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2020 1
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Page 1
Inferring and perturbing cell fate regulomes in human brain organoids.
Fleck JS, Jansen SMJ, Wollny D, Zenk F, Seimiya M, Jain A, Okamoto R, Santel M, He Z, Camp JG, Treutlein B. Fleck JS, et al. Nature. 2023 Sep;621(7978):365-372. doi: 10.1038/s41586-022-05279-8. Epub 2022 Oct 5. Nature. 2023. PMID: 36198796 Free PMC article.
We find that certain factors regulate the abundance of cell fates, whereas other factors affect neuronal cell states after differentiation. We show that the transcription factor GLI3 is required for cortical fate establishment in humans, recapitulating previous research pe …
We find that certain factors regulate the abundance of cell fates, whereas other factors affect neuronal cell states after differentiation. …
Two Nonsense GLI3 Variants Are Identified in Two Chinese Families With Polydactyly.
Qi Y, Liu K, Wei Y, Liu X, Jiang L, Teng J, Chong B, Zheng S, Zhao X, Li L. Qi Y, et al. Mol Genet Genomic Med. 2025 Mar;13(3):e70088. doi: 10.1002/mgg3.70088. Mol Genet Genomic Med. 2025. PMID: 40052367 Free PMC article.
The c.3342dupC and c.4431dupT mutant plasmids were transfected into HEK293T cells, and the effects of GLI3 mutations on transcription and protein levels were analyzed via qRT-PCR and Western blot. ...CONCLUSION: The mutations p. A1115Rfs*14 and p. Glu1478Ter in GLI3 …
The c.3342dupC and c.4431dupT mutant plasmids were transfected into HEK293T cells, and the effects of GLI3 mutations on transcription …
Two nonsense GLI3 variants are associated with polydactyly and syndactyly in two families by affecting the sonic hedgehog signaling pathway.
Shen X, Zhang S, Zhang X, Zhou T, Rui Y. Shen X, et al. Mol Genet Genomic Med. 2022 Apr;10(4):e1895. doi: 10.1002/mgg3.1895. Epub 2022 Feb 26. Mol Genet Genomic Med. 2022. PMID: 35218158 Free PMC article.
Western blot and real-time quantitative PCR were used to analyze the expression of GLI3 and Shh. RESULTS: In these two families, the known GLI3 variant (NM_000168.6:c.2374C>T) and the novel GLI3 variant (NM_000168.6:c.1728C>A) contributed to polydactyly …
Western blot and real-time quantitative PCR were used to analyze the expression of GLI3 and Shh. RESULTS: In these two families, the …
miR-200c targeting GLI3 inhibits cell proliferation and promotes apoptosis in non-small cell lung cancer cells.
Yi X, Chen X, Li Z. Yi X, et al. Medicine (Baltimore). 2024 Sep 20;103(38):e39658. doi: 10.1097/MD.0000000000039658. Medicine (Baltimore). 2024. PMID: 39312343 Free PMC article.
This study explored whether miR-200c could regulate the biological behavior of non-small cell lung cancer cells through targeting GLI3. Luciferase reporter gene analysis was used to verify the interaction between miR-200c-3p and GLI3. miR-200c-3p and GLI3 wer …
This study explored whether miR-200c could regulate the biological behavior of non-small cell lung cancer cells through targeting GLI3 …
Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling.
Havrylov S, Chrystal P, van Baarle S, French CR, MacDonald IM, Avasarala J, Rogers RC, Berry FB, Kume T, Waskiewicz AJ, Lehmann OJ. Havrylov S, et al. Sci Rep. 2024 Aug 31;14(1):20278. doi: 10.1038/s41598-024-71159-y. Sci Rep. 2024. PMID: 39217245 Free PMC article.
Meningeal expression of the core Hh signaling components Gli1, Gli3 and Sufu was dysregulated, with comparable dysregulation of Pdgfralpha signaling evident from significantly altered Pdgfralpha and phosphorylated Pdgfralpha expression. ...
Meningeal expression of the core Hh signaling components Gli1, Gli3 and Sufu was dysregulated, with comparable dysregulation of Pdgfr …
An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling.
Tao B, Wang Z, Wang X, Song A, Liu J, Wang J, Zhang Q, Chen Z, Wang Z, Xu W, Sun M, Wang Y, Zhang P, Xu T, Wei GH, Chen FX, Wang M. Tao B, et al. J Clin Invest. 2025 Feb 25;135(8):e179617. doi: 10.1172/JCI179617. eCollection 2025 Apr 15. J Clin Invest. 2025. PMID: 39998882 Free PMC article.
