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2022 3
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METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
Tang Y, Hong F, Ding S, Yang J, Zhang M, Ma Y, Zheng Q, Yang D, Jin Y, Ma C. Tang Y, et al. Cell Rep. 2023 Jun 27;42(6):112589. doi: 10.1016/j.celrep.2023.112589. Epub 2023 Jun 2. Cell Rep. 2023. PMID: 37270777 Free article.
In this study, we find that the expressions of long noncoding RNA (lncRNA) IGFBP7-OT and its maternal gene, IGFBP7, are upregulated and positively correlated in osteoarthritic cartilage. ...Further mechanistic research reveals that IGFBP7-OT promotes OA progr …
In this study, we find that the expressions of long noncoding RNA (lncRNA) IGFBP7-OT and its maternal gene, IGFBP7, are upregu …
Personalized acute kidney injury treatment.
Porschen C, Strauss C, Meersch M, Zarbock A. Porschen C, et al. Curr Opin Crit Care. 2023 Dec 1;29(6):551-558. doi: 10.1097/MCC.0000000000001089. Epub 2023 Oct 6. Curr Opin Crit Care. 2023. PMID: 37861191 Review.
Biomarkers, such as Cystatin C, NGAL, TIMP2 IGFBP7, CCL14, and DKK-3, have shown promise in predicting AKI development, renal recovery, and prognosis. ...
Biomarkers, such as Cystatin C, NGAL, TIMP2 IGFBP7, CCL14, and DKK-3, have shown promise in predicting AKI development, renal recover …
Telomere Length, Oxidative Stress, and Kidney Damage Biomarkers in Fabry Nephropathy.
Levstek T, Bahčič E, Vujkovac B, Cokan Vujkovac A, Tesovnik T, Remec ŽI, Čuk V, Trebušak Podkrajšek K. Levstek T, et al. Cells. 2025 Feb 4;14(3):218. doi: 10.3390/cells14030218. Cells. 2025. PMID: 39937009 Free PMC article.
Oxidative stress biomarkers showed no differences between patients and controls, while significant differences were observed in urinary IGFBP7, EGF, and OPN levels between Fabry patients with stable kidney function and those with progressive nephropathy (FDR = 0.021, 0.002 …
Oxidative stress biomarkers showed no differences between patients and controls, while significant differences were observed in urinary I …
Genetics of ALS - genes and modifier.
Menge S, Decker L, Freischmidt A. Menge S, et al. Curr Opin Neurol. 2025 Oct 1;38(5):568-573. doi: 10.1097/WCO.0000000000001416. Epub 2025 Aug 7. Curr Opin Neurol. 2025. PMID: 40772638 Free PMC article. Review.
A rare hyperactive variant of ER stress associated transcription factor CREB3 was linked to both substantially decreased ALS risk and slower disease progression. Furthermore, variants in IGFBP7 were linked to rare "ALS reversals", but existence of such phenotypes is contro …
A rare hyperactive variant of ER stress associated transcription factor CREB3 was linked to both substantially decreased ALS risk and slower …
Development of a novel non-invasive biomarker panel for hepatic fibrosis in MASLD.
Verschuren L, Mak AL, van Koppen A, Özsezen S, Difrancesco S, Caspers MPM, Snabel J, van der Meer D, van Dijk AM, Rashu EB, Nabilou P, Werge MP, van Son K, Kleemann R, Kiliaan AJ, Hazebroek EJ, Boonstra A, Brouwer WP, Doukas M, Gupta S, Kluft C, Nieuwdorp M, Verheij J, Gluud LL, Holleboom AG, Tushuizen ME, Hanemaaijer R. Verschuren L, et al. Nat Commun. 2024 May 29;15(1):4564. doi: 10.1038/s41467-024-48956-0. Nat Commun. 2024. PMID: 38811591 Free PMC article.
The resulting biomarker panel consists of IGFBP7, SSc5D and Sema4D. LightGBM modeling using this panel demonstrates high accuracy in predicting MASLD fibrosis stage (F0/F1: AUC = 0.82; F2: AUC = 0.89; F3/F4: AUC = 0.87), which is replicated in an independent validation coh …
The resulting biomarker panel consists of IGFBP7, SSc5D and Sema4D. LightGBM modeling using this panel demonstrates high accuracy in …
Pinpointing Novel Plasma and Brain Proteins for Common Ocular Diseases: A Comprehensive Cross-Omics Integration Analysis.
