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Mechanisms underlying TRPV4-mediated regulation of miR-146a expression.
Dutta B, Mahanty M, Kesavalu L, Rahaman SO. Dutta B, et al. Front Immunol. 2024 Sep 30;15:1437540. doi: 10.3389/fimmu.2024.1437540. eCollection 2024. Front Immunol. 2024. PMID: 39403372 Free PMC article.
Our study investigates how transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, interacts with microRNA-146a (miR-146a), within the context of inflammation and atherosclerosis. Micro-RNAs play a critical role in controlling gene expressi …
Our study investigates how transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, interacts with microRNA- …
Unveiling the therapeutic potential of miR-146a: Targeting innate inflammation in atherosclerosis.
Ardinal AP, Wiyono AV, Estiko RI. Ardinal AP, et al. J Cell Mol Med. 2024 Oct;28(19):e70121. doi: 10.1111/jcmm.70121. J Cell Mol Med. 2024. PMID: 39392102 Free PMC article. Review.
Notably, research has demonstrated that the modulation of microRNA-146a (miR-146a) expression impacts innate inflammation, effectively halts atherosclerosis progression, and enhances plaque stability by targeting interleukin-1 receptor-associated kinase (IRAK) and a …
Notably, research has demonstrated that the modulation of microRNA-146a (miR-146a) expression impacts innate inflammation, eff …
Genetic Variability in Oxidative Stress, Inflammatory, and Neurodevelopmental Pathways: Impact on the Susceptibility and Course of Spinal Muscular Atrophy.
Barbo M, Koritnik B, Leonardis L, Blagus T, Dolžan V, Ravnik-Glavač M. Barbo M, et al. Cell Mol Neurobiol. 2024 Oct 27;44(1):71. doi: 10.1007/s10571-024-01508-y. Cell Mol Neurobiol. 2024. PMID: 39463208 Free PMC article.
The polymorphisms CARD8 rs2043211 and BDNF rs6265 were associated with SMA type, while SOD2 rs4880, CAT rs1001179, and MIR146A rs2910164 were associated with age at onset of symptoms after adjustment for clinical parameters. In addition, GPX1 rs1050450 and HMOX1 rs2071747 …
The polymorphisms CARD8 rs2043211 and BDNF rs6265 were associated with SMA type, while SOD2 rs4880, CAT rs1001179, and MIR146A rs2910 …
A precision medicine approach to the myelodysplastic syndrome with isolated deletion 5q, 50 years after its discovery.
Roncador M, Bernard E, Hasserjian R, Boultwood J, Elena C, Gallì A, Gurnari C, Mecucci C, Michaux L, Mittelman M, Sarchi M, Travaglino E, McLornan DP, Ogawa S, Papaemmanuil E, Hellström Lindberg E, Malcovati L, Cazzola M. Roncador M, et al. Blood. 2025 Oct 16;146(16):1883-1896. doi: 10.1182/blood.2025028619. Blood. 2025. PMID: 40758958 Review.
Haploinsufficiency production of multiple gene transcripts, primarily involving CSNK1A1, RPS14, MIR145, and MIR146A, results in myelodysplastic hematopoiesis. Lenalidomide can selectively suppress the del(5q)-mutant clone by promoting proteasomal degradation of casein kina …
Haploinsufficiency production of multiple gene transcripts, primarily involving CSNK1A1, RPS14, MIR145, and MIR146A, results in myelo …
85 results