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2020 1
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Page 1
A spatially resolved transcriptome landscape during thyroid cancer progression.
Liao T, Zeng Y, Xu W, Shi X, Shen C, Du Y, Zhang M, Zhang Y, Li L, Ding P, Hu W, Huang Z, Fung MHM, Ji Q, Wang Y, Li S, Wei W. Liao T, et al. Cell Rep Med. 2025 Apr 15;6(4):102043. doi: 10.1016/j.xcrm.2025.102043. Epub 2025 Mar 28. Cell Rep Med. 2025. PMID: 40157360 Free PMC article.
We reveal stage-specific tumor leading edge remodeling and establish high-confidence cell-cell interactions, such as COL8A1-ITHB1 in PTC, LAMB2-ITGB4 in LPTC, and SERPINE1-PLAUR in ATC. Notably, both SERPINE1 expression level and SERPINE1(+) fibroblast abundance correlate …
We reveal stage-specific tumor leading edge remodeling and establish high-confidence cell-cell interactions, such as COL8A1-ITHB1 in PTC, LA …
Genotype and phenotype correlations in 441 patients with epidermolysis bullosa from China.
Chen F, Wei R, Deng D, Zhang X, Cao Y, Pan C, Wang Y, Cao Q, Wang J, Zeng M, Huang L, Gu Y, Yao Z, Li M. Chen F, et al. J Eur Acad Dermatol Venereol. 2023 Feb;37(2):411-419. doi: 10.1111/jdv.18692. Epub 2022 Nov 5. J Eur Acad Dermatol Venereol. 2023. PMID: 36287101
In 16 probands with presumptive recessive EB, failed to find the second allele, COL7A1 (10), COL17A1 (4), LAMB3 (1) and ITGB4 (1). De novo mutations are common in dominant EB (63.8% in EBS, 27.5% in DEB) but extremely rare in recessive DEB (RDEB; 0.74%). ...
In 16 probands with presumptive recessive EB, failed to find the second allele, COL7A1 (10), COL17A1 (4), LAMB3 (1) and ITGB4 (1). De …
Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells.
Myeong J, Lee M, Lee B, Kim JH, Nam Y, Choi Y, Kim J, Jeon SY, Shim H, Jung DR, Shin Y, Jeong M, Oh B, Jung J, Kim CS, Han HS, Shin JH, Lee YH, Park NJ, Chong GO, Jeong Y. Myeong J, et al. Nat Commun. 2025 Mar 8;16(1):2327. doi: 10.1038/s41467-025-57323-6. Nat Commun. 2025. PMID: 40057497 Free PMC article.
By establishing normal and precancerous cervical organoids and an intralingual transplantation system, we show that ITGB4 and CD24 enable enrichment of human and murine ectocervical stem cells. We discover that Lactobacilli-derived lactic acid regulates cervical stem cells …
By establishing normal and precancerous cervical organoids and an intralingual transplantation system, we show that ITGB4 and CD24 en …
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer.
Zhou J, He M, Zhao Q, Shi E, Wang H, Ponkshe V, Song J, Wu Z, Ji D, Kranz G, Tscherne A, Schwenk-Zieger S, Razak NA, Hess J, Belka C, Zitzelsberger H, Ourailidis I, Stögbauer F, Boxberg M, Budczies J, Reichel CA, Canis M, Baumeister P, Wang H, Unger K, Mock A, Gires O. Zhou J, et al. Mol Cancer. 2025 Mar 22;24(1):94. doi: 10.1186/s12943-025-02290-1. Mol Cancer. 2025. PMID: 40121428 Free PMC article.
InvGRN comprises the central hubs inhibin subunit beta alpha (INHBA) and snail family transcriptional repressor 2 (SNAI2), and druggable fDEGs integrin subunit beta 4 (ITGB4), laminin 5 (LAMB3/LAMC2), and sphingosine kinase 1 (SPHK1). ...
InvGRN comprises the central hubs inhibin subunit beta alpha (INHBA) and snail family transcriptional repressor 2 (SNAI2), and druggable fDE …
MFAP2 upregulation promotes ESCC metastasis via FAK-AKT signaling pathway.
Deng Y, Huang X, Yang Y, Zhang Y, Zeng B, Bao Y, Cao L, Wang X, Ma L, Wang J. Deng Y, et al. FASEB J. 2024 Dec 13;38(24):e70266. doi: 10.1096/fj.202402411R. FASEB J. 2024. PMID: 39698924
Mechanistically, MFAP2 was shown to bind to the FERM domain of focal adhesion kinase (FAK) and to alleviate FAK intramolecular inhibition, resulting in the enhanced binding affinity between FAK and integrin beta 4 (ITGB4) and activation of the FAK-AKT …
Mechanistically, MFAP2 was shown to bind to the FERM domain of focal adhesion kinase (FAK) and to alleviate FAK intramolecular inhibition, r …
Single-Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment.
