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2020 34
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110 results

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YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis.
Chang G, Shi L, Ye Y, Shi H, Zeng L, Tiwary S, Huse JT, Huo L, Ma L, Ma Y, Zhang S, Zhu J, Xie V, Li P, Han L, He C, Huang S. Chang G, et al. Cancer Cell. 2020 Dec 14;38(6):857-871.e7. doi: 10.1016/j.ccell.2020.10.004. Epub 2020 Oct 29. Cancer Cell. 2020. PMID: 33125861 Free PMC article.
Mechanistically, YTHDF3 enhances the translation of m(6)A-enriched transcripts for ST6GALNAC5, GJA1, and EGFR, all associated with brain metastasis. Furthermore, overexpression of YTHDF3 in brain metastases is attributed to increased gene copy number and the autoregulation …
Mechanistically, YTHDF3 enhances the translation of m(6)A-enriched transcripts for ST6GALNAC5, GJA1, and EGFR, all associated with br …
Hypoxic pancreatic cancer derived exosomal miR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression.
Chen K, Wang Q, Liu X, Wang F, Yang Y, Tian X. Chen K, et al. Int J Biol Sci. 2022 Jan 1;18(3):1220-1237. doi: 10.7150/ijbs.67675. eCollection 2022. Int J Biol Sci. 2022. PMID: 35173549 Free PMC article.
Hypoxic PDAC cells derived exosomes could promote tube formation and endothelial cells migration via miR-30b-5p mediated downregulation of gap junction protein GJA1. Moreover, hypoxic PDAC cells derived exosomes increased new microvascular density in vivo. ...Conclusions: …
Hypoxic PDAC cells derived exosomes could promote tube formation and endothelial cells migration via miR-30b-5p mediated downregulation of g …
Cytomembrane Trafficking Pathways of Connexin 26, 30, and 43.
Zong YJ, Liu XZ, Tu L, Sun Y. Zong YJ, et al. Int J Mol Sci. 2023 Jun 19;24(12):10349. doi: 10.3390/ijms241210349. Int J Mol Sci. 2023. PMID: 37373495 Free PMC article. Review.
Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly expressed connexins in the inner ear. Connexin 43, which is encoded by GJA1, appears to be widely expressed in various organs, including the heart, skin, the brain, and the inner ear. The …
Connexins 26 and 30, encoded by GJB2 and GJB6, respectively, are the most abundantly expressed connexins in the inner ear. Connexin 43, whic …
Analysis of the function and therapeutic strategy of connexin 43 from its subcellular localization.
Xiong X, Chen W, Chen C, Wu Q, He C. Xiong X, et al. Biochimie. 2024 Mar;218:1-7. doi: 10.1016/j.biochi.2023.08.011. Epub 2023 Aug 22. Biochimie. 2024. PMID: 37611889 Free article. Review.
Cx43, encoded by the gap junction protein alpha 1 (GJA1) gene, assembles into a hexameric structure in the Golgi apparatus and translocates to the plasma membrane to form hemichannels (Hcs), which pair with those of the cells in contact with each other and form gap junctio …
Cx43, encoded by the gap junction protein alpha 1 (GJA1) gene, assembles into a hexameric structure in the Golgi apparatus and transl …
The genetic and molecular basis of a connexin-linked skin disease.
Lucaciu SA, Laird DW. Lucaciu SA, et al. Biochem J. 2024 Nov 20;481(22):1639-1655. doi: 10.1042/BCJ20240374. Biochem J. 2024. PMID: 39513663 Free PMC article. Review.
This disorder has been associated with variants in three connexin encoding genes (GJA1, GJB3, GJB4) and four unrelated genes (KRT83, KDSR, TRPM4, PERP). Most cases of connexin-linked EKVP exhibit an autosomal dominant mode of inheritance, with rare autosomal recessive case …
This disorder has been associated with variants in three connexin encoding genes (GJA1, GJB3, GJB4) and four unrelated genes (KRT83, …
Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production.
Wu X, Azizan EAB, Goodchild E, Garg S, Hagiyama M, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Kuan JL, Tiang Z, David A, Murakami M, Mein CA, Wozniak E, Zhao W, Marker A, Buss F, Saleeb RS, Salsbury J, Tezuka Y, Satoh F, Oki K, Udager AM, Cohen DL, Wachtel H, King PJ, Drake WM, Gurnell M, Ceral J, Ryska A, Mustangin M, Wong YP, Tan GC, Solar M, Reincke M, Rainey WE, Foo RS, Takaoka Y, Murray SA, Zennaro MC, Beuschlein F, Ito A, Brown MJ. Wu X, et al. Nat Genet. 2023 Jun;55(6):1009-1021. doi: 10.1038/s41588-023-01403-0. Epub 2023 Jun 8. Nat Genet. 2023. PMID: 37291193 Free PMC article.
Human adrenal zona glomerulosa (ZG) expression of GJA1 (the main GJ protein) was patchy, and annular GJs (sequelae of GJ communication) were less prominent in CYP11B2-positive micronodules than adjacent ZG. ...
Human adrenal zona glomerulosa (ZG) expression of GJA1 (the main GJ protein) was patchy, and annular GJs (sequelae of GJ communicatio …
Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations.
Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley WW, Miller BL, Ullian EM, Krummel MF, Kriegstein AR, Huang EJ. Marsan E, et al. J Clin Invest. 2023 Mar 15;133(6):e164919. doi: 10.1172/JCI164919. J Clin Invest. 2023. PMID: 36602862 Free PMC article.
By performing comparative single-cell transcriptomics in the thalamus and frontal cortex of Grn-/- mice and patients with FTLD-GRN, we have uncovered a highly conserved astroglial pathology characterized by upregulation of gap junction protein GJA1, water channel AQP4, and …
By performing comparative single-cell transcriptomics in the thalamus and frontal cortex of Grn-/- mice and patients with FTLD-GRN, we have …
Mechanisms of Diseases Associated with Mutation in GJC2/Connexin 47.
Abrams CK. Abrams CK. Biomolecules. 2023 Apr 21;13(4):712. doi: 10.3390/biom13040712. Biomolecules. 2023. PMID: 37189458 Free PMC article. Review.
Astroglia express connexin 30 (Cx30)-GJB6 and Cx43-GJA1, while oligodendroglia express Cx29/Cx31.3-GJC3, Cx32-GJB1, and Cx47-GJC2. Connexins organize into hexameric hemichannels (homomeric if all subunits are identical or heteromeric if one or more differs). ...
Astroglia express connexin 30 (Cx30)-GJB6 and Cx43-GJA1, while oligodendroglia express Cx29/Cx31.3-GJC3, Cx32-GJB1, and Cx47-GJC2. Co …
110 results