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Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis.
Ziff OJ, Parfitt GM, Jolly S, Casey JM, Granat L, Samra S, Setó-Salvia N, Alatza A, Phadke L, Galet B, Ravassard P, Potier MC, Hardy J, Salih DA, Whiting P, Ducotterd F, Patani R, Wray S, Arber C. Ziff OJ, et al. Mol Neurodegener. 2025 Jun 20;20(1):73. doi: 10.1186/s13024-025-00864-7. Mol Neurodegener. 2025. PMID: 40542358 Free PMC article.
Presenilin 1 hemizygosity has no overt deleterious phenotypic outcomes in sheep: Potential implications for therapeutic targets in Alzheimer's disease.
Mckean NE, Liu J, Rudiger SR, Kelly JM, McLaughlan C, Verma PJ, Hardy J, Gusella JF, Zetterberg H, Reid SJ, Handley RH, Lehnert K, Sutherland GT, Heslegrave A, Veleva E, Laban R, Pearson JF, Bawden SC, Snell RG. Mckean NE, et al. Neurobiol Aging. 2025 Aug;152:25-33. doi: 10.1016/j.neurobiolaging.2025.04.006. Epub 2025 Apr 25. Neurobiol Aging. 2025. PMID: 40315540 Free article.
Plasma p-tau231 in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: A cross-sectional and longitudinal cohort study.
Malotaux V, Ashton NJ, Öhrfelt A, Chen Y, Su Y, Garcia-Ospina G, Guzman-Martínez C, Villegas-Lanau A, Gómez-Ramirez J, Giraldo-Chica M, Aguillon D, Tirado V, Baena A, Munoz C, Acosta-Baena N, Pruzin JJ, Ghisays V, Rios-Romenets S, Vila-Castelar C, Martínez JE, Giudicessi A, Tariot PN, Zetterberg H, Blennow K, Reiman EM, Quiroz YT. Malotaux V, et al. Alzheimers Dement. 2025 Jul;21(7):e70421. doi: 10.1002/alz.70421. Alzheimers Dement. 2025. PMID: 40588692 Free PMC article.
42 results