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2022 1
2023 17
2024 12

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Understanding the Genetics of Early-Onset Obesity in a Cohort of Children From Qatar.
Mohammed I, Haris B, Al-Barazenji T, Vasudeva D, Tomei S, Al Azwani I, Dauleh H, Shehzad S, Chirayath S, Mohamadsalih G, Petrovski G, Khalifa A, Love DR, Al-Shafai M, Hussain K. Mohammed I, et al. J Clin Endocrinol Metab. 2023 Nov 17;108(12):3201-3213. doi: 10.1210/clinem/dgad366. J Clin Endocrinol Metab. 2023. PMID: 37329217 Free PMC article.
RESULTS: Thirty rare variants potentially associated with obesity were identified in 36 of 243 (14.8%) probands in 15 candidate genes (LEP, LEPR, POMC, MC3R, MC4R, MRAP2, SH2B1, BDNF, NTRK2, DYRK1B, SIM1, GNAS, ADCY3, RAI1, and BBS2). ...
RESULTS: Thirty rare variants potentially associated with obesity were identified in 36 of 243 (14.8%) probands in 15 candidate genes (LEP, …
Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model.
Tao Y, Zhang Y, Jin X, Hua N, Liu H, Qi R, Huang Z, Sun Y, Jiang D, Snutch TP, Jiang X, Tao J. Tao Y, et al. Nat Commun. 2023 Nov 9;14(1):7234. doi: 10.1038/s41467-023-43022-7. Nat Commun. 2023. PMID: 37945654 Free PMC article.
Further, increased miR-203a-3p was found to maintain neuropathic pain by targeting proprotein convertase 1, an endopeptidase necessary for the cleavage of proopiomelanocortin, the precursor of beta-EP. The identified mechanism may provide an avenue for the development of n …
Further, increased miR-203a-3p was found to maintain neuropathic pain by targeting proprotein convertase 1, an endopeptidase necessary for t …
Melanocortin-4 receptor and proopiomelanocortin: Candidate genes for obesity in domestic shorthair cats.
Jerjen CP, Kumaran SJ, Liesegang A, Hall E, Wichert B, Haase B. Jerjen CP, et al. Anim Genet. 2023 Oct;54(5):637-642. doi: 10.1111/age.13335. Epub 2023 Jun 26. Anim Genet. 2023. PMID: 37365843
Two genes coding for proteins known to play a critical role in energy homeostasis across species are the proopiomelanocortin (POMC) gene and the melanocortin-4 receptor (MC4R) gene. A missense variant in the coding sequence of the feline MC4R (MC4R:c.92C>T) has b …
Two genes coding for proteins known to play a critical role in energy homeostasis across species are the proopiomelanocortin (POMC …
Epigenome-wide association study of systemic effects of obesity susceptibility in human twins.
Duncan GE, Avery A, Maamar MB, Nilsson EE, Beck D, Skinner MK. Duncan GE, et al. Epigenetics. 2023 Dec;18(1):2268834. doi: 10.1080/15592294.2023.2268834. Epub 2023 Oct 23. Epigenetics. 2023. PMID: 37871278 Free PMC article.
The DMR and WGCNA epigenetic sites were near genes (e.g., CIDEC, SPP1, ZFPG9, and POMC) with previously identified obesity associated pathways (e.g., metabolism, cholesterol, and fat digestion). ...
The DMR and WGCNA epigenetic sites were near genes (e.g., CIDEC, SPP1, ZFPG9, and POMC) with previously identified obesity associated …
Gene-environment interaction between HPA-axis genes and trauma exposure in the suicide behavior: A systematic review.
González-Castro TB, Juárez-Rojop IE, Tovilla-Zárate CA, Ovando-Ricárdez JA, Hernández-Díaz Y, López-Narváez ML, Genis-Mendoza AD, Rodríguez-Pérez C. González-Castro TB, et al. J Psychiatr Res. 2023 Aug;164:162-170. doi: 10.1016/j.jpsychires.2023.06.011. Epub 2023 Jun 15. J Psychiatr Res. 2023. PMID: 37352812 Review.
Gene-environment interaction was reported for CRHR1 (n = 6), CRHR2 (n = 2), FKBP5 (n = 2), and CRHBP (n = 1), however, for CRH, NR3C1, MC2R, and POMC genes no found gene-environment effects on SB. Trauma exposure could be one mechanism that links HPA-axis genes activity wi …
Gene-environment interaction was reported for CRHR1 (n = 6), CRHR2 (n = 2), FKBP5 (n = 2), and CRHBP (n = 1), however, for CRH, NR3C1, MC2R, …
Proopiomelanocortin and its potential functions in the pathological synovium of patients with osteoarthritis.
