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Year Number of Results
2016 7
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2019 19
2020 20
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160 results

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Page 1
Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy.
Mukhopadhyay S, Huang HY, Lin Z, Ranieri M, Li S, Sahu S, Liu Y, Ban Y, Guidry K, Hu H, Lopez A, Sherman F, Tan YJ, Lee YT, Armstrong AP, Dolgalev I, Sahu P, Zhang T, Lu W, Gray NS, Christensen JG, Tang TT, Velcheti V, Khodadadi-Jamayran A, Wong KK, Neel BG. Mukhopadhyay S, et al. Cancer Res. 2023 Dec 15;83(24):4095-4111. doi: 10.1158/0008-5472.CAN-23-2729. Cancer Res. 2023. PMID: 37729426 Free PMC article.
Recurrent, potentially targetable, synthetic lethal (SL) genes were identified, including serine-threonine kinases, tRNA-modifying and proteoglycan synthesis enzymes, and YAP/TAZ/TEAD pathway components. ...
Recurrent, potentially targetable, synthetic lethal (SL) genes were identified, including serine-threonine kinases, tRNA-modifying an …
Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants.
Weinmann J, Weis S, Sippel J, Tulalamba W, Remes A, El Andari J, Herrmann AK, Pham QH, Borowski C, Hille S, Schönberger T, Frey N, Lenter M, VandenDriessche T, Müller OJ, Chuah MK, Lamla T, Grimm D. Weinmann J, et al. Nat Commun. 2020 Oct 28;11(1):5432. doi: 10.1038/s41467-020-19230-w. Nat Commun. 2020. PMID: 33116134 Free PMC article.
Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or synthetic viral isolates that are under intense preclinical evaluation. Here, we report a versatile pipeline that enabl …
Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors der …
Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR.
Follo C, Vidoni C, Morani F, Ferraresi A, Seca C, Isidoro C. Follo C, et al. Cell Commun Signal. 2019 May 2;17(1):39. doi: 10.1186/s12964-019-0354-2. Cell Commun Signal. 2019. PMID: 31046771 Free PMC article.
METHODS: As an inducer of the AAR, we used halofuginone (HF), an alkaloid that binds to the prolyl-tRNA synthetase thus mimicking the unavailability of proline (PRO). Induction of AAR was determined assessing the phosphorylation of the eukaryotic translation initiation fac …
METHODS: As an inducer of the AAR, we used halofuginone (HF), an alkaloid that binds to the prolyl-tRNA synthetase thus mimicking the …
Towards a Cure for HARS Disease.
Wilhelm SDP, Kenana R, Qiu Y, O'Donoghue P, Heinemann IU. Wilhelm SDP, et al. Genes (Basel). 2023 Jan 18;14(2):254. doi: 10.3390/genes14020254. Genes (Basel). 2023. PMID: 36833180 Free PMC article. Review.
Histidyl-tRNA synthetase (HARS) ligates histidine to its cognate transfer RNA (tRNA(His)). Mutations in HARS cause the human genetic disorders Usher syndrome type 3B (USH3B) and Charcot-Marie-Tooth syndrome type 2W (CMT2W). ...We discuss recent advance …
Histidyl-tRNA synthetase (HARS) ligates histidine to its cognate transfer RNA (tRNA(His)). Mutations in HARS cau …
Efficacy and Safety of Switching to Dolutegravir/Lamivudine Versus Continuing a Tenofovir Alafenamide-Based 3- or 4-Drug Regimen for Maintenance of Virologic Suppression in Adults Living With Human Immunodeficiency Virus Type 1: Results Through Week 144 From the Phase 3, Noninferiority TANGO Randomized Trial.
Osiyemi O, De Wit S, Ajana F, Bisshop F, Portilla J, Routy JP, Wyen C, Ait-Khaled M, Leone P, Pappa KA, Wang R, Wright J, George N, Wynne B, Aboud M, van Wyk J, Smith KY. Osiyemi O, et al. Clin Infect Dis. 2022 Sep 29;75(6):975-986. doi: 10.1093/cid/ciac036. Clin Infect Dis. 2022. PMID: 35079789 Free PMC article. Clinical Trial.
At week 144, the proportion of participants with an HIV-1 RNA level 50 copies/mL (primary end point, Snapshot; intention-to-treat-exposed population) after switching to DTG/3TC was 0.3% (1 of 369) versus 1.3% (5 of 372) for those continuing TAF-based regimens, demonstrati …
At week 144, the proportion of participants with an HIV-1 RNA level 50 copies/mL (primary end point, Snapshot; intention-to-treat-ex …
Efficacy and Safety of Switching to the 2-Drug Regimen Dolutegravir/Lamivudine Versus Continuing a 3- or 4-Drug Regimen for Maintaining Virologic Suppression in Adults Living With Human Immunodeficiency Virus 1 (HIV-1): Week 48 Results From the Phase 3, Noninferiority SALSA Randomized Trial.
