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Page 1
Citrullination of pyruvate kinase M2 by PADI1 and PADI3 regulates glycolysis and cancer cell proliferation.
Coassolo S, Davidson G, Negroni L, Gambi G, Daujat S, Romier C, Davidson I. Coassolo S, et al. Nat Commun. 2021 Mar 19;12(1):1718. doi: 10.1038/s41467-021-21960-4. Nat Commun. 2021. PMID: 33741961 Free PMC article.
Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2). ...Citrullination thus by …
Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulatin …
Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.
Mondal S, Thompson PR. Mondal S, et al. Acc Chem Res. 2019 Mar 19;52(3):818-832. doi: 10.1021/acs.accounts.9b00024. Epub 2019 Mar 7. Acc Chem Res. 2019. PMID: 30844238 Free PMC article.
Structure-activity relationships identified numerous covalent PAD-inhibitors with different bioavailability, in vivo stability, and isozyme-selectivity (PAD1-selective: D-Cl-amidine; PAD2-selective: compounds 16-20; PAD3-selective: Cl4-amidine; and PAD4-selective: TDFA). F …
Structure-activity relationships identified numerous covalent PAD-inhibitors with different bioavailability, in vivo stability, and isozyme- …
Deimination in epidermal barrier and hair formation.
Méchin MC, Simon M. Méchin MC, et al. Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220245. doi: 10.1098/rstb.2022.0245. Epub 2023 Oct 2. Philos Trans R Soc Lond B Biol Sci. 2023. PMID: 37778378 Free PMC article. Review.
Three PADs are expressed in the epidermis, where their roles begin to be deciphered. PAD1 and PAD3 are involved in keratinocyte differentiation, particularly in the epidermal barrier function, keratins, filaggrin and filaggrin-related proteins being the most abundant deimi …
Three PADs are expressed in the epidermis, where their roles begin to be deciphered. PAD1 and PAD3 are involved in keratinocyte diffe …
Predictive value of anti-CarP and anti-PAD3 antibodies alone or in combination with RF and ACPA for the severity of rheumatoid arthritis.
Lamacchia C, Courvoisier DS, Jarlborg M, Bas S, Roux-Lombard P, Möller B, Ciurea A, Finckh A, Bentow C, Martinez-Prat L, Mahler M, Gabay C, Nissen MJ; SCQM Rheumatologists. Lamacchia C, et al. Rheumatology (Oxford). 2021 Oct 2;60(10):4598-4608. doi: 10.1093/rheumatology/keab050. Rheumatology (Oxford). 2021. PMID: 33502443 Free article.
At baseline, RA patients with anti-PAD3 had higher DAS28 (4.2 vs 3.7; P= 0.005) and significantly more radiographic damage (14.9 vs 8.8; P= 0.02) than anti-PAD3-negative patients. In the ACPA-negative subgroup, baseline Ratingen scores were significantly higher in a …
At baseline, RA patients with anti-PAD3 had higher DAS28 (4.2 vs 3.7; P= 0.005) and significantly more radiographic damage (14.9 vs 8 …
Variant PADI3 in Central Centrifugal Cicatricial Alopecia.
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E. Malki L, et al. N Engl J Med. 2019 Feb 28;380(9):833-841. doi: 10.1056/NEJMoa1816614. Epub 2019 Feb 13. N Engl J Med. 2019. PMID: 30763140
PADI3 encodes peptidyl arginine deiminase, type III (PADI3), an enzyme that post-translationally modifies other proteins that are essential to hair-shaft formation. ...Immunofluorescence staining showed decreased expression of PADI3 in biopsy samples of scalp …
PADI3 encodes peptidyl arginine deiminase, type III (PADI3), an enzyme that post-translationally modifies other proteins that …
Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.
Uysal-Onganer P, MacLatchy A, Mahmoud R, Kraev I, Thompson PR, Inal JM, Lange S. Uysal-Onganer P, et al. Int J Mol Sci. 2020 Feb 22;21(4):1495. doi: 10.3390/ijms21041495. Int J Mol Sci. 2020. PMID: 32098295 Free PMC article.
Here, two GBM cell lines were treated with PAD2, PAD3 and PAD4 isozyme-specific inhibitors. Effects were assessed on extracellular vesicle (EV) signatures, including EV-microRNA cargo (miR21, miR126 and miR210), and on changes in cellular protein expression relevant for mi …
Here, two GBM cell lines were treated with PAD2, PAD3 and PAD4 isozyme-specific inhibitors. Effects were assessed on extracellular ve …
PADI3 inhibits epithelial-mesenchymal transition by targeting CKS1-induced signal transduction in colon cancer.
Chai Z, Zhu C, Wang X, Zheng Y, Han F, Xie Q, Liu C. Chai Z, et al. J Cancer Res Ther. 2024 Aug 1;20(4):1323-1333. doi: 10.4103/jcrt.jcrt_558_24. Epub 2024 Aug 29. J Cancer Res Ther. 2024. PMID: 39206995 Free article.
BACKGROUND: Protein arginine deiminase 3 (PADI3) is involved in various biological processes of human disease. PADI3 has recently received increasing attention due to its role in tumorigenesis. ...PADI3 can suppress colon cancer cell migration and reduce the …
BACKGROUND: Protein arginine deiminase 3 (PADI3) is involved in various biological processes of human disease. PADI3 has recen …
Targeting Peptidylarginine Deiminase 3 to Efficiently Suppress Herpes Simplex Virus Type 2 Infection.
Pasquero S, Gugliesi F, Biolatti M, Albano C, Bajetto G, Trifirò L, Raviola S, Dell'Oste V, De Andrea M. Pasquero S, et al. Int J Mol Sci. 2024 Aug 9;25(16):8709. doi: 10.3390/ijms25168709. Int J Mol Sci. 2024. PMID: 39201398 Free PMC article.
Here, we demonstrate that HSV-2 manipulates the overall protein citrullination profile by activating three PAD isoforms: PAD2, PAD3, and PAD4. However, as previously observed during HSV-1 infection, PAD3 is the most significantly upregulated isoform, both at the mRN …
Here, we demonstrate that HSV-2 manipulates the overall protein citrullination profile by activating three PAD isoforms: PAD2, PAD3, …
Identification of prognostic biomarkers and development of a prediction model for prostate cancer.
Chen D, Chen W, Ye R, Li L, Miao F, Kong X, Ning W, Jia J, Chen Q, Wang P, Yin B. Chen D, et al. Front Immunol. 2026 Jan 5;16:1709264. doi: 10.3389/fimmu.2025.1709264. eCollection 2025. Front Immunol. 2026. PMID: 41562091 Free PMC article.
A total of nine genes emerged, including CPNE6, RASL10B, GCNT4, STAC2, RBPMS2, PADI3, PLXNA4, S100A14, and MMP9, as potential targets using the support vector machine (SVM) and LASSO methods, with MMP9 highly expressed in tumor cells. ...
A total of nine genes emerged, including CPNE6, RASL10B, GCNT4, STAC2, RBPMS2, PADI3, PLXNA4, S100A14, and MMP9, as potential targets …
32 results