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2013 1
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65 results

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Page 1
Mitochondrial calcium exchange in physiology and disease.
Garbincius JF, Elrod JW. Garbincius JF, et al. Physiol Rev. 2022 Apr 1;102(2):893-992. doi: 10.1152/physrev.00041.2020. Epub 2021 Oct 26. Physiol Rev. 2022. PMID: 34698550 Free PMC article. Review.
Here, we present an overview of the phenomenon of (m)Ca(2+) transport and a comprehensive examination of the molecular machinery that mediates calcium flux across the inner mitochondrial membrane: the mitochondrial uniporter complex (consisting of MCU, EMRE, MICU1, MICU2, MICU3, …
Here, we present an overview of the phenomenon of (m)Ca(2+) transport and a comprehensive examination of the molecular machinery that mediat …
LETM1 is required for mitochondrial homeostasis and cellular viability (Review).
Li Y, Tran Q, Shrestha R, Piao L, Park S, Park J, Park J. Li Y, et al. Mol Med Rep. 2019 May;19(5):3367-3375. doi: 10.3892/mmr.2019.10041. Epub 2019 Mar 15. Mol Med Rep. 2019. PMID: 30896806 Free PMC article. Review.
Leucine zipper/EF-hand-containing transmembrane protein 1 (LETM1) has been identified as the gene responsible for Wolf-Hirschhorn syndrome (WHS), which is characterized by intellectual disability, epilepsy, growth delay and craniofacial d
Leucine zipper/EF-hand-containing transmembrane protein 1 (LETM1) has been identified as the gene
Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement.
Kaiyrzhanov R, Mohammed SEM, Maroofian R, Husain RA, Catania A, Torraco A, Alahmad A, Dutra-Clarke M, Grønborg S, Sudarsanam A, Vogt J, Arrigoni F, Baptista J, Haider S, Feichtinger RG, Bernardi P, Zulian A, Gusic M, Efthymiou S, Bai R, Bibi F, Horga A, Martinez-Agosto JA, Lam A, Manole A, Rodriguez DP, Durigon R, Pyle A, Albash B, Dionisi-Vici C, Murphy D, Martinelli D, Bugiardini E, Allis K, Lamperti C, Reipert S, Risom L, Laugwitz L, Di Nottia M, McFarland R, Vilarinho L, Hanna M, Prokisch H, Mayr JA, Bertini ES, Ghezzi D, Østergaard E, Wortmann SB, Carrozzo R, Haack TB, Taylor RW, Spinazzola A, Nowikovsky K, Houlden H. Kaiyrzhanov R, et al. Am J Hum Genet. 2022 Sep 1;109(9):1692-1712. doi: 10.1016/j.ajhg.2022.07.007. Am J Hum Genet. 2022. PMID: 36055214 Free PMC article.
Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) encodes an inner mitochondrial membrane protein with an osmoregulatory function controlling mitochondrial volume and ion homeostasis. The putative association of LETM1
Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) encodes an inner mitochondrial m
LETM1: Essential for Mitochondrial Biology and Cation Homeostasis?
Austin S, Nowikovsky K. Austin S, et al. Trends Biochem Sci. 2019 Aug;44(8):648-658. doi: 10.1016/j.tibs.2019.04.002. Epub 2019 May 14. Trends Biochem Sci. 2019. PMID: 31101453 Free article. Review.
High-throughput screening has identified essential genes required for cellular survival and fitness. One such gene is LETM1. The undisputed function of LETM1 from yeast to human is to maintain the mitochondrial osmotic balance. ...In this Opinion, we report and disc …
High-throughput screening has identified essential genes required for cellular survival and fitness. One such gene is LETM1. The undi …
Emerging role of LETM1/GRP78 axis in lung cancer.
Tran Q, Lee H, Jung JH, Chang SH, Shrestha R, Kong G, Park J, Kim SH, Park KS, Rhee HW, Yun J, Cho MH, Kim KP, Park J. Tran Q, et al. Cell Death Dis. 2022 Jun 10;13(6):543. doi: 10.1038/s41419-022-04993-5. Cell Death Dis. 2022. PMID: 35680871 Free PMC article.
Mitochondrial dysfunction, mitophagy, and apoptosis have been suggested to be interrelated in various human lung carcinomas. Leucine zipper EF-hand-containing transmembrane protein-1 (LETM1) was cloned in an attempt to identify candidate …
Mitochondrial dysfunction, mitophagy, and apoptosis have been suggested to be interrelated in various human lung carcinomas. Leucine
Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease.
Lin QT, Stathopulos PB. Lin QT, et al. Int J Mol Sci. 2019 Jan 12;20(2):286. doi: 10.3390/ijms20020286. Int J Mol Sci. 2019. PMID: 30642051 Free PMC article. Review.
Given the intimate link to both life and death processes, it is imperative that mitochondria tightly regulate intramitochondrial Ca(2+) levels with a high degree of precision. Among the Ca(2+) handling tools of mitochondria, the leucine zipper EF-hand
Given the intimate link to both life and death processes, it is imperative that mitochondria tightly regulate intramitochondrial Ca(2+) leve …
LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14).
Zhao Q, Chen S, Chen L. Zhao Q, et al. Bioengineered. 2021 Dec;12(1):7656-7665. doi: 10.1080/21655979.2021.1982275. Bioengineered. 2021. PMID: 34605738 Free PMC article.
Finally, the angiogenesis was assessed using tubule formation assay. The co-immunoprecipitation results showed that LETM1 could bind to KIF14. The cytological and protein results demonstrated that interference with LETM1 caused downregulation of KIF14 expression, wh …
Finally, the angiogenesis was assessed using tubule formation assay. The co-immunoprecipitation results showed that LETM1 could bind …
Mitochondrial protein LETM1 and its-mediated CTMP are potential therapeutic targets for endometrial cancer.
Niu F, Duan Y, Man Y, Liu W, Dai T, Zhang H, Li C, Wei D. Niu F, et al. Anticancer Drugs. 2022 Aug 1;33(7):632-641. doi: 10.1097/CAD.0000000000001301. Epub 2022 Mar 23. Anticancer Drugs. 2022. PMID: 35324530
Leucine zipper/EF hand-containing transmembrane-1 (LETM1) is an important mitochondrial protein, while its function in endometrial cancer remains unknown. ...In addition, CTMP was downregulated by LETM1 silencing in KLE cells, and
Leucine zipper/EF hand-containing transmembrane-1 (LETM1) is an important mitochondrial protein, w
The leucine zipper EF-hand containing transmembrane protein-1 EF-hand is a tripartite calcium, temperature, and pH sensor.
Lin QT, Lee R, Feng AL, Kim MS, Stathopulos PB. Lin QT, et al. Protein Sci. 2021 Apr;30(4):855-872. doi: 10.1002/pro.4042. Epub 2021 Mar 2. Protein Sci. 2021. PMID: 33576522 Free PMC article.
Leucine Zipper EF-hand containing transmembrane protein-1 (LETM1) is an inner mitochondrial membrane protein that mediates mitochondrial calcium (Ca(2+) )/proton exchange. The matrix residing carboxyl (C)-terminal domain contains a sequen
Leucine Zipper EF-hand containing transmembrane protein-1 (LETM1) is an inner mitochondrial membra
Mitochondrial calcium at the synapse.
Datta S, Jaiswal M. Datta S, et al. Mitochondrion. 2021 Jul;59:135-153. doi: 10.1016/j.mito.2021.04.006. Epub 2021 Apr 23. Mitochondrion. 2021. PMID: 33895346 Review.
65 results