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Construction of Fzd6(Q152E )mice through CRISPR/Cas9 technology and their reproduction and identification.
Yan X, Yang J, Xiao L, Gao J, Xu G, Wang L, Qi Y, Song G. Yan X, et al. Mol Biol Rep. 2022 Oct;49(10):9575-9584. doi: 10.1007/s11033-022-07848-6. Epub 2022 Aug 18. Mol Biol Rep. 2022. PMID: 35980530
BACKGROUND: The CRISPR/Cas9 system is widely used for genome editing in human, rat and mouse cells. In this study, we established Fzd6 mutant mice using CRISPR/Cas9 technology, and obtained Fzd6 homozygous mutant (Fzd6(Q152E)) mice through breeding. ...CONCLU …
BACKGROUND: The CRISPR/Cas9 system is widely used for genome editing in human, rat and mouse cells. In this study, we established Fzd6 …
Targeting FZD6 creates therapeutically actionable vulnerabilities for advanced prostate cancer.
Li Y, Zhou Z, Zhang Y, Jia D, Wang D, Reiger MC, Creighton CJ, Nelson PS, Corey E, Morrissey C, Xin L. Li Y, et al. Oncogene. 2025 Dec;44(50):4868-4877. doi: 10.1038/s41388-025-03631-6. Epub 2025 Nov 24. Oncogene. 2025. PMID: 41286306 Free PMC article.
Knockdown of FZD6 suppresses both in vitro and in vivo growth of various prostate cancer cell lines and patient-derived xenograft models. ...Knockdown of FZD6 enhances the therapeutic efficacy of genotoxic agents for prostate cancer cells. ...
Knockdown of FZD6 suppresses both in vitro and in vivo growth of various prostate cancer cell lines and patient-derived xenograft mod …
FZD6 promotes 5-fluorouracil resistance through inhibiting pyroptosis in colorectal cancer.
He Z, Yang J, Zhang Y, Zhang T, Guo T, Jin L, Mao Y, Wang T. He Z, et al. Carcinogenesis. 2025 Sep 4;46(3):bgaf041. doi: 10.1093/carcin/bgaf041. Carcinogenesis. 2025. PMID: 40810359
Finally, beta-catenin knockdown enhanced pyroptosis and decreased 5-FU resistance. Thus, FZD6 promotes 5-FU resistance in CRC cells by inhibiting pyroptosis through increased nuclear translocation of beta-catenin. This study provides the first evidence that FZD6 reg …
Finally, beta-catenin knockdown enhanced pyroptosis and decreased 5-FU resistance. Thus, FZD6 promotes 5-FU resistance in CRC cells b …
The Significance of the Wnt/β-Catenin Pathway and Related Proteins in Gastrointestinal Malignancies.
Romanowicz A, Łukaszewicz-Zając M. Romanowicz A, et al. Int J Mol Sci. 2025 Aug 22;26(17):8130. doi: 10.3390/ijms26178130. Int J Mol Sci. 2025. PMID: 40943055 Free PMC article. Review.
Esophageal cancer specimens exhibit co-overexpression of Wnt2 and Wnt5A, as well as receptors such as FZD2 and FZD6, which are linked to worse prognosis and reduced survival. Liver cancer tissue commonly harbors CTNNB1 mutations, which encode beta-catenin and are associate …
Esophageal cancer specimens exhibit co-overexpression of Wnt2 and Wnt5A, as well as receptors such as FZD2 and FZD6, which are linked …
miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6.
Hong SA, Lee S, Park J, Hong M, Yoon JS, Lee H, Lee JH, Kim S, Won HS, Kang K, Ko YH, Ahn YH. Hong SA, et al. Sci Rep. 2023 Oct 14;13(1):17480. doi: 10.1038/s41598-023-44716-0. Sci Rep. 2023. PMID: 37838767 Free PMC article.
Using the 3'-untranslated region (UTR) luciferase assay, Frizzled-6 (FZD6) was confirmed to be a direct target of miR-199a/b in GC cells. siRNA-mediated depletion of FZD6 enhanced the motility of SNU601 cells, and addback of FZD6 restored cancer …
Using the 3'-untranslated region (UTR) luciferase assay, Frizzled-6 (FZD6) was confirmed to be a direct target of miR-1 …
CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/beta-catenin signaling pathway.
