Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase.
Meyer C, Garzia A, Miller MW, Huggins DJ, Myers RW, Hoffmann HH, Ashbrook AW, Jannath SY, Liverton N, Kargman S, Zimmerman M, Nelson AM, Sharma V, Dolgov E, Cangialosi J, Penalva-Lopez S, Alvarez N, Chang CW, Oswal N, Gonzalez I, Rasheed R, Goldgirsh K, Davis JA, Ramos-Espiritu L, Menezes MR, Larson C, Nitsche J, Ganichkin O, Alwaseem H, Molina H, Steinbacher S, Glickman JF, Perlin DS, Rice CM, Meinke PT, Tuschl T.
Meyer C, et al. Among authors: rice cm, glickman jf, perlin ds, tuschl t.
Nature. 2025 Jan;637(8048):1178-1185. doi: 10.1038/s41586-024-08320-0. Epub 2024 Dec 11.
Nature. 2025.
PMID: 39663451
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)(1). The rapid development of highly effective vaccines(2,3) against SARS-CoV-2 has altered the trajectory of the pandemic, and antiviral therapeutics(4) hav …
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)(1). The rapid developme …