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Year Number of Results
2020 3
2021 8
2022 5
2023 5
2024 2

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METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
Tang Y, Hong F, Ding S, Yang J, Zhang M, Ma Y, Zheng Q, Yang D, Jin Y, Ma C. Tang Y, et al. Cell Rep. 2023 Jun 27;42(6):112589. doi: 10.1016/j.celrep.2023.112589. Epub 2023 Jun 2. Cell Rep. 2023. PMID: 37270777 Free article.
Further mechanistic research reveals that IGFBP7-OT promotes OA progression by upregulating IGFBP7 expression. Specifically, IGFBP7-OT suppresses the occupancy of DNMT1 and DNMT3a on the IGFBP7 promoter, thereby inhibiting methylation of the IGFBP7
Further mechanistic research reveals that IGFBP7-OT promotes OA progression by upregulating IGFBP7 expression. Specifically, …
Exercise protects proliferative muscle satellite cells against exhaustion via the Igfbp7-Akt-mTOR axis.
Chen Z, Li L, Wu W, Liu Z, Huang Y, Yang L, Luo Q, Chen J, Hou Y, Song G. Chen Z, et al. Theranostics. 2020 May 16;10(14):6448-6466. doi: 10.7150/thno.43577. eCollection 2020. Theranostics. 2020. PMID: 32483463 Free PMC article.
Proliferative SCs in "exercised mice" required suppressed mTOR activity to limit mitochondrial metabolism, maintaining the "limited activation status" of SCs against exhaustion. Mechanistically, exercise upregulated the expression of Igfbp7, thereby impeding the phosphoryl …
Proliferative SCs in "exercised mice" required suppressed mTOR activity to limit mitochondrial metabolism, maintaining the "limited activati …
Plasma Insulin-like Growth Factor Binding Protein 7 Contributes Causally to ARDS 28-Day Mortality: Evidence From Multistage Mendelian Randomization.
Dong X, Zhu Z, Wei Y, Ngo D, Zhang R, Du M, Huang H, Lin L, Tejera P, Su L, Chen F, Ahasic AM, Thompson BT, Meyer NJ, Christiani DC. Dong X, et al. Chest. 2021 Mar;159(3):1007-1018. doi: 10.1016/j.chest.2020.10.074. Epub 2020 Nov 12. Chest. 2021. PMID: 33189655 Free PMC article.
Causal mediation analysis detected the role of platelet count in mediating the effect of protein on ARDS prognosis. RESULTS: Plasma insulin-like growth factor binding protein 7 (IGFBP7) moderately increased ARDS 28-day morta …
Causal mediation analysis detected the role of platelet count in mediating the effect of protein on ARDS prognosis. RESULTS: Plasma insul
Association of insulin-like growth factor binding protein-7 promoter methylation with esophageal cancer in peripheral blood.
Kaya Z, Almalı N, Sahin ES, Duran S, Görgisen G, Ates C. Kaya Z, et al. Mol Biol Rep. 2022 May;49(5):3423-3431. doi: 10.1007/s11033-022-07173-y. Epub 2022 Jan 25. Mol Biol Rep. 2022. PMID: 35076852
Methylation specific PCR (MSP) was used to examine IGFBP7's promoter methylation and real-time quantitative reverse transcription PCR (qRT-PCR) was used to assess IGFBP7 mRNA expression. ...The globulin level and reflux were significantly higher in IGFBP7-unm …
Methylation specific PCR (MSP) was used to examine IGFBP7's promoter methylation and real-time quantitative reverse transcription PCR …
Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies.
Mann TD, Kopel E, Eisenberg E, Levanon EY. Mann TD, et al. PLoS Comput Biol. 2023 Apr 10;19(4):e1010923. doi: 10.1371/journal.pcbi.1010923. eCollection 2023 Apr. PLoS Comput Biol. 2023. PMID: 37036839 Free PMC article.
We describe a single recoding editing site and suggest it as a target for focused research. This recoding editing site in the IGFBP7 gene is one of the only evolutionary conserved sites between mammals, and we found it exhibits consistently increased levels of editing in t …
We describe a single recoding editing site and suggest it as a target for focused research. This recoding editing site in the IGFBP7
Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development.
