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2024 9
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2026 5

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Page 1
Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection.
Benito-Martínez S, Salavessa L, Macé AS, Rouabah M, Lardier N, Fraisier V, Sirés-Campos J, Jani RA, Romao M, Roca V, Gayrard C, Plessis M, Hurbain I, Nait-Meddour C, Etienne-Manneville S, Morel E, Boniotto M, Manneville JB, Bernerd F, Duval C, Raposo G, Delevoye C. Benito-Martínez S, et al. Nat Cell Biol. 2026 Jan;28(1):98-112. doi: 10.1038/s41556-025-01817-4. Epub 2025 Dec 15. Nat Cell Biol. 2026. PMID: 41398050
Here, by developing a model of human keratinocytes internalizing extracellular melanin into pigment organelles, we show that keratin 5 and keratin 14 intermediate filaments and microtubules control the three-dimensional perinuclear position of pigments, shielding DN …
Here, by developing a model of human keratinocytes internalizing extracellular melanin into pigment organelles, we show that keratin 5 and …
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype.
Bergson S, Sarig O, Giladi M, Mohamad J, Mogezel-Salem M, Smorodinsky-Atias K, Sade O, Manori B, Assaf S, Malovitski K, Feller Y, Pavlovsky M, Hainzl S, Kocher T, Hummel JI, Eretz Kdosha N, Khair LG, Zauner R, Pinon Hofbauer J, Shalom-Feuerstein R, Wally V, Koller U, Samuelov L, Haitin Y, Ashery U, Rubinstein R, Sprecher E. Bergson S, et al. J Exp Med. 2025 May 5;222(5):e20240827. doi: 10.1084/jem.20240827. Epub 2025 Feb 20. J Exp Med. 2025. PMID: 39976600 Free PMC article.
We identified three deleterious variants in HMCN1 that co-segregated with a more severe phenotype in a group of 20 individuals with EBS caused by mutations in KRT14, encoding keratin 14 (K14). HMCN1 codes for hemicentin-1. Protein modeling, molecular dynamics …
We identified three deleterious variants in HMCN1 that co-segregated with a more severe phenotype in a group of 20 individuals with EBS caus …
Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives.
Bchetnia M, Powell J, McCuaig C, Boucher-Lafleur AM, Morin C, Dupéré A, Laprise C. Bchetnia M, et al. Int J Mol Sci. 2024 Aug 31;25(17):9495. doi: 10.3390/ijms25179495. Int J Mol Sci. 2024. PMID: 39273442 Free PMC article. Review.
It most often results from dominant mutations in the genes coding for keratin (K) 5 or 14 proteins (KRT5 and KRT14). A disruptive mutation in KRT5 or KRT14 will not only structurally impair the cytoskeleton, but it will also activate a cascade of biochemical mechani …
It most often results from dominant mutations in the genes coding for keratin (K) 5 or 14 proteins (KRT5 and KRT14). A disruptive mut …
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry.
Bhat-Nakshatri P, Gao H, Khatpe AS, Adebayo AK, McGuire PC, Erdogan C, Chen D, Jiang G, New F, German R, Emmert L, Sandusky G, Storniolo AM, Liu Y, Nakshatri H. Bhat-Nakshatri P, et al. Nat Med. 2024 Dec;30(12):3482-3494. doi: 10.1038/s41591-024-03011-9. Epub 2024 Aug 9. Nat Med. 2024. PMID: 39122969 Free PMC article.
In addition to the known cell identity genes FOXA1 (luminal hormone sensing), EHF and ELF5 (LASP), TP63 and KRT14 (basal-myoepithelial), epithelial subtypes displayed several uncharacterized markers and inferred gene regulatory networks. ...
In addition to the known cell identity genes FOXA1 (luminal hormone sensing), EHF and ELF5 (LASP), TP63 and KRT14 (basal-myoepithelia …
KRT14 is a promising prognostic biomarker of breast cancer related to immune infiltration.
