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Page 1
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis.
Hagbohm C, Ouellette R, Flanagan EP, Jonsson DI, Piehl F, Banwell B, Wickström R, Iacobaeus E, Granberg T, Ineichen BV. Hagbohm C, et al. Eur J Neurol. 2024 Jul;31(7):e16284. doi: 10.1111/ene.16284. Epub 2024 Mar 20. Eur J Neurol. 2024. PMID: 38506182 Free PMC article.
OBJECTIVE: This study was undertaken to provide a comprehensive review of neuroimaging characteristics and corresponding clinical phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A), a rare but severe neuroinflammato …
OBJECTIVE: This study was undertaken to provide a comprehensive review of neuroimaging characteristics and corresponding clinical phenotypes …
Mutations in GFAP Alter Early Lineage Commitment of Organoids.
Dykstra W, Matusova Z, Battaglia RA, Abaffy P, Goya-Iglesias N, Pérez-Sala D, Ahlenius H, Kubista M, Pasterkamp RJ, Li L, Chao J, Shi Y, Valihrach L, Pekny M, Hol EM. Dykstra W, et al. Glia. 2025 Nov;73(11):2167-2188. doi: 10.1002/glia.70049. Epub 2025 Jul 30. Glia. 2025. PMID: 40735838 Free PMC article.
Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astrocytes in the central nervous system. Mutations in GFAP cause Alexander disease (AxD), a rare and fatal neurological disorder. How ex …
Glial fibrillary acidic protein (GFAP) is a type-3 intermediate filament protein mainly expressed in astr …
A systematic review and meta-analysis of GFAP gene variants in Alexander disease.
Grossi A, Rosamilia F, Carestiato S, Salsano E, Ceccherini I, Bachetti T. Grossi A, et al. Sci Rep. 2024 Oct 17;14(1):24341. doi: 10.1038/s41598-024-75383-4. Sci Rep. 2024. PMID: 39420046 Free PMC article.
In an attempt to clarify the effects of GFAP variants in ALXDRD, numerous studies were collected and analyzed. In particular, we systematically searched for GFAP variants associated with ALXDRD and collected information on the location within the gene and protein, p …
In an attempt to clarify the effects of GFAP variants in ALXDRD, numerous studies were collected and analyzed. In particular, we syst …
Glial fibrillary acidic protein is pathologically modified in Alexander disease.
Lin NH, Jian WS, Snider N, Perng MD. Lin NH, et al. J Biol Chem. 2024 Jul;300(7):107402. doi: 10.1016/j.jbc.2024.107402. Epub 2024 May 21. J Biol Chem. 2024. PMID: 38782207 Free PMC article.
This is a primary genetic disorder of astrocyte caused by dominant gain-of-function mutations in the gene coding for an intermediate filament protein glial fibrillary acidic protein (GFAP). Pathologically, this disease is characterized by …
This is a primary genetic disorder of astrocyte caused by dominant gain-of-function mutations in the gene coding for an intermediate filamen …
Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease.
Matusova Z, Dykstra W, de Pablo Y, Zetterdahl OG, Canals I, van Gelder CAGH, Vos HR, Pérez-Sala D, Kubista M, Abaffy P, Ahlenius H, Valihrach L, Hol EM, Pekny M. Matusova Z, et al. Glia. 2025 Jan;73(1):57-79. doi: 10.1002/glia.24618. Epub 2024 Sep 23. Glia. 2025. PMID: 39308436 Free PMC article.
Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant GFAP influences …
Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic …
Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms.
Freudenberg-Hua Y, Giliberto L, d'Abramo C, Li W, Ma Y, Goate A, Koppel J. Freudenberg-Hua Y, et al. Mol Psychiatry. 2025 Oct;30(10):4985-4991. doi: 10.1038/s41380-025-03098-7. Epub 2025 Jul 15. Mol Psychiatry. 2025. PMID: 40659842
Plasma levels of glial fibrillary acidic protein (GFAP) and neurofilament light (NEFL) are key dementia biomarkers. ...The results show that APOE4 is associated with elevated levels of plasma GFAP, and to a lesser extent, NEFL. The APOE4 …
Plasma levels of glial fibrillary acidic protein (GFAP) and neurofilament light (NEFL) are key dementia b …
Genetic and epigenetic analysis of plasma glial fibrillary acidic protein (GFAP) levels in PTSD.
Miller MW, Zhao X, Wolf EJ, Milberg WP, Fortier CB, Logue MW. Miller MW, et al. Mol Psychiatry. 2026 Jan;31(1):352-361. doi: 10.1038/s41380-025-03232-5. Epub 2025 Sep 10. Mol Psychiatry. 2026. PMID: 40931166 Free PMC article.
Glial fibrillary acidic protein (GFAP) is an astrocytic marker that can be assessed in blood using single molecule array technology. ...This study clarifies the genetic and epigenetic basis of the association between PTSD and plasma GFAP …
Glial fibrillary acidic protein (GFAP) is an astrocytic marker that can be assessed in blood using single …
STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.
Hagemann TL, Coyne S, Levin A, Wang L, Feany MB, Messing A. Hagemann TL, et al. Cells. 2023 Mar 23;12(7):978. doi: 10.3390/cells12070978. Cells. 2023. PMID: 37048051 Free PMC article.
Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament expressed by astrocytes in the central nervous system. ...Conditional knockout of Stat3 in cells expressing Gfap …
Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an …
The GFAP proteoform puzzle: How to advance GFAP as a fluid biomarker in neurological diseases.
Gogishvili D, Honey MIJ, Verberk IMW, Vermunt L, Hol EM, Teunissen CE, Abeln S. Gogishvili D, et al. J Neurochem. 2025 Jan;169(1):e16226. doi: 10.1111/jnc.16226. Epub 2024 Sep 17. J Neurochem. 2025. PMID: 39289040 Free PMC article. Review.
Glial fibrillary acidic protein (GFAP) is a well-established biomarker of reactive astrogliosis in the central nervous system because of its elevated levels following brain injury and various neurological disorders. ...In this review, we explore …
Glial fibrillary acidic protein (GFAP) is a well-established biomarker of reactive astrogliosis in the ce …
NFL and GFAP in (pre)symptomatic RVCL-S carriers: a monogenic cerebral small vessel disease.
Wilms AE, de Boer I, Pelzer N, In't Veld SGJG, Middelkoop HAM, Teunissen CE, Terwindt GM. Wilms AE, et al. J Neurol. 2024 Jul;271(7):4138-4145. doi: 10.1007/s00415-024-12292-6. Epub 2024 Apr 6. J Neurol. 2024. PMID: 38581544 Free PMC article.
BACKGROUND: Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have emerged as biomarkers for cerebral small vessel disease (SVD). ...DISCUSSION: Higher levels of serum NfL and GFAP are associated with worse cognit …
BACKGROUND: Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have emerged as bi …
32 results