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Year Number of Results
2019 7
2020 9
2021 14
2022 11
2024 0

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39 results

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Hara T, Chanoch-Myers R, Mathewson ND, Myskiw C, Atta L, Bussema L, Eichhorn SW, Greenwald AC, Kinker GS, Rodman C, Gonzalez Castro LN, Wakimoto H, Rozenblatt-Rosen O, Zhuang X, Fan J, Hunter T, Verma IM, Wucherpfennig KW, Regev A, Suvà ML, Tirosh I. Hara T, et al. Cancer Cell. 2021 Jun 14;39(6):779-792.e11. doi: 10.1016/j.ccell.2021.05.002. Epub 2021 Jun 3. Cancer Cell. 2021. PMID: 34087162 Free PMC article.
This effect is mediated, both in vitro and in vivo, by macrophage-derived oncostatin M (OSM) that interacts with its receptors (OSMR or LIFR) in complex with GP130 on glioblastoma cells and activates STAT3. ...
This effect is mediated, both in vitro and in vivo, by macrophage-derived oncostatin M (OSM) that interacts with its receptors (OSMR …
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer.
Rajamäki K, Taira A, Katainen R, Välimäki N, Kuosmanen A, Plaketti RM, Seppälä TT, Ahtiainen M, Wirta EV, Vartiainen E, Sulo P, Ravantti J, Lehtipuro S, Granberg KJ, Nykter M, Tanskanen T, Ristimäki A, Koskensalo S, Renkonen-Sinisalo L, Lepistö A, Böhm J, Taipale J, Mecklin JP, Aavikko M, Palin K, Aaltonen LA. Rajamäki K, et al. Gastroenterology. 2021 Aug;161(2):592-607. doi: 10.1053/j.gastro.2021.04.042. Epub 2021 Apr 27. Gastroenterology. 2021. PMID: 33930428 Free article.
Enrichment of hypomethylation at HNF4alpha binding sites was detected solely in sCRC genomes. PIGR and OSMR involved in mucosal immunity were dysregulated via epigenetic modifications in IBD-CRCs. ...CONCLUSIONS: Distinct mechanisms of WNT pathway dysregulation skew IBD-CR …
Enrichment of hypomethylation at HNF4alpha binding sites was detected solely in sCRC genomes. PIGR and OSMR involved in mucosal immun …
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
Lindström S, Wang L, Smith EN, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody JA, Pattee JW, Haessler J, Brumpton BM, Chasman DI, Suchon P, Chen MH, Turman C, Germain M, Wiggins KL, MacDonald J, Braekkan SK, Armasu SM, Pankratz N, Jackson RD, Nielsen JB, Giulianini F, Puurunen MK, Ibrahim M, Heckbert SR, Damrauer SM, Natarajan P, Klarin D; Million Veteran Program; de Vries PS, Sabater-Lleal M, Huffman JE; CHARGE Hemostasis Working Group; Bammler TK, Frazer KA, McCauley BM, Taylor K, Pankow JS, Reiner AP, Gabrielsen ME, Deleuze JF, O'Donnell CJ, Kim J, McKnight B, Kraft P, Hansen JB, Rosendaal FR, Heit JA, Psaty BM, Tang W, Kooperberg C, Hveem K, Ridker PM, Morange PE, Johnson AD, Kabrhel C, Trégouët DA, Smith NL. Lindström S, et al. Blood. 2019 Nov 7;134(19):1645-1657. doi: 10.1182/blood.2019000435. Blood. 2019. PMID: 31420334 Free PMC article.
This included 11 newly associated genetic loci (C1orf198, PLEK, OSMR-AS1, NUGGC/SCARA5, GRK5, MPHOSPH9, ARID4A, PLCG2, SMG6, EIF5A, and STX10) of which 6 replicated, and 3 new independent signals in 3 known genes. ...
This included 11 newly associated genetic loci (C1orf198, PLEK, OSMR-AS1, NUGGC/SCARA5, GRK5, MPHOSPH9, ARID4A, PLCG2, SMG6, EIF5A, a …
Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.
Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P. Geethadevi A, et al. Cancer Res. 2021 Oct 15;81(20):5336-5352. doi: 10.1158/0008-5472.CAN-21-0483. Epub 2021 Aug 11. Cancer Res. 2021. PMID: 34380633 Free PMC article.
To identify new therapeutic targets, we performed single-cell and nuclear RNA-seq data set analyses on 17 human ovarian cancer specimens, revealing the oncostatin M receptor (OSMR) as highly expressed in ovarian cancer cells. ...Human monoclonal antibo …
To identify new therapeutic targets, we performed single-cell and nuclear RNA-seq data set analyses on 17 human ovarian cancer specimens, re …
Oncostatin M sensitizes keratinocytes to UVB-induced inflammation via GSDME-mediated pyroptosis.
