanistically, HNMT reduced intracellular S-adenosylmethionine (SAM) and impaired enhancer of zeste homologue 2 (EZH2) function, decreasing histone 3 lysine 27 trimethylation (H3K27me3) modification at the frizzled-2 (Fzd2) promoter. FZD2 up-regulati …
Mechanistically, HNMT reduced intracellular S-adenosylmethionine (SAM) and impaired enhancer of zeste homologue 2 (EZH2) function, decreasin …
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation.
Chidiac R, Yang A, Kubarakos E, Mikolajewicz N, Han H, Almeida MP, Thibeault PE, Lin S, MacLeod G, Gratton JP, Moffat J, Angers S. Chidiac R, et al. Stem Cell Reports. 2025 Feb 11;20(2):102391. doi: 10.1016/j.stemcr.2024.102391. Epub 2025 Jan 16. Stem Cell Reports. 2025. PMID: 39824186 Free PMC article.
Specifically, FZD7 activation enhances both paraxial and lateral mesoderm differentiation, whereas FZD2 activation favors paraxial mesoderm. Mechanistically, FZD2 activation promotes sustained Wnt-beta-catenin levels, guiding hPSCs differentiation toward paraxial me …
Specifically, FZD7 activation enhances both paraxial and lateral mesoderm differentiation, whereas FZD2 activation favors paraxial me …
Fzd2 orchestrates canonical and non-canonical Wnt signaling to regulate lung development and fibrosis.
Zhou J, Lou X, Wei Z, Mao X, Zhang J, Jin X, Li B, Zheng C, Siwu X, Yang Y, Zhang Y, Chen W, Jiang M. Zhou J, et al. Cell Commun Signal. 2025 Nov 19;23(1):498. doi: 10.1186/s12964-025-02501-8. Cell Commun Signal. 2025. PMID: 41257888 Free PMC article.
Here, we identify distinct, spatiotemporal expression patterns of Wnt ligands and Frizzled receptors in the developing lung, with Fzd2 broadly expressed in epithelial, mesenchymal, and endothelial compartments. Using conditional knockout models, we demonstrate that Fzd2 …
Here, we identify distinct, spatiotemporal expression patterns of Wnt ligands and Frizzled receptors in the developing lung, with Fzd2 …
FZD2 regulates cell proliferation and invasion in tongue squamous cell carcinoma.
Huang L, Luo EL, Xie J, Gan RH, Ding LC, Su BH, Zhao Y, Lin LS, Zheng DL, Lu YG. Huang L, et al. Int J Biol Sci. 2019 Aug 24;15(11):2330-2339. doi: 10.7150/ijbs.33881. eCollection 2019. Int J Biol Sci. 2019. PMID: 31595151 Free PMC article.
The upregulation of FZD2 in clinical tongue cancer tissues was validated by real-time PCR. Knockdown of FZD2 inhibited the proliferation, migration and invasion of CAL-27 and TCA-8113 cells, whereas overexpression of FZD2 led to the opposite results. ...These …
The upregulation of FZD2 in clinical tongue cancer tissues was validated by real-time PCR. Knockdown of FZD2 inhibited the pro …
FZD2 regulates limb development by mediating beta-catenin-dependent and -independent Wnt signaling pathways.
Zhu X, Xu M, Leu NA, Morrisey EE, Millar SE. Zhu X, et al. Dis Model Mech. 2023 Mar 1;16(3):dmm049876. doi: 10.1242/dmm.049876. Epub 2023 Mar 24. Dis Model Mech. 2023. PMID: 36867021 Free PMC article.
Human Robinow syndrome (RS) and dominant omodysplasia type 2 (OMOD2), characterized by skeletal limb and craniofacial defects, are associated with heterozygous mutations in the Wnt receptor FZD2. However, as FZD2 can activate both canonical and non-canonical Wnt pat …
Human Robinow syndrome (RS) and dominant omodysplasia type 2 (OMOD2), characterized by skeletal limb and craniofacial defects, are associate …
MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2.
Zhou Y, Yang G, Liu J, Yao S, Jia J, Tang X, Gong X, Wan F, Wu R, Zhao Z, Liang H, Liu L, Liu Q, Xie S, Long X, Xiang X, Wang G, Xiao B. Zhou Y, et al. Biochim Biophys Acta Mol Basis Dis. 2025 Jun;1871(5):167798. doi: 10.1016/j.bbadis.2025.167798. Epub 2025 Mar 12. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 40081619
TGF-beta induced EMT and elevated MBD2 expressions in alveolar epithelial cells, which was mitigated by MBD2 knockdown and aggravated by MBD2 overexpression. Frizzled 2 (FZD2) was found to be the potential target of MBD2. Single-cell sequencing analysis of AR …
TGF-beta induced EMT and elevated MBD2 expressions in alveolar epithelial cells, which was mitigated by MBD2 knockdown and aggravated by MBD …
Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance.
Yin P, Wang W, Gao J, Bai Y, Wang Z, Na L, Sun Y, Zhao C. Yin P, et al. Oncol Res. 2020 May 29;28(3):273-284. doi: 10.3727/096504020X15783052025051. Epub 2020 Jan 6. Oncol Res. 2020. PMID: 31907106 Free PMC article.
Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced human breast cancer (BC) cell stemness via noncanonical Wnt pathways …
Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 …
The Significance of the Wnt/β-Catenin Pathway and Related Proteins in Gastrointestinal Malignancies.
Romanowicz A, Łukaszewicz-Zając M. Romanowicz A, et al. Int J Mol Sci. 2025 Aug 22;26(17):8130. doi: 10.3390/ijms26178130. Int J Mol Sci. 2025. PMID: 40943055 Free PMC article. Review.
Esophageal cancer specimens exhibit co-overexpression of Wnt2 and Wnt5A, as well as receptors such as FZD2 and FZD6, which are linked to worse prognosis and reduced survival. Liver cancer tissue commonly harbors CTNNB1 mutations, which encode beta-catenin and are associate …
Esophageal cancer specimens exhibit co-overexpression of Wnt2 and Wnt5A, as well as receptors such as FZD2 and FZD6, which are linked …
Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma.
Han Z, Ren H, Sun J, Jin L, Wang Q, Guo C, Tian Z. Han Z, et al. J Transl Med. 2022 Jan 5;20(1):15. doi: 10.1186/s12967-021-03204-7. J Transl Med. 2022. PMID: 34986855 Free PMC article.
According to immunohistochemistry (IHC) staining, the expression level of FZD2 was higher in low-grade IMPA than in high-grade IMPA. CONCLUSION: FZD2 shows an expression dynamic that is negatively correlated with the clinical malignancy of IMPA and it plays a centra …
According to immunohistochemistry (IHC) staining, the expression level of FZD2 was higher in low-grade IMPA than in high-grade IMPA. …
83 results