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JAK: Not Just Another Kinase.
Agashe RP, Lippman SM, Kurzrock R. Agashe RP, et al. Mol Cancer Ther. 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. Mol Cancer Ther. 2022. PMID: 36252553 Free PMC article. Review.
Numerous cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK2) noncovalently associate with cytokine receptors, mediate receptor tyrosine phosphorylation, and recruit 1 STAT proteins (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6). . …
Numerous cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK2) noncovalently associate with cytokine …
IL-7: Comprehensive review.
Winer H, Rodrigues GOL, Hixon JA, Aiello FB, Hsu TC, Wachter BT, Li W, Durum SK. Winer H, et al. Cytokine. 2022 Dec;160:156049. doi: 10.1016/j.cyto.2022.156049. Epub 2022 Oct 3. Cytokine. 2022. PMID: 36201890 Review.
IL-7 RECEPTOR SIGNAL TRANSDUCTION PATHWAYS: Major signals through JAK1, JAK3 to STAT5 and through non-canonical STAT3, STAT1, PI3K/AKT and MEK/ERK pathways. BIOLOGICAL ACTIVITY OF IL-7: Required for survival of immature thymocytes, naive T-cells, memory T-cells, pro-B-cell …
IL-7 RECEPTOR SIGNAL TRANSDUCTION PATHWAYS: Major signals through JAK1, JAK3 to STAT5 and through non-canonical STAT3, STAT1, PI3K/AK …
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications.
Leonard WJ, Lin JX, O'Shea JJ. Leonard WJ, et al. Immunity. 2019 Apr 16;50(4):832-850. doi: 10.1016/j.immuni.2019.03.028. Immunity. 2019. PMID: 30995502 Free article. Review.
Mutation of the gene encoding gamma(c) results in X-linked severe combined immunodeficiency in humans, and gamma(c) family cytokines collectively regulate development, proliferation, survival, and differentiation of immune cells. ...Moreover, we discuss how s …
Mutation of the gene encoding gamma(c) results in X-linked severe combined immunodeficiency in humans, and gamma(c) fam …
Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models.
Okada S, Vaeteewoottacharn K, Kariya R. Okada S, et al. Cells. 2019 Aug 13;8(8):889. doi: 10.3390/cells8080889. Cells. 2019. PMID: 31412684 Free PMC article. Review.
The engraftment rate increases with the introduction of Non-obese diabetic Severe combined immunodeficiency (NOD/SCID)-based immunocompromised mice, especially the NK-deficient NOD strains NOD/SCID/interleukin-2 receptor gamma chain(IL2Rgamma)(n …
The engraftment rate increases with the introduction of Non-obese diabetic Severe combined immunodeficiency (NOD/SCI …
Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation.
Basheer F, Lee E, Liongue C, Ward AC. Basheer F, et al. Biomolecules. 2022 Oct 20;12(10):1521. doi: 10.3390/biom12101521. Biomolecules. 2022. PMID: 36291730 Free PMC article.
JAK3 is principally activated by members of the interleukin-2 receptor family and plays an essential role in lymphoid development, with inactivating JAK3 mutations causing autosomal-recessive severe combined immunodeficiency (SCID). This …
JAK3 is principally activated by members of the interleukin-2 receptor family and plays an essential role in lymphoid development, wi …
Translating JAKs to Jakinibs.
Gadina M, Chisolm DA, Philips RL, McInness IB, Changelian PS, O'Shea JJ. Gadina M, et al. J Immunol. 2020 Apr 15;204(8):2011-2020. doi: 10.4049/jimmunol.1901477. J Immunol. 2020. PMID: 32253269 Review.
This was quickly followed by discoveries pointing to their essential functions, including identification of JAK3 mutations as a cause of SCID. This and other findings predicted the use of therapeutically targeting JAKs as a new strategy for treating immune and infla …
This was quickly followed by discoveries pointing to their essential functions, including identification of JAK3 mutations as a cause …
The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 Definitions.