Du GW, Zhang FW, Gao WL, Yin ZS. Du GW, et al. Eur Rev Med Pharmacol Sci. 2023 Oct;27(19):9132-9144. doi: 10.26355/eurrev_202310_33939. Eur Rev Med Pharmacol Sci. 2023. PMID: 37843327 Free article.
These OA-associated DEGs were further incorporated into a protein-protein interaction (PPI) network. Gene proopiomelanocortin (POMC) was identified in the largest cluster of PPI network with Cytoscape. ...Other GEO datasets of osteoarthritis synovial tissues, includ …
These OA-associated DEGs were further incorporated into a protein-protein interaction (PPI) network. Gene proopiomelanocortin (POM …
DNA Methylation of POMC and NR3C1-1F and Its Implication in Major Depressive Disorder and Electroconvulsive Therapy.
Maier HB, Moschny N, Eberle F, Jahn K, Folsche T, Schülke R, Bleich S, Frieling H, Neyazi A. Maier HB, et al. Pharmacopsychiatry. 2023 Mar;56(2):64-72. doi: 10.1055/a-2034-6536. Epub 2023 Mar 21. Pharmacopsychiatry. 2023. PMID: 36944329 Free PMC article.
METHODS: Since epigenetics of the stress response system seem to play a role in MDD, we analyzed the DNA methylation (DNAm) of genes encoding the glucocorticoid receptor (NR3C1) and proopiomelanocortin (POMC) through Sanger Sequencing. For analysis, blood was taken …
METHODS: Since epigenetics of the stress response system seem to play a role in MDD, we analyzed the DNA methylation (DNAm) of genes encodin …
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
Lechner L, Opitz R, Silver MJ, Krabusch PM, Prentice AM, Field MS, Stachelscheid H, Leitão E, Schröder C, Fernandez Vallone V, Horsthemke B, Jöckel KH, Schmidt B, Nöthen MM, Hoffmann P, Herms S, Kleyn PW, Megges M, Blume-Peytavi U, Weiss K, Mai K, Blankenstein O, Obermayer B, Wiegand S, Kühnen P. Lechner L, et al. Sci Transl Med. 2023 Jul 19;15(705):eadg1659. doi: 10.1126/scitranslmed.adg1659. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467315
Increasing evidence points toward epigenetic variants as a risk factor for developing obesity. We analyzed DNA methylation of the POMC (pro-opiomelanocortin) gene, which is pivotal for satiety regulation. We identified sex-specific and nongenetically determined POMC …
Increasing evidence points toward epigenetic variants as a risk factor for developing obesity. We analyzed DNA methylation of the POMC …
A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight.
Rojo D, Hael CE, Soria A, de Souza FSJ, Low MJ, Franchini LF, Rubinstein M. Rojo D, et al. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2322692121. doi: 10.1073/pnas.2322692121. Epub 2024 Apr 23. Proc Natl Acad Sci U S A. 2024. PMID: 38652744
Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin (POMC) gene. In mammals, arcuate-specific POMC expression is driven by two cis-acting transcriptional enhancers known as nPE1 an …
Food intake and energy balance are tightly regulated by a group of hypothalamic arcuate neurons expressing the proopiomelanocortin ( …
Endocrine and behavioural features of Lowe syndrome and their potential molecular mechanisms.
Sena C, Iannello G, Skowronski AA, Dannheim K, Cheung L, Agrawal PB, Hirschhorn JN, Zeitler P, LeDuc CA, Stratigopoulos G, Thaker VV. Sena C, et al. J Med Genet. 2022 Dec;59(12):1171-1178. doi: 10.1136/jmedgenet-2022-108490. Epub 2022 Jul 8. J Med Genet. 2022. PMID: 35803701 Free PMC article.
OCRL is expressed in human and mouse hypothalami, and in hypothalamic cell clusters expressing Ghrh, Sst, Oxt, Pomc and pituitary cells expressing Gh and Prl. CONCLUSIONS: There is a wide spectrum of the clinical phenotype of LS. ...
OCRL is expressed in human and mouse hypothalami, and in hypothalamic cell clusters expressing Ghrh, Sst, Oxt, Pomc and pituitary cel …
29 results