Mechanistically, the risk allele G is associated with enhanced USP47 expression, mediated by altered recruitment of the transcription factor GLI3 and changes in the epigenetic status at promoter. CRISPR/Cas9-mediated single-nucleotide conversion into risk allele G results …
Mechanistically, the risk allele G is associated with enhanced USP47 expression, mediated by altered recruitment of the transcription factor …
Variant characterisation and clinical profile in a large cohort of patients with Ellis-van Creveld syndrome and a family with Weyers acrofacial dysostosis.
Altunoglu U, Palencia-Campos A, Güneş N, Turgut GT, Nevado J, Lapunzina P, Valencia M, Iturrate A, Otaify G, Elhossini R, Ashour A, K Amin A, Elnahas RF, Fernandez-Nuñez E, Flores CL, Arias P, Tenorio J, Chamorro Fernández CI, Güven Y, Özsu E, Eklioğlu BS, Ibarra-Ramirez M, Diness BR, Burnyte B, Ajmi H, Yüksel Z, Yıldırım R, Ünal E, Abdalla E, Aglan M, Kayserili H, Tuysuz B, Ruiz-Pérez V. Altunoglu U, et al. J Med Genet. 2024 Jun 20;61(7):633-644. doi: 10.1136/jmg-2023-109546. J Med Genet. 2024. PMID: 38531627 Free article.
Patients from each of the two remaining families were found with a homozygous splicing variant in WDR35 and a de novo heterozygous frameshift variant in GLI3, respectively. The phenotype of these patients showed a remarkable overlap with EvC. ...We also provide comprehensi …
Patients from each of the two remaining families were found with a homozygous splicing variant in WDR35 and a de novo heterozygous frameshif …
The Principle of Cortical Development and Evolution.
Yang Z. Yang Z. Neurosci Bull. 2025 Mar;41(3):461-485. doi: 10.1007/s12264-024-01259-2. Epub 2024 Jul 18. Neurosci Bull. 2025. PMID: 39023844 Free PMC article. Review.
The core mechanism, which has been identified in our recent studies, is the extracellular signal-regulated kinase (ERK)-bone morphogenic protein 7 (BMP7)-GLI3 repressor form (GLI3R)-sonic hedgehog (SHH) positive feedback loop. Additionally, I propose that the molecular bas …
The core mechanism, which has been identified in our recent studies, is the extracellular signal-regulated kinase (ERK)-bone morphogenic pro …
Transcriptome Profiling Associated with CARD11 Overexpression in Colorectal Cancer Implicates a Potential Role for Tumor Immune Microenvironment and Cancer Pathways Modulation via NF-κB.
Alhosani F, Ilce BY, Alhamidi RS, Bhamidimarri PM, Hamad AM, Alkhayyal N, Künstner A, Khandanpour C, Busch H, Al-Ramadi B, Sayed K, AlFazari A, Bendardaf R, Hamoudi R. Alhosani F, et al. Int J Mol Sci. 2024 Sep 26;25(19):10367. doi: 10.3390/ijms251910367. Int J Mol Sci. 2024. PMID: 39408697 Free PMC article.
In patient samples, adenoma patients exhibited increased expression of genes associated with the tumor immune microenvironment, such as IL6ST, collagen family members, and CRC transition markers, such as GLI3 and PIEZO2, in CARD11+ adenoma patients. Carcinoma patients show …
In patient samples, adenoma patients exhibited increased expression of genes associated with the tumor immune microenvironment, such as IL6S …
Oncogenic potential of truncated-Gli3 via the Gsk3beta/Gli3/AR-V7 axis in castration-resistant prostate cancer.
Kaushal JB, Raut P, Halder S, Alsafwani ZW, Parte S, Sharma G, Abdullah KM, Seshacharyulu P, Lele SM, Batra SK, Siddiqui JA. Kaushal JB, et al. Oncogene. 2025 Apr;44(15):1007-1023. doi: 10.1038/s41388-024-03266-z. Epub 2025 Jan 16. Oncogene. 2025. PMID: 39821099 Free PMC article.
Our study unveiled a novel role of the truncated form of Gli (t-Gli3) in advancing CRPC. Investigation into Gli3 regulation revealed a Smo-independent mechanism for its activation. Despite lacking a transactivation domain, t-Gli3 relies on androgen receptor v …
Our study unveiled a novel role of the truncated form of Gli (t-Gli3) in advancing CRPC. Investigation into Gli3 regulation re …
67 results