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Estrogen Induces LCAT to Maintain Cholesterol Homeostasis and Suppress Hepatocellular Carcinoma Development.
He W, Wang M, Zhang X, Wang Y, Zhao D, Li W, Lei F, Peng M, Zhang Z, Yuan Y, Huang Z. He W, et al. Cancer Res. 2024 Aug 1;84(15):2417-2431. doi: 10.1158/0008-5472.CAN-23-3966. Cancer Res. 2024. PMID: 38718297
Here, we performed transcriptomic analyses on mouse and human liver cancer and identified lecithin cholesterol acyltransferase (LCAT) as the most highly estrogen-upregulated gene and a biomarker of favorable prognosis. ...Furthermore, LCAT defic …
Here, we performed transcriptomic analyses on mouse and human liver cancer and identified lecithin cholesterol acyltransfer …
Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges.
Vitali C, Rader DJ, Cuchel M. Vitali C, et al. Curr Opin Lipidol. 2023 Apr 1;34(2):35-43. doi: 10.1097/MOL.0000000000000864. Epub 2022 Dec 6. Curr Opin Lipidol. 2023. PMID: 36473023 Review.
PURPOSE OF REVIEW: Genetic lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare, inherited, recessive disease, which manifests as two different syndromes: Familial LCAT deficiency (FLD) and Fish-eye disease (FED), characterized by lo …
PURPOSE OF REVIEW: Genetic lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare, inherited, recessiv …
Lipid-Related Genetic Variants for Personalized Dietary Interventions: A Systematic Review.
Rivera-Íñiguez I, González-Becerra K, Ramos-Lopez O, Peréz-Beltrán YE, Chagüén-Hernández MS, Martínez-López E, Mendivil EJ. Rivera-Íñiguez I, et al. Mol Nutr Food Res. 2023 Jul;67(14):e2200675. doi: 10.1002/mnfr.202200675. Epub 2023 Jun 13. Mol Nutr Food Res. 2023. PMID: 37186438
The genes included are FABP2, MTTP related to CM synthesis and secretion; LPL, LIPC involved in triglyceride hydrolysis; CETP, APOA1, LCAT, ABCA1, and APOA5 related to lipoprotein metabolism, and APOE, LDLR, SCARB1, APOC3 involved in lipid clearance. ...
The genes included are FABP2, MTTP related to CM synthesis and secretion; LPL, LIPC involved in triglyceride hydrolysis; CETP, APOA1, LCA …
Identification of Potential Drug Targets for Myopia Through Mendelian Randomization.
Qin Y, Lei C, Lin T, Han X, Wang D. Qin Y, et al. Invest Ophthalmol Vis Sci. 2024 Aug 1;65(10):13. doi: 10.1167/iovs.65.10.13. Invest Ophthalmol Vis Sci. 2024. PMID: 39110588 Free PMC article.
RESULTS: This systematic drug target identification has unveiled 6 putative genetically causal targets for myopia-CD34, CD55, Wnt3, LCAT, BTN3A1, and TSSK6-each backed by colocalization evidence in adult blood eQTL datasets. ...Finally, drug prediction and molecular dockin …
RESULTS: This systematic drug target identification has unveiled 6 putative genetically causal targets for myopia-CD34, CD55, Wnt3, LCAT …
Proteomics-driven discovery of LCAT as a novel biomarker for liver metastasis in colorectal cancer.
Wang Y, Yang Z, Li Z, Huang L, Hou S, Wang J, Yu Y, Yin J, Wu J. Wang Y, et al. BMC Cancer. 2025 Mar 15;25(1):480. doi: 10.1186/s12885-025-13882-x. BMC Cancer. 2025. PMID: 40089671 Free PMC article.
Enrichment analysis linked these proteins to steroid and alcohol metabolism, inflammation, lipoproteins, and HDL particles, with key pathways in cholesterol and retinol metabolism. Lecithin cholesterol acyltransferase (LCAT), an important enzyme in thi …
Enrichment analysis linked these proteins to steroid and alcohol metabolism, inflammation, lipoproteins, and HDL particles, with key pathway …
A Novel Symptomatic Lecithin-Cholesterol Acyltransferase Gene Mutation With Corneal Amyloidosis.
