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2021 7
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Page 1
Protein palmitoylation in cancer: molecular functions and therapeutic potential.
Zhou B, Hao Q, Liang Y, Kong E. Zhou B, et al. Mol Oncol. 2023 Jan;17(1):3-26. doi: 10.1002/1878-0261.13308. Epub 2022 Sep 10. Mol Oncol. 2023. PMID: 36018061 Free PMC article. Review.
The reverse reaction, depalmitoylation, is catalyzed by palmitoyl-protein thioesterases (PPTs), including acyl-protein thioesterases (APT1/2), palmitoyl protein thioesterases (PPT1/2), or alpha/beta hydrolase domain-containing protein 17A/B/C (ABHD17A/B/C). Proteins encode …
The reverse reaction, depalmitoylation, is catalyzed by palmitoyl-protein thioesterases (PPTs), including acyl-protein thioesterases (APT1/2 …
Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing.
Lv D, Cao X, Zhong L, Dong Y, Xu Z, Rong Y, Xu H, Wang Z, Yang H, Yin R, Chen M, Ke C, Hu Z, Deng W, Tang B. Lv D, et al. Cell Rep Med. 2023 Aug 15;4(8):101129. doi: 10.1016/j.xcrm.2023.101129. Epub 2023 Jul 21. Cell Rep Med. 2023. PMID: 37480849 Free PMC article.
Mechanistically, phenylpyruvate is ingested into macrophages in a scavenger receptor CD36-dependent manner, binds to PPT1, and inhibits depalmitoylase activity, thus increasing palmitoylation of the NLRP3 protein. ...
Mechanistically, phenylpyruvate is ingested into macrophages in a scavenger receptor CD36-dependent manner, binds to PPT1, and inhibi …
Enhancing Gpx1 palmitoylation to inhibit angiogenesis by targeting PPT1.
Ma Y, Yuan X, Wei A, Li X, Patar A, Su S, Wang S, Ma G, Zhu J, Kong E. Ma Y, et al. Redox Biol. 2024 Nov;77:103376. doi: 10.1016/j.redox.2024.103376. Epub 2024 Oct 5. Redox Biol. 2024. PMID: 39423458 Free PMC article.
In this study, we demonstrate that Gpx1 undergoes palmitoylation at cysteine-76 and -113, with PPT1 playing a crucial role in modulating the depalmitoylation of Gpx1. Furthermore, we find that PPT1-regulated depalmitoylation negatively impacts Gpx1 protein stability …
In this study, we demonstrate that Gpx1 undergoes palmitoylation at cysteine-76 and -113, with PPT1 playing a crucial role in modulat …
Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice.
Ni H, Wang Y, Yao K, Wang L, Huang J, Xiao Y, Chen H, Liu B, Yang CY, Zhao J. Ni H, et al. Nat Commun. 2024 Jan 2;15(1):1. doi: 10.1038/s41467-023-43650-z. Nat Commun. 2024. PMID: 38169466 Free PMC article.
PPT1 promotes the secretion of IFNalpha by plasmacytoid dendritic cells (pDCs) and TNF by macrophages. Genetic deficiency in or chemical inhibition of PPT1 reduces anti-nuclear antibody levels and attenuates nephritis in B6.Sle1yaa mice. ...
PPT1 promotes the secretion of IFNalpha by plasmacytoid dendritic cells (pDCs) and TNF by macrophages. Genetic deficiency in or chemi …
STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders.
Tang Z, Xing C, Araszkiewicz A, Yang K, Huai W, Jeltema D, Dobbs N, Zhang Y, Sun LO, Yan N. Tang Z, et al. Mol Cell. 2025 Apr 17;85(8):1624-1639.e5. doi: 10.1016/j.molcel.2025.03.008. Epub 2025 Apr 3. Mol Cell. 2025. PMID: 40185098 Free PMC article.
Here, we show that STING mediates a neuroinflammatory gene signature in three distinct LSD mouse models, Galc(twi/twi), Ppt1(-/-), and Cln7(-/-). Transcriptomic analysis of Galc(twi/twi) mouse brain tissue revealed that STING also mediates the expression of lysosomal genes …
Here, we show that STING mediates a neuroinflammatory gene signature in three distinct LSD mouse models, Galc(twi/twi), Ppt1(-/-), an …
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.
