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Page 1
The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda AM, Simovic D, Karin V, Kardum V, Vranic S, Serman L. Skoda AM, et al. Bosn J Basic Med Sci. 2018 Feb 20;18(1):8-20. doi: 10.17305/bjbms.2018.2756. Bosn J Basic Med Sci. 2018. PMID: 29274272 Free PMC article. Review.
The components of the Hh signaling pathway involved in the signaling transfer to the Gli transcription factors include Hedgehog ligands (Sonic Hh [SHh], Indian Hh [IHh], and Desert Hh [DHh]), Patched receptor (Ptch1, Ptch2), Smoothened receptor (Smo), Suppressor of fused homolog …
The components of the Hh signaling pathway involved in the signaling transfer to the Gli transcription factors include Hedgehog ligands (Son …
P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression.
Li Q, Liu Y, Wu J, Zhu Z, Fan J, Zhai L, Wang Z, Du G, Zhang L, Hu J, Ma DK, Liu JO, Huang H, Tan M, Dang Y, Jiang W. Li Q, et al. Leukemia. 2024 Aug;38(8):1751-1763. doi: 10.1038/s41375-024-02313-8. Epub 2024 Jun 22. Leukemia. 2024. PMID: 38909089 Free PMC article.
A critical facet of Hh signal transduction involves the dynamic regulation of the suppressor of fused homolog (SUFU)-glioma-associated oncogene homolog (GLI) complex within the kinesin family member 7 (KIF7)-supported ciliary tip compartment. Ho …
A critical facet of Hh signal transduction involves the dynamic regulation of the suppressor of fused homolog (SUFU)-glioma-associated oncog …
Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7.
Blasius TL, Yue Y, Prasad R, Liu X, Gennerich A, Verhey KJ. Blasius TL, et al. J Cell Sci. 2021 Jul 1;134(13):jcs258464. doi: 10.1242/jcs.258464. Epub 2021 Jul 8. J Cell Sci. 2021. PMID: 34114033 Free PMC article.
The kinesin-4 member KIF7 plays critical roles in Hedgehog signaling in vertebrate cells. KIF7 is an atypical kinesin as it binds to microtubules but is immotile. ...We identify a segment, the inhibitory coiled coil (inhCC), that is required for auto-inhibition of …
The kinesin-4 member KIF7 plays critical roles in Hedgehog signaling in vertebrate cells. KIF7 is an atypical kinesin as it bi …
Low expression of KIF7 indicates poor prognosis in epithelial ovarian cancer.
Yao Y, Liu L, He W, Lin X, Zhang X, Lin Z, Zeng Z, Guo S. Yao Y, et al. Cancer Biomark. 2019;26(4):481-489. doi: 10.3233/CBM-190328. Cancer Biomark. 2019. PMID: 31658044 Free article.
The aim of the present study was to investigate kinesin family member 7 (KIF7) expression in epithelial ovarian cancer tissues (paraffin-embedded tissues and fresh) and to explore its expression, association with clinicopathological parameters a …
The aim of the present study was to investigate kinesin family member 7 (KIF7) expression in epithelial o …
Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish.
Terhune EA, Cuevas MT, Monley AM, Wethey CI, Chen X, Cattell MV, Bayrak MN, Bland MR, Sutphin B, Trahan GD, Taylor MRG, Niswander LA, Jones KL, Baschal EE, Antunes L, Dobbs M, Gurnett C, Appel B, Gray R, Hadley Miller N. Terhune EA, et al. Hum Mutat. 2021 Apr;42(4):392-407. doi: 10.1002/humu.24162. Epub 2021 Feb 7. Hum Mutat. 2021. PMID: 33382518 Free PMC article.
Subsequently, we generated a mutant zebrafish model of kif7 using CRISPR-Cas9. kif7(co63/co63) zebrafish displayed severe scoliosis, presenting in juveniles and progressing through adulthood. ...This study suggests defects in KIF7-dependent Hh signaling, whic …
Subsequently, we generated a mutant zebrafish model of kif7 using CRISPR-Cas9. kif7(co63/co63) zebrafish displayed severe scol …
Genetic Variants in KIF7 May Contribute to Supernumerary Tooth Formation.
