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Page 1
Effect of abrocitinib on skin biomarkers in patients with moderate-to-severe atopic dermatitis.
Guttman-Yassky E, Facheris P, Gomez-Arias PJ, Del Duca E, Da Rosa JC, Weidinger S, Bissonnette R, Armstrong AW, Seneschal J, Eyerich K, Estrada YD, Bose SN, Xu D, Chen A, Tatulych S, Güler E, Chan G, Page KM, Kerkmann U. Guttman-Yassky E, et al. Allergy. 2024 May;79(5):1258-1270. doi: 10.1111/all.15969. Epub 2023 Dec 18. Allergy. 2024. PMID: 38108208 Clinical Trial.
The primary endpoint was change from baseline in markers of inflammation (matrix metalloproteinase [MMP]-12), epidermal hyperplasia (keratin-16 [KRT16]), T-helper 2 (Th2) immune response (C-C motif chemokine ligand [CCL]17, CCL18, and CCL26), and Th22 immune …
The primary endpoint was change from baseline in markers of inflammation (matrix metalloproteinase [MMP]-12), epidermal hyperplasia (kera …
Adenosine A2A receptor activation regulates the M1 macrophages activation to initiate innate and adaptive immunity in psoriasis.
Lu Y, Zhu W, Zhang GX, Chen JC, Wang QL, Mao MY, Deng SC, Jin LP, Liu H, Kuang YH. Lu Y, et al. Clin Immunol. 2024 Sep;266:110309. doi: 10.1016/j.clim.2024.110309. Epub 2024 Jul 11. Clin Immunol. 2024. PMID: 39002795
Mechanistically, A2AR activation inhibited M1 macrophage activation via the NF-kappaB-KRT16 pathway to reduce the secretion of CXCL10/11 and inhibit Th1/17 differentiation. Notably, the KRT16 expression was first found in M1 macrophage in our study, not only in kera …
Mechanistically, A2AR activation inhibited M1 macrophage activation via the NF-kappaB-KRT16 pathway to reduce the secretion of CXCL10 …
Molecular and clinical effects of selective tyrosine kinase 2 inhibition with deucravacitinib in psoriasis.
Catlett IM, Hu Y, Gao L, Banerjee S, Gordon K, Krueger JG. Catlett IM, et al. J Allergy Clin Immunol. 2022 Jun;149(6):2010-2020.e8. doi: 10.1016/j.jaci.2021.11.001. Epub 2021 Nov 10. J Allergy Clin Immunol. 2022. PMID: 34767869 Free article. Clinical Trial.
Markers of keratinocyte dysregulation, keratin-16, and beta-defensin genes approached nonlesional levels with effective doses. ...
Markers of keratinocyte dysregulation, keratin-16, and beta-defensin genes approached nonlesional levels with effective doses. …
Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type-specific immune regulation in atopic dermatitis.
Rojahn TB, Vorstandlechner V, Krausgruber T, Bauer WM, Alkon N, Bangert C, Thaler FM, Sadeghyar F, Fortelny N, Gernedl V, Rindler K, Elbe-Bürger A, Bock C, Mildner M, Brunner PM. Rojahn TB, et al. J Allergy Clin Immunol. 2020 Nov;146(5):1056-1069. doi: 10.1016/j.jaci.2020.03.041. Epub 2020 Apr 25. J Allergy Clin Immunol. 2020. PMID: 32344053
Using single-cell RNA sequencing, we found comparable transcriptional profiles of key inflammatory pathways between blister and biopsy AD, but suction blistering was superior in cell-specific resolution for high-abundance transcripts (KRT1/KRT10, KRT16/KRT6A, S100A8/S100A9 …
Using single-cell RNA sequencing, we found comparable transcriptional profiles of key inflammatory pathways between blister and biopsy AD, b …
YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.
Jiang D, Qiu T, Peng J, Li S, Tala, Ren W, Yang C, Wen Y, Chen CH, Sun J, Wu Y, Liu R, Zhou J, Wu K, Liu W, Mao X, Zhou Z, Chen C. Jiang D, et al. Cell Death Differ. 2022 Jun;29(6):1283-1295. doi: 10.1038/s41418-021-00920-x. Epub 2022 Jan 13. Cell Death Differ. 2022. PMID: 35022570 Free PMC article.
Additionally, ribosomal S6 kinase 2 (RSK2) mediated YB-1 phosphorylation at Ser102 promotes YB-1/KLF5 transcriptional complex formation, which co-regulates the expression of BLBC specific genes, Keratin 16 (KRT16) and lymphocyte antigen 6 family member D (Ly6 …
Additionally, ribosomal S6 kinase 2 (RSK2) mediated YB-1 phosphorylation at Ser102 promotes YB-1/KLF5 transcriptional complex formation, whi …
Pachyonychia congenita: A father and son with a novel variant in the KRT16 gene.
Tran TNA, Vu TTP, Pham NN, Bui CB, Nguyen HT. Tran TNA, et al. Pediatr Dermatol. 2025 Jan-Feb;42(1):109-111. doi: 10.1111/pde.15701. Epub 2024 Jul 8. Pediatr Dermatol. 2025. PMID: 38978313
His father exhibited similar symptoms. Genetic testing revealed a KRT16 pathogenic variant (c.616 T > G) in both the patient and his father, marking it as a novel variant in the PC literature. ...
His father exhibited similar symptoms. Genetic testing revealed a KRT16 pathogenic variant (c.616 T > G) in both the patient and h …
97 results