Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2015 3
2016 9
2017 5
2018 5
2019 2
2020 2
2021 3
2022 7
2023 7
2024 10
2025 7

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

55 results

Results by year

Filters applied: . Clear all
Page 1
Identification of cuproptosis-related genes in Alzheimer's disease based on bioinformatic analysis.
Ma MM, Zhao J, Liu L, Wu CY. Ma MM, et al. Eur J Med Res. 2024 Oct 12;29(1):495. doi: 10.1186/s40001-024-02093-y. Eur J Med Res. 2024. PMID: 39396083 Free PMC article.

Next, the hub genes associated with apoptosis (TRADD, FADD, BIRC2, and CASP2) and cuproptosis (MAP2K1, SLC31A1, and PDHB) in AD were identified, which were used to construct apoptosis and cuproptosis models to distinguish AD patients from the control group (P < 0.05). .

…
Next, the hub genes associated with apoptosis (TRADD, FADD, BIRC2, and CASP2) and cuproptosis (MAP2K1, SLC31A1, and PDHB) in AD were …
Leigh Syndrome: Spectrum of Molecular Defects and Clinical Features in Russia.
Kistol D, Tsygankova P, Krylova T, Bychkov I, Itkis Y, Nikolaeva E, Mikhailova S, Sumina M, Pechatnikova N, Kurbatov S, Bostanova F, Migiaev O, Zakharova E. Kistol D, et al. Int J Mol Sci. 2023 Jan 13;24(2):1597. doi: 10.3390/ijms24021597. Int J Mol Sci. 2023. PMID: 36675121 Free PMC article.
Using next generation sequencing (NGS) technique, we were able to detect pathogenic variants in other nuclear genes: NDUFV1, NDUFS2, NDUFS8, NDUFAF5, NDUFAF6, NDUFA10, SUCLG1, GFM2, COX10, PMPCB, NARS2, PDHB and SLC19A3, including two genes previously associated with Leigh …
Using next generation sequencing (NGS) technique, we were able to detect pathogenic variants in other nuclear genes: NDUFV1, NDUFS2, NDUFS8, …
PDHB-AS suppresses cervical cancer progression and cisplatin resistance via inhibition on Wnt/beta-catenin pathway.
Chi C, Hou W, Zhang Y, Chen J, Shen Z, Chen Y, Li M. Chi C, et al. Cell Death Dis. 2023 Feb 7;14(2):90. doi: 10.1038/s41419-022-05547-5. Cell Death Dis. 2023. PMID: 36750722 Free PMC article.
Besides, overexpression of PDHB-AS repressed CC cell malignant behaviors. HKF-derived exosomes carried miR-4536-5p to CC cells and thereby inhibited PDHB-AS expression. ...In addition, miR-582-5p could bind with both PDHB-AS and Dickkopf-1 (DKK1). PDHB …
Besides, overexpression of PDHB-AS repressed CC cell malignant behaviors. HKF-derived exosomes carried miR-4536-5p to CC cells and th …
Risk factor prediction and immune correlation analysis of cuproptosis-related gene in osteoarthritis.
Che J, Yang X, Zhao X, Li Y, Jin Z, Xu C. Che J, et al. J Cell Mol Med. 2024 Aug;28(15):e18574. doi: 10.1111/jcmm.18574. J Cell Mol Med. 2024. PMID: 39087591 Free PMC article.
Datasets from the GEO databases were analysed the differential expression of CRGs, leading to the identification of 10 key CRGs (CDKN2A, DLD, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, DLAT and PDHB). A logistic regression analysis and calibration curves were used to show excell …
Datasets from the GEO databases were analysed the differential expression of CRGs, leading to the identification of 10 key CRGs (CDKN2A, DLD …
Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism.
Zhao L, Qi H, Liu W, Lv H, Li P, Liu W, Sun R, Wang Q, Wang X. Zhao L, et al. Commun Biol. 2025 Feb 8;8(1):205. doi: 10.1038/s42003-025-07622-x. Commun Biol. 2025. PMID: 39922943 Free PMC article.
PDHB overexpression drives tumor growth and metastasis in vitro and in vivo. Mechanistically, PDHB mediates metabolic reprogramming by binding to the promoter regions of SLC2A1, GPI, and PKM2, promoting glycolysis-related gene transcription, contributes to HCC soraf …
PDHB overexpression drives tumor growth and metastasis in vitro and in vivo. Mechanistically, PDHB mediates metabolic reprogra …
