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Year Number of Results
2003 1
2007 1
2010 1
2011 1
2012 3
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2018 2
2020 1
2021 1
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2026 1

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23 results

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Page 1
Integrated Analysis of Single-Cell and Bulk RNA Sequencing Reveals HSD3B7 as a Prognostic Biomarker and Potential Therapeutic Target in ccRCC.
Liu G, Liu Q, Zhao J, Luo R, Wan Y, Luo Z. Liu G, et al. Int J Mol Sci. 2024 Dec 1;25(23):12929. doi: 10.3390/ijms252312929. Int J Mol Sci. 2024. PMID: 39684640 Free PMC article.
Elevated HSD3B7 expression correlated with aggressive clinical features such as advanced TNM stages, histologic grades, and metastasis. ...Our findings reveal that HSD3B7 is a novel biomarker for ccRCC, providing insights into its role in tumor progression and poten …
Elevated HSD3B7 expression correlated with aggressive clinical features such as advanced TNM stages, histologic grades, and metastasi …
Neonatal Cholestasis: Exploring Genetic Causes and Clinical Outcomes.
Gürcan Kaya N, Öztürk H, Sarı S, Eğritaş Gürkan Ö, Dalgıç B. Gürcan Kaya N, et al. J Paediatr Child Health. 2025 Jul;61(7):1049-1055. doi: 10.1111/jpc.70072. Epub 2025 Apr 29. J Paediatr Child Health. 2025. PMID: 40302296
RESULTS: Genetic disorders were identified in 28.0% of 378 cases, including mutations in ATP8B1, ABCB11, ABCB4, DCDC2, DGUOK, KIF12, USP53, and genes related to bile acid synthesis (HSD3B7, PEX1). GGT levels played a significant role in diagnosis: patients with low or norm …
RESULTS: Genetic disorders were identified in 28.0% of 378 cases, including mutations in ATP8B1, ABCB11, ABCB4, DCDC2, DGUOK, KIF12, USP53, …
Construction of ceRNA Network and Disease Diagnosis Model for Keloid Based on Tumor Suppressor ERRFI1.
Chen P, Su Q, Lin X, Zhou X, Yao W, Hua X, Huang Y, Xie R, Liu H, Wang C. Chen P, et al. Exp Dermatol. 2024 Nov;33(11):e70004. doi: 10.1111/exd.70004. Exp Dermatol. 2024. PMID: 39563082
Finally, a 2-gene diagnostic prediction model (ERRFI1, HSD3B7) was constructed and externally validated and the results suggested that the model had good diagnostic performance. ...
Finally, a 2-gene diagnostic prediction model (ERRFI1, HSD3B7) was constructed and externally validated and the results suggested tha …
The association between HSD3B7 gene variant and Parkinson's disease in ethnic Chinese.
Lu ZJ, Wang L, Sun XY, Li JY, Cheng L, Li NN, Peng R. Lu ZJ, et al. Brain Behav. 2018 Feb 17;8(4):e00913. doi: 10.1002/brb3.913. eCollection 2018 Apr. Brain Behav. 2018. PMID: 29670816 Free PMC article.
OBJECTIVES: Studies at the genomewide level of Parkinson's disease (PD) suggested a significant association between the Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta isomerase 7 (HSD3B7) gene rs9938550 variant and a decreased risk for PD. But its effect …
OBJECTIVES: Studies at the genomewide level of Parkinson's disease (PD) suggested a significant association between the Hydroxy-delta-5-ster …
Dissection of shared genetic architecture and biological association between psoriasis and cardiovascular disease based on genome-wide association studies.
Zhou P, Jiang X, Wang W, Wang D. Zhou P, et al. Hum Immunol. 2025 Sep;86(5):111565. doi: 10.1016/j.humimm.2025.111565. Epub 2025 Aug 9. Hum Immunol. 2025. PMID: 40784299
Gene-level analysis pinpointed 97 candidate genes, and through multi-evidence integration, we prioritized four (SLC22A5, LMAN2, HSD3B7, and ZNF668) as high-confidence therapeutic targets. Enrichment analyses showed these shared genes are highly expressed in blood and immun …
Gene-level analysis pinpointed 97 candidate genes, and through multi-evidence integration, we prioritized four (SLC22A5, LMAN2, HSD3B7 …
Dysregulated expression of androgen metabolism genes and genetic analysis in hypospadias.
Chen Z, Lin X, Wang Y, Xie H, Chen F. Chen Z, et al. Mol Genet Genomic Med. 2020 Aug;8(8):e1346. doi: 10.1002/mgg3.1346. Epub 2020 Jun 8. Mol Genet Genomic Med. 2020. PMID: 32515122 Free PMC article.

