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2023 3
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Page 1
Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk.
Liu W, Pircher J, Schuermans A, Ul Ain Q, Zhang Z, Honigberg MC, Yalcinkaya M, Nakao T, Pournamadri A, Xiao T, Hajebrahimi MA, Wasner L, Stegner D, Petzold T, Natarajan P, Massberg S, Tall AR, Schulz C, Wang N. Liu W, et al. Blood. 2024 Apr 11;143(15):1539-1550. doi: 10.1182/blood.2023022260. Blood. 2024. PMID: 38142422 Free PMC article.
Megakaryocytes in Jak2VF CH showed elevated proplatelet formation and release, increasing prothrombogenic reticulated platelet counts. Gp1ba-Cre-mediated expression of Jak2VF in platelets (VFGp1ba) increased platelet counts to a similar level as in 20% Jak2VF CH mice while …
Megakaryocytes in Jak2VF CH showed elevated proplatelet formation and release, increasing prothrombogenic reticulated platelet counts. Gp …
Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States.
Bashore AC, Xue C, Kim E, Yan H, Zhu LY, Pan H, Kissner M, Ross LS, Zhang H, Li M, Reilly MP. Bashore AC, et al. Circ Res. 2024 Aug 30;135(6):685-700. doi: 10.1161/CIRCRESAHA.124.324457. Epub 2024 Aug 6. Circ Res. 2024. PMID: 39105287 Free PMC article.
Using flow cytometry, we validated the existence of MHCII(+)CD275(+) MHCII(hi), CD42b(+) monocyte-platelet aggregates, CD16(+)CD99(-) nonclassical monocytes, and CD99(+) classical monocytes. ...
Using flow cytometry, we validated the existence of MHCII(+)CD275(+) MHCII(hi), CD42b(+) monocyte-platelet aggregates, CD16(+)CD99(-) …
Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be Associated with Serum sIgE and Blood Eosinophil Levels in Chinese Patients with Allergic Diseases.
Tang R, Lyu X, Sun J, Li H. Tang R, et al. Endocr Metab Immune Disord Drug Targets. 2024;24(10):1215-1223. doi: 10.2174/0118715303285101240118062549. Endocr Metab Immune Disord Drug Targets. 2024. PMID: 38299390 Free PMC article.
OBJECTIVE: This study aims to investigate the relationship between the serum specific Immunoglobulin E (sIgE), blood eosinophil, and the polymorphisms of glycoprotein Ib alpha gene (GP1BA) rs6065, platelet endothelial aggregation receptor 1 gene (PEAR1) rs12041331, and pla …
OBJECTIVE: This study aims to investigate the relationship between the serum specific Immunoglobulin E (sIgE), blood eosinophil, and the pol …
Genetic Associations of ITGB3, FGG, GP1BA, PECAM1, and PEAR1 Polymorphisms and the Platelet Activation Pathway with Recurrent Pregnancy Loss in the Korean Population.
Ko EJ, Ahn EH, Park HW, Lee JH, Kim DH, Kim YR, Kim JH, Kim NK. Ko EJ, et al. Int J Mol Sci. 2025 Aug 3;26(15):7505. doi: 10.3390/ijms26157505. Int J Mol Sci. 2025. PMID: 40806633 Free PMC article.
This study examined the associations of platelet receptor and ligand gene variants, including integrin subunit beta 3 (ITGB3) rs2317676 A > G, rs3809865 A > T; fibrinogen gamma chain (FGG) rs1049636 T > C, rs2066865 T > C; glycoprotein 1b subunit alpha (GP1BA) …
This study examined the associations of platelet receptor and ligand gene variants, including integrin subunit beta 3 (ITGB3) rs2317676 A &g …
Increased RhoA pathway activation downstream of αIIbβ3/SRC contributes to heterozygous Bernard Soulier syndrome.
Lordier L, Di Buduo CA, Kauskot A, Balayn N, Lavenu-Bombled C, Baschieri F, Proulle V, Oyarzun CPM, Careddu F, Biunno I, Manoliu T, Rameau P, Plo I, Papadopoulos N, Constantinescu S, Vainchenker W, Nguyen GN, Ballerini P, Favier R, Balduini A, Raslova H. Lordier L, et al. Haematologica. 2025 Jul 1;110(7):1596-1609. doi: 10.3324/haematol.2024.286424. Epub 2025 Mar 6. Haematologica. 2025. PMID: 40045897 Free PMC article.