Abu Dail Y, Flockerzi E, Flockerzi F, Matthaei M, Cursiefen C, Seitz B. Abu Dail Y, et al. Cornea. 2024 Nov 1;43(11):1427-1430. doi: 10.1097/ICO.0000000000003671. Epub 2024 Aug 22. Cornea. 2024. PMID: 39177400
PURPOSE: To present ocular clinical, histological, systemic, and genetic findings of a patient with familial lecithin-cholesterol acyltransferase (LCAT) deficiency caused by a novel genetic variant of the LCAT gene associated with secondary corn …
PURPOSE: To present ocular clinical, histological, systemic, and genetic findings of a patient with familial lecithin-cholesterol …
From genes to therapy: a lipid Metabolism-Related genetic risk model predicts HCC outcomes and enhances immunotherapy.
Xu L, Xiao T, Chao T, Xiong H, Yao W. Xu L, et al. BMC Cancer. 2025 May 19;25(1):895. doi: 10.1186/s12885-025-14306-6. BMC Cancer. 2025. PMID: 40389832 Free PMC article.
RESULTS: This study identified six lipid metabolism-related genes, ADH4, LCAT, CYP2C9, CYP17A1, LPCAT1, and ACACA, to construct a lipid metabolism-related gene risk model that can divide HCC patients into low- and high-risk groups. ...
RESULTS: This study identified six lipid metabolism-related genes, ADH4, LCAT, CYP2C9, CYP17A1, LPCAT1, and ACACA, to construct a lip …
Targeting DNA methylation in diabetic kidney disease: A new perspective.
Akhouri V, Majumder S, Gaikwad AB. Akhouri V, et al. Life Sci. 2023 Dec 15;335:122256. doi: 10.1016/j.lfs.2023.122256. Epub 2023 Nov 9. Life Sci. 2023. PMID: 37949210 Review.
The aberrant DNA methylation pattern at CpGs sites within several genes, such as mTOR, RPTOR, IRS2, GRK5, SLC27A3, LCAT, and SLC1A5, associated with the accompanying risk factors exacerbate the DKD progression. ...
The aberrant DNA methylation pattern at CpGs sites within several genes, such as mTOR, RPTOR, IRS2, GRK5, SLC27A3, LCAT, and SLC1A5, …
LCAT in Cancer Biology: Embracing Epigenetic Regulation, Immune Interactions, and Therapeutic Implications.
Gao M, Zhang W, Li X, Li S, Wang W, Han P. Gao M, et al. Int J Mol Sci. 2025 Feb 10;26(4):1453. doi: 10.3390/ijms26041453. Int J Mol Sci. 2025. PMID: 40003919 Free PMC article. Review.
Lecithin cholesterol acyltransferase (LCAT) is a crucial enzyme in high-density lipoprotein (HDL) metabolism that is often dysregulated in cancers, affecting tumor growth and therapy response. ...In ACC and COAD, LCAT may promote tumor growth, w …
Lecithin cholesterol acyltransferase (LCAT) is a crucial enzyme in high-density lipoprotein (HDL) metabolism tha …
Association of Plasma Vitamins and Carotenoids, DNA Methylation of LCAT, and Risk of Age-Related Macular Degeneration.
Li Z, Li Y, Hou Y, Fan Y, Jiang H, Li B, Zhu H, Liu Y, Zhang L, Zhang J, Wu M, Ma T, Zhao T, Ma L. Li Z, et al. Nutrients. 2023 Jun 30;15(13):2985. doi: 10.3390/nu15132985. Nutrients. 2023. PMID: 37447314 Free PMC article.
Dysregulation of lipid metabolism has been implicated in age-related macular degeneration (AMD), the leading cause of blindness among the elderly. Lecithin cholesterol acyltransferase (LCAT) is an important enzyme responsible for lipid metabolism, whic …
Dysregulation of lipid metabolism has been implicated in age-related macular degeneration (AMD), the leading cause of blindness among the el …
25 results