Liu J, Zhong Y, Liu H, Yang H, Lu P, Shi Y, Wang X, Zheng W, Yu X, Xu Y, Yang B. Liu J, et al. J Dermatol Sci. 2021 Nov;104(2):95-103. doi: 10.1016/j.jdermsci.2021.09.004. Epub 2021 Sep 20. J Dermatol Sci. 2021. PMID: 34674925
METHODS: NHEKs and HaCaT cells were treated with OSM. Knockout of OSM receptor (OSMR) with CRISPR/Cas9 system, knockdown of GSDME with small interfering RNA and primary keratinocytes from Osmr-/- and Gsdme-/- mice were used to study the effect of OSMR and GSD …
METHODS: NHEKs and HaCaT cells were treated with OSM. Knockout of OSM receptor (OSMR) with CRISPR/Cas9 system, knockdown of GSDME wit …
Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma.
Matsumoto Y, Ichikawa T, Kurozumi K, Otani Y, Fujimura A, Fujii K, Tomita Y, Hattori Y, Uneda A, Tsuboi N, Kaneda K, Makino K, Date I. Matsumoto Y, et al. Acta Neuropathol Commun. 2020 Apr 5;8(1):42. doi: 10.1186/s40478-020-00916-7. Acta Neuropathol Commun. 2020. PMID: 32248843 Free PMC article.
Here, we further explored the role of ANXA2 in regulating phenotypic transition in GBM. We identified oncostatin M receptor (OSMR) as a key ANXA2 target gene in GBM utilizing microarray analysis and hierarchical clustering analysis of the Ivy Glioblast …
Here, we further explored the role of ANXA2 in regulating phenotypic transition in GBM. We identified oncostatin M receptor …
Clinical and genetic features of Chinese patients with lichen and macular primary localized cutaneous amyloidosis.
Lu P, Wu FF, Rong ZL, Fang C, Deng CC, Bin LH, Yang B. Lu P, et al. Clin Exp Dermatol. 2019 Jun;44(4):e110-e117. doi: 10.1111/ced.13925. Epub 2019 Feb 7. Clin Exp Dermatol. 2019. PMID: 30734345
The genetic basis of familial (f)PLCA involves mutations in the oncostatin M receptor (OSMR) and interleukin-31 receptor A (IL31RA) genes, but the disease pathophysiology is not fully understood. ...The male/female ratio of patients carrying a homozygo …
The genetic basis of familial (f)PLCA involves mutations in the oncostatin M receptor (OSMR) and interleukin-31 …
Current status and relevance of single nucleotide polymorphisms in IL-6-/IL-12-type cytokine receptors.
Scheller J, Berg A, Moll JM, Floss DM, Jungesblut C. Scheller J, et al. Cytokine. 2021 Dec;148:155550. doi: 10.1016/j.cyto.2021.155550. Epub 2021 Jun 30. Cytokine. 2021. PMID: 34217594 Review.
Here, we engineered an algorithm to directly align dbSNP information to DNA and protein sequence information to clearly illustrate a genetic SNP landscape exemplified for all tall cytokine receptors of the IL-6/IL-12 family, including IL-23R, IL-12Rbeta1, IL-12Rbeta2, gp130, LIFR …
Here, we engineered an algorithm to directly align dbSNP information to DNA and protein sequence information to clearly illustrate a genetic …
LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma.
Zhu YX, Li CH, Li G, Feng H, Xia T, Wong CH, Fung FKC, Tong JH, To KF, Chen R, Chen Y. Zhu YX, et al. Cell Mol Gastroenterol Hepatol. 2020;10(4):811-828. doi: 10.1016/j.jcmgh.2020.06.009. Epub 2020 Jun 29. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32615164 Free PMC article.
Patients had significantly shorter survival (6 months) if they bore tumors expressing low LLGL1 level than tumors with high LLGL1 level (20 months) (hazard ratio, 0.1567; 95% CI, 0.05966-0.4117). Loss of LLGL1 promoted cytokine receptor oncostatin M receptor …
Patients had significantly shorter survival (6 months) if they bore tumors expressing low LLGL1 level than tumors with high LLGL1 level (20 …
Association of oncostatin M receptor polymorphisms with clinical recurrence of ovarian cancer in the Chinese Han population.
Li Q, Wang Y, Li Z, Su M, Song Y, Hu Q, Zhou B, Zhang L. Li Q, et al. Biomark Med. 2022 Apr;16(6):461-471. doi: 10.2217/bmm-2021-0989. Epub 2022 Mar 24. Biomark Med. 2022. PMID: 35321549
Aim: Ovarian cancer (OC) is a gynecological malignancy with a challenging judgment of prognosis due to complicated etiology and high recurrence rate. The oncostatin M receptor (OSMR) from members of the IL-6 receptor family is associated with tumor dev …
Aim: Ovarian cancer (OC) is a gynecological malignancy with a challenging judgment of prognosis due to complicated etiology and high recurre …
39 results