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Year Number of Results
2016 6
2017 11
2018 11
2019 13
2020 5
2021 9
2022 7
2023 8
2024 10
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2026 2

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83 results

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Nuclear glycine decarboxylase suppresses STAT1-dependent MHC-I and promotes cancer immune evasion.
Liu R, Li HF, Jiang Q, Shi JG, Ruan ZL, Ren P, Li YN, Shu HB, Li S. Liu R, et al. EMBO J. 2025 Oct;44(20):5712-5733. doi: 10.1038/s44318-025-00557-3. Epub 2025 Sep 8. EMBO J. 2025. PMID: 40926122 Free PMC article.
Inadequate antigen presentation by MHC-I in tumor microenvironment (TME) is a common immune escape mechanism. Here, we show that glycine decarboxylase (GLDC), a key enzyme in glycine metabolism, functions as an inhibitor of MHC-I expression in EGFR-activated …
Inadequate antigen presentation by MHC-I in tumor microenvironment (TME) is a common immune escape mechanism. Here, we show that glycine …
Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.
Krupenko SA, Cole SA, Hou R, Haack K, Laston S, Mehta NR, Comuzzie AG, Butte NF, Voruganti VS. Krupenko SA, et al. Am J Clin Nutr. 2022 Aug 4;116(2):500-510. doi: 10.1093/ajcn/nqac091. Am J Clin Nutr. 2022. PMID: 35460232 Free PMC article.

The strongest associations for the serine-glycine ratio were with single nucleotide polymorphisms (SNPs) in aldehyde dehydrogenase 1 family member L1 (ALDH1L1) and glycine decarboxylase (GLDC) and for glycine with GLDC (P < 3.5 10-8; effect sizes,