Dvorak CC, Haddad E, Heimall J, Dunn E, Cowan MJ, Pai SY, Kapoor N, Satter LF, Buckley RH, O'Reilly RJ, Chandra S, Bednarski JJ, Williams O, Rayes A, Moore TB, Ebens CL, Davila Saldana BJ, Petrovic A, Chellapandian D, Cuvelier GDE, Vander Lugt MT, Caywood EH, Chandrakasan S, Eissa H, Goldman FD, Shereck E, Aquino VM, Desantes KB, Madden LM, Miller HK, Yu L, Broglie L, Gillio A, Shah AJ, Knutsen AP, Andolina JP, Joshi AY, Szabolcs P, Kapadia M, Martinez CA, Parrot RE, Sullivan KE, Prockop SE, Abraham RS, Thakar MS, Leiding JW, Kohn DB, Pulsipher MA, Griffith LM, Notarangelo LD, Puck JM. Dvorak CC, et al. J Allergy Clin Immunol. 2023 Feb;151(2):547-555.e5. doi: 10.1016/j.jaci.2022.10.021. Epub 2022 Nov 28. J Allergy Clin Immunol. 2023. PMID: 36456360 Free PMC article.
BACKGROUND: Shearer et al in 2014 articulated well-defined criteria for the diagnosis and classification of severe combined immunodeficiency (SCID) as part of the Primary Immune Deficiency Treatment Consortium's (PIDTC's) prospective and retrospective …
BACKGROUND: Shearer et al in 2014 articulated well-defined criteria for the diagnosis and classification of severe combined …
Newborn screening for severe combined immunodeficiency: The results of the first pilot TREC and KREC study in Ukraine with involving of 10,350 neonates.
Boyarchuk O, Yarema N, Kravets V, Shulhai O, Shymanska I, Chornomydz I, Hariyan T, Volianska L, Kinash M, Makukh H. Boyarchuk O, et al. Front Immunol. 2022 Sep 15;13:999664. doi: 10.3389/fimmu.2022.999664. eCollection 2022. Front Immunol. 2022. PMID: 36189201 Free PMC article.
Severe combined immunodeficiency (SCID) is a group of inborn errors of immunity (IEI) characterized by severe T- and/or B-lymphopenia. ...In Ukraine, the expansion of hemostatic stem cell transplantation and the development of a registry of bone marrow …
Severe combined immunodeficiency (SCID) is a group of inborn errors of immunity (IEI) characterized by severe T- …
Mucosal Epithelial Jak Kinases in Health and Diseases.
Kumar N, Kuang L, Villa R, Kumar P, Mishra J. Kumar N, et al. Mediators Inflamm. 2021 Mar 16;2021:6618924. doi: 10.1155/2021/6618924. eCollection 2021. Mediators Inflamm. 2021. PMID: 33814980 Free PMC article. Review.
Mutations that abrogate Jak3 functions cause an autosomal severe combined immunodeficiency disease (SCID) while activating Jak3 mutations lead to the development of hematologic and epithelial cancers. ...Here, we also focus on the consequ …
Mutations that abrogate Jak3 functions cause an autosomal severe combined immunodeficiency disease (SCID) …
Neonatal Lymphopenia Screening Is Important for Early Diagnosis of Severe Combined Immunodeficiency.
Poyraz A, Cansever M, Muderris I, Patiroglu T. Poyraz A, et al. Am J Perinatol. 2023 May;40(7):748-752. doi: 10.1055/s-0041-1731044. Epub 2021 Jun 11. Am J Perinatol. 2023. PMID: 34116583
OBJECTIVE: T-cell receptor excision circles are expensive for neonatal severe combined immunodeficiency screening in developing countries. We aimed to detect immunodeficiencies presenting with lymphopenia to enable screening in the general population and to i …
OBJECTIVE: T-cell receptor excision circles are expensive for neonatal severe combined immunodeficiency screening in de …
61 results