Bernard Soulier syndrome (BSS) is a severe bleeding disorder with moderate to severe thrombocytopenia, giant platelets, and platelet dysfunction, caused by biallelic mutations in GP1BA, GP1BB, or GP9 genes. We generated induced pluripotent stem cells (iPSC) from a BSS pati …
Bernard Soulier syndrome (BSS) is a severe bleeding disorder with moderate to severe thrombocytopenia, giant platelets, and platelet dysfunc …
Association of CYP2C19 and GP1BA Genetic Variants With Antiplatelet Efficacy, and Prognosis in Patients With Acute Cerebral Infarction, and the Development of a Prognostic Risk Nomogram Model.
Sun H, Li Y. Sun H, et al. Br J Hosp Med (Lond). 2025 Nov 25;86(11):1-15. doi: 10.12968/hmed.2024.0776. Epub 2025 Nov 7. Br J Hosp Med (Lond). 2025. PMID: 41284249 Free article.
Methods A total of 200 ACI patients treated at First Affiliated Hospital of Bengbu Medical University between January 2021 and May 2024 were enrolled. The distributions of CYP2C19 and GP1BA gene polymorphisms were determined. Differences in platelet inhibition rates among …
Methods A total of 200 ACI patients treated at First Affiliated Hospital of Bengbu Medical University between January 2021 and May 2024 were …
Predicting laboratory aspirin resistance in Chinese stroke patients using machine learning models by GP1BA polymorphism.
Liu J, Pan L, Wang S, Li Y, Wu Y, Luan J, Yang K. Liu J, et al. Pharmacogenomics. 2024;25(12-13):539-550. doi: 10.1080/14622416.2024.2411939. Epub 2024 Oct 23. Pharmacogenomics. 2024. PMID: 39440554
GP1BA rs6065 mutation frequency is 5.26% and LTC4S rs730012 is 14.78%. GP1BA rs6065 CT patients have more sensitivity to aspirin than CC genotype. ...Findings suggest pre-identifying GP1BA rs6065 could optimize aspirin treatment, enabling personalized care an …
GP1BA rs6065 mutation frequency is 5.26% and LTC4S rs730012 is 14.78%. GP1BA rs6065 CT patients have more sensitivity to aspir …
A new case of platelet-type von Willebrand disease supports the recent findings of gain-of-function GP1BA variants outside the C-terminal disulphide loop enhances affinity for von Willebrand factor.
Monteiro C, Gonçalves A, Pereira M, Lau C, Morais S, Santos R. Monteiro C, et al. Br J Haematol. 2023 Nov;203(4):673-677. doi: 10.1111/bjh.19025. Epub 2023 Aug 17. Br J Haematol. 2023. PMID: 37592722
Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder characterized by an increased ristocetin-induced platelet aggregation (RIPA) and enhanced affinity of platelet glycoprotein Ibalpha (GPIbalpha) to von Willebrand factor (VWF). To d …
Platelet-type von Willebrand disease (PT-VWD) is a rare autosomal dominant bleeding disorder characterized by an increased ristocetin-induce …
The associations of candidate gene polymorphisms with aspirin resistance in patients with ischemic disease: a meta-analysis.
Li CX, Sun LC, Wang YQ, Liu TT, Cai JR, Liu H, Ren Z, Yi Z. Li CX, et al. Hum Genomics. 2024 Dec 2;18(1):135. doi: 10.1186/s40246-024-00699-1. Hum Genomics. 2024. PMID: 39617913 Free PMC article.
However, results for ABCB1(rs1045642) and GP1BA(rs2243093) vary by regions, requiring further research....
However, results for ABCB1(rs1045642) and GP1BA(rs2243093) vary by regions, requiring further research....
Revealing Causal Protein Biomarkers and Potential Therapeutic Targets for Histologic-Specific Lung Cancer.
Sun W, Liu J, Li J, Li N, Zhang X, Li C, Zhang L, He Y, Wu L, Wang X, Ji J, Zheng D. Sun W, et al. J Cell Mol Med. 2025 Dec;29(23):e70866. doi: 10.1111/jcmm.70866. J Cell Mol Med. 2025. PMID: 41340014 Free PMC article.
Tier 1 proteins passed all evaluations, including GP1BA (squamous cell carcinoma) and ACADSB (small cell carcinoma). Tier 2 proteins, supported by transcriptomic evidence but not sensitivity analyses, included AGRN, ITGB2, SEPTIN3 (adenocarcinoma) and DPP10 (squamous cell …
Tier 1 proteins passed all evaluations, including GP1BA (squamous cell carcinoma) and ACADSB (small cell carcinoma). Tier 2 proteins, …
27 results