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2021 33
2022 57
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NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C. Chen H, et al. Nature. 2024 Jul;631(8021):663-669. doi: 10.1038/s41586-024-07620-9. Epub 2024 Jul 3. Nature. 2024. PMID: 38961290 Free PMC article.
Here we report that lactate-driven lactylation of NBS1 promotes homologous recombination (HR)-mediated DNA repair. Lactylation of NBS1 at lysine 388 (K388) is essential for MRE11-RAD50-NBS1 (MRN) complex formation and the accumulation of HR repair proteins at …
Here we report that lactate-driven lactylation of NBS1 promotes homologous recombination (HR)-mediated DNA repair. Lactylation of …
BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality.
Murai J, Pommier Y. Murai J, et al. Cancer Res. 2023 Apr 14;83(8):1173-1174. doi: 10.1158/0008-5472.CAN-23-0628. Cancer Res. 2023. PMID: 37057596
They genetically revealed that deficiency in HR-related genes (RAD51, RAD54, DSS1, and RPA1), DNA damage signaling genes (ATR, ATM, CHK1, CHK2, and NBS1), or Fanconi anemia-related genes (FANCD2, FANCA, and FANCC) conferred sensitivity to PARP inhibitors. ...
They genetically revealed that deficiency in HR-related genes (RAD51, RAD54, DSS1, and RPA1), DNA damage signaling genes (ATR, ATM, CHK1, CH …
Genetics of ovarian insufficiency and defects of folliculogenesis.
França MM, Mendonca BB. França MM, et al. Best Pract Res Clin Endocrinol Metab. 2022 Jan;36(1):101594. doi: 10.1016/j.beem.2021.101594. Epub 2021 Oct 14. Best Pract Res Clin Endocrinol Metab. 2022. PMID: 34794894 Review.
Thirty-four of these genes (AARS2, AIRE, ANTXR1, ATM, BMPR1B, CLPP, CYP17A1, CYP19A1, DCAF17, EIF2B, ERAL1, FANCA, FANCC, FMR1, FOXL2, GALT, GNAS, HARS2, HSD17B4, LARS2, LMNA, MGME1, NBN, PMM2, POLG, PREPL, RCBTB1, RECQL2/3/4, STAR, TWNK, and XRCC4/9) have been linked to s …
Thirty-four of these genes (AARS2, AIRE, ANTXR1, ATM, BMPR1B, CLPP, CYP17A1, CYP19A1, DCAF17, EIF2B, ERAL1, FANCA, FANCC, FMR1, FOXL2, GALT, …
Homologous Recombination Deficiencies and Hereditary Tumors.
Yamamoto H, Hirasawa A. Yamamoto H, et al. Int J Mol Sci. 2021 Dec 29;23(1):348. doi: 10.3390/ijms23010348. Int J Mol Sci. 2021. PMID: 35008774 Free PMC article. Review.
Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1(NBN), PALB2, RAD51C, and RAD51D, lead to inherited susceptibility to specific types of cancers, including those of the breast, ovaries, prostate, …
Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1(NBN), …
MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.
Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP. Cho MG, et al. Nature. 2024 Jan;625(7995):585-592. doi: 10.1038/s41586-023-06889-6. Epub 2024 Jan 10. Nature. 2024. PMID: 38200309 Free PMC article.
We demonstrate that binding of the MRE11-RAD50-NBN complex to nucleosome fragments is necessary to displace cGAS from acidic-patch-mediated sequestration, which enables its mobilization and activation by dsDNA. ...
We demonstrate that binding of the MRE11-RAD50-NBN complex to nucleosome fragments is necessary to displace cGAS from acidic-patch-me …
STK39-mediated amplification of γ-H2A.X promotes homologous recombination and contributes to PARP inhibitor resistance.
Xu Y, Li C, Yin H, Nowsheen S, Xu X, Kang W, Liu X, Chen L, Lou Z, Yi J, Deng M. Xu Y, et al. Nucleic Acids Res. 2024 Dec 11;52(22):13881-13895. doi: 10.1093/nar/gkae1099. Nucleic Acids Res. 2024. PMID: 39588777 Free PMC article.
We demonstrate that after DNA damage, STK39 undergoes phosphorylation by the ATM kinase, facilitating its interaction with the Mre11-Rad50-Nbs1 complex and subsequent recruitment to chromatin. This recruitment enables STK39 to further phosphorylate H2A.X, thus amplifying g …
We demonstrate that after DNA damage, STK39 undergoes phosphorylation by the ATM kinase, facilitating its interaction with the Mre11-Rad50- …
MRNIP condensates promote DNA double-strand break sensing and end resection.
Wang YL, Zhao WW, Bai SM, Feng LL, Bie SY, Gong L, Wang F, Wei MB, Feng WX, Pang XL, Qin CL, Yin XK, Wang YN, Zhou W, Wahl DR, Liu Q, Chen M, Hung MC, Wan XB. Wang YL, et al. Nat Commun. 2022 May 12;13(1):2638. doi: 10.1038/s41467-022-30303-w. Nat Commun. 2022. PMID: 35551189 Free PMC article.
The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. ...
The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA …
Clinicopathologic Features, Molecular Landscape, and Prognostic Implications of Ovarian Low-grade Serous Tumors with Histologic Transformation.
Chui MH, Kang EY, Kahn RM, Chiang S, Zhou Q, Iasonos A, Manning-Geist B, Selenica P, Da Cruz Paula A, Long Roche K, Weigelt B, Grisham RN. Chui MH, et al. Clin Cancer Res. 2025 Jul 15;31(14):3084-3095. doi: 10.1158/1078-0432.CCR-24-3168. Clin Cancer Res. 2025. PMID: 40327333 Free PMC article.
Alterations in DNA damage response genes (BRCA2, PALB2, CHEK2, ATM, NBN, and RECQL4) were identified in LGS-HT lacking TP53 genetic alterations. Synchronous low-grade and higher-grade tumor components at initial diagnosis were associated with poorer OS (median, 59.7 months …
Alterations in DNA damage response genes (BRCA2, PALB2, CHEK2, ATM, NBN, and RECQL4) were identified in LGS-HT lacking TP53 genetic a …
Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets.
Peng X, Du J. Peng X, et al. Mol Biomed. 2025 Jun 9;6(1):38. doi: 10.1186/s43556-025-00275-6. Mol Biomed. 2025. PMID: 40484921 Free PMC article. Review.
For instance, non-histone proteins such as AARS1-K120la, ACSS2-Kla, MRE11-K673la, NBS1-K388la and GNAT13-Kla has illuminated novel regulatory mechanisms and reinforced the potential of non-histone Kla as a promising avenue for research. ...
For instance, non-histone proteins such as AARS1-K120la, ACSS2-Kla, MRE11-K673la, NBS1-K388la and GNAT13-Kla has illuminated novel re …
215 results