Shah AM, Myhre PL, Arthur V, Dorbala P, Rasheed H, Buckley LF, Claggett B, Liu G, Ma J, Nguyen NQ, Matsushita K, Ndumele C, Tin A, Hveem K, Jonasson C, Dalen H, Boerwinkle E, Hoogeveen RC, Ballantyne C, Coresh J, Omland T, Yu B. Shah AM, et al. Nat Commun. 2024 Jan 15;15(1):528. doi: 10.1038/s41467-023-44680-3. Nat Commun. 2024. PMID: 38225249 Free PMC article.
Mendelian randomization supported causal effects of 10 on HF, HF risk factors, or left ventricular size and function, including matricellular (e.g. SPON1, MFAP4), senescence-associated (FSTL3, IGFBP7), and inflammatory (SVEP1, CCL15, ITIH3) proteins. Protein co-regulation …
Mendelian randomization supported causal effects of 10 on HF, HF risk factors, or left ventricular size and function, including matricellula …
The Insight into Insulin-Like Growth Factors and Insulin-Like Growth-Factor-Binding Proteins and Metabolic Profile in Pediatric Obesity.
Czogała W, Strojny W, Tomasik P, Multanowski MB, Wójcik M, Miklusiak K, Krzysztofik E, Wróbel A, Miklusiak K, Skoczeń S. Czogała W, et al. Nutrients. 2021 Jul 15;13(7):2432. doi: 10.3390/nu13072432. Nutrients. 2021. PMID: 34371941 Free PMC article.
The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese children (OB) and 34 healthy control (HC), and their correlation with essential parameters associated with childhood obesity. The gene expressio …
The aim of the study was to analyze the expression of chosen IGF-axis genes and the concentration of their protein products in 28 obese chil …
Total NT-proBNP, a novel biomarker related to recurrent atrial fibrillation.
Staszewsky L, Meessen JMTA, Novelli D, Wienhues-Thelen UH, Disertori M, Maggioni AP, Masson S, Tognoni G, Franzosi MG, Lucci D, Latini R. Staszewsky L, et al. BMC Cardiovasc Disord. 2021 Nov 19;21(1):553. doi: 10.1186/s12872-021-02358-y. BMC Cardiovasc Disord. 2021. PMID: 34798808 Free PMC article. Clinical Trial.
METHODS: A total of 382 patients of the GISSI-AF trial in sinus rhythm with a history of AF, echocardiographic variables, total NT-proBNP, NT-proBNP and nine additional biomarkers [Total N-terminal pro-B type natriuretic peptide (Total NT proBNP), N-terminal pro-B type natriureti …
METHODS: A total of 382 patients of the GISSI-AF trial in sinus rhythm with a history of AF, echocardiographic variables, total NT-proBNP, N …
Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice: Assessing Differences in Igfbp7, Pcsk1, Nhlh2 and Nlgn3 Expression.
Kummerfeld DM, Skryabin BV, Brosius J, Vakhrushev SY, Rozhdestvensky TS. Kummerfeld DM, et al. Int J Mol Sci. 2022 Aug 5;23(15):8729. doi: 10.3390/ijms23158729. Int J Mol Sci. 2022. PMID: 35955861 Free PMC article.
Using these reference genes, we revealed significant differences in the expression patterns of Igfbp7, Nlgn3 and three HPA associated genes: Pcsk1, Pcsk2 and Nhlh2 across investigated brain regions of wild-type and PWScr mice. ...
Using these reference genes, we revealed significant differences in the expression patterns of Igfbp7, Nlgn3 and three HPA associated …
Obese-Inflammatory Phenotypes in Heart Failure With Preserved Ejection Fraction.
Sabbah MS, Fayyaz AU, de Denus S, Felker GM, Borlaug BA, Dasari S, Carter RE, Redfield MM. Sabbah MS, et al. Circ Heart Fail. 2020 Aug;13(8):e006414. doi: 10.1161/CIRCHEARTFAILURE.119.006414. Epub 2020 Jul 29. Circ Heart Fail. 2020. PMID: 32809874 Free PMC article.
Associations of clusters with HFpEF severity and fibrosis biomarkers (PIIINP [procollagen III N-terminal peptide], CITP [C-telopeptide for type I collagen], IGFBP7 [insulin-like growth factor-binding protein-7], and GAL-3 [g …
Associations of clusters with HFpEF severity and fibrosis biomarkers (PIIINP [procollagen III N-terminal peptide], CITP [C-telopeptide for t …
21 results