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2021 15
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Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3.
Li F, Xu T, Chen P, Sun R, Li C, Zhao X, Ou J, Li J, Liu T, Zeng M, Zheng W, Lin Y, Yang L, Li Z, Chen H, Zhang Q. Li F, et al. Int J Biol Sci. 2022 Sep 24;18(15):5858-5872. doi: 10.7150/ijbs.76162. eCollection 2022. Int J Biol Sci. 2022. PMID: 36263165 Free PMC article.
Here we found that the distant metastasis of NPC patients was positively correlated with the expression levels of integrin beta3 (ITGB3) in platelet-derived extracellular vesicles (EVs) from NPC patients (P-EVs). We further revealed that EVs transfer occurred from platelet …
Here we found that the distant metastasis of NPC patients was positively correlated with the expression levels of integrin beta3 (ITGB3 …
Gene Expression Linked to Reepithelialization of Human Skin Wounds.
Ågren MS, Litman T, Eriksen JO, Schjerling P, Bzorek M, Gjerdrum LMR. Ågren MS, et al. Int J Mol Sci. 2022 Dec 12;23(24):15746. doi: 10.3390/ijms232415746. Int J Mol Sci. 2022. PMID: 36555389 Free PMC article.
We identified 22 upregulated differentially expressed genes (DEGs) in descending order of fold change (MMP1, MMP3, IL6, CXCL8, SERPINE1, IL1B, PTGS2, HBEGF, CXCL5, CXCL2, TIMP1, CYR61, CXCL1, MMP12, MMP9, HGF, CTGF, ITGB3, MT2A, FGF7, COL4A1 and PLAUR). The expression of t …
We identified 22 upregulated differentially expressed genes (DEGs) in descending order of fold change (MMP1, MMP3, IL6, CXCL8, SERPINE1, IL1 …
lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling.
Lin X, Zhuang S, Chen X, Du J, Zhong L, Ding J, Wang L, Yi J, Hu G, Tang G, Luo X, Liu W, Ye F. Lin X, et al. Mol Ther. 2022 Feb 2;30(2):688-702. doi: 10.1016/j.ymthe.2021.08.011. Epub 2021 Aug 8. Mol Ther. 2022. PMID: 34371180 Free PMC article.
Mechanistically, ITGB8-AS1 could sponge miR-33b-5p and let-7c-5p/let-7d-5p to regulate the expression of integrin family genes ITGA3 and ITGB3, respectively, in the cytosol of cells. Targeting ITGB8-AS1 using antisense oligonucleotide (ASO) markedly reduced cell proliferat …
Mechanistically, ITGB8-AS1 could sponge miR-33b-5p and let-7c-5p/let-7d-5p to regulate the expression of integrin family genes ITGA3 and …
Promotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation.
Wu M, Zhang JB, Xiong YW, Zhao YX, Zheng MG, Huang XL, Huang F, Wu XX, Li X, Fan WJ, Hu L, Zeng YY, Cheng XJ, Yue JC, Du JJ, Chen NN, Wei WX, Yao QH, Lu XM, Huang C, Deng J, Chang ZJ, Liu HB, Zhao TC, Chinn YE. Wu M, et al. Adv Sci (Weinh). 2023 Jan;10(3):e2205462. doi: 10.1002/advs.202205462. Epub 2022 Dec 1. Adv Sci (Weinh). 2023. PMID: 36453571 Free PMC article.
Here it is described that multiple acetyl-vWA domain-carrying proteins including integrin beta3 (ITGB3) and collagen 6A (COL6A) are deacetylated by Sirtuin family member SIRT2 in extracellular space. ...In lung cancer patients, significantly increased serum eSIRT2 level co …
Here it is described that multiple acetyl-vWA domain-carrying proteins including integrin beta3 (ITGB3) and collagen 6A (COL6A) are d …
Exploring a shared genetic signature and immune infiltration between spontaneous intracerebral hemorrhage and Helicobacter pylori infection.
Liu X, Li M, Han Q, Zuo Z, Wang Q, Su D, Fan M, Chen T. Liu X, et al. Microb Pathog. 2023 May;178:106067. doi: 10.1016/j.micpath.2023.106067. Epub 2023 Mar 11. Microb Pathog. 2023. PMID: 36914055
In addition, the cytoHubba plugin identified 15 important hub genes, namely PLEK, NCF2, CXCR4, CXCL1, FGR, CXCL12, CXCL2, CD69, NOD2, RGS1, SLA, LCP1, HMOX1, EDN1, and ITGB3.Also, the correlation analysis of immune cell fractions revealed a limited link between their immun …
In addition, the cytoHubba plugin identified 15 important hub genes, namely PLEK, NCF2, CXCR4, CXCL1, FGR, CXCL12, CXCL2, CD69, NOD2, RGS1, …
Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients.
