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Page 1
Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges.
Vitali C, Rader DJ, Cuchel M. Vitali C, et al. Curr Opin Lipidol. 2023 Apr 1;34(2):35-43. doi: 10.1097/MOL.0000000000000864. Epub 2022 Dec 6. Curr Opin Lipidol. 2023. PMID: 36473023 Review.
PURPOSE OF REVIEW: Genetic lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare, inherited, recessive disease, which manifests as two different syndromes: Familial LCAT deficiency (FLD) and Fish-eye disease (FED), characterized by lo …
PURPOSE OF REVIEW: Genetic lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare, inherited, recessiv …
Genetic variation and intestinal cholesterol absorption in humans: A systematic review and a gene network analysis.
Mokhtar FBA, Plat J, Mensink RP. Mokhtar FBA, et al. Prog Lipid Res. 2022 Apr;86:101164. doi: 10.1016/j.plipres.2022.101164. Epub 2022 Apr 4. Prog Lipid Res. 2022. PMID: 35390434 Free article. Review.
Finally, a network with fifteen additional genes (APOA1, APOA4, APOB, APOC2, APOC3, CETP, HSPG2, LCAT, LDLRAP1, LIPC, LRP1, OLR1, P4HB, SAR1B, and SDC1) was generated. ...
Finally, a network with fifteen additional genes (APOA1, APOA4, APOB, APOC2, APOC3, CETP, HSPG2, LCAT, LDLRAP1, LIPC, LRP1, OLR1, P4H …
Lipid-Related Genetic Variants for Personalized Dietary Interventions: A Systematic Review.
Rivera-Íñiguez I, González-Becerra K, Ramos-Lopez O, Peréz-Beltrán YE, Chagüén-Hernández MS, Martínez-López E, Mendivil EJ. Rivera-Íñiguez I, et al. Mol Nutr Food Res. 2023 Jul;67(14):e2200675. doi: 10.1002/mnfr.202200675. Epub 2023 Jun 13. Mol Nutr Food Res. 2023. PMID: 37186438
The genes included are FABP2, MTTP related to CM synthesis and secretion; LPL, LIPC involved in triglyceride hydrolysis; CETP, APOA1, LCAT, ABCA1, and APOA5 related to lipoprotein metabolism, and APOE, LDLR, SCARB1, APOC3 involved in lipid clearance. ...
The genes included are FABP2, MTTP related to CM synthesis and secretion; LPL, LIPC involved in triglyceride hydrolysis; CETP, APOA1, LCA …
Current Status of Familial LCAT Deficiency in Japan.
Kuroda M, Bujo H, Yokote K, Murano T, Yamaguchi T, Ogura M, Ikewaki K, Koseki M, Takeuchi Y, Nakatsuka A, Hori M, Matsuki K, Miida T, Yokoyama S, Wada J, Harada-Shiba M. Kuroda M, et al. J Atheroscler Thromb. 2021 Jul 1;28(7):679-691. doi: 10.5551/jat.RV17051. Epub 2021 Apr 18. J Atheroscler Thromb. 2021. PMID: 33867422 Free PMC article. Review.
Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the acyl chain from the second position of lecithin to the hydroxyl group of cholesterol (FC) on plasma lipoproteins to form cholesteryl acylester …
Lecithin cholesterol acyltransferase (LCAT) is a lipid-modification enzyme that catalyzes the transfer of the ac …
A systematic review of the natural history and biomarkers of primary lecithin:cholesterol acyltransferase deficiency.
Vitali C, Bajaj A, Nguyen C, Schnall J, Chen J, Stylianou K, Rader DJ, Cuchel M. Vitali C, et al. J Lipid Res. 2022 Mar;63(3):100169. doi: 10.1016/j.jlr.2022.100169. Epub 2022 Jan 20. J Lipid Res. 2022. PMID: 35065092 Free PMC article. Review.
Syndromes associated with LCAT deficiency, a rare autosomal recessive condition, include fish-eye disease (FED) and familial LCAT deficiency (FLD). ...In FLD, higher levels of total, non-HDL, and unesterified cholesterol were associated with severe CKD. We reveal a …
Syndromes associated with LCAT deficiency, a rare autosomal recessive condition, include fish-eye disease (FED) and familial LCAT …
Targeting DNA methylation in diabetic kidney disease: A new perspective.
