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2017 3
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Page 1
Keratin 4 regulates the development of human white sponge nevus.
Zhang J, Quan J, Ren Y, Chen M, Yang J, Zhang X. Zhang J, et al. J Oral Pathol Med. 2018 Jul;47(6):598-605. doi: 10.1111/jop.12728. Epub 2018 May 27. J Oral Pathol Med. 2018. PMID: 29738605
BACKGROUND: The aim of this study was to investigate the roles of keratin 4 (KRT4) gene in the development of human white sponge nevus (WSN). METHODS: Transgenic mice were created using the microinjection method with pcDNA3.1 vectors expressing KRT4 wi …
BACKGROUND: The aim of this study was to investigate the roles of keratin 4 (KRT4) gene in the development of human whi …
CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.
Takashima K, Fujii S, Komatsuzaki R, Komatsu M, Takahashi M, Kojima T, Daiko H, Minashi K, Chiwaki F, Muto M, Sasaki H, Yano T. Takashima K, et al. Int J Oncol. 2020 Mar;56(3):835-847. doi: 10.3892/ijo.2020.4963. Epub 2020 Jan 17. Int J Oncol. 2020. PMID: 32124945
From our previous microarray study, CD24 and keratin 4 (KRT4), which encodes cytokeratin 4 (CK4), were overexpressed in the favorable prognostic epithelial subtype with SIM bHLH transcription factor 2 (SIM2) expression. ...Notably, in cases with low CD24 or C …
From our previous microarray study, CD24 and keratin 4 (KRT4), which encodes cytokeratin 4 (CK4), were overexpressed in …
MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE-30.
Mahmoudian RA, Bahadori B, Rad A, Abbaszadegan MR, Forghanifard MM. Mahmoudian RA, et al. Mol Genet Genomic Med. 2019 Jul;7(7):e00746. doi: 10.1002/mgg3.746. Epub 2019 May 14. Mol Genet Genomic Med. 2019. PMID: 31090196 Free PMC article.
Following RNA extraction and cDNA synthesis, mRNA expression of MEIS1 and the selected genes including TWIST1, EGF, CDX2, and KRT4 was examined using relative comparative real-time PCR. RESULTS: Retroviral transduction caused a significant underexpression of MEIS1 in GFP-h …
Following RNA extraction and cDNA synthesis, mRNA expression of MEIS1 and the selected genes including TWIST1, EGF, CDX2, and KRT4 wa …
Bisphenol A exposure modulates ovarian cancer gene expression and oxidative stress markers: a case-control study.
Alsaeed SA, Lymona AM, Atef A, Moawad AM, Morsi H, Alkaffas M, Nassar A, Aboubakr HM. Alsaeed SA, et al. Food Chem Toxicol. 2026 Jan;207:115810. doi: 10.1016/j.fct.2025.115810. Epub 2025 Oct 16. Food Chem Toxicol. 2026. PMID: 41109595
BPA levels in the urine, oxidative stress markers (reactive oxygen species (ROS) and superoxide dismutase (SOD) activity), and Keratin 4 (KRT4) gene expression were analyzed in 30 patients and 30 controls. Significant risk factors for BPA exposure included co …
BPA levels in the urine, oxidative stress markers (reactive oxygen species (ROS) and superoxide dismutase (SOD) activity), and Keratin …
An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates.
Carroll SH, Macias Trevino C, Li EB, Kawasaki K, Myers N, Hallett SA, Alhazmi N, Cotney J, Carstens RP, Liao EC. Carroll SH, et al. Development. 2020 Dec 23;147(24):dev194498. doi: 10.1242/dev.194498. Development. 2020. PMID: 33234718 Free PMC article.
Analysis of aberrant cells within the cleft revealed expression of sox10, col1a1 and irf6, and these cells were adjacent to krt4(+) and krt5(+) cells. Breeding of mouse Irf6; Esrp1; Esrp2 compound mutants suggested genetic interaction, as the triple homozygote and the Irf6 …
Analysis of aberrant cells within the cleft revealed expression of sox10, col1a1 and irf6, and these cells were adjacent to krt4(+) a …
Mutations in the genes for keratin-4 and keratin-13 in Swedish patients with white sponge nevus.
