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Year Number of Results
2016 3
2017 4
2018 4
2019 7
2020 4
2021 5
2022 2
2023 3
2024 4
2025 3
2026 2

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39 results

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Page 1
Identification of senescence related hub genes and potential therapeutic compounds for dilated cardiomyopathy via comprehensive transcriptome analysis.
Du C, Wang S, Shi X, Jing P, Wang H, Wang L. Du C, et al. Comput Biol Med. 2024 Sep;179:108901. doi: 10.1016/j.compbiomed.2024.108901. Epub 2024 Jul 18. Comput Biol Med. 2024. PMID: 39029429
RESULTS: Three DCM- and senescence-related characteristic genes (MME, GNMT and PLA2G2A) were ultimately identified through comprehensive transcriptome analysis, and were experimentally verified in the doxorubicin induced mouse DCM. ...CONCLUSION: Our study presents three c …
RESULTS: Three DCM- and senescence-related characteristic genes (MME, GNMT and PLA2G2A) were ultimately identified through comprehens …
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate.
Mack TM, Raddatz MA, Pershad Y, Nachun DC, Taylor KD, Guo X, Shuldiner AR, O'Connell JR, Kenny EE, Loos RJF, Redline S, Cade BE, Psaty BM, Bis JC, Brody JA, Silverman EK, Yun JH, Cho MH, DeMeo DL, Levy D, Johnson AD, Mathias RA, Yanek LR, Heckbert SR, Smith NL, Wiggins KL, Raffield LM, Carson AP, Rotter JI, Rich SS, Manichaikul AW, Gu CC, Chen YI, Lee WJ, Shoemaker MB, Roden DM, Kooperberg C, Auer PL, Desai P, Blackwell TW, Smith AV, Reiner AP, Jaiswal S, Weinstock JS, Bick AG. Mack TM, et al. Nat Aging. 2024 Aug;4(8):1043-1052. doi: 10.1038/s43587-024-00647-7. Epub 2024 Jun 4. Nat Aging. 2024. PMID: 38834882 Free PMC article.
A proteome-wide search identified predicted circulating levels of myeloid zinc finger 1 and anti-Mullerian hormone as associated with an increased CHIP clonal expansion rate and tissue inhibitor of metalloproteinase 1 and glycine N-methyltransferase as associ …
A proteome-wide search identified predicted circulating levels of myeloid zinc finger 1 and anti-Mullerian hormone as associated with an inc …
The complex role of glycine N-methyltransferase in metabolism-a review.
Suzauddula M, Islam MN, Ahmed T. Suzauddula M, et al. Mol Biol Rep. 2025 Mar 1;52(1):271. doi: 10.1007/s11033-025-10374-w. Mol Biol Rep. 2025. PMID: 40025311 Review.
BACKGROUND: Glycine N-methyltransferase (GNMT) is an enzyme predominantly found in the liver, playing a crucial role in various metabolic pathways. ...OBJECTIVE: To provide a comprehensive review of the impact of Glycine N-methyltransf …
BACKGROUND: Glycine N-methyltransferase (GNMT) is an enzyme predominantly found in the liver, playing a crucial …
Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma.
Chen M, Yang MH, Chang MM, Tyan YC, Chen YA. Chen M, et al. Toxicol Appl Pharmacol. 2019 Sep 1;378:114607. doi: 10.1016/j.taap.2019.114607. Epub 2019 Jun 3. Toxicol Appl Pharmacol. 2019. PMID: 31170416 Review.
Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in the one carbon metabolism pathway, it plays a role in the detoxification of environmental carcinogens such as benzo[a]pyrene, aflatoxin B1, …
Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in …
Downregulation of Methionine Cycle Genes MAT1A and GNMT Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis.
Chen PM, Tsai CH, Huang CC, Hwang HH, Li JR, Liu CC, Ko HA, Chiang EI. Chen PM, et al. Int J Mol Sci. 2022 Jan 1;23(1):481. doi: 10.3390/ijms23010481. Int J Mol Sci. 2022. PMID: 35008908 Free PMC article.
Methionine adenosyltransferase 1A (MAT1A) and glycine N-methyltransferase (GNMT) are two key enzymes involved in the functional implications of that variation. ...Cell models expressing various MAT1A and GNMT proved that simultaneous restoring t …
Methionine adenosyltransferase 1A (MAT1A) and glycine N-methyltransferase (GNMT) are two key enzymes involved in …
Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma.
