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AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination.
Haffner MC, Esopi DM, Chaux A, Gürel M, Ghosh S, Vaghasia AM, Tsai H, Kim K, Castagna N, Lam H, Hicks J, Wyhs N, Biswal Shinohara D, Hurley PJ, Simons BW, Schaeffer EM, Lotan TL, Isaacs WB, Netto GJ, De Marzo AM, Nelson WG, An SS, Yegnasubramanian S. Haffner MC, et al. Nat Commun. 2017 Jul 26;8(1):142. doi: 10.1038/s41467-017-00084-8. Nat Commun. 2017. PMID: 28747635 Free PMC article.
These invasive properties involve altered dynamics of the cytoskeleton and one of its major structural components beta-actin. Here we identify AIM1 (absent in melanoma 1) as an actin-binding protein that suppresses pro-invasive properties in benign prostate epitheli …
These invasive properties involve altered dynamics of the cytoskeleton and one of its major structural components beta-actin. Here we identi …
Mutational Analysis on Membrane Associated Transporter Protein (MATP) and Their Structural Consequences in Oculocutaeous Albinism Type 4 (OCA4)-A Molecular Dynamics Approach.
Kamaraj B, Purohit R. Kamaraj B, et al. J Cell Biochem. 2016 Nov;117(11):2608-19. doi: 10.1002/jcb.25555. Epub 2016 Aug 8. J Cell Biochem. 2016. PMID: 27019209
Oculocutaneous albinism type IV (OCA4) is an autosomal recessive inherited disorder which is characterized by reduced biosynthesis of melanin pigmentation in skin, hair, and eyes and caused by the genetic mutations in the membrane-associated transporter pr …
Oculocutaneous albinism type IV (OCA4) is an autosomal recessive inherited disorder which is characterized by reduced biosynthesis of melani …
Locking the gates of immortality: targeting alternative lengthening of telomeres (ALT) pathways.
Mishra A, Patel TN. Mishra A, et al. Med Oncol. 2025 Feb 18;42(3):78. doi: 10.1007/s12032-025-02627-2. Med Oncol. 2025. PMID: 39964637 Review.
ALT is primarily observed in sarcomas and neuroepithelial tumors and it is characterized by hallmarks such as heterogeneous telomere lengths, the presence of ALT-associated PML bodies (APBs), extrachromosomal telomeric repeats (ECTRs), and elevated replication stress. This review …
ALT is primarily observed in sarcomas and neuroepithelial tumors and it is characterized by hallmarks such as heterogeneous telomere lengths …
Deregulation of lncRNA HIST1H2AG-6 and AIM1-3 in peripheral blood mononuclear cells is associated with newly diagnosed type 2 diabetes.
Jiang H, Lou P, Chen X, Wu C, Shao S. Jiang H, et al. BMC Med Genomics. 2021 Jun 6;14(1):149. doi: 10.1186/s12920-021-00994-z. BMC Med Genomics. 2021. PMID: 34092238 Free PMC article.
Multivariate logistic regression analysis revealed that lnc-HIST1H2AG-6 and lnc-AIM1-3 were significantly correlated with T2DM (OR = 5.791 and 0.071, respectively, both P = 0.000). Furthermore, the ROC curve showed that the expression of lnc-HIST1H2AG-6 and lnc-AIM1 …
Multivariate logistic regression analysis revealed that lnc-HIST1H2AG-6 and lnc-AIM1-3 were significantly correlated with T2DM (OR = …
Strabismus and nystagmus in oculocutaneous albinism: clinical perspectives, diagnosis, and role of neurotransmitters.
Dobhal V, Kumar A, Garg I, Kumar A, Goel F. Dobhal V, et al. Neurogenetics. 2025 Jun 18;26(1):50. doi: 10.1007/s10048-025-00830-x. Neurogenetics. 2025. PMID: 40531243 Review.
Genes that are majorly involved in different types of oculocutaneous albinism (OCA) are the TYR, MATP, SLC24A5, TYRP1, and SLCA5A2. Also, gene sequences LYST and HPS1 account for Chediak-Higashi syndrome and Hermansky-Pudlak syndrome, respectively, which have clinical symp …
Genes that are majorly involved in different types of oculocutaneous albinism (OCA) are the TYR, MATP, SLC24A5, TYRP1, and SLCA5A2. A …
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
de Carvalho FM, Valiatti TB, Santos FF, Silveira ACO, Guimarães APC, Gerber AL, Souza CO, Cassu Corsi D, Brasiliense DM, Castelo-Branco DSCM, Anzai EK, Bessa-Neto FO, Guedes GMM, de Souza GHA, Lemos LN, Ferraz LFC, Bahia MNM, Vaz MSM, da Silva RGB, Veiga R, Simionatto S, Monteiro WAP, Lima WAO, Kiffer CRV, Campos Pignatari AC, Cayô R, de Vasconcelos ATR, Gales AC. de Carvalho FM, et al. Microbiol Spectr. 2022 Oct 26;10(5):e0056522. doi: 10.1128/spectrum.00565-22. Epub 2022 Aug 22. Microbiol Spectr. 2022. PMID: 35993730 Free PMC article.
