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HSP90 N-terminal inhibition promotes mitochondria-derived vesicles related metastasis by reducing TFEB transcription via decreased HSP90AA1-HCFC1 interaction in liver cancer.
Liu L, Zheng Z, Huang Y, Su H, Wu G, Deng Z, Li Y, Xie G, Li J, Zou F, Chen X. Liu L, et al. Autophagy. 2025 Mar;21(3):639-663. doi: 10.1080/15548627.2024.2421703. Epub 2024 Nov 11. Autophagy. 2025. PMID: 39461872 Free PMC article.
Because TFEB (transcription factor EB) is the most important mitophagy transcription factor, and the HSP90 client HCFC1 (host cell factor C1) regulates TFEB transcription, there should be a hidden connection between TFEB, HCFC1 and HSP90 …
Because TFEB (transcription factor EB) is the most important mitophagy transcription factor, and the HSP90 client HCFC1 (host …
Hippocampal and peripheral blood DNA methylation signatures correlate at the gene and pathway level in a mouse model of autism.
Alberca CD, Papale LA, Madrid A, Alisch RS. Alberca CD, et al. Hum Mol Genet. 2023 Dec 1;32(24):3312-3322. doi: 10.1093/hmg/ddad137. Hum Mol Genet. 2023. PMID: 37658766
Sixty-six differentially methylated regions (DMRs) share the same genomic coordinates in these two tissues, many of which are linked to risk genes for neurodevelopmental disorders and intellectual disabilities (e.g. Prkch, Ptn, Hcfc1, Mid1, and Nfia). Gene ontological path …
Sixty-six differentially methylated regions (DMRs) share the same genomic coordinates in these two tissues, many of which are linked to risk …
HCFC1 variants in the proteolysis domain are associated with X-linked idiopathic partial epilepsy: Exploring the underlying mechanism.
He N, Guan BZ, Wang J, Liu HK, Mao Y, Liu ZG, Yin F, Peng J, Xiao B, Tang BS, Zhou D, Huang G, Dai QL, Zeng Y, Han H, Zhai QX, Li B, Tang B, Li WB, Song W, Liu L, Shi YW, Li BM, Su T, Zhou P, Liu XR, Guo LW, Yi YH, Liao WP. He N, et al. Clin Transl Med. 2023 Jun;13(6):e1289. doi: 10.1002/ctm2.1289. Clin Transl Med. 2023. PMID: 37264743 Free PMC article.
BACKGROUND: HCFC1 encodes transcriptional co-regulator HCF-1, which undergoes an unusual proteolytic maturation at a centrally located proteolysis domain. ...Functional studies determined the effects of the variants on the proteolytic maturation of HCF …
BACKGROUND: HCFC1 encodes transcriptional co-regulator HCF-1, which undergoes an unusual proteolytic maturation at a ce …
Dissecting the role of vitamin B12 metabolism in craniofacial development through analysis of clinical phenotypes and model organism discoveries.
Pinales BE, Palomino CE, Rosas-Acosta G, Francia G, Quintana AM. Pinales BE, et al. Differentiation. 2025 Mar-Apr;142:100831. doi: 10.1016/j.diff.2024.100831. Epub 2024 Dec 10. Differentiation. 2025. PMID: 39676000 Free PMC article. Review.
We identified dysmorphic facial features in cblC, cblX, cblG, cblF, and cblJ, which are caused by mutations in MMACHC, HCFC1, MTR, LMBRD1, and ABCD4, respectively. Other complementation groups were associated primarily with microcephaly. ...
We identified dysmorphic facial features in cblC, cblX, cblG, cblF, and cblJ, which are caused by mutations in MMACHC, HCFC1, MTR, LM …
Unveiling the Power of Mitochondrial Fission and Fusion: A Five- Gene Signature for Personalized Prognosis in Gastric Cancer.
Zhou B, Tie P, Li D, Lu Y, Liu Y. Zhou B, et al. Curr Med Chem. 2025;32(40):9194-9211. doi: 10.2174/0109298673339515240930053412. Curr Med Chem. 2025. PMID: 39385415
RESULTS: These MDs-related subtypes exhibited different prognosis and immune filtration patterns. A five-gene signature, comprising AGT, HCFC1, KIFC3, NOX4, and RIN1, was developed. There was a clear distinction in overall survival between low- and high-risk patients. ...T …
RESULTS: These MDs-related subtypes exhibited different prognosis and immune filtration patterns. A five-gene signature, comprising AGT, …
Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML.
