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2024 12
2025 191
2026 24

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202 results

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Page 1
PRMT1-Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma.
Liu S, Zhang W, Liu W, Ding Z, Zhang R, Han Y, Niu Z, Zhang M, Li H, Li D, Wang Z, Peng J, Wu Y, Han Y, Xie Z, Wu J, Qin L, Hu Z, Chen X, Hu Y, Liu Y, Ma S, Zha X. Liu S, et al. Adv Sci (Weinh). 2025 Jun;12(22):e2417460. doi: 10.1002/advs.202417460. Epub 2025 Apr 24. Adv Sci (Weinh). 2025. PMID: 40270464 Free PMC article.
Mechanistically, PRMT1 recruits the SWI/SNF chromatin remodeling complex via direct interaction with SMARCC1, leading to the transcriptional activation of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), which enhances CBP resistan …
Mechanistically, PRMT1 recruits the SWI/SNF chromatin remodeling complex via direct interaction with SMARCC1, leading to the transcriptional …
circFUT8 promotes proplatelet formation by interacting with IGF2BP2 and stabilizing TNS1 mRNA in megakaryocytes.
Wu H, Lu Y, Sun D, Miao Z, Chen S, Xia W, Chen Y, Yu Y, Zhang W, Chen W, Stegner D, Lo SH, Wen A. Wu H, et al. Blood. 2025 Oct 23;146(17):2119-2132. doi: 10.1182/blood.2025028527. Blood. 2025. PMID: 40700582
Mechanistically, we revealed that circFUT8 interacts with insulin-like growth factor 2 messenger RNA (mRNA)-binding protein 2 to stabilize tensin-1 (TNS1) mRNA in an m6A-dependent manner. ...
Mechanistically, we revealed that circFUT8 interacts with insulin-like growth factor 2 messenger RNA (mRN …
M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression.
Ling L, Hu T, Zhou C, Dai Y, Hu L, Chen Y, Hu Z, Huang K, Chen J, Wang Y. Ling L, et al. Mol Cancer. 2025 Jul 8;24(1):192. doi: 10.1186/s12943-025-02399-3. Mol Cancer. 2025. PMID: 40629330 Free PMC article.
Mechanistic investigations revealed that circRAPGEF5 directly interacts with the KH3-4 functional domain of Insulin-like Growth Factor 2 mRNA-Binding Protein 2 (IGF2BP2), an m6A reader protein. This interaction facilitated IGF2BP2-mediated stabi …
Mechanistic investigations revealed that circRAPGEF5 directly interacts with the KH3-4 functional domain of Insulin-like Gr …
Tumor-associated Schwann cells promote salivary adenoid cystic carcinoma stem-like reprogramming via IGF2/IGF1R induced histone H3 lysine 18 lactylation.
Chen S, Huang G, Guo Z, Guo Z, Cao C, Zhao G, Lubamba GP, Huang Y, Yang J, Lian H, Hua Y, Miao C, Shen J, Xuan M, Tang X, Ding Z, Li C. Chen S, et al. Cancer Lett. 2025 Sep 28;628:217847. doi: 10.1016/j.canlet.2025.217847. Epub 2025 Jun 2. Cancer Lett. 2025. PMID: 40466903
We further discovered that TA-SCs elevate histone lactylation in SACC via paracrine IGF2 signaling. Inhibition of IGF2/IGF1R signaling curbed histone H3 lysine 18 lactylation (H3K18la) in SACC and attenuated the IGF2-driven stem-like reprogramming effect, whi …
We further discovered that TA-SCs elevate histone lactylation in SACC via paracrine IGF2 signaling. Inhibition of IGF2/IGF1R s …
Insulin-like growth factor 2 in spermatogenesis dysfunction (Review).
Tang P, Wang J, Tang X, Li Y, Li S. Tang P, et al. Mol Med Rep. 2025 May;31(5):129. doi: 10.3892/mmr.2025.13494. Epub 2025 Mar 21. Mol Med Rep. 2025. PMID: 40116127 Free PMC article. Review.
Inflammation, oxidative stress, endoplasmic reticulum stress and obesity are important factors leading to spermatogenesis dysfunction. It has been demonstrated that insulin-like growth factor 2 (IGF2) is closely related to the aforementio …
Inflammation, oxidative stress, endoplasmic reticulum stress and obesity are important factors leading to spermatogenesis dysfunction. It ha …
WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma.
Huang T, You Q, Liu J, Shen X, Huang D, Tao X, He Z, Wu C, Xi X, Yu S, Liu F, Wu Z, Mao W, Zhu S. Huang T, et al. Adv Sci (Weinh). 2025 Sep;12(33):e06529. doi: 10.1002/advs.202506529. Epub 2025 Jun 5. Adv Sci (Weinh). 2025. PMID: 40470706 Free PMC article.
In addition, wilms tumor 1-associated protein (WTAP) mediated m6A modification enhances the stability of PDIA3P1 through Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) dependent recognition. Taken together, these findings reveal t …
In addition, wilms tumor 1-associated protein (WTAP) mediated m6A modification enhances the stability of PDIA3P1 through Insulin-l …
The Role of Epigenetics in Preeclampsia.
Karkampouna A, Papakonstantinou E, Bacopoulou F, Vlahos N, Chrousos GP, Vlachakis D. Karkampouna A, et al. Adv Exp Med Biol. 2026;1490:383-388. doi: 10.1007/978-3-032-03402-1_40. Adv Exp Med Biol. 2026. PMID: 41479102 Review.
Focus is given to the role of altered DNA methylation patterns, such as those observed in the HSD11B2 and IGF2 genes, which could serve as potential biomarkers for early diagnosis. Understanding these epigenetic changes offers opportunities for developing novel diagnostic …
Focus is given to the role of altered DNA methylation patterns, such as those observed in the HSD11B2 and IGF2 genes, which could ser …
Therapeutic strategies for adrenocortical carcinoma: integrating genomic insights, molecular targeting, and immunotherapy.
Sun J, Huai J, Zhang W, Zhao T, Shi R, Wang X, Li M, Jiao X, Zhou X. Sun J, et al. Front Immunol. 2025 Mar 12;16:1545012. doi: 10.3389/fimmu.2025.1545012. eCollection 2025. Front Immunol. 2025. PMID: 40145087 Free PMC article. Review.
This review discusses the complex molecular pathogenesis of ACC, focusing on critical pathways implicated in the tumorigenesis and providing potential targets for therapy: the Wnt/beta-catenin signaling pathway, the IGF2/IGF1R axis, and the apoptosis pathway regulated by p …
This review discusses the complex molecular pathogenesis of ACC, focusing on critical pathways implicated in the tumorigenesis and providing …
202 results