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2014 4
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Page 1
Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs).
Khatami F, Mohammadamoli M, Tavangar SM. Khatami F, et al. Endocr Regul. 2018 Jan 1;52(1):41-54. doi: 10.2478/enr-2018-0006. Endocr Regul. 2018. PMID: 29453919 Free article. Review.
According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B …
According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, a …
Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis.
Luo YY, Zhang HP, Huang AL, Hu JL. Luo YY, et al. BMC Med Genet. 2019 Apr 4;20(1):59. doi: 10.1186/s12881-019-0778-y. BMC Med Genet. 2019. PMID: 30947687 Free PMC article.
CONCLUSIONS: G-allele appears to be a protective allele of KIF1B for HCC, especially in HBV-positive and Chinese populations. More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 …
CONCLUSIONS: G-allele appears to be a protective allele of KIF1B for HCC, especially in HBV-positive and Chinese populations. More we …
Head and Neck Paragangliomas-A Genetic Overview.
Majewska A, Budny B, Ziemnicka K, Ruchała M, Wierzbicka M. Majewska A, et al. Int J Mol Sci. 2020 Oct 16;21(20):7669. doi: 10.3390/ijms21207669. Int J Mol Sci. 2020. PMID: 33081307 Free PMC article. Review.
We found that the etiology of the tumors in question is based on genetic changes in the form of either germinal or somatic mutations. 40% of PCC and PGL have a predisposing germline mutation (including VHL, SDHB, SDHD, RET, NF1, THEM127, MAX, SDHC, SDHA, SDHAF2, HIF2A, HRAS, K …
We found that the etiology of the tumors in question is based on genetic changes in the form of either germinal or somatic mutations. 40% of …
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
Chen S, Han M, Chen W, He Y, Huang B, Zhao P, Huang Q, Gao L, Qu X, Li X. Chen S, et al. Oncol Rep. 2016 Feb;35(2):971-7. doi: 10.3892/or.2015.4426. Epub 2015 Nov 16. Oncol Rep. 2016. PMID: 26576027
Our previous study demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) was involved in Kinesin family member 1B (KIF1B)-modulated invasion of gastric cancer cells. ...In conclusion, targeting KIF1B may be an option for an …
Our previous study demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) was involved in Kinesin family memb …
Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.
Yang SZ, Wang JT, Yu WW, Liu Q, Wu YF, Chen SG. Yang SZ, et al. World J Gastroenterol. 2015 Jul 21;21(27):8418-24. doi: 10.3748/wjg.v21.i27.8418. World J Gastroenterol. 2015. PMID: 26217094 Free PMC article.
AIM: To compare kinesin family member 1B (KIF1B) expression with clinicopathologic parameters and prognosis in hepatocellular carcinoma (HCC) patients. ...CONCLUSION: Downregulation of KIF1B in HCC tissues is associated with poor prognosi …
AIM: To compare kinesin family member 1B (KIF1B) expression with clinicopathologic parameters and prognos …
Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort.
Chen JH, Wang YY, Lv WB, Gan Y, Chang W, Tian NN, Huang XH, Liu L, Yu XF, Chen SD. Chen JH, et al. World J Gastroenterol. 2016 Apr 28;22(16):4183-90. doi: 10.3748/wjg.v22.i16.4183. World J Gastroenterol. 2016. PMID: 27122668 Free PMC article.
AIM: To examine the effect of the potential interaction between KIF1B variants (rs17401966 and rs3748578) and environmental factors on the risk of hepatocellular carcinoma (HCC) in a high-risk region in China. ...Clinical characteristics were collected by reviewing the com …
AIM: To examine the effect of the potential interaction between KIF1B variants (rs17401966 and rs3748578) and environmental factors o …
Genetic and Clinical Profiles of Pheochromocytoma and Paraganglioma: A Single Center Study.
Ma X, Li M, Tong A, Wang F, Cui Y, Zhang X, Zhang Y, Chen S, Li Y. Ma X, et al. Front Endocrinol (Lausanne). 2020 Dec 11;11:574662. doi: 10.3389/fendo.2020.574662. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33362715 Free PMC article. Clinical Trial.
To detect the genetic and clinical profile of Chinese PPGL patients, we examined the variants of 12 known germline pathogenic genes (SDHA, SDHB, SDHC, SDHD, SDHAF2, FH, VHL, RET, NF1, MAX, TMEM127, and KIF1B) by next-generation sequencing and Sanger sequencing in 314 Chine …
To detect the genetic and clinical profile of Chinese PPGL patients, we examined the variants of 12 known germline pathogenic genes (SDHA, S …
A case of juvenile-onset pheochromocytoma with KIF1B p.V1529M germline mutation.
Nezu M, Hirotsu Y, Amemiya K, Katsumata M, Watanabe T, Takizawa S, Inoue M, Mochizuki H, Hosaka K, Oyama T, Omata M. Nezu M, et al. Endocr J. 2022 Jun 28;69(6):705-716. doi: 10.1507/endocrj.EJ21-0475. Epub 2022 Jan 19. Endocr J. 2022. PMID: 35046208 Free article.
However, in 2020, the same research group reported that the cause of PCC in this family was a MAX germline mutation and was not due to the KIF1B mutation. In this study, we investigated the pathogenicity of a KIF1B germline mutation detected in a 26-year-old woman w …
However, in 2020, the same research group reported that the cause of PCC in this family was a MAX germline mutation and was not due to the …
Association between KIF1B rs17401966 polymorphism and hepatocellular carcinoma risk: a meta-analysis involving 17,210 subjects.
Zhang Z. Zhang Z. Tumour Biol. 2014 Sep;35(9):9405-10. doi: 10.1007/s13277-014-2192-6. Epub 2014 Jun 22. Tumour Biol. 2014. PMID: 24952890
Some publications have evaluated the correlation between KIF1B rs17401966 polymorphism and hepatocellular carcinoma (HCC) with conflicting results. ...We also found a significant association between KIF1B rs17401966 polymorphism and HCC risk in Chinese (OR = 0.77, 9 …
Some publications have evaluated the correlation between KIF1B rs17401966 polymorphism and hepatocellular carcinoma (HCC) with confli …
49 results