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JAK: Not Just Another Kinase.
Agashe RP, Lippman SM, Kurzrock R. Agashe RP, et al. Mol Cancer Ther. 2022 Dec 2;21(12):1757-1764. doi: 10.1158/1535-7163.MCT-22-0323. Mol Cancer Ther. 2022. PMID: 36252553 Free PMC article. Review.
Numerous cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK2) noncovalently associate with cytokine receptors, mediate receptor tyrosine phosphorylation, and recruit 1 STAT proteins (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6). . …
Numerous cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK2) noncovalently associate with cytokine …
IL-7: Comprehensive review.
Winer H, Rodrigues GOL, Hixon JA, Aiello FB, Hsu TC, Wachter BT, Li W, Durum SK. Winer H, et al. Cytokine. 2022 Dec;160:156049. doi: 10.1016/j.cyto.2022.156049. Epub 2022 Oct 3. Cytokine. 2022. PMID: 36201890 Review.
IL-7 RECEPTOR SIGNAL TRANSDUCTION PATHWAYS: Major signals through JAK1, JAK3 to STAT5 and through non-canonical STAT3, STAT1, PI3K/AKT and MEK/ERK pathways. BIOLOGICAL ACTIVITY OF IL-7: Required for survival of immature thymocytes, naive T-cells, memory T-cells, pro-B-cell …
IL-7 RECEPTOR SIGNAL TRANSDUCTION PATHWAYS: Major signals through JAK1, JAK3 to STAT5 and through non-canonical STAT3, STAT1, PI3K/AK …
Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models.
Okada S, Vaeteewoottacharn K, Kariya R. Okada S, et al. Cells. 2019 Aug 13;8(8):889. doi: 10.3390/cells8080889. Cells. 2019. PMID: 31412684 Free PMC article. Review.
The engraftment rate increases with the introduction of Non-obese diabetic Severe combined immunodeficiency (NOD/SCID)-based immunocompromised mice, especially the NK-deficient NOD strains NOD/SCID/interleukin-2 receptor gamma chain(IL2Rgamma)(n …
The engraftment rate increases with the introduction of Non-obese diabetic Severe combined immunodeficiency (NOD/SCI …
The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications.
Leonard WJ, Lin JX, O'Shea JJ. Leonard WJ, et al. Immunity. 2019 Apr 16;50(4):832-850. doi: 10.1016/j.immuni.2019.03.028. Immunity. 2019. PMID: 30995502 Free article. Review.
Mutation of the gene encoding gamma(c) results in X-linked severe combined immunodeficiency in humans, and gamma(c) family cytokines collectively regulate development, proliferation, survival, and differentiation of immune cells. ...Moreover, we discuss how s …
Mutation of the gene encoding gamma(c) results in X-linked severe combined immunodeficiency in humans, and gamma(c) fam …
Translating JAKs to Jakinibs.
Gadina M, Chisolm DA, Philips RL, McInness IB, Changelian PS, O'Shea JJ. Gadina M, et al. J Immunol. 2020 Apr 15;204(8):2011-2020. doi: 10.4049/jimmunol.1901477. J Immunol. 2020. PMID: 32253269 Review.
This was quickly followed by discoveries pointing to their essential functions, including identification of JAK3 mutations as a cause of SCID. This and other findings predicted the use of therapeutically targeting JAKs as a new strategy for treating immune and infla …
This was quickly followed by discoveries pointing to their essential functions, including identification of JAK3 mutations as a cause …
Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting.
Chang CW, Lai YS, Westin E, Khodadadi-Jamayran A, Pawlik KM, Lamb LS Jr, Goldman FD, Townes TM. Chang CW, et al. Cell Rep. 2015 Sep 8;12(10):1668-77. doi: 10.1016/j.celrep.2015.08.013. Epub 2015 Aug 28. Cell Rep. 2015. PMID: 26321643 Free article.
Mutations of the Janus family kinase JAK3 gene cause severe combined immunodeficiency (SCID). JAK3 deficiency in humans is characterized by the absence of circulating T cells and natural killer (NK) cells with normal numbers of poorly fun …
Mutations of the Janus family kinase JAK3 gene cause severe combined immunodeficiency (SCID). JAK3 …
Zebrafish Model of Severe Combined Immunodeficiency (SCID) Due to JAK3 Mutation.