Mo Q, Liu X, Gong W, Wang Y, Yuan Z, Sun X, Wang S. Mo Q, et al. Int J Mol Sci. 2024 Sep 24;25(19):10236. doi: 10.3390/ijms251910236. Int J Mol Sci. 2024. PMID: 39408566 Free PMC article.
Combined with a drug exploration analysis, we found that the drugs related to C3 and TXN have been used for the treatment of ODs, and another eight genes (GSTM3 for senile cataract, IGFBP7 and CFHR1 for AMD, PTPMT1 for glaucoma, EFEMP1 and ACP1 for myopia, SIRPG and CTSH f …
Combined with a drug exploration analysis, we found that the drugs related to C3 and TXN have been used for the treatment of ODs, and anothe …
Exploring the link: DNA methylation and kidney injury markers in farmers exposed to glyphosate-surfactant herbicides.
Khacha-Ananda S, Intayoung U, Kohsuwan K, Wunnapuk K. Khacha-Ananda S, et al. Regul Toxicol Pharmacol. 2025 Feb;156:105765. doi: 10.1016/j.yrtph.2024.105765. Epub 2024 Dec 17. Regul Toxicol Pharmacol. 2025. PMID: 39701272
This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biomarkers-specifically DNA methylation, KIM-1, TIMP2, and IGFBP7-in farmers regularly exposed to these chemicals. Two urine samples, pre-task (0-h) and post-task (24-h) …
This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biomarkers-specifically DNA methylat …
Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development.
Shah AM, Myhre PL, Arthur V, Dorbala P, Rasheed H, Buckley LF, Claggett B, Liu G, Ma J, Nguyen NQ, Matsushita K, Ndumele C, Tin A, Hveem K, Jonasson C, Dalen H, Boerwinkle E, Hoogeveen RC, Ballantyne C, Coresh J, Omland T, Yu B. Shah AM, et al. Nat Commun. 2024 Jan 15;15(1):528. doi: 10.1038/s41467-023-44680-3. Nat Commun. 2024. PMID: 38225249 Free PMC article.
SPON1, MFAP4), senescence-associated (FSTL3, IGFBP7), and inflammatory (SVEP1, CCL15, ITIH3) proteins. Protein co-regulation network analyses identified 5 modules associated with HF risk, two of which were influenced by genetic variants that implicated trans hotspots withi …
SPON1, MFAP4), senescence-associated (FSTL3, IGFBP7), and inflammatory (SVEP1, CCL15, ITIH3) proteins. Protein co-regulation network …
Single-Cell Meta-Analysis Uncovers the Pancreatic Endothelial Cell Transcriptomic Signature and Reveals a Key Role for NKX2-3 in PLVAP Expression.
Khan ST, Ahuja N, Taïb S, Vohra S, Cleaver O, Nunes SS. Khan ST, et al. Arterioscler Thromb Vasc Biol. 2024 Dec;44(12):2596-2615. doi: 10.1161/ATVBAHA.124.321781. Epub 2024 Oct 24. Arterioscler Thromb Vasc Biol. 2024. PMID: 39445426 Free PMC article.
We identified and validated a specialized islet capillary subpopulation characterized by genes involved in permeability (PLVAP and EHD4), immune-modulation (FABP5, HLA-C, and B2M), ECM composition (SPARC and SPARCL1), IGF (insulin-like growth factor) signaling (IGFBP7), an …
We identified and validated a specialized islet capillary subpopulation characterized by genes involved in permeability (PLVAP and EHD4), im …
Vitamin C Mediates IGFBP7 to Alleviate Chronic Atrophic Gastritis via the HIF-1alpha/VEGF Pathway.
Cheng X, Gu H, Chong Y, Li F, Bei S, Li H, Jiang J, Pan M, Feng L, Zhang X. Cheng X, et al. J Cell Mol Med. 2025 Feb;29(4):e70392. doi: 10.1111/jcmm.70392. J Cell Mol Med. 2025. PMID: 40012220 Free PMC article.
WGCNA identified that the blue module was significantly associated with CAG with a correlation coefficient 0.924. Among 93 overlapping genes, IGFBP7 was notably underexpressed and selected as a hub gene. ROC analysis confirmed the high diagnostic performance of IGFBP7 …
WGCNA identified that the blue module was significantly associated with CAG with a correlation coefficient 0.924. Among 93 overlapping genes …
48 results