Westin M, Rekabdar E, Blomstrand L, Klintberg P, Jontell M, Robledo-Sierra J. Westin M, et al. J Oral Pathol Med. 2018 Feb;47(2):152-157. doi: 10.1111/jop.12652. Epub 2017 Nov 1. J Oral Pathol Med. 2018. PMID: 29047160
DNA was subsequently extracted and amplified using touchdown-PCR. The keratin-4 and keratin-13 genes were sequenced, and a genetic analysis was performed. RESULTS: A novel heterozygous missense mutation was identified in exon 1A of the keratin-4 gene i …
DNA was subsequently extracted and amplified using touchdown-PCR. The keratin-4 and keratin-13 genes were sequenced, and a gen …
Genome-wide association analysis unveils candidate genes and loci associated with aplasia cutis congenita in pigs.
Zhou F, Wang S, Qin H, Zeng H, Ye J, Yang J, Cai G, Wu Z, Zhang Z. Zhou F, et al. BMC Genomics. 2023 Nov 21;24(1):701. doi: 10.1186/s12864-023-09803-6. BMC Genomics. 2023. PMID: 37990155 Free PMC article.
By annotating candidate genes within a 1 Mb region surrounding the significant SNPs, a total of 11 candidate genes were identified on SSC5 and SSC13, including KRT71, KRT1, KRT4, ITGB7, CSAD, RARG, SP7, PFKL, TRPM2, SUMO3, and TSPEAR. CONCLUSIONS: The results of this study …
By annotating candidate genes within a 1 Mb region surrounding the significant SNPs, a total of 11 candidate genes were identified on SSC5 a …
White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report.
Qiao Y, Liu B, Bai R, Cai J, Peng Q. Qiao Y, et al. Genes (Basel). 2022 Nov 22;13(12):2184. doi: 10.3390/genes13122184. Genes (Basel). 2022. PMID: 36553451 Free PMC article.
White sponge nevus (WSN) is a rare autosomal dominant disease with a family history, often caused by mutations of the keratin 4 (K4) and keratin 13 (K13) genes in patients. It is characterized by frequently occurred white corrugated folds in the bilateral buccal muc …
White sponge nevus (WSN) is a rare autosomal dominant disease with a family history, often caused by mutations of the keratin 4 …
Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus.
Kürklü E, Öztürk Ş, Cassidy AJ, Ak G, Koray M, Çefle K, Palandüz Ş, Güllüoğlu MG, Tanyeri H, McLean WH. Kürklü E, et al. Med Oral Patol Oral Cir Bucal. 2018 Mar 1;23(2):e144-e150. doi: 10.4317/medoral.21437. Med Oral Patol Oral Cir Bucal. 2018. PMID: 29476668 Free PMC article.
BACKGROUND: Oral white sponge nevus (WSN) is a rare autosomal dominant benign condition, characterized by asymptomatic spongy white plaques. Mutations in Keratin 4 (KRT4) and 13 (KRT13) have been shown to cause WSN. Familial cases are uncommon due to irregula …
BACKGROUND: Oral white sponge nevus (WSN) is a rare autosomal dominant benign condition, characterized by asymptomatic spongy white plaques. …
Identification of immune-related genes contributing to head and neck squamous cell carcinoma development using weighted gene co-expression network analysis.
Guo Q, Lu T, Xu H, Luo Q, Liu Z, Jiang S, Pan J, Lin S, Lin M, Guo F. Guo Q, et al. Cancer Rep (Hoboken). 2023 May;6(5):e1808. doi: 10.1002/cnr2.1808. Epub 2023 Apr 24. Cancer Rep (Hoboken). 2023. PMID: 37092360 Free PMC article.
PPI network analysis demonstrated that PPL, SCEL, KRT4, KRT24, KRT78, KRT13, SPRR3, TGM3, CRCT1, and CRNN were key components in the brown module. Furthermore, the expression levels of KRT4, KRT78, KRT13, and SPRR3 in HNSCC correlated with infiltration levels of CD8 …
PPI network analysis demonstrated that PPL, SCEL, KRT4, KRT24, KRT78, KRT13, SPRR3, TGM3, CRCT1, and CRNN were key components in the …
19 results