Interestingly, carbapenemase-encoding genes such as bla(AIM-1), bla(CAM-1), bla(GIM-2), and bla(HMB-1) were identified in distinct hosts. Our results revealed that, in general, the bacterial communities from humans were present in isolated clusters, except for the N …
Interestingly, carbapenemase-encoding genes such as bla(AIM-1), bla(CAM-1), bla(GIM-2), and bla(HMB-1) were identified in dist …
The "Latines Lideres En Salud (LaLiSa)" study: Rationale and design.
Torres P, Bujanda C, Arroyo J, Lucio A, Pan V, Ganschow P, Andersen K, Charchalac-Zapeta C, Barragan M, Neuschler E, Kim SJ, Chen Z, Martinez M, Madrid S, Stackhouse N, Gastala NM, McClellan S, Molina Y. Torres P, et al. Contemp Clin Trials. 2024 Nov;146:107689. doi: 10.1016/j.cct.2024.107689. Epub 2024 Sep 13. Contemp Clin Trials. 2024. PMID: 39265781
For Aim 1, eligible participants: (1) are female; (2) are Latine; (3) are 30+ years old; (4) have personal or family history of BC or cancers with shared hereditary mutations; (5) have at least one SDOH risk; and (6) have not received any cancer genetic services. .. …
For Aim 1, eligible participants: (1) are female; (2) are Latine; (3) are 30+ years old; (4) have personal or family history o …
Role of Physical Activity and Fitness in the Characterization and Prognosis of the Metabolically Healthy Obesity Phenotype: A Systematic Review and Meta-analysis.
Ortega FB, Cadenas-Sanchez C, Migueles JH, Labayen I, Ruiz JR, Sui X, Blair SN, Martínez-Vizcaino V, Lavie CJ. Ortega FB, et al. Prog Cardiovasc Dis. 2018 Jul-Aug;61(2):190-205. doi: 10.1016/j.pcad.2018.07.008. Epub 2018 Jul 6. Prog Cardiovasc Dis. 2018. PMID: 30122522
Our systematic review identified 67 cross-sectional studies to address aim 1, and 11 longitudinal studies to address aim 2. The major findings and conclusions from the current meta-analysis are: 1) MHO individuals are more active, spend less time in SB, and have a h …
Our systematic review identified 67 cross-sectional studies to address aim 1, and 11 longitudinal studies to address aim 2. Th …
Melanocyte progenitor cells reside in human subcutaneous adipose tissue.
Ikeda Y, Wada A, Hasegawa T, Yokota M, Koike M, Ikeda S. Ikeda Y, et al. PLoS One. 2021 Aug 25;16(8):e0256622. doi: 10.1371/journal.pone.0256622. eCollection 2021. PLoS One. 2021. PMID: 34432824 Free PMC article.
First, we examined the expression of human melanoma black 45 (HMB45) and microphthalmia-associated transcription factor (MITF) in undifferentiated adipose-derived stem cells (ADSCs) by immunostaining, RT-PCR, and western blotting. These two markers were detected in undiffe …
First, we examined the expression of human melanoma black 45 (HMB45) and microphthalmia-associated transcription factor (MITF) in und …
Worldwide distribution and environmental origin of the Adelaide imipenemase (AIM-1), a potent carbapenemase in Pseudomonas aeruginosa.
Amsalu A, Sapula SA, Whittall JJ, Hart BJ, Bell JM, Turnidge J, Venter H. Amsalu A, et al. Microb Genom. 2021 Dec;7(12):000715. doi: 10.1099/mgen.0.000715. Microb Genom. 2021. PMID: 34919514 Free PMC article.
One isolate from wastewater contained the Adelaide imipenemase gene (bla(AIM-1)) and was compared phenotypically with a highly carbapenem-resistant clinical isolate containing the bla(AIM-1) gene. ...A blast search revealed the presence of the bla(A …
One isolate from wastewater contained the Adelaide imipenemase gene (bla(AIM-1)) and was compared phenotypically with a highly …
23 results