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Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review.
Hernández-Díaz Y, Genis-Mendoza AD, González-Castro TB, Tovilla-Zárate CA, Juárez-Rojop IE, López-Narváez ML, Nicolini H. Hernández-Díaz Y, et al. Genes (Basel). 2021 Oct 13;12(10):1608. doi: 10.3390/genes12101608. Genes (Basel). 2021. PMID: 34681002 Free PMC article. Review.
Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. CONCLUSIONS: Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB....
Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. CONCLUSIONS: Our findings suggest tha …
Misfolded G Protein-Coupled Receptors and Endocrine Disease. Molecular Mechanisms and Therapeutic Prospects.
Ulloa-Aguirre A, Zariñán T, Jardón-Valadez E. Ulloa-Aguirre A, et al. Int J Mol Sci. 2021 Nov 15;22(22):12329. doi: 10.3390/ijms222212329. Int J Mol Sci. 2021. PMID: 34830210 Free PMC article. Review.
Several endocrine diseases due to inactivating mutations in GPCRs have been described, including X-linked nephrogenic diabetes insipidus, thyroid disorders, familial hypocalciuric hypercalcemia, obesity, familial glucocorticoid deficiency [melanocortin-2 receptor …
Several endocrine diseases due to inactivating mutations in GPCRs have been described, including X-linked nephrogenic diabetes insipidus, th …
Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations.
Lim JS, Plaska SW, Rege J, Rainey WE, Turcu AF. Lim JS, et al. Front Endocrinol (Lausanne). 2021 Mar 16;12:644382. doi: 10.3389/fendo.2021.644382. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 33796077 Free PMC article.
OBJECTIVE: To analyze the transcript expression of type 1 angiotensin II receptors (AGTR1), ACTH receptors (MC2R), and melanocortin 2 receptor accessory protein (MRAP) in APAs with known aldosterone-driver somatic mutations. ...MC2R and CYP11B2 …
OBJECTIVE: To analyze the transcript expression of type 1 angiotensin II receptors (AGTR1), ACTH receptors (MC2R), and melanocorti …
Functional characterization of melanocortin 2 receptor (Mc2r) from a lobe-finned fish (Protopterus annectens) and insights into the molecular evolution of melanocortin receptors.
Shaughnessy CA, Le K, Myhre VD, Dores RM. Shaughnessy CA, et al. Gen Comp Endocrinol. 2023 Nov 1;343:114356. doi: 10.1016/j.ygcen.2023.114356. Epub 2023 Aug 9. Gen Comp Endocrinol. 2023. PMID: 37562700
Here, we offer the first molecular and functional characterization of an Mc2r from a lobe-finned fish, the West African lungfish (Protopterus annectens). Plasmids containing cDNA constructs of lungfish (lf) Mc2r and Mrap1 were expressed in mammalian and zebrafish ce …
Here, we offer the first molecular and functional characterization of an Mc2r from a lobe-finned fish, the West African lungfish (Pro …
Gene-environment interaction between HPA-axis genes and trauma exposure in the suicide behavior: A systematic review.
González-Castro TB, Juárez-Rojop IE, Tovilla-Zárate CA, Ovando-Ricárdez JA, Hernández-Díaz Y, López-Narváez ML, Genis-Mendoza AD, Rodríguez-Pérez C. González-Castro TB, et al. J Psychiatr Res. 2023 Aug;164:162-170. doi: 10.1016/j.jpsychires.2023.06.011. Epub 2023 Jun 15. J Psychiatr Res. 2023. PMID: 37352812 Review.
Gene-environment interaction was reported for CRHR1 (n = 6), CRHR2 (n = 2), FKBP5 (n = 2), and CRHBP (n = 1), however, for CRH, NR3C1, MC2R, and POMC genes no found gene-environment effects on SB. Trauma exposure could be one mechanism that links HPA-axis genes activity wi …
Gene-environment interaction was reported for CRHR1 (n = 6), CRHR2 (n = 2), FKBP5 (n = 2), and CRHBP (n = 1), however, for CRH, NR3C1, MC …
Evaluating interactions between the melanocortin-5 receptor, MRAP1, and ACTH(1-24): A phylogenetic study.
Dores RM, Oberer N, Hoglin B, Thomas A, Faught E, Vijayan MM. Dores RM, et al. Gen Comp Endocrinol. 2020 Aug 1;294:113476. doi: 10.1016/j.ygcen.2020.113476. Epub 2020 Mar 31. Gen Comp Endocrinol. 2020. PMID: 32243958
The melanocortin-2 receptor (MC2R) and the melanocortin-5 receptor (MC5R) are found on the same chromosome in most vertebrate genomes, and for the species analyzed in this study, MC2R and MC5R are co-expressed in glucocorticoid-producing cells t …
The melanocortin-2 receptor (MC2R) and the melanocortin-5 receptor (MC5R) are found on the same chromosome in mo …
The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families.
Wu R, Gragnoli C. Wu R, et al. J Ovarian Res. 2024 Dec 5;17(1):242. doi: 10.1186/s13048-024-01567-1. J Ovarian Res. 2024. PMID: 39633478 Free PMC article.
We have recently reported the association of melanocortin receptor genes (MC1R, MC2R, MC3R, MC4R, and MC5R) with the risk of type 2 diabetes (T2D) and/or major depressive disorder (MDD). ...We identified 1 SNP in MC1R, 1 SNP in MC2R, 2 SNPs in MC3R, and 2 SNPs in MC …
We have recently reported the association of melanocortin receptor genes (MC1R, MC2R, MC3R, MC4R, and MC5R) with the risk of type 2 d …
Identification of genes associated with human-canine communication in canine evolution.
Tonoike A, Otaki KI, Terauchi G, Ogawa M, Katayama M, Sakata H, Miyasako F, Mogi K, Kikusui T, Nagasawa M. Tonoike A, et al. Sci Rep. 2022 Jun 9;12(1):6950. doi: 10.1038/s41598-022-11130-x. Sci Rep. 2022. PMID: 35680934 Free PMC article.
We examined gene polymorphisms in oxytocin, oxytocin receptor, melanocortin 2 receptor, and a Williams-Beuren syndrome-related gene (WBSCR17), as candidate genes of dog domestication. The single-nucleotide polymorphisms on melanocortin 2 rece …
We examined gene polymorphisms in oxytocin, oxytocin receptor, melanocortin 2 receptor, and a Williams-Beuren syndrome- …
A rare homozygous variant of MC2R gene identified in a Chinese family with familial glucocorticoid deficiency type 1: A case report.
Liu S, Zeng T, Luo C, Peng D, Xu X, Liu Q, Wu Q, Lu Q, Huang F. Liu S, et al. Front Endocrinol (Lausanne). 2023 Feb 24;14:1113234. doi: 10.3389/fendo.2023.1113234. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36909322 Free PMC article.
BACKGROUND: Melanocortin-2 receptor (MC2R), a member of the G protein-coupled receptor family, is selectively activated by adrenocorticotropic hormone (ACTH). variants in MC2R are associated with family glucocorticoid deficiency 1 (FGD1). ...CON …
BACKGROUND: Melanocortin-2 receptor (MC2R), a member of the G protein-coupled receptor family, is selectively ac …
22 results