Nguyen NHK, Rafiee R, Parcha PK, Tagmount A, Rubnitz J, Ribeiro R, Cao X, Pounds SB, Vulpe CD, Lamba JK. Nguyen NHK, et al. Blood Adv. 2025 Mar 11;9(5):1078-1091. doi: 10.1182/bloodadvances.2024014157. Blood Adv. 2025. PMID: 39715471 Free PMC article.
We were able to identify several mediators that represent clinically and biologically significant marker genes for ADE treatment, such as BCL2, CLIP2, and VAV3, which are resistant markers to ADE, with high expression associated with poor outcomes in pAML treated with ADE, and GR …
We were able to identify several mediators that represent clinically and biologically significant marker genes for ADE treatment, such as BC …
Anchoring super-enhancer-driven oncogenic lncRNAs for anti-tumor therapy in hepatocellular carcinoma.
Yuan XQ, Zhou N, Wang JP, Yang XZ, Wang S, Zhang CY, Li GC, Peng L. Yuan XQ, et al. Mol Ther. 2023 Jun 7;31(6):1756-1774. doi: 10.1016/j.ymthe.2022.11.013. Epub 2022 Dec 2. Mol Ther. 2023. PMID: 36461633 Free PMC article.
Especially, HSAL3 is identified as an uncharacterized SE-driven oncogenic lncRNA, which is activated by transcription factors HCFC1 and HSF1 via its super-enhancer. HSAL3 interference negatively regulates NOTCH signaling, implying the potential mechanism of its tumor-promo …
Especially, HSAL3 is identified as an uncharacterized SE-driven oncogenic lncRNA, which is activated by transcription factors HCFC1 a …
An essential gene signature of breast cancer metastasis reveals targetable pathways.
Zhang Y, Chen F, Balic M, Creighton CJ. Zhang Y, et al. Breast Cancer Res. 2024 Jun 12;26(1):98. doi: 10.1186/s13058-024-01855-0. Breast Cancer Res. 2024. PMID: 38867323 Free PMC article.
Transcription factors MYC, MAX, HDAC3, and HCFC1 each bound significant fractions of essential genes. CONCLUSIONS: Associations involving the essential gene signature of breast cancer metastasis indicate true biological changes intrinsic to cancer cells, with important imp …
Transcription factors MYC, MAX, HDAC3, and HCFC1 each bound significant fractions of essential genes. CONCLUSIONS: Associations invol …
Genomic Profiling Reveals the Variant Landscape of Sporadic Parathyroid Adenomas in Chinese Population.
Tao X, Xu T, Lin X, Xu S, Fan Y, Guo B, Deng X, Jiao Q, Chen L, Wei Z, Chen C, Yang W, Zhang Z, Yu X, Yue H. Tao X, et al. J Clin Endocrinol Metab. 2023 Jun 16;108(7):1768-1775. doi: 10.1210/clinem/dgad002. J Clin Endocrinol Metab. 2023. PMID: 36611251 Free PMC article.
Several novel recurrent somatic variants were detected, such as KMT2D (15/73), MUC4 (14/73), POTEH (13/73), CD22 (12/73), HSPA2 (12/73), HCFC1 (11/73), MAGEA1 (11/73), and SLC4A3 (11/73), besides the previously reported PA-related genes, including MEN1 (11/73), CASR (6/73) …
Several novel recurrent somatic variants were detected, such as KMT2D (15/73), MUC4 (14/73), POTEH (13/73), CD22 (12/73), HSPA2 (12/73), …
The H4K20-mono-methyltransferase SETD8 promotes global accessibility of infecting herpes simplex virus genomes.
Arbuckle JH, Yanez AA, Baksh SS, Markowitz TE, Vogel JL, McBride AA, Kristie TM. Arbuckle JH, et al. J Virol. 2025 Dec 23;99(12):e0129325. doi: 10.1128/jvi.01293-25. Epub 2025 Nov 19. J Virol. 2025. PMID: 41258712 Free PMC article.
Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the state of HSV-1 chromatin. Although some aspects of HSV-1 chromatin biology have been elucidated, many epigenetic factors controlling HSV-1 c …
Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the …