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Beta-adrenergic regulation of the heart expressing the Ser1700A/Thr1704A mutated Cav1.2 channel.
Poomvanicha M, Matthes J, Domes K, Patrucco E, Angermeier E, Laugwitz KL, Schneider T, Hofmann F. Poomvanicha M, et al. Among authors: matthes j. J Mol Cell Cardiol. 2017 Oct;111:10-16. doi: 10.1016/j.yjmcc.2017.07.119. Epub 2017 Aug 1. J Mol Cell Cardiol. 2017. PMID: 28778765
Mutation of Ser 1700 and Thr 1704 to alanine results in the Cav1.2PKA_P2(-/-) mice. Cav1.2PKA_P2(-/-) mice display reduced cardiac L-type current. Fractional shortening and ejection fraction in the intact animal and I(Ca) in isolated cardiomyocytes (CM) are stimulat …
Mutation of Ser 1700 and Thr 1704 to alanine results in the Cav1.2PKA_P2(-/-) mice. Cav1.2PKA_P2(-/-) mice display reduced car …
Pharmacoresistant Cav 2·3 (E-type/R-type) voltage-gated calcium channels influence heart rate dynamics and may contribute to cardiac impulse conduction.
Galetin T, Tevoufouet EE, Sandmeyer J, Matthes J, Nguemo F, Hescheler J, Weiergräber M, Schneider T. Galetin T, et al. Among authors: matthes j. Cell Biochem Funct. 2013 Jul;31(5):434-49. doi: 10.1002/cbf.2918. Epub 2012 Oct 22. Cell Biochem Funct. 2013. PMID: 23086800
We have investigated heart rate dynamics in control and Cav 2.3-deficient mice using implantable electrocardiogram radiotelemetry and pharmacological injection experiments. ...It remained unaffected after administering propranolol in Cav 2.3(-|-) mice. Heart rate fr …
We have investigated heart rate dynamics in control and Cav 2.3-deficient mice using implantable electrocardiogram radiotelemetry and …
Effect of MANT-nucleotides on L-type calcium currents in murine cardiomyocytes.
Hübner M, Dizayee S, Matthes J, Seifert R, Herzig S. Hübner M, et al. Among authors: matthes j. Naunyn Schmiedebergs Arch Pharmacol. 2011 Jun;383(6):573-83. doi: 10.1007/s00210-011-0626-x. Epub 2011 Apr 12. Naunyn Schmiedebergs Arch Pharmacol. 2011. PMID: 21484439
Cardiac apoptosis and development of cardiac dysfunction is prevented in mice lacking AC 5, a predominant isoform in the heart. In the search for a potent and selective AC 5 inhibitor, we recently identified 2'(3')-methylanthraniloyl-inosine-5'-triphosphate(MANT-ITP) as th …
Cardiac apoptosis and development of cardiac dysfunction is prevented in mice lacking AC 5, a predominant isoform in the heart. In th …
Gαi2- and Gαi3-specific regulation of voltage-dependent L-type calcium channels in cardiomyocytes.
Dizayee S, Kaestner S, Kuck F, Hein P, Klein C, Piekorz RP, Meszaros J, Matthes J, Bjrnbaumer L, Nürnberg B, Herzig S. Dizayee S, et al. Among authors: matthes j. PLoS One. 2011;6(9):e24979. doi: 10.1371/journal.pone.0024979. Epub 2011 Sep 26. PLoS One. 2011. PMID: 21966394 Free PMC article.
METHODS: Ventricular tissues and isolated myocytes were obtained from mice with targeted deletion of either Galpha(i2) (Galpha(i2) (-/-)) or Galpha(i3) (Galpha(i3) (-/-)). mRNA levels of Galpha(i/o) isoforms and L-VDCC subunits were quantified by real-time PCR. ...I …
METHODS: Ventricular tissues and isolated myocytes were obtained from mice with targeted deletion of either Galpha(i2) (Galpha …
Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice.
