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2021 10
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Page 1
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer.
Rajamäki K, Taira A, Katainen R, Välimäki N, Kuosmanen A, Plaketti RM, Seppälä TT, Ahtiainen M, Wirta EV, Vartiainen E, Sulo P, Ravantti J, Lehtipuro S, Granberg KJ, Nykter M, Tanskanen T, Ristimäki A, Koskensalo S, Renkonen-Sinisalo L, Lepistö A, Böhm J, Taipale J, Mecklin JP, Aavikko M, Palin K, Aaltonen LA. Rajamäki K, et al. Gastroenterology. 2021 Aug;161(2):592-607. doi: 10.1053/j.gastro.2021.04.042. Epub 2021 Apr 27. Gastroenterology. 2021. PMID: 33930428 Free article.
Enrichment of hypomethylation at HNF4alpha binding sites was detected solely in sCRC genomes. PIGR and OSMR involved in mucosal immunity were dysregulated via epigenetic modifications in IBD-CRCs. ...CONCLUSIONS: Distinct mechanisms of WNT pathway dysregulation skew IBD-CR …
Enrichment of hypomethylation at HNF4alpha binding sites was detected solely in sCRC genomes. PIGR and OSMR involved in mucosal immun …
Integrative analysis of PANoptosis-related genes in diabetic retinopathy: machine learning identification and experimental validation.
Chen H, Chen E, Cao T, Feng F, Lin M, Wang X, Xu Y. Chen H, et al. Front Immunol. 2024 Dec 4;15:1486251. doi: 10.3389/fimmu.2024.1486251. eCollection 2024. Front Immunol. 2024. PMID: 39697326 Free PMC article.
Machine learning algorithms identified six PANoptosis-related hub genes (BEX2, CASP2, CD36, FASN, OSMR, and PLSCR3) as potential biomarkers. A diagnostic nomogram based on these hub genes showed high diagnostic accuracy. ...
Machine learning algorithms identified six PANoptosis-related hub genes (BEX2, CASP2, CD36, FASN, OSMR, and PLSCR3) as potential biom …
Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts.
Kokkotis G, Filidou E, Tarapatzi G, Spathakis M, Kandilogiannakis L, Dovrolis N, Arvanitidis K, Drygiannakis I, Valatas V, Vradelis S, Manolopoulos VG, Paspaliaris V, Kolios G, Bamias G. Kokkotis G, et al. Inflamm Bowel Dis. 2024 Nov 4;30(11):2162-2173. doi: 10.1093/ibd/izae098. Inflamm Bowel Dis. 2024. PMID: 38717842

Oncostatin-M did not induce the expression of collagen I, III, and fibronectin. Oncostatin-M receptor expression was positively correlated with CCL2, CXCL9, CXCL10, and CXCL11 expression in mucosal biopsies (P < .001; P < .001; P = .045; P = .033). ...O

…
Oncostatin-M did not induce the expression of collagen I, III, and fibronectin. Oncostatin-M receptor expression was po …
Multi-omics identifies OSM-OSMR as a key receptor-ligand in the tumor environment of endometrial adenocarcinoma.
Zhou Q, Wu Z, Gu J, Tang X, Li N, Yu M, Lin C. Zhou Q, et al. Int Immunopharmacol. 2025 Jul 28;160:114933. doi: 10.1016/j.intimp.2025.114933. Epub 2025 May 31. Int Immunopharmacol. 2025. PMID: 40450916 Free article.
The exogenous cytokine OSM induced Ishikawa cell proliferation and abnormal lipids metabolism, while the transcriptome sequencing results reveal that the pathways enriched with differentially expressed genes include AKT signaling pathways. The OSMR-knockout inhibited the t …
The exogenous cytokine OSM induced Ishikawa cell proliferation and abnormal lipids metabolism, while the transcriptome sequencing results re …
The combined inhibition of SLC1A3 and glutaminase in osimertinib-resistant EGFR mutant cells.
Ochi N, Miyake N, Takeyama M, Yamane H, Fukazawa T, Nagasaki Y, Kawahara T, Ichiyama N, Kosaka Y, Mimura A, Nakanishi H, Hiraki A, Kiura K, Takigawa N. Ochi N, et al. Biochim Biophys Acta Gen Subj. 2024 Oct;1868(10):130675. doi: 10.1016/j.bbagen.2024.130675. Epub 2024 Jul 24. Biochim Biophys Acta Gen Subj. 2024. PMID: 39059510
A second osimertinib-resistant line (M1/OsmR) was established through continuous exposure to osimertinib using M1 cells. RESULTS: SLC1A3 had the highest mRNA expression level in PC-9/OsmR2 compared to PC-9 cells by microarray analysis and SLC1A3 was increased by flow cytom …
A second osimertinib-resistant line (M1/OsmR) was established through continuous exposure to osimertinib using M1 cells. RESULTS: SLC …
Molecular architecture of human dermal sleeping nociceptors.