Llibre JM, Brites C, Cheng CY, Osiyemi O, Galera C, Hocqueloux L, Maggiolo F, Degen O, Taylor S, Blair E, Man C, Wynne B, Oyee J, Underwood M, Curtis L, Bontempo G, van Wyk J. Llibre JM, et al. Clin Infect Dis. 2023 Feb 18;76(4):720-729. doi: 10.1093/cid/ciac130. Clin Infect Dis. 2023. PMID: 35235656 Free PMC article. Clinical Trial.
The phase 3 SALSA study evaluated efficacy and safety of switching to DTG/3TC compared with continuing various 3-/4-drug current antiretroviral regimens (CARs). METHODS: Adults with HIV-1 RNA <50 copies/mL and no previous virologic failure were randomized (1:1, stratifi …
The phase 3 SALSA study evaluated efficacy and safety of switching to DTG/3TC compared with continuing various 3-/4-drug current antiretrovi …
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus.
Thompson JR, Nelson ED, Tippani M, Ramnauth AD, Divecha HR, Miller RA, Eagles NJ, Pattie EA, Kwon SH, Bach SV, Kaipa UM, Yao J, Hou C, Kleinman JE, Collado-Torres L, Han S, Maynard KR, Hyde TM, Martinowich K, Page SC, Hicks SC. Thompson JR, et al. Nat Neurosci. 2025 Sep;28(9):1990-2004. doi: 10.1038/s41593-025-02022-0. Epub 2025 Jul 30. Nat Neurosci. 2025. PMID: 40739059 Free PMC article.
Here we generated spatially-resolved transcriptomics (SRT) and single-nucleus RNA-sequencing (snRNA-seq) data from anterior human hippocampus in ten adult neurotypical donors. Using non-negative matrix factorization (NMF) and label transfer, we integrated these data …
Here we generated spatially-resolved transcriptomics (SRT) and single-nucleus RNA-sequencing (snRNA-seq) data from anterior human hip …
tRNA Fragments in Diabetes Mellitus.
Zhang J, Liu M, Li Z. Zhang J, et al. Clin Chim Acta. 2025 Aug 15;576:120405. doi: 10.1016/j.cca.2025.120405. Epub 2025 May 29. Clin Chim Acta. 2025. PMID: 40449709 Review.
This review summarizes the research progress on tRNA-derived small RNAs (tsRNAs) in diabetes mellitus and diabetic complications. tsRNAs, categorized into tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs), are involved in gene expres …
This review summarizes the research progress on tRNA-derived small RNAs (tsRNAs) in diabetes mellitus and diabetic complications. tsR …
Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis.
Su Y, Silva JD, Doherty D, Simpson DA, Weiss DJ, Rolandsson-Enes S, McAuley DF, O'Kane CM, Brazil DP, Krasnodembskaya AD. Su Y, et al. Thorax. 2023 Jun;78(6):617-630. doi: 10.1136/thoraxjnl-2021-218194. Epub 2022 Aug 10. Thorax. 2023. PMID: 35948417 Free PMC article.
Protein expression was measured by Western blot. EV micro RNA (miRNA) content was determined by miRNA sequencing. In vivo: LPS-injured C57BL/6 mice were given EVs isolated from MSCs in which miR-181a had been silenced by miRNA inhibitor or overexpressed using miRNA mimic. …
Protein expression was measured by Western blot. EV micro RNA (miRNA) content was determined by miRNA sequencing. In vivo: LPS-injure …
Human Thg1 displays tRNA-inducible GTPase activity.
Antika TR, Nazilah KR, Lee YH, Lo YT, Yeh CS, Yeh FL, Chang TH, Wang TL, Wang CC. Antika TR, et al. Nucleic Acids Res. 2022 Sep 23;50(17):10015-10025. doi: 10.1093/nar/gkac768. Nucleic Acids Res. 2022. PMID: 36107775 Free PMC article.
G-1 is unique to tRNAHis and is crucial for recognition by histidyl-tRNA synthetase (HisRS). Yeast Thg1 requires ATP for G-1 addition to tRNAHis opposite A73, whereas archaeal Thg1 requires either ATP or GTP for G-1 addition to tRNAHis opposite C73. ...Although HsThg1 coul …
G-1 is unique to tRNAHis and is crucial for recognition by histidyl-tRNA synthetase (HisRS). Yeast Thg1 requires ATP for G-1 addition …
160 results