Kant R, Yen CH, Hung JH, Lu CK, Tung CY, Chang PC, Chen YH, Tyan YC, Chen YA. Kant R, et al. Sci Rep. 2019 Feb 13;9(1):1968. doi: 10.1038/s41598-018-37292-1. Sci Rep. 2019. PMID: 30760754 Free PMC article.
Recently, we identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside (PGG) as a GNMT promoter enhancer compound in HCC. In this study, we aimed to delineate the mechanism by which PGG enhances GNMT expression and to investigate its effect on GNMT suppress …
Recently, we identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside (PGG) as a GNMT promoter enhancer compound in HCC. In this s …
Chemical Constituents with GNMT-Promoter-Enhancing and NRF2-Reduction Activities from Taiwan Agarwood Excoecaria formosana.
Wu HC, Cheng MJ, Yen CH, Chen YA, Chen YS, Chen IS, Chang HS. Wu HC, et al. Molecules. 2020 Apr 10;25(7):1746. doi: 10.3390/molecules25071746. Molecules. 2020. PMID: 32290267 Free PMC article.
After screening 3000 methanolic extracts from the Formosan plant extract bank, Excoecaria formosana showed glycine N-methyltransferase (GNMT)-promoter-enhancing and nuclear factor erythroid 2-related factor 2 (NRF2)-suppressing activities. ...Among the …
After screening 3000 methanolic extracts from the Formosan plant extract bank, Excoecaria formosana showed glycine N-methyl …
ERVK13-1/miR-873-5p/GNMT Axis Promotes Metastatic Potential in Human Bladder Cancer though Sarcosine Production.
Kishi S, Mori S, Fujiwara-Tani R, Ogata R, Sasaki R, Ikemoto A, Goto K, Sasaki T, Miyake M, Sasagawa S, Kawaichi M, Luo Y, Bhawal UK, Fujimoto K, Nakagawa H, Kuniyasu H. Kishi S, et al. Int J Mol Sci. 2023 Nov 15;24(22):16367. doi: 10.3390/ijms242216367. Int J Mol Sci. 2023. PMID: 38003554 Free PMC article.
In contrast, RT4 cells derived from non-invasive cancers expressed low GNMT, and SAM treatment did not produce sarcosine and did not promote malignant phenotypes. In T24 cells, the expression of miR-873-5p, which suppresses GNMT expression, was suppressed, and the e …
In contrast, RT4 cells derived from non-invasive cancers expressed low GNMT, and SAM treatment did not produce sarcosine and did not …
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.
Fernández-Tussy P, Fernández-Ramos D, Lopitz-Otsoa F, Simón J, Barbier-Torres L, Gomez-Santos B, Nuñez-Garcia M, Azkargorta M, Gutiérrez-de Juan V, Serrano-Macia M, Rodríguez-Agudo R, Iruzubieta P, Anguita J, Castro RE, Champagne D, Rincón M, Elortza F, Arslanow A, Krawczyk M, Lammert F, Kirchmeyer M, Behrmann I, Crespo J, Lu SC, Mato JM, Varela-Rey M, Aspichueta P, Delgado TC, Martínez-Chantar ML. Fernández-Tussy P, et al. Mol Metab. 2019 Nov;29:40-54. doi: 10.1016/j.molmet.2019.08.008. Epub 2019 Aug 16. Mol Metab. 2019. PMID: 31668391 Free PMC article.
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metabolic pathways, mitochondrial functionality and unbalanced lipid import/export, lead to lipid accumulation and progression to inflammation and f …
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is a complex pathology in which several dysfunctions, including alterations in metaboli …
GNMT and Its Regulatory MicroRNAs as Biomarkers and Therapeutic Targets for Metabolic Dysfunction-Associated Fatty Liver Disease and Hepatocellular Carcinoma.
Lin YC, Li WY, Chen YA. Lin YC, et al. Int J Mol Sci. 2026 Feb 24;27(5):2090. doi: 10.3390/ijms27052090. Int J Mol Sci. 2026. PMID: 41828318 Free PMC article. Review.
Glycine N-methyltransferase (GNMT), a S-adenosylmethionine (SAM)-dependent methyltransferase, is primarily expressed in the liver and plays a key role in regulating liver metabolism and protecting against liver injury. ...This review provides an overvi …
Glycine N-methyltransferase (GNMT), a S-adenosylmethionine (SAM)-dependent methyltransferase, is primarily expre …
39 results