Integrative analysis of single-cell and bulk RNA seq to reveal the prognostic model and tumor microenvironment remodeling mechanisms of cuproptosis-related genes in colorectal cancer.
Chu B, Wang Y, Yang J, Dong B. Chu B, et al. Aging (Albany NY). 2023 Dec 8;15(23):14422-14444. doi: 10.18632/aging.205324. Epub 2023 Dec 8. Aging (Albany NY). 2023. PMID: 38078879 Free PMC article.
RESULTS: AOC3, CCS, CDKN2A, COX11, COX17, COX19, DLD, DLAT, and PDHB have been recognized as prognostic CRGs in CRC. The high-risk group exhibited the worst prognosis, an immune-deficient phenotype, and were more resistant to ICB treatment. ...
RESULTS: AOC3, CCS, CDKN2A, COX11, COX17, COX19, DLD, DLAT, and PDHB have been recognized as prognostic CRGs in CRC. The high-risk gr …
Comprehensive bioinformatics analytics and in vivo validation reveal SLC31A1 as an emerging diagnostic biomarker for acute myocardial infarction.
Zhou S, Wang L, Huang X, Wang T, Tang Y, Liu Y, Xu M. Zhou S, et al. Aging (Albany NY). 2024 May 6;16(9):8361-8377. doi: 10.18632/aging.205199. Epub 2024 May 6. Aging (Albany NY). 2024. PMID: 38713173 Free PMC article.
RESULTS: A merged machine learning model containing 4 Cuproptosis-related genes (i.e., PDHB, CDKN2A, GLS, and SLC31A1) for robust AMI diagnosis was developed, in which SLC31A1 served as the key contributor. ...
RESULTS: A merged machine learning model containing 4 Cuproptosis-related genes (i.e., PDHB, CDKN2A, GLS, and SLC31A1) for robust AMI …
Comprehensive analysis of cuproptosis genes and cuproptosis-related genes as prognosis factors in esophageal squamous cell carcinoma.
Wu Z, Huang Z, Zhou X, Gao C, Peng Z, Zheng X, Zhang Y, Du Z, Wu B. Wu Z, et al. Genomics. 2023 Nov;115(6):110732. doi: 10.1016/j.ygeno.2023.110732. Epub 2023 Oct 20. Genomics. 2023. PMID: 37866660 Free article.
The expression patterns of 10 CUGs (FDX1, LIPT1, LIAS, DLAT, DLD, PDHA1, PDHB, GLS, MTF1, and CDKN2A) were analyzed to identify ESCC-relevant targets. Weighted correlation network analysis (WGCNA) was performed to obtain CUG-related genes (CRGs). A total of seven different …
The expression patterns of 10 CUGs (FDX1, LIPT1, LIAS, DLAT, DLD, PDHA1, PDHB, GLS, MTF1, and CDKN2A) were analyzed to identify ESCC- …
Role of immune-related endoplasmic reticulum stress genes in sepsis-induced cardiomyopathy: Novel insights from bioinformatics analysis.
Zhen WJ, Zhang Y, Fu WD, Fu XL, Yan X. Zhen WJ, et al. PLoS One. 2024 Dec 13;19(12):e0315582. doi: 10.1371/journal.pone.0315582. eCollection 2024. PLoS One. 2024. PMID: 39671358 Free PMC article.
Diagnostic models incorporating five genes (NOX4, PDHB, ACTC1, DLAT, NSDHL) were validated using the LASSO algorithm, highlighting only the prognostic significance of serum PDHB levels in predicting the survival of septic patients. Additionally, decreased PDHB …
Diagnostic models incorporating five genes (NOX4, PDHB, ACTC1, DLAT, NSDHL) were validated using the LASSO algorithm, highlighting on …
An fusaric acid-based CRISPR library screen identifies MDH2 as a broad-spectrum regulator of Fusarium toxin-induced cell death.
Shi WT, Yao CP, Liu WH, Cao WY, Shao W, Liao SQ, Yu T, Zhu QF, Chen Z, Zang YJ, Farooq M, Wei WK, Zhang XA. Shi WT, et al. J Hazard Mater. 2024 Dec 5;480:135937. doi: 10.1016/j.jhazmat.2024.135937. Epub 2024 Sep 23. J Hazard Mater. 2024. PMID: 39342847
We found that MDH2 and PDHB depletion reduced FA-induced cell death, ROS accumulation, and the expression of caspase-3 and HIF-1alpha. The cell viability assays and flow cytometry demonstrated that MDH2 knockout but not PDHB decreased DON, ZEA, T-2, and FB1-induced …
We found that MDH2 and PDHB depletion reduced FA-induced cell death, ROS accumulation, and the expression of caspase-3 and HIF-1alpha …
55 results