Song H, Tong Z, Xie G, Li Y, Zhao Y, Fan F, Yang Z, Shi Q, Zhang Q, Wen F, Meng H, Li H, Guo P, Hou D, Zhang Z, Yin Z, Liu Z, Wang J, Zhang P, Dai P, Li C, Teng L, Xu Y, Ding D, Xu T, Li J, Chen Y, Qiu Y, Hu X, Liu W, Wu L, Nawroth R, Li G, Su H, Deng Z, Wang Z, Wang D, Xu W. Song H, et al. Adv Sci (Weinh). 2025 Sep;12(33):e00216. doi: 10.1002/advs.202500216. Epub 2025 Jun 5. Adv Sci (Weinh). 2025. PMID: 40470730 Free PMC article.
This subtype exhibited enhanced basal-like and stemness features and showed high LAMC2 expression, which activated laminin-integrin signaling via ITGA6/ITGB4, promoting tumor invasiveness. Furthermore, the results indicated that HPV-positive basal stem-like neoplasm …
This subtype exhibited enhanced basal-like and stemness features and showed high LAMC2 expression, which activated laminin-integrin s …
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.
Mohanty A, Nam A, Srivastava S, Jones J, Lomenick B, Singhal SS, Guo L, Cho H, Li A, Behal A, Mirzapoiazova T, Massarelli E, Koczywas M, Arvanitis LD, Walser T, Villaflor V, Hamilton S, Mambetsariev I, Sattler M, Nasser MW, Jain M, Batra SK, Soldi R, Sharma S, Fakih M, Mohanty SK, Mainan A, Wu X, Chen Y, He Y, Chou TF, Roy S, Orban J, Kulkarni P, Salgia R. Mohanty A, et al. Sci Adv. 2023 Oct 13;9(41):eade3816. doi: 10.1126/sciadv.ade3816. Epub 2023 Oct 13. Sci Adv. 2023. PMID: 37831779 Free PMC article.
Here, we demonstrate that acquired resistance to sotorasib in isogenic cells correlated with increased expression of integrin beta4 (ITGB4), a component of the focal adhesion complex. Silencing ITGB4 in tolerant cells improved sotorasib sensitivity, while ove …
Here, we demonstrate that acquired resistance to sotorasib in isogenic cells correlated with increased expression of integrin beta4 ( …
A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O. Schinke H, et al. Mol Cancer. 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. Mol Cancer. 2022. PMID: 36076232 Free PMC article.
A 5-gene risk score comprising DDIT4, FADD, ITGB4, NCEH1, and TIMP1 prognosticated overall survival (OS) in TCGA and was confirmed in independent HNSCC cohorts. ...In vitro, ITGB4 knock-down reduced EGFR-mediated migration and invasion and ITGB4-antagonizing …
A 5-gene risk score comprising DDIT4, FADD, ITGB4, NCEH1, and TIMP1 prognosticated overall survival (OS) in TCGA and was confirmed in …
NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.
Shi Y, Fang N, Wu Y, Xu H, Ning A, Zhang W, Liu Y, Tao X, Chen Q, Tian T, Zhang L, Chu M, Cui J. Shi Y, et al. Cell Commun Signal. 2024 Jun 3;22(1):302. doi: 10.1186/s12964-024-01685-9. Cell Commun Signal. 2024. PMID: 38831335 Free PMC article.
Based on co-immunoprecipitation and proteome analysis, the NEDD4L ubiquitination-degraded protein ITGB4 was obtained. In terms of the mechanism, the HECT domain of NEDD4L specifically bound to the Galx-beta domain of ITGB4, which modified the K915 site of ITGB4 …
Based on co-immunoprecipitation and proteome analysis, the NEDD4L ubiquitination-degraded protein ITGB4 was obtained. In terms of the …
Integrin alpha6 and integrin beta4 in exosomes promote lung metastasis of colorectal cancer.
Cong F, Huang J, Wu C, Zhong H, Qiu G, Luo T, Tang W. Cong F, et al. J Cancer Res Ther. 2024 Dec 1;20(7):2082-2093. doi: 10.4103/jcrt.jcrt_230_24. Epub 2025 Jan 10. J Cancer Res Ther. 2024. PMID: 39792419 Free article.
METHODS: We used the Cancer Genome Atlas dataset to compare mRNA expression patterns of integrin alpha6 (ITGA6) and integrin beta4 (ITGB4) in patients with CRC. We measured ITGA6 and ITGB4 expression levels in highly metastatic (i.e., HCT116 and SW620) …
METHODS: We used the Cancer Genome Atlas dataset to compare mRNA expression patterns of integrin alpha6 (ITGA6) and integrin b …
87 results