Han H, Xu M, Wang J, Li MD, Yang Z. Han H, et al. J Adv Res. 2024 Apr;58:129-138. doi: 10.1016/j.jare.2023.06.001. Epub 2023 Jun 14. J Adv Res. 2024. PMID: 37321345 Free PMC article.
OBJECTIVES: To demonstrate Frizzled class receptor 6 (FZD6) functions in depression through disrupting Wnt/beta-catenin signal pathway. METHODS: The FZD6 edited cell line and mouse model were generated by using CRISPR/Cas9 technique. ...RESULTS: Among patients with …
OBJECTIVES: To demonstrate Frizzled class receptor 6 (FZD6) functions in depression through disrupting Wnt/beta-catenin signal pathwa …
FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt/beta-catenin signaling to drive cervical cancer proliferation, invasion, and EMT.
Wang T, Li W, Ye B, Zhang S, Lei X, Zhang D. Wang T, et al. J BUON. 2021 Jul-Aug;26(4):1279-1291. J BUON. 2021. PMID: 34564982 Free article.
However, the role of FZD6 in CC is unknown. The present study explored the function of FZD6 and its mechanism in CC. ...Luciferase reporter analysis, FISH, subcellular fractionation, chromatin immunoprecipitation and RNA immunoprecipitation were performed for invest …
However, the role of FZD6 in CC is unknown. The present study explored the function of FZD6 and its mechanism in CC. ...Lucife …
Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2.
Feng T, Zhang Q, Li SH, Ping YL, Tian MQ, Zhou SH, Wang X, Wang JM, Liang FR, Yu SG, Wu QF. Feng T, et al. Elife. 2024 May 21;12:RP92645. doi: 10.7554/eLife.92645. Elife. 2024. PMID: 38770735 Free PMC article.
Furthermore, bioinformatics analysis and experimental validation identified Gcnt2 and Fzd6 as potential target genes of MiR-199b-5p. Thus, these results indicated that MiR-199b-5p/Gcnt2 and Fzd6 axis might be a novel therapeutic target for the treatment of OA....
Furthermore, bioinformatics analysis and experimental validation identified Gcnt2 and Fzd6 as potential target genes of MiR-199b-5p. …
Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing.
Shah R, Amador C, Poe AJ, Spektor TM, Bhandary P, Wang Y, Wang ZP, Weisenberger DJ, Borges VF, Sawant OB, Maguen E, Hamrah P, Kramerov AA, Saghizadeh M, Ljubimov AV. Shah R, et al. Invest Ophthalmol Vis Sci. 2025 Feb 3;66(2):64. doi: 10.1167/iovs.66.2.64. Invest Ophthalmol Vis Sci. 2025. PMID: 39998459 Free PMC article.

RESULTS: Single-cell RNA sequencing analysis revealed differential gene expression of Wnt receptors, ROR2, MCAM, FZD5, FZD6, and FZD7. DNA methylation arrays showed hypomethylation of ROR2 gene promoter in diabetic versus non-diabetic LECs by 41.3% (**P < 0.01) resultin

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RESULTS: Single-cell RNA sequencing analysis revealed differential gene expression of Wnt receptors, ROR2, MCAM, FZD5, FZD6, and FZD7 …
FZD6 triggers Wnt-signalling driven by WNT10B(IVS1) expression and highlights new targets in T-cell acute lymphoblastic leukemia.
Cassaro A, Grillo G, Notaro M, Gliozzo J, Esposito I, Reda G, Trojani A, Valentini G, Di Camillo B, Cairoli R, Beghini A. Cassaro A, et al. Hematol Oncol. 2021 Aug;39(3):364-379. doi: 10.1002/hon.2840. Epub 2021 Feb 16. Hematol Oncol. 2021. PMID: 33497493 Free PMC article.
Identifying Wnt agonists and antagonists, it results that the expression of FZD6, LRP5, and PROM1 genes stands out in WNT10B(IVS1) positive patients compared to negative ones. ...These results describe the molecular circuit induced by WNT10B and suggest WNT10B/FZD6 …
Identifying Wnt agonists and antagonists, it results that the expression of FZD6, LRP5, and PROM1 genes stands out in WNT10B(IVS1) po …
25 results