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Year Number of Results
2013 7
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93 results
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Expression and prognostic impact of FZDs in pancreatic adenocarcinoma.
Li Y, Liu Z, Zhang Y. Li Y, et al. BMC Gastroenterol. 2021 Feb 22;21(1):79. doi: 10.1186/s12876-021-01643-6. BMC Gastroenterol. 2021. PMID: 33618667 Free PMC article.
We aimed to investigate the expression level, mutation, and clinical significance of the Frizzled (FZD) family in PAAD so as to establish a sufficient scientific evidence for clinical decisions and risk management. ...RESULTS: In total, 179 PAAD tissues and 171 paracancero …
We aimed to investigate the expression level, mutation, and clinical significance of the Frizzled (FZD) family in PAAD so as to estab …
FZD5 prevents epithelial-mesenchymal transition in gastric cancer.
Dong D, Na L, Zhou K, Wang Z, Sun Y, Zheng Q, Gao J, Zhao C, Wang W. Dong D, et al. Cell Commun Signal. 2021 Feb 22;19(1):21. doi: 10.1186/s12964-021-00708-z. Cell Commun Signal. 2021. PMID: 33618713 Free PMC article.
BACKGROUND: Frizzled (FZD) proteins function as receptors for WNT ligands. Members in FZD family including FZD2, FZD4, FZD7, FZD8 and FZD10 have been demonstrated to mediate cancer cell epithelial-mesenchymal transition (EMT). ...
BACKGROUND: Frizzled (FZD) proteins function as receptors for WNT ligands. Members in FZD family including FZD2, FZD4, FZD7, F …
Elevated Wnt2 and Wnt4 activate NF-κB signaling to promote cardiac fibrosis by cooperation of Fzd4/2 and LRP6 following myocardial infarction.
Yin C, Ye Z, Wu J, Huang C, Pan L, Ding H, Zhong L, Guo L, Zou Y, Wang X, Wang Y, Gao P, Jin X, Yan X, Zou Y, Huang R, Gong H. Yin C, et al. EBioMedicine. 2021 Dec;74:103745. doi: 10.1016/j.ebiom.2021.103745. Epub 2021 Dec 12. EBioMedicine. 2021. PMID: 34911029 Free PMC article.
In addition, Wnt2 or Wnt4 upregulated the expression of these Wnt co-receptors, frizzled (Fzd) 2, Fzd4 and (low-density lipoprotein receptor-related protein 6 (LRP6). Further analysis revealed that Wnt2 or Wnt4 activated beta-catenin /NF-kappaB by the co-operation o …
In addition, Wnt2 or Wnt4 upregulated the expression of these Wnt co-receptors, frizzled (Fzd) 2, Fzd4 and (low-density lipopr …
FZD2 regulates cell proliferation and invasion in tongue squamous cell carcinoma.
Huang L, Luo EL, Xie J, Gan RH, Ding LC, Su BH, Zhao Y, Lin LS, Zheng DL, Lu YG. Huang L, et al. Int J Biol Sci. 2019 Aug 24;15(11):2330-2339. doi: 10.7150/ijbs.33881. eCollection 2019. Int J Biol Sci. 2019. PMID: 31595151 Free PMC article.
According to TCGA-HNSC dataset, among the 10 Frizzled receptors, FZD2 exhibited the highest degree of differential expression between cancer tissues and normal tissues, and the overall survival of patients with higher FZD2 levels was shown to be significantly …
According to TCGA-HNSC dataset, among the 10 Frizzled receptors, FZD2 exhibited the highest degree of differential expression …
Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance.
Yin P, Wang W, Gao J, Bai Y, Wang Z, Na L, Sun Y, Zhao C. Yin P, et al. Oncol Res. 2020 May 29;28(3):273-284. doi: 10.3727/096504020X15783052025051. Epub 2020 Jan 6. Oncol Res. 2020. PMID: 31907106 Free PMC article.
Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced human breast cancer (BC) cell stemness via noncanonical Wnt p …
Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 …
FZD2 inhibits the cell growth and migration of salivary adenoid cystic carcinomas.
Ding LC, Huang XY, Zheng FF, Xie J, She L, Feng Y, Su BH, Zheng DL, Lu YG. Ding LC, et al. Oncol Rep. 2016 Feb;35(2):1006-12. doi: 10.3892/or.2015.3811. Epub 2015 Feb 19. Oncol Rep. 2016. PMID: 25695658
Immunohistochemical staining was used to detect the expression of FZD2 in clinical SACC samples with or without metastasis. Cell proliferation and Transwell assays were performed to explore the effects of FZD2 on cell growth and migration following the silencing of …
Immunohistochemical staining was used to detect the expression of FZD2 in clinical SACC samples with or without metastasis. Cell prol …
Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma.
Han Z, Ren H, Sun J, Jin L, Wang Q, Guo C, Tian Z. Han Z, et al. J Transl Med. 2022 Jan 5;20(1):15. doi: 10.1186/s12967-021-03204-7. J Transl Med. 2022. PMID: 34986855 Free PMC article.
According to immunohistochemistry (IHC) staining, the expression level of FZD2 was higher in low-grade IMPA than in high-grade IMPA. CONCLUSION: FZD2 shows an expression dynamic that is negatively correlated with the clinical malignancy of IMPA and it plays a centra …
According to immunohistochemistry (IHC) staining, the expression level of FZD2 was higher in low-grade IMPA than in high-grade IMPA. …
Analysis of the role of Frizzled 2 in different cancer types.
Zhou M, Sun X, Zhu Y. Zhou M, et al. FEBS Open Bio. 2021 Apr;11(4):1195-1208. doi: 10.1002/2211-5463.13111. Epub 2021 Feb 25. FEBS Open Bio. 2021. PMID: 33565732 Free PMC article.
Frizzled 2 (FZD2) is an important receptor in the Wnt pathway, which is highly expressed in malignant tumors and helps regulate multiple tumor behaviors. ...Here, bioinformatic analysis was performed to understand the expression of FZD2 in different tu …
Frizzled 2 (FZD2) is an important receptor in the Wnt pathway, which is highly expressed in malignant tumors and helps …
Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma.
Asano T, Yamada S, Fuchs BC, Takami H, Hayashi M, Sugimoto H, Fujii T, Tanabe KK, Kodera Y. Asano T, et al. Int J Oncol. 2017 May;50(5):1647-1654. doi: 10.3892/ijo.2017.3937. Epub 2017 Mar 27. Int J Oncol. 2017. PMID: 28350091
The epithelial-to-mesenchymal transition (EMT) is an initial, critical step in hepatocellular carcinoma (HCC) tumor invasion and metastasis. Frizzled 2 (Fzd2) expression might drive EMT through the non-canonical Wnt pathway, one of the various EMT signaling p …
The epithelial-to-mesenchymal transition (EMT) is an initial, critical step in hepatocellular carcinoma (HCC) tumor invasion and metastasis. …
Frizzled 2-induced epithelial-mesenchymal transition correlates with vasculogenic mimicry, stemness, and Hippo signaling in hepatocellular carcinoma.
Ou H, Chen Z, Xiang L, Fang Y, Xu Y, Liu Q, Hu Z, Li X, Huang Y, Yang D. Ou H, et al. Cancer Sci. 2019 Apr;110(4):1169-1182. doi: 10.1111/cas.13949. Epub 2019 Mar 6. Cancer Sci. 2019. PMID: 30677195 Free PMC article.
Prior observation has indicated that Frizzled 2 (FZD2)-induced epithelial-mesenchymal transition (EMT) could be a key step in metastasis and early recurrence of hepatocellular carcinoma (HCC). ...We found that FZD2 was highly expressed in two cohorts o …
Prior observation has indicated that Frizzled 2 (FZD2)-induced epithelial-mesenchymal transition (EMT) could be a key s …
93 results