Basheer F, Lee E, Liongue C, Ward AC. Basheer F, et al. Biomolecules. 2022 Oct 20;12(10):1521. doi: 10.3390/biom12101521. Biomolecules. 2022. PMID: 36291730 Free PMC article.
JAK3 is principally activated by members of the interleukin-2 receptor family and plays an essential role in lymphoid development, with inactivating JAK3 mutations causing autosomal-recessive severe combined immunodeficiency (SCID). This …
JAK3 is principally activated by members of the interleukin-2 receptor family and plays an essential role in lymphoid development, wi …
The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 Definitions.
Dvorak CC, Haddad E, Heimall J, Dunn E, Cowan MJ, Pai SY, Kapoor N, Satter LF, Buckley RH, O'Reilly RJ, Chandra S, Bednarski JJ, Williams O, Rayes A, Moore TB, Ebens CL, Davila Saldana BJ, Petrovic A, Chellapandian D, Cuvelier GDE, Vander Lugt MT, Caywood EH, Chandrakasan S, Eissa H, Goldman FD, Shereck E, Aquino VM, Desantes KB, Madden LM, Miller HK, Yu L, Broglie L, Gillio A, Shah AJ, Knutsen AP, Andolina JP, Joshi AY, Szabolcs P, Kapadia M, Martinez CA, Parrot RE, Sullivan KE, Prockop SE, Abraham RS, Thakar MS, Leiding JW, Kohn DB, Pulsipher MA, Griffith LM, Notarangelo LD, Puck JM. Dvorak CC, et al. J Allergy Clin Immunol. 2023 Feb;151(2):547-555.e5. doi: 10.1016/j.jaci.2022.10.021. Epub 2022 Nov 28. J Allergy Clin Immunol. 2023. PMID: 36456360 Free PMC article.
BACKGROUND: Shearer et al in 2014 articulated well-defined criteria for the diagnosis and classification of severe combined immunodeficiency (SCID) as part of the Primary Immune Deficiency Treatment Consortium's (PIDTC's) prospective and retrospective …
BACKGROUND: Shearer et al in 2014 articulated well-defined criteria for the diagnosis and classification of severe combined …
Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India.
Vignesh P, Rawat A, Kumrah R, Singh A, Gummadi A, Sharma M, Kaur A, Nameirakpam J, Jindal A, Suri D, Gupta A, Khadwal A, Saikia B, Minz RW, Sharma K, Desai M, Taur P, Gowri V, Pandrowala A, Dalvi A, Jodhawat N, Kambli P, Madkaikar MR, Bhattad S, Ramprakash S, Cp R, Jayaram A, Sivasankaran M, Munirathnam D, Balaji S, Rajendran A, Aggarwal A, Singh K, Na F, George B, Mehta A, Lashkari HP, Uppuluri R, Raj R, Bartakke S, Gupta K, Sreedharanunni S, Ogura Y, Kato T, Imai K, Chan KW, Leung D, Ohara O, Nonoyama S, Hershfield M, Lau YL, Singh S. Vignesh P, et al. Front Immunol. 2021 Feb 8;11:619146. doi: 10.3389/fimmu.2020.619146. eCollection 2020. Front Immunol. 2021. PMID: 33628209 Free PMC article.
Data on SCID from developing countries are scarce. OBJECTIVE: To describe clinical and laboratory features of SCID diagnosed at immunology centers across India. ...Diagnosis of SCID/combined immune deficiency (CID) was based on 2018 European Society for Immun …
Data on SCID from developing countries are scarce. OBJECTIVE: To describe clinical and laboratory features of SCID diagnosed a …
The Common Cytokine Receptor γ Chain Family of Cytokines.
Lin JX, Leonard WJ. Lin JX, et al. Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9):a028449. doi: 10.1101/cshperspect.a028449. Cold Spring Harb Perspect Biol. 2018. PMID: 29038115 Free PMC article. Review.
The IL2RG gene is located on the X chromosome and is mutated in humans with X-linked severe combined immunodeficiency (XSCID). The breadth of the defects in XSCID could not be explained solely by defects in IL-2 signaling, and it is now clear that gammac is a …
The IL2RG gene is located on the X chromosome and is mutated in humans with X-linked severe combined immunodeficiency ( …
63 results