Beetz N, Hein L, Meszaros J, Gilsbach R, Barreto F, Meissner M, Hoppe UC, Schwartz A, Herzig S, Matthes J. Beetz N, et al. Among authors: matthes j. Cardiovasc Res. 2009 Dec 1;84(3):396-406. doi: 10.1093/cvr/cvp251. Epub 2009 Jul 20. Cardiovasc Res. 2009. PMID: 19620129 Free PMC article.
In order to determine whether prolonged alteration of Ca(2+)-channel gating by beta(2)-subunits contributes to heart failure pathogenesis, we generated and characterized transgenic mice with cardiac overexpression of a beta(2a)-subunit or the pore Ca(v)1.2 or both, respect …
In order to determine whether prolonged alteration of Ca(2+)-channel gating by beta(2)-subunits contributes to heart failure pathogenesis, w …
Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio]triphosphate.
Rottlaender D, Matthes J, Vatner SF, Seifert R, Herzig S. Rottlaender D, et al. Among authors: matthes j. J Pharmacol Exp Ther. 2007 May;321(2):608-15. doi: 10.1124/jpet.106.118422. Epub 2007 Feb 6. J Pharmacol Exp Ther. 2007. PMID: 17284671
The leftward shift of current-voltage curves was abolished by 1 microM but not by 100 nM MANT-GTPgammaS. In myocytes from AC5-/- mice, the residual stimulation of ICa,L was not further attenuated by the nucleotide, indicating AC5 to be the major AC isoform mediating …
The leftward shift of current-voltage curves was abolished by 1 microM but not by 100 nM MANT-GTPgammaS. In myocytes from AC5-/- m …
Increased expression of the auxiliary beta(2)-subunit of ventricular L-type Ca(2)+ channels leads to single-channel activity characteristic of heart failure.
Hullin R, Matthes J, von Vietinghoff S, Bodi I, Rubio M, D'Souza K, Friedrich Khan I, Rottländer D, Hoppe UC, Mohacsi P, Schmitteckert E, Gilsbach R, Bünemann M, Hein L, Schwartz A, Herzig S. Hullin R, et al. Among authors: matthes j. PLoS One. 2007 Mar 14;2(3):e292. doi: 10.1371/journal.pone.0000292. PLoS One. 2007. PMID: 17356701 Free PMC article.
In HEK293-cells we show differential modulation of single L-VDCC activity by coexpression of several human cardiac beta-subunits: Unlike beta(1) or beta(3) isoforms, beta(2a) and beta(2b) induce a high-activity channel behavior typical of failing myocytes. ...Here i …
In HEK293-cells we show differential modulation of single L-VDCC activity by coexpression of several human cardiac beta-subunits: Unl …
Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice.
Pereira L, Matthes J, Schuster I, Valdivia HH, Herzig S, Richard S, Gómez AM. Pereira L, et al. Among authors: matthes j. Diabetes. 2006 Mar;55(3):608-15. doi: 10.2337/diabetes.55.03.06.db05-1284. Diabetes. 2006. PMID: 16505222
We analyzed Ca2+-induced Ca2+ release and excitation-contraction coupling in db/db obese type 2 diabetic mice and their control littermates. Echocardiography showed a systolic dysfunction in db/db mice. ...Macroscopic I(Ca) was reduced in db/db cells, but sin …
We analyzed Ca2+-induced Ca2+ release and excitation-contraction coupling in db/db obese type 2 diabetic mice and their control litte …
An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit.
Christ T, Wüst M, Matthes J, Jänchen M, Jürgens S, Herzig S, Wettwer E, Dobrev D, Matschke K, Mebs D, Ravens U. Christ T, et al. Among authors: matthes j. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):474-83. doi: 10.1007/s00210-004-0996-4. Epub 2004 Nov 18. Naunyn Schmiedebergs Arch Pharmacol. 2004. PMID: 15599709
Sponges were collected from various locations and their aqueous extracts were freeze dried. Murine right and left atria were used to screen 75 extracts for putative cardiac effects. ...To elucidate one possible mode of action the effects of C47 on L-type Ca(2+) current (I( …
Sponges were collected from various locations and their aqueous extracts were freeze dried. Murine right and left atria were used to …
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