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2024 12
2025 61

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Page 1
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis.
Dang D, Deogharkar A, McKolay J, Smith KS, Panwalkar P, Hoffman S, Tian W, Ji S, Azambuja AP, Natarajan SK, Lum J, Bayliss J, Manzeck K, Sweha SR, Hamanishi E, Pun M, Patel D, Rau S, Animasahun O, Achreja A, Ogrodzinski MP, Diessl J, Cotter J, Hawes D, Yang F, Doherty R, Franson AT, Hanaford AR, Eberhart CG, Raabe EH, Orr BA, Wechsler-Reya RJ, Chen B, Lyssiotis CA, Shah YM, Lunt SY, Banerjee R, Judkins AR, Prensner JR, Koschmann C, Waszak SM, Nagrath D, Simoes-Costa M, Northcott PA, Venneti S. Dang D, et al. Cancer Cell. 2025 Jun 9;43(6):1159-1174.e8. doi: 10.1016/j.ccell.2025.04.013. Epub 2025 May 15. Cancer Cell. 2025. PMID: 40378837
Long-term results from the AGILE study of azacitidine plus ivosidenib vs placebo in newly diagnosed IDH1-mutated AML.
Montesinos P, Marchione DM, Recher C, Heuser M, Vives S, Zarzycka E, Wang J, Riva M, Calado RT, Schuh AC, Yeh SP, Tron AE, Hui J, Gianolio DA, Choe S, Patel P, De Botton S, DiNardo CD, Döhner H. Montesinos P, et al. Blood Adv. 2025 Oct 28;9(20):5177-5189. doi: 10.1182/bloodadvances.2025016399. Blood Adv. 2025. PMID: 40706052 Free PMC article. Clinical Trial.
Measurable residual mutated IDH1 before allogeneic transplant for acute myeloid leukemia.
Gui G, Ravindra N, Hegde PS, Andrew G, Mukherjee D, Wong Z, Auletta JJ, El Chaer F, Chen EC, Chen YB, Corner A, Devine SM, Iyer SG, Jimenez Jimenez AM, De Lima MJG, Litzow MR, Kebriaei P, Saber W, Spellman SR, Zeger SL, Page KM, Dillon LW, Hourigan CS. Gui G, et al. Bone Marrow Transplant. 2025 Feb;60(2):154-160. doi: 10.1038/s41409-024-02447-4. Epub 2024 Nov 6. Bone Marrow Transplant. 2025. PMID: 39506075 Free PMC article.
Mutant IDH1 cooperates with NPM1c or FLT3(ITD) to drive distinct myeloid diseases and molecular outcomes.
Sakamoto T, Leca J, Zhang X, Meydan C, Foox J, Ramachandran P, Hendrikse LD, Zhou W, Berger T, Fortin J, Chan SM, Chiang MF, Inoue S, Li WY, Chu MF, Duncan GS, Wakeham A, Lemonnier F, Tobin C, Mcwilliam R, Colonna I, Bontoux C, Jafari SM, Bowman RL, Nicolay B, Ronseaux S, Narayanaswamy R, Levine RL, Melnick AM, Mason CE, Minden MD, Mak TW. Sakamoto T, et al. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2415779122. doi: 10.1073/pnas.2415779122. Epub 2025 May 16. Proc Natl Acad Sci U S A. 2025. PMID: 40377995 Free PMC article.
Analysis of IDH1 and IDH2 mutations as causes of the hypermethylator phenotype in colorectal cancer.
Ward JC, Morgan M, Wood J, Woolley C, de Menezes AAN, Finch A, Sherwood K, Huang Q, Henry CS, Fernández-Tajes J, Soriano I, Thorn S, Legge I, McCullagh J, Kerr D, Kerr R, Hejmadi RK, Arends MJ; S:CORT Consortium; Domingo E, Maughan T, Bardella C, Tomlinson I. Ward JC, et al. J Pathol. 2025 Sep;267(1):40-55. doi: 10.1002/path.6446. Epub 2025 Jun 22. J Pathol. 2025. PMID: 40545636 Free PMC article.
62 results