Akhouri V, Majumder S, Gaikwad AB. Akhouri V, et al. Life Sci. 2023 Dec 15;335:122256. doi: 10.1016/j.lfs.2023.122256. Epub 2023 Nov 9. Life Sci. 2023. PMID: 37949210 Review.
The aberrant DNA methylation pattern at CpGs sites within several genes, such as mTOR, RPTOR, IRS2, GRK5, SLC27A3, LCAT, and SLC1A5, associated with the accompanying risk factors exacerbate the DKD progression. ...
The aberrant DNA methylation pattern at CpGs sites within several genes, such as mTOR, RPTOR, IRS2, GRK5, SLC27A3, LCAT, and SLC1A5, …
LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred.
Mehta R, Elías-López D, Martagón AJ, Pérez-Méndez OA, Sánchez MLO, Segura Y, Tusié MT, Aguilar-Salinas CA. Mehta R, et al. Lipids Health Dis. 2021 Jul 13;20(1):70. doi: 10.1186/s12944-021-01498-6. Lipids Health Dis. 2021. PMID: 34256778 Free PMC article.
BACKGROUND: LCAT (lecithin-cholesterol acyltransferase) deficiency is characterized by two distinct phenotypes, familial LCAT deficiency (FLD) and Fish Eye disease (FED). ...Of the Mexican probands, one showed a novel LCAT mutation. CONCL …
BACKGROUND: LCAT (lecithin-cholesterol acyltransferase) deficiency is characterized by two distinct phenotypes, …
Association of Plasma Vitamins and Carotenoids, DNA Methylation of LCAT, and Risk of Age-Related Macular Degeneration.
Li Z, Li Y, Hou Y, Fan Y, Jiang H, Li B, Zhu H, Liu Y, Zhang L, Zhang J, Wu M, Ma T, Zhao T, Ma L. Li Z, et al. Nutrients. 2023 Jun 30;15(13):2985. doi: 10.3390/nu15132985. Nutrients. 2023. PMID: 37447314 Free PMC article.
Dysregulation of lipid metabolism has been implicated in age-related macular degeneration (AMD), the leading cause of blindness among the elderly. Lecithin cholesterol acyltransferase (LCAT) is an important enzyme responsible for lipid metabolism, whic …
Dysregulation of lipid metabolism has been implicated in age-related macular degeneration (AMD), the leading cause of blindness among the el …
Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.
Hasni SA, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Carlucci PM, Wang X, Naqi M, Playford MP, Goel RR, Li X, Biehl AJ, Ochoa-Navas I, Manna Z, Shi Y, Thomas D, Chen J, Biancotto A, Apps R, Cheung F, Kotliarov Y, Babyak AL, Zhou H, Shi R, Stagliano K, Tsai WL, Vian L, Gazaniga N, Giudice V, Lu S, Brooks SR, MacKay M, Gregersen P, Mehta NN, Remaley AT, Diamond B, O'Shea JJ, Gadina M, Kaplan MJ. Hasni SA, et al. Nat Commun. 2021 Jun 7;12(1):3391. doi: 10.1038/s41467-021-23361-z. Nat Commun. 2021. PMID: 34099646 Free PMC article. Clinical Trial.
Tofacitinib improves high-density lipoprotein cholesterol levels (p = 0.0006, CI 95%: 4.12, 13.32) and particle number (p = 0.0008, CI 95%: 1.58, 5.33); lecithin: cholesterol acyltransferase concentration (p = 0.024, CI 95%: 1.1, -26.5), cholesterol efflux ca …
Tofacitinib improves high-density lipoprotein cholesterol levels (p = 0.0006, CI 95%: 4.12, 13.32) and particle number (p = 0.0008, CI 95%: …
A stemness-based eleven-gene signature correlates with the clinical outcome of hepatocellular carcinoma.
Hong L, Zhou Y, Xie X, Wu W, Shi C, Lin H, Shi Z. Hong L, et al. BMC Cancer. 2021 Jun 19;21(1):716. doi: 10.1186/s12885-021-08351-0. BMC Cancer. 2021. PMID: 34147074 Free PMC article.
Next, we identified 11 prognostic genes (CDX2, PON1, ADH4, RBP2, LCAT, GAL, LPA, CYP19A1, GAST, SST and UGT1A8) and then constructed a prognostic 11-gene module and validated its robustness in all three datasets. ...
Next, we identified 11 prognostic genes (CDX2, PON1, ADH4, RBP2, LCAT, GAL, LPA, CYP19A1, GAST, SST and UGT1A8) and then constructed …
20 results