RESULTS: The average expression of androgen receptor (AR) and CYP19A1 were significantly decreased in severe hypospadias (p < .01) and mild hypospadias (p < .05), whereas expression of several other androgen metabolism enzymes, including CYP3A4, HSD17B14, HSD3B7, HSD

…

RESULTS: The average expression of androgen receptor (AR) and CYP19A1 were significantly decreased in severe hypospadias (p < .01) and mi

…
The Mutational Landscape Of Genetic Cholestatic Diseases In Pakistani Children.
Cheema HA, Waheed N, Saeed A, Anjum MN, Fayyaz Z, Ijaz S. Cheema HA, et al. J Pak Med Assoc. 2023 Aug;73(8):1610-1621. doi: 10.47391/JPMA.7069. J Pak Med Assoc. 2023. PMID: 37697751
Exome sequencing identified pathogenic mutations in 13 genes underlying the hereditary cholestasis; ATP8B1, ABCB11, ABCB4, TJP2, NR1H4, DCDC2, ACOX2, AKR1D1, HSD3B7, ABCC2, USP53, SLC10A1, and SLC51A. Of the 70 variants identified, 50(71.4%) were novel variants. ...
Exome sequencing identified pathogenic mutations in 13 genes underlying the hereditary cholestasis; ATP8B1, ABCB11, ABCB4, TJP2, NR1H4, DCDC …
Identification of Novel Therapeutic Targets for Hypertension.
Zheng Z, Chen R, Liu M, Ding Y, Xu S, Hou C, Li S. Zheng Z, et al. Hypertension. 2025 Jun;82(6):1056-1070. doi: 10.1161/HYPERTENSIONAHA.124.24277. Epub 2025 Mar 20. Hypertension. 2025. PMID: 40109242
Colocalization analysis identified 14 hypertension-related drug targets, including ACE, AIMP1, CDC25A, EHMT2, FES, GPX1, GRK4, HSD3B7, NEK4, PTPN12, SIK2, SLC22A4, SLC2A4, and TNFSF12. Survival analysis revealed individuals with the A allele at rs4308 in the ACE gene had a …
Colocalization analysis identified 14 hypertension-related drug targets, including ACE, AIMP1, CDC25A, EHMT2, FES, GPX1, GRK4, HSD3B7 …
Bile Acid Synthesis Disorders in Japan: Long-Term Outcome and Chenodeoxycholic Acid Treatment.
Kimura A, Mizuochi T, Takei H, Ohtake A, Mori J, Shinoda K, Hashimoto T, Kasahara M, Togawa T, Murai T, Iida T, Nittono H. Kimura A, et al. Dig Dis Sci. 2021 Nov;66(11):3885-3892. doi: 10.1007/s10620-020-06722-4. Epub 2021 Jan 1. Dig Dis Sci. 2021. PMID: 33385262
All 7 patients, who had homozygous or compound heterozygous mutations in the HSD3B7, SRD5B1, or CYP7B1 gene, are currently in good health without liver dysfunction. ...
All 7 patients, who had homozygous or compound heterozygous mutations in the HSD3B7, SRD5B1, or CYP7B1 gene, are currently in good he …
23 results