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Page 1
Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism.
Bai Y, Nan Y, Wu T, Zhu A, Xie X, Sun Y, Deng Y, Dou Z, Hu X, Zhou R, Xu S, Zhang Y, Fan J, Ju D. Bai Y, et al. Adv Sci (Weinh). 2024 Aug;11(31):e2400493. doi: 10.1002/advs.202400493. Epub 2024 Jun 18. Adv Sci (Weinh). 2024. PMID: 38894572 Free PMC article.
Furthermore, the increase of phosphatidylcholine and phosphatidylethanolamine levels can be observed in the NAFLD mice livers after Rubicon silencing, along with regulatory effects on metabolism-related genes such as CD36, Gpcpd1, Chka, and Lpin2. The results indicate that …
Furthermore, the increase of phosphatidylcholine and phosphatidylethanolamine levels can be observed in the NAFLD mice livers after Rubicon …
LPIN2 -related Majeed syndrome: report of two Indian patients with novel variants in LPIN2 and review of literature.
Badiger VA, Balan S, Madan S, Gogineni KS, Shah H, Narayanan DL. Badiger VA, et al. Clin Dysmorphol. 2024 Jan 1;33(1):27-30. doi: 10.1097/MCD.0000000000000476. Epub 2023 Oct 12. Clin Dysmorphol. 2024. PMID: 37865862 Review.
LPIN2 -related Majeed syndrome (MIM# 609628) is a rare non-inflammasome autoinflammatory disease, caused due to biallelic variants in LPIN2 (MIM* 605519). ...LPIN2 -related Majeed syndrome should be considered as a differential diagnosis in an individual with …
LPIN2 -related Majeed syndrome (MIM# 609628) is a rare non-inflammasome autoinflammatory disease, caused due to biallelic variants in …
Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon.
de Pablo N, Meana C, Martínez-García J, Martínez-Vicente P, Albert M, Guerra S, Angulo A, Balsinde J, Balboa MA. de Pablo N, et al. EMBO Rep. 2023 Dec 6;24(12):e57238. doi: 10.15252/embr.202357238. Epub 2023 Nov 6. EMBO Rep. 2023. PMID: 37929625 Free PMC article.
Lipin-2 inhibits viral replication both in vitro and in vivo. Moreover, lipin-2 also acts as a regulator of inflammation in a viral context by reducing the signaling through TLR3 and the generation of ROS and release of mtDNA that ultimately activate t …
Lipin-2 inhibits viral replication both in vitro and in vivo. Moreover, lipin-2 also acts as a regulator of infl …
Mammalian lipin phosphatidic acid phosphatases in lipid synthesis and beyond: metabolic and inflammatory disorders.
Reue K, Wang H. Reue K, et al. J Lipid Res. 2019 Apr;60(4):728-733. doi: 10.1194/jlr.S091769. Epub 2019 Feb 25. J Lipid Res. 2019. PMID: 30804008 Free PMC article. Review.
The regulation of cellular lipid storage and membrane lipid composition plays a critical role in metabolic homeostasis, and dysregulation may contribute to disorders such as obesity, fatty liver, type 2 diabetes, and cardiovascular disease. The mammalian lipin proteins (lipin 1, …
The regulation of cellular lipid storage and membrane lipid composition plays a critical role in metabolic homeostasis, and dysregulation ma …
Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.
Liu YX, Huang H, Wang F, Zhao MF, Jin JY, Dong Y, Wang Q, Fan LL, Xiang R. Liu YX, et al. Int J Biol Sci. 2025 Aug 11;21(12):5185-5205. doi: 10.7150/ijbs.110125. eCollection 2025. Int J Biol Sci. 2025. PMID: 40959286 Free PMC article.
Lipin proteins, including Lipin 1, Lipin 2 and Lipin3, play a vital role in lipid metabolism. Despite their significance, there is limited understanding of the involvement of Lipin proteins in kidney diseases. ...
Lipin proteins, including Lipin 1, Lipin 2 and Lipin3, play a vital role in lipid metabolism. Despite their significance, ther …
Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.
Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H. Watahiki A, et al. Biochem Biophys Res Commun. 2020 Apr 2;524(2):477-483. doi: 10.1016/j.bbrc.2020.01.119. Epub 2020 Jan 31. Biochem Biophys Res Commun. 2020. PMID: 32008742
Lipin-2 is a phosphatidate phosphatase with key roles in regulating lipid storage and energy homeostasis. ...Here, we demonstrate that Lipin-2 interacts with beta-TRCP, a substrate receptor subunit of the SCF(beta)(-)(TRCP) E3 ligase, and undergoes ubi …
Lipin-2 is a phosphatidate phosphatase with key roles in regulating lipid storage and energy homeostasis. ...Here, we demonstr …
Update on the genetics of nonbacterial osteomyelitis in humans.
Cox AJ, Ferguson PJ. Cox AJ, et al. Curr Opin Rheumatol. 2018 Sep;30(5):521-525. doi: 10.1097/BOR.0000000000000530. Curr Opin Rheumatol. 2018. PMID: 29912021 Review.
Past discoveries identified several single gene defects (LPIN2, Pstpip2 and IL1RN) that cause IL-1-mediated sterile multifocal osteomyelitis. Recently Lorden et al.'...
Past discoveries identified several single gene defects (LPIN2, Pstpip2 and IL1RN) that cause IL-1-mediated sterile multifocal osteom …
Human Inborn Errors of Immunity in Pyoderma Gangrenosum: A Systematic Review.
Oprea Y, Antohi DR, Vague M, Delbourgo Patton C, Wu B, Ortega-Loayza AG. Oprea Y, et al. Am J Clin Dermatol. 2024 Sep;25(5):701-716. doi: 10.1007/s40257-024-00875-y. Epub 2024 Jul 1. Am J Clin Dermatol. 2024. PMID: 38951460
Genetic mutations such as BTK, IL1RN, ITGB2, LPIN2, MEFV, NFkB1, NLRP3, NLRP12, NOD2, PSMB8, PLCG2, PSTPIP1, RAG1, TTC37, and WDR1, as well as complement component 2/complement component 4 (C2/C4) and complement component 7 (C7) deficiencies were identified in the presence …
Genetic mutations such as BTK, IL1RN, ITGB2, LPIN2, MEFV, NFkB1, NLRP3, NLRP12, NOD2, PSMB8, PLCG2, PSTPIP1, RAG1, TTC37, and WDR1, a …
Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis.
Bhuyan F, de Jesus AA, Mitchell J, Leikina E, VanTries R, Herzog R, Onel KB, Oler A, Montealegre Sanchez GA, Johnson KA, Bichell L, Marrero B, De Castro LF, Huang Y, Calvo KR, Collins MT, Ganesan S, Chernomordik LV, Ferguson PJ, Goldbach-Mansky R. Bhuyan F, et al. Arthritis Rheumatol. 2021 Jun;73(6):1021-1032. doi: 10.1002/art.41624. Epub 2021 May 9. Arthritis Rheumatol. 2021. PMID: 33314777 Free PMC article.
She had a 17.8-kb deletion on the maternal LPIN2 allele and a splice site mutation, p.R517H, that variably spliced out exons 10 and 11 on the paternal LPIN2 allele. ...CONCLUSION: We report 2 novel compound heterozygous disease-causing mutations in LPIN2 in a …
She had a 17.8-kb deletion on the maternal LPIN2 allele and a splice site mutation, p.R517H, that variably spliced out exons 10 and 1 …
Majeed Syndrome: Five Cases With Novel Mutations From Unrelated Families in India With a Review of Literature.
Chavan PP, Aksentijevich I, Daftary A, Panwala H, Khemani C, Khan A, Khubchandani R. Chavan PP, et al. J Rheumatol. 2021 Dec;48(12):1850-1855. doi: 10.3899/jrheum.201663. Epub 2021 May 15. J Rheumatol. 2021. PMID: 33993107 Review.
We analyzed a cohort of uncharacterized Indian patients for pathogenic variants in LPIN2 and other genes associated with SAIDs. METHODS: We performed whole-exome sequencing (WES) for 1 patient and next-generation sequencing (NGS) targeted gene panel for SAIDs in 3 patients …
We analyzed a cohort of uncharacterized Indian patients for pathogenic variants in LPIN2 and other genes associated with SAIDs. METHO …
43 results