Lu J, Wang H, Zhang H, Li J, Li H, Chen Q, Han D, Liu J, Lv L, Xiong J, Yuan K, Wei X, Sheng S, Liu F, Shi Y, Dong Z, Li Y. Lu J, et al. Adv Sci (Weinh). 2025 Sep;12(34):e01070. doi: 10.1002/advs.202501070. Epub 2025 Jun 20. Adv Sci (Weinh). 2025. PMID: 40539882 Free PMC article.
IPA reversed aging-induced increase in PPT1 expression. Using PPT1(flox/flox) Lyz2-cre mice, it is demonstrated that macrophage-specific deletion of PPT1 significantly reduced cardiac inflammation and myocardial fibrosis in aged mice. ...Additionally, IPA inf …
IPA reversed aging-induced increase in PPT1 expression. Using PPT1(flox/flox) Lyz2-cre mice, it is demonstrated that macrophag …
Emerging dimensions of autophagy in melanoma.
Pangilinan C, Klionsky DJ, Liang C. Pangilinan C, et al. Autophagy. 2024 Aug;20(8):1700-1711. doi: 10.1080/15548627.2024.2330261. Epub 2024 Mar 21. Autophagy. 2024. PMID: 38497492 Free PMC article. Review.
Here, we examine current knowledge of the mechanisms and functions of autophagy in highly plastic and aggressive melanoma as a model disease of human malignancy, while highlighting emerging dimensions indicating that autophagy is at play beyond its classical face.Abbreviation: AM …
Here, we examine current knowledge of the mechanisms and functions of autophagy in highly plastic and aggressive melanoma as a model disease …
Divergent effects of acute and chronic PPT1 inhibition in melanoma.
Crissey MAS, Versace A, Bhardwaj M, Jain V, Liu S, Singh A, Beer LA, Tang HY, Villanueva J, Gimotty PA, Xu X, Amaravadi RK. Crissey MAS, et al. Autophagy. 2025 Feb;21(2):394-406. doi: 10.1080/15548627.2024.2403152. Epub 2024 Sep 19. Autophagy. 2025. PMID: 39265628 Free PMC article.
However, the role of PPT1 in tumorigenesis remains poorly understood. Here we report that in melanoma cells, acute siRNA or pharmacological PPT1 inhibition led to increased ferroptosis sensitivity and significant loss of viability, whereas chronic PPT1 knocko …
However, the role of PPT1 in tumorigenesis remains poorly understood. Here we report that in melanoma cells, acute siRNA or pharmacol …
The palmitoylation of AEG-1 dynamically modulates the progression of hepatocellular carcinoma.
Zhou B, Wang Y, Zhang L, Shi X, Kong H, Zhang M, Liu Y, Shao X, Liu Z, Song H, Li W, Gao X, Chang Y, Dou C, Guo W, Zhang S, Kang X, Gao J, Liang Y, Zheng J, Kong E. Zhou B, et al. Theranostics. 2022 Oct 3;12(16):6898-6914. doi: 10.7150/thno.78377. eCollection 2022. Theranostics. 2022. PMID: 36276642 Free PMC article.
Moreover, it was demonstrated that AEG-1 palmitoylation is dynamically regulated by zDHHC6 and PPT1/2. Accordingly, suppressing the level of AEG-1 palmitoylation by the deletion of Zdhhc6 reproduces the enhanced tumor-progression phenotype in DEN-induced HCC mouse model. M …
Moreover, it was demonstrated that AEG-1 palmitoylation is dynamically regulated by zDHHC6 and PPT1/2. Accordingly, suppressing the l …
The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity.
Wang P, Du S, Guo C, Ni Z, Huang Z, Deng N, Bao H, Deng W, Lu J, Kong S, Zhang H, Wang H. Wang P, et al. Autophagy. 2024 Jan;20(1):58-75. doi: 10.1080/15548627.2023.2247747. Epub 2023 Aug 22. Autophagy. 2024. PMID: 37584546 Free PMC article.
ACTB: actin beta; AREG: amphiregulin; ATP6V0A4: ATPase, H(+) transporting, lysosomal V0 subunit A4; Baf A1: bafilomycin A(1); BSA: bovine serum albumin; CLDN1: claudin 1; CTSB: cathepsin B; DEGs: differentially expressed genes; E(2): 17beta-estradiol; ESR: estrogen receptor; GATA …
ACTB: actin beta; AREG: amphiregulin; ATP6V0A4: ATPase, H(+) transporting, lysosomal V0 subunit A4; Baf A1: bafilomycin A(1); BSA: bovine se …
83 results