Körner J, Howard D, Solinski HJ, Mancilla Moreno M, Haag N, Fiebig A, Maxion A, Bhuiyan SA, Toklucu I, Bott RA, Sankaranarayanan I, Tavares-Ferreira D, Shiers S, Inturi NN, Eberhardt E, Ernst L, Bonaguro L, Schulte-Schrepping J, Beyer MD, Stiehl T, Renthal W, Kurth I, Tigerholm J, Serra J, Price TJ, Schmelz M, Namer B, Tripathy S, Lampert A. Körner J, et al. Cell. 2026 Mar 19;189(6):1820-1835.e22. doi: 10.1016/j.cell.2025.12.048. Epub 2026 Feb 4. Cell. 2026. PMID: 41643676 Free PMC article.
We functionally identified CMis in pig sensory neurons with patch clamp, using adapted protocols from human microneurography. We identified oncostatin M receptor (OSMR) and somatostatin (SST) as marker genes for CMis. Following dermal injection in heal …
We functionally identified CMis in pig sensory neurons with patch clamp, using adapted protocols from human microneurography. We identified …
Human oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome.
Garrigue A, Kermasson L, Susini S, Fert I, Mahony CB, Sadek H, Luce S, Chouteau M, Cavazzana M, Six E, Le Bousse-Kerdilès MC, Anginot A, Souraud JB, Cormier-Daire V, Willems M, Sirvent A, Russello J, Callebaut I, André I, Bertrand JY, Lagresle-Peyrou C, Revy P. Garrigue A, et al. J Clin Invest. 2025 Jan 23;135(6):e180981. doi: 10.1172/JCI180981. J Clin Invest. 2025. PMID: 39847438 Free PMC article.
Oncostatin M (OSM) is a cytokine with the unique ability to interact with both the OSM receptor (OSMR) and the leukemia inhibitory factor receptor (LIFR). On the other hand, OSMR interacts with IL31RA to form the interleukin-31 receptor. ...While monoallelic loss-of …
Oncostatin M (OSM) is a cytokine with the unique ability to interact with both the OSM receptor (OSMR) and the leukemia inhibitory fa …
Exploring the role of OSMR in gastric cancer: from oncogenic functions to relevant immune features.
Lan Y, Weng X, Wang X, Pan Z, Lin F, Wang Y, Chen J, Zhong D, Kong L. Lan Y, et al. Int Immunopharmacol. 2025 Dec 10;167:115649. doi: 10.1016/j.intimp.2025.115649. Epub 2025 Oct 18. Int Immunopharmacol. 2025. PMID: 41110174
The Oncostatin M receptor (OSMR) has been demonstrated to play a key regulatory role in multiple cancer types; however, the functional role of OSMR in gastric cancer (GC) remains poorly understood. ...OSMR expression levels were assessed …
The Oncostatin M receptor (OSMR) has been demonstrated to play a key regulatory role in multiple cancer types; h …
Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.
Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P. Geethadevi A, et al. Cancer Res. 2021 Oct 15;81(20):5336-5352. doi: 10.1158/0008-5472.CAN-21-0483. Epub 2021 Aug 11. Cancer Res. 2021. PMID: 34380633 Free PMC article.
To identify new therapeutic targets, we performed single-cell and nuclear RNA-seq data set analyses on 17 human ovarian cancer specimens, revealing the oncostatin M receptor (OSMR) as highly expressed in ovarian cancer cells. Conversely, oncostatin M ( …
To identify new therapeutic targets, we performed single-cell and nuclear RNA-seq data set analyses on 17 human ovarian cancer specimens, re …
Nasal transcriptome differences preceding recurrent wheezing in infancy.
Dhar P, O'Hely M, Sominsky L, Ashley S, Ranganathan SC, Sly PD, Collier F, Tang MLK, Morgan R, Mansell T, Saffery R, Burgner D, Ponsonby AL, Vuillermin P; Barwon Infant Study Investigator Group. Dhar P, et al. J Allergy Clin Immunol. 2025 Aug;156(2):361-372. doi: 10.1016/j.jaci.2025.03.021. Epub 2025 Apr 4. J Allergy Clin Immunol. 2025. PMID: 40189157 Free article.
TNF emerged as the key driver (adjusted P value and z score) of DEG patterns in the recurrent wheeze group, with OSMR and IL21 identified as master regulators. CONCLUSION: The nasal transcriptome in early infancy is associated with subsequent recurrent wheezes, indicating …
TNF emerged as the key driver (adjusted P value and z score) of DEG patterns in the recurrent wheeze group, with OSMR and IL21 identi …
39 results