Chainaphaphorn P, Ngamphiw C, Tongsima S, Chintakanon K, Kawasaki K, Cox TC, Ohazama A, Ketudat Cairns JR, Kantaputra PN. Chainaphaphorn P, et al. Int Dent J. 2025 Oct;75(5):100928. doi: 10.1016/j.identj.2025.100928. Epub 2025 Aug 7. Int Dent J. 2025. PMID: 40774045 Free PMC article.
OBJECTIVE: Kinesin Family Member 7 (KIF7) regulates ciliary integrity. Cilia-mediated sonic hedgehog signalling regulates tooth number, position, and morphology. ...Immunohistochemistry of Kif7 expression during early odontogenesis was pe …
OBJECTIVE: Kinesin Family Member 7 (KIF7) regulates ciliary integrity. Cilia-mediated sonic hedgehog sign …
Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7.
Hu Y, Wu MZ, Gu NJ, Xu HT, Li QC, Wu GP. Hu Y, et al. Thorac Cancer. 2020 Nov;11(11):3175-3180. doi: 10.1111/1759-7714.13640. Epub 2020 Sep 18. Thorac Cancer. 2020. PMID: 32945133 Free PMC article.
RESULTS: E6 but not E7 significantly downregulated the expression of tumor suppressor KIF7 at protein level, and the inhibition of KIF7 further reduced the expression of LKB1 both in the nuclei and in the cytoplasm, whereas reduced the expression of p-LKB1 in the cy …
RESULTS: E6 but not E7 significantly downregulated the expression of tumor suppressor KIF7 at protein level, and the inhibition of …
Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling.
Asadollahi R, Strauss JE, Zenker M, Beuing O, Edvardson S, Elpeleg O, Strom TM, Joset P, Niedrist D, Otte C, Oneda B, Boonsawat P, Azzarello-Burri S, Bartholdi D, Papik M, Zweier M, Haas C, Ekici AB, Baumer A, Boltshauser E, Steindl K, Nothnagel M, Schinzel A, Stoeckli ET, Rauch A. Asadollahi R, et al. Eur J Hum Genet. 2018 Feb;26(2):197-209. doi: 10.1038/s41431-017-0019-9. Epub 2018 Jan 10. Eur J Hum Genet. 2018. PMID: 29321670 Free PMC article.
We found (likely) pathogenic variants of KIF7 in 5 out of 9 families, including the original ACLS patients, and delineated 1000 to 4000-year-old Swiss founder alleles. ...Nevertheless, long-term follow-up revealed that C5orf42-mutated patients showed catch-up development a …
We found (likely) pathogenic variants of KIF7 in 5 out of 9 families, including the original ACLS patients, and delineated 1000 to 40 …
Rare and novel variant load threshold for KIF7, GJA1 and PDE1C genes elevates the risk of severity of congenital heart defects in Down syndrome.
Ganguly A, Pal S, Chatterjee S, Das M, Sarkar S, Ghosh S. Ganguly A, et al. PLoS One. 2025 Jun 26;20(6):e0326566. doi: 10.1371/journal.pone.0326566. eCollection 2025. PLoS One. 2025. PMID: 40569905 Free PMC article.
Our findings revealed two rare variants, KIF7 rs138354681 and GJA1 rs778110855, as well as one novel variant, PDE1C PP785745, present in children with DS and CHD but absent in those without CHD. ...The frequencies of the heterozygous genotypes for KIF7 rs138354681, …
Our findings revealed two rare variants, KIF7 rs138354681 and GJA1 rs778110855, as well as one novel variant, PDE1C PP785745, present …
Genetic and Lifestyle-Related Factors Influencing Serum Hyper-Propionylcarnitine Concentrations and Their Association with Metabolic Syndrome and Cardiovascular Disease Risk.
Lee YH, Park S. Lee YH, et al. Int J Mol Sci. 2023 Oct 31;24(21):15810. doi: 10.3390/ijms242115810. Int J Mol Sci. 2023. PMID: 37958793 Free PMC article.
Multiple C2 And Transmembrane Domain Containing-1 (MCTP1)_rs4290997, Kinesin Family Member-7 (KIF7)_rs2350480, Coagulation Factor-II (F2)_rs2070850, Peroxisomal Biogenesis Factor-3 (PEX3)_rs223231, TBC1 Domain Family Member-22A (TBC1D22A)_rs9105 …
Multiple C2 And Transmembrane Domain Containing-1 (MCTP1)_rs4290997, Kinesin Family Member-7 (KIF7)_rs235 …
33 results