Hirata TDC, Dagli-Hernandez C, Genvigir FDV, Lauschke VM, Zhou Y, Hirata MH, Hirata RDC. Hirata TDC, et al. Mol Diagn Ther. 2021 Nov;25(6):735-755. doi: 10.1007/s40291-021-00549-z. Epub 2021 Aug 6. Mol Diagn Ther. 2021. PMID: 34357562 Review.
Few pharmacogenomics studies have explored antiplatelet drugs in Brazilian cohorts, finding associations between CYP2C19*2, PON1 rs662 and ABCC3 rs757421 genotypes and platelet responsiveness or clopidogrel PK in subjects with coronary artery disease (CAD) or acute coronary syndr …
Few pharmacogenomics studies have explored antiplatelet drugs in Brazilian cohorts, finding associations between CYP2C19*2, PON1 rs662 and A …
Simultaneous genotyping for human platelet antigen systems and HLA-A and HLA-B loci by targeted next-generation sequencing.
Wang J, You X, He Y, Hong X, He J, Tao S, Zhu F. Wang J, et al. Front Immunol. 2022 Sep 29;13:945994. doi: 10.3389/fimmu.2022.945994. eCollection 2022. Front Immunol. 2022. PMID: 36263028 Free PMC article.
A RNA capture probe panel was designed covering all exon sequences of the GP1BA, GP1BB, ITGA2, CD109, ITGB3, and ITGA2B genes and HLA-A and HLA-B loci. The HLA-A, HLA-B, and 34 HPA systems were genotyped using a targeted next-generation sequencing (NGS) method. ...
A RNA capture probe panel was designed covering all exon sequences of the GP1BA, GP1BB, ITGA2, CD109, ITGB3, and ITGA2B genes and HLA …
Positive feedback regulation of lncRNA TPT1-AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer.
Cheng C, Liu D, Liu Z, Li M, Wang Y, Sun B, Kong R, Chen H, Wang G, Li L, Hu J, Li Y, Chen H, Zhao Z, Zhang T, Zhu S, Pan S. Cheng C, et al. Cancer Sci. 2022 Sep;113(9):2986-3001. doi: 10.1111/cas.15388. Epub 2022 May 23. Cancer Sci. 2022. PMID: 35534983 Free PMC article.
Mechanistically, TPT1-AS1 functioned as an endogenous sponge for miR-30a-5p, which increased integrin beta3 (ITGB3) level in pancreatic cancer cells. Conversely, our data revealed that ITGB3 could activate the transcription factor signal transducer and activator of …
Mechanistically, TPT1-AS1 functioned as an endogenous sponge for miR-30a-5p, which increased integrin beta3 (ITGB3) level in pancreat …
SINE-VNTR-Alu retrotransposon insertion as a novel mutational event underlying Glanzmann thrombasthenia.
Zhang J, Tang J, Li G, Li N, Wang J, Yao R, Yu T. Zhang J, et al. J Thromb Haemost. 2023 Dec;21(12):3597-3607. doi: 10.1016/j.jtha.2023.08.012. Epub 2023 Aug 20. J Thromb Haemost. 2023. PMID: 37604334
The 5' truncated SVA element was inserted in a sense orientation in intron 11 of ITGB3, resulting in aberrant splicing of ITGB3 and significantly reducing beta3 protein content. ...CONCLUSION: Novel compound heterozygous ITGB3 mutations were identified in the …
The 5' truncated SVA element was inserted in a sense orientation in intron 11 of ITGB3, resulting in aberrant splicing of ITGB3 …
Exploration and validation of hub genes and pathways in the progression of hypoplastic left heart syndrome via weighted gene co-expression network analysis.
Liu X, Shang H, Li B, Zhao L, Hua Y, Wu K, Hu M, Fan T. Liu X, et al. BMC Cardiovasc Disord. 2021 Jun 15;21(1):300. doi: 10.1186/s12872-021-02108-0. BMC Cardiovasc Disord. 2021. PMID: 34130651 Free PMC article.
We identified five hub genes in the black module (including Fbn1, Itga8, Itga11, Itgb5 and Thbs2), and five hub genes (including Cblb, Ccl2, Edn1, Itgb3 and Map2k1) in the pink module for HLHS. Their abnormal expression was verified in the GSE23959 dataset. ...
We identified five hub genes in the black module (including Fbn1, Itga8, Itga11, Itgb5 and Thbs2), and five hub genes (including Cblb, Ccl2, …
44 results