…
The strongest associations for the serine-glycine ratio were with single nucleotide polymorphisms (SNPs) in aldehyde dehydrogenase 1 family …
Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma.
Zhuang H, Wu F, Wei W, Dang Y, Yang B, Ma X, Han F, Li Y. Zhuang H, et al. Cell Death Dis. 2019 Feb 25;10(3):192. doi: 10.1038/s41419-019-1446-z. Cell Death Dis. 2019. PMID: 30804330 Free PMC article.
Glycine decarboxylase (GLDC) belongs to the glycine cleavage system and is involved in one-carbon metabolism. ...GLDC overexpression significantly induced cell autophagy, whereas GLDC downregulation reduced cell autophagy. ...
Glycine decarboxylase (GLDC) belongs to the glycine cleavage system and is involved in one-carbon metabolism. ...GLD …
Identification and characterization of GLDC as host susceptibility gene to severe influenza.
Zhou J, Wang D, Wong BH, Li C, Poon VK, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze KH, Chan JF, Chu H, To KK, Yuen KY. Zhou J, et al. EMBO Mol Med. 2019 Jan;11(1):e9528. doi: 10.15252/emmm.201809528. EMBO Mol Med. 2019. PMID: 30498026 Free PMC article.
Glycine decarboxylase (GLDC) was prioritized as a candidate susceptibility gene to severe influenza in humans. ...We sought to characterize GLDC as functional susceptibility gene that GLDC may intrinsically regulate antiviral response, thereby i …
Glycine decarboxylase (GLDC) was prioritized as a candidate susceptibility gene to severe influenza in humans. ...We so …
GLDC alleviates cisplatin-induced apoptosis, cellular senescence, and production of reactive oxygen species via regulating UCP1 in the kidney.
Bui AP, Pham TTM, Kim M, Park JH, Kim JI, Seo JH, Jung J, Kim JY, Ha E. Bui AP, et al. Life Sci. 2025 May 1;368:123502. doi: 10.1016/j.lfs.2025.123502. Epub 2025 Feb 24. Life Sci. 2025. PMID: 40010632
AIMS: Glycine decarboxylase (GLDC) is a mitochondrial enzyme that mediates the degradation of glycine as part of the glycine cleavage system. ...Moreover, GLDC overexpression stimulated proliferation of HK-2 cells, while GLDC knockdown attenuate …
AIMS: Glycine decarboxylase (GLDC) is a mitochondrial enzyme that mediates the degradation of glycine as part of the gl …
The genetic basis of classic nonketotic hyperglycinemia due to mutations in GLDC and AMT.
Coughlin CR 2nd, Swanson MA, Kronquist K, Acquaviva C, Hutchin T, Rodríguez-Pombo P, Väisänen ML, Spector E, Creadon-Swindell G, Brás-Goldberg AM, Rahikkala E, Moilanen JS, Mahieu V, Matthijs G, Bravo-Alonso I, Pérez-Cerdá C, Ugarte M, Vianey-Saban C, Scharer GH, Van Hove JL. Coughlin CR 2nd, et al. Genet Med. 2017 Jan;19(1):104-111. doi: 10.1038/gim.2016.74. Epub 2016 Jun 30. Genet Med. 2017. PMID: 27362913 Free article.
RESULTS: In 578 families, genetic analyses identified 410 unique mutations, including 246 novel mutations. 80% of subjects had mutations in GLDC. Missense mutations were noted in 52% of all GLDC alleles, most private. Missense mutations were 1.5 times as likely to b …
RESULTS: In 578 families, genetic analyses identified 410 unique mutations, including 246 novel mutations. 80% of subjects had mutations in …
Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis.
Duarte IF, Caio J, Moedas MF, Rodrigues LA, Leandro AP, Rivera IA, Silva MFB. Duarte IF, et al. Cell Mol Life Sci. 2021 Dec;78(23):7451-7468. doi: 10.1007/s00018-021-03996-3. Epub 2021 Oct 31. Cell Mol Life Sci. 2021. PMID: 34718827 Free PMC article. Review.
DLD is also a key enzyme of alpha-ketoglutarate dehydrogenase, branched-chain alpha-keto acid dehydrogenase, alpha-ketoadipate dehydrogenase, and the glycine decarboxylase complexes. The molecular effects of VPA will be reviewed underlining the data that sustain a p …
DLD is also a key enzyme of alpha-ketoglutarate dehydrogenase, branched-chain alpha-keto acid dehydrogenase, alpha-ketoadipate dehydrogenase …
GLDC mitigated by miR-30e regulates cell proliferation and tumor immune infiltration in TNBC.
Xie H, Yan T, Lu X, Du Y, Xu S, Kong Y, Yu L, Sun J, Zhou L, Ma J. Xie H, et al. Front Immunol. 2022 Oct 7;13:1033367. doi: 10.3389/fimmu.2022.1033367. eCollection 2022. Front Immunol. 2022. PMID: 36275705 Free PMC article.
Overexpression of GLDC facilitated the proliferation of TNBC cells, whereas GLDC knockdown had the opposite effects. Additionally, miR-30e acts as a functional upstream regulator of GLDC and the inhibitory effects of miR-30e on cell proliferation were mitigat …
Overexpression of GLDC facilitated the proliferation of TNBC cells, whereas GLDC knockdown had the opposite effects. Additiona …
GLDC attenuates liver ischemia-reperfusion injury by inhibiting macrophage recruitment and activation via PTBP1/P2RY6.
Li Z, Jin L, Fang Y, Qu S, Yuan B, Gan K, Huang H. Li Z, et al. Cell Signal. 2025 Nov;135:111976. doi: 10.1016/j.cellsig.2025.111976. Epub 2025 Jul 3. Cell Signal. 2025. PMID: 40617371
Liver ischemia-reperfusion injury (LIRI) represents a significant cause of hepatic dysfunction, with glycine decarboxylase (GLDC) emerging as a crucial molecular marker. This study investigated how GLDC attenuates LIRI by inhibiting macrophage recruitm …
Liver ischemia-reperfusion injury (LIRI) represents a significant cause of hepatic dysfunction, with glycine decarboxylase ( …
Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress.
Jog R, Chen G, Wang J, Leff T. Jog R, et al. Physiol Rep. 2021 Aug;9(15):e14991. doi: 10.14814/phy2.14991. Physiol Rep. 2021. PMID: 34342168 Free PMC article.
The glycine cleavage system and its rate-limiting enzyme, glycine decarboxylase (GLDC), is a major determinant of plasma glycine levels. The goals of this study were to determine if the increased expression of GLDC contributes to the reduced plasma gly …
The glycine cleavage system and its rate-limiting enzyme, glycine decarboxylase (GLDC), is a major determinant of plasm …
83 results