Liao S, Zhang X, Chen L, Zhang J, Lu W, Rao M, Zhang Y, Ye Z, Ivanova D, Li F, Chen X, Wang Y, Song A, Xie B, Wang M. Liao S, et al. Mol Immunol. 2025 Apr;180:55-73. doi: 10.1016/j.molimm.2025.02.016. Epub 2025 Feb 26. Mol Immunol. 2025. PMID: 40014952
METHODS: RNA sequencing data from The Cancer Genome Atlas database and Gene Expression Omnibus database were utilized to download to evaluate expression levels and prognostic significance of Keratin 14 (KRT14). Methylation of KRT14 was also assessed. T …
METHODS: RNA sequencing data from The Cancer Genome Atlas database and Gene Expression Omnibus database were utilized to download to evaluat …
Identification of key genes linking bisphenols exposure and breast cancer.
Wang Z, Cao M, Gao T, Xu X, Yu W, Liu J, Liu R, Zhang X, Li F, Hai C. Wang Z, et al. Toxicology. 2025 Jun;514:154123. doi: 10.1016/j.tox.2025.154123. Epub 2025 Mar 23. Toxicology. 2025. PMID: 40132786 Free article.
In this study, we identified four key genes [keratin 14 (KRT14), keratin 5 (KRT5), acyl-CoA synthetase long chain family member 1 (ACSL1) and matrix metallopeptidase 1 (MMP1)] related to both bisphenols exposure and BC by employing the Comparative Toxicogenom …
In this study, we identified four key genes [keratin 14 (KRT14), keratin 5 (KRT5), acyl-CoA synthetase long chain famil …
Cytoskeletal protein KRT14 governs cisplatin resistance by modulating eIF4H-dependent ACOX2 translation and lipid metabolism in bladder cancer.
Liu S, Liu T, Yang C, Mou Z, Zou L, Jiang H. Liu S, et al. Cell Death Dis. 2025 Dec 24;17(1):134. doi: 10.1038/s41419-025-08369-3. Cell Death Dis. 2025. PMID: 41444318 Free PMC article.
Although known mechanisms-such as alterations in drug efflux, DNA repair, and key signaling pathways-have been implicated, they fail to fully explain the clinical complexity of cisplatin resistance, indicating that additional molecular drivers remain undiscovered. Keratin …
Although known mechanisms-such as alterations in drug efflux, DNA repair, and key signaling pathways-have been implicated, they fail to full …
Genetic profiling of epidermolysis bullosa in a large Brazilian cohort.
Ota VK, Mariath LM, Torrelio RMF, Arashiro CS, Schuler-Faccini L, Fernandes JM, Rossi LL, Magno JA, Martin PKM. Ota VK, et al. Clin Exp Dermatol. 2025 Nov 25;50(12):2397-2409. doi: 10.1093/ced/llaf303. Clin Exp Dermatol. 2025. PMID: 40701620
The most frequent variants affected residue 125 of KRT14. Junctional EB comprised 6.7% of cases (n = 24/359), with 22 variants (8 novel) identified. ...
The most frequent variants affected residue 125 of KRT14. Junctional EB comprised 6.7% of cases (n = 24/359), with 22 variants (8 nov …
Single-cell RNA sequencing identifies potential critical prognostic biomarkers in bladder carcinoma.
Zhao S, Li R, Tian T, Zhang J, Li Y, Gao W, Zhou Y, Jiang Y, He S, Li X, Gong Y, Guo Y. Zhao S, et al. Sci Rep. 2025 Nov 7;15(1):39105. doi: 10.1038/s41598-025-23975-z. Sci Rep. 2025. PMID: 41203683 Free PMC article.
Univariate and multivariate Cox regression analyses further confirmed that the risk score was an independent predictor of overall survival. Furthermore, IGFBP5, KRT14 and SERPINF1 were found to be linked to poor survival outcomes in BC, with their expression levels notably …
Univariate and multivariate Cox regression analyses further confirmed that the risk score was an independent predictor of overall survival. …
Loss of keratin 14 expression from immortalized keratinocytes by promoter methylation.
Koh R, Szeverenyi I, Lunny DP, Eng GH, Lane EB. Koh R, et al. Exp Dermatol. 2024 Aug;33(8):e15143. doi: 10.1111/exd.15143. Exp Dermatol. 2024. PMID: 39073059 Free PMC article.
We show that K14 repression occurs by DNA promoter methylation of KRT14 gene and is compounded by histone deacetylation and by the presence of EGF. In vivo, keratinocytes shut down K14 synthesis as they commit to terminal differentiation and move from the basal to spinous …
We show that K14 repression occurs by DNA promoter methylation of KRT14 gene and is compounded by histone deacetylation and by the pr …
31 results