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465 results

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The following term was not found in PubMed: MAVDA
Page 1
LP.8.1-directed COVID-19 mRNA vaccines durably boost neutralizing antibodies and mitigate ancestral immune imprinting.
Mellis IA, Wu M, Hong H, Bowen A, Daniel K, Gherasim C, Pierce VM, Yin MT, Gordon A, Guo Y, Ho DD. Mellis IA, et al. Among authors: ho dd. bioRxiv [Preprint]. 2026 Mar 10:2026.01.03.697434. doi: 10.64898/2026.01.03.697434. bioRxiv. 2026. PMID: 41959005 Free PMC article. Preprint.
In response, vaccine manufacturers have updated COVID-19 vaccines annually since 2022, though immune imprinting to the ancestral strain has blunted antibody responses to modern viral variants. ...Further, it is important to quantify the extent to which immune imprinting co …
In response, vaccine manufacturers have updated COVID-19 vaccines annually since 2022, though immune imprinting to the ancestral stra …
Tmn blocks phage spread via plasmolysis and triggers synergistic defence responses.
Wu Y, Zhang Z, Garushyants SK, Li R, Doherty R, Milton JA, Cooper MJ, Gençay YE, Amen T, Bakshi S, Patel DJ, Koonin EV, Nobrega FL. Wu Y, et al. Among authors: patel dj. bioRxiv [Preprint]. 2026 Mar 2:2026.03.01.708804. doi: 10.64898/2026.03.01.708804. bioRxiv. 2026. PMID: 41867856 Free PMC article. Preprint.
Here we characterise Tmn, a YobI-family transmembrane P-loop NTPase that protects bacteria from phage infection by establishing a plasmolysis-associated antiviral state. Upon recognising phage T2 RIIB protein, Tmn enhances ATP turnover and selectively exports Mg(2+), causi …
Here we characterise Tmn, a YobI-family transmembrane P-loop NTPase that protects bacteria from phage infection by establishing a plasmolysi …
Dissection of innate-immune-ligand- and interferon-protein-mediated transcriptional responses in human THP1 cell states.
Lama L, Morozov P, Garzia A, Tuschl T. Lama L, et al. Among authors: tuschl t. Commun Biol. 2026 Feb 12;9(1):239. doi: 10.1038/s42003-025-09343-7. Commun Biol. 2026. PMID: 41680413 Free PMC article.
We compare IRF3- and IRF7-induced gene signatures and note the strong direct induction of a subset of antiviral-acting ISGs by IRF3 or IRF7. LPS treatment induces NF-kappaB responses in monocyte and macrophage state cells, however, IFNs and ISGs are only co-induced in the …
We compare IRF3- and IRF7-induced gene signatures and note the strong direct induction of a subset of antiviral-acting ISGs by IRF3 o …
ACE-2-like Enzymatic Activity in Anti-SARS-CoV-2 Spike Protein Monoclonal Antibodies.
Song Y, Mehl F, No T, Livingston L, Barbosa JSQ, Hayashi J, Serrero G, Bortz PS, Wilson JM, Crowe JE Jr, Ho DD, Yin MT, Tan J, Zeichner SL. Song Y, et al. Among authors: ho dd. bioRxiv [Preprint]. 2026 Feb 3:2026.02.02.703244. doi: 10.64898/2026.02.02.703244. bioRxiv. 2026. PMID: 41676584 Free PMC article. Preprint.
Many people are affected by post-acute sequelae of COVID-19 (PASC/long COVID, LC). LC has severely affected public health. Features of LC including blood pressure dysregulation, coagulopathies, hyperinflammation, and neuropsychiatric complaints. ...We previously sho …
Many people are affected by post-acute sequelae of COVID-19 (PASC/long COVID, LC). LC has severely affected public health. Fea …
Structural basis for pan-coronavirus inhibition of 3CL protease.
Reddem ER, Forouhar F, Liu C, Stevens SK, Jekle A, Chang CW, Oswal N, McGowan DC, Vandyck K, Smith DB, Raboisson P, Beigelman LN, Katsamba PS, Bahna F, Mannepalli S, Blatt L, Perlin D, Symons JA, Shapiro L, Stoycheva AD. Reddem ER, et al. Among authors: symons ja, perlin d, shapiro l. Structure. 2026 Apr 2;34(4):562-571.e8. doi: 10.1016/j.str.2026.01.003. Epub 2026 Feb 5. Structure. 2026. PMID: 41650964
A methylome-derived m6-dAMP trigger assembles a PUA-Cal-HAD immune filament that depletes dNTPs to abort phage infection.
Zhang Z, Wu Y, Lee YJ, Nicastro GG, Chakravarti A, Fang H, Taverner D, Weigele P, Aravind L, Patel DJ, Nobrega FL. Zhang Z, et al. Among authors: patel dj. bioRxiv [Preprint]. 2026 Jan 16:2026.01.15.699771. doi: 10.64898/2026.01.15.699771. bioRxiv. 2026. PMID: 41648444 Free PMC article. Preprint.
More broadly, our findings extend a conserved, cross-kingdom paradigm of immune filament assembly to nucleotide-depletion antiviral defence and suggest modified-nucleotide sensing by related PUA-Calcineurin-CE modules as a widespread, underappreciated bacterial strategy... …
More broadly, our findings extend a conserved, cross-kingdom paradigm of immune filament assembly to nucleotide-depletion antiviral d …
Bacterial TIR-based immune systems sense phage capsids to initiate defense.
Roberts CG, Fishman CB, Zhang Z, Banh DV, Patel DJ, Marraffini LA. Roberts CG, et al. Among authors: patel dj. Nat Microbiol. 2025 Nov;10(11):2892-2902. doi: 10.1038/s41564-025-02150-0. Epub 2025 Oct 24. Nat Microbiol. 2025. PMID: 41136732 Free PMC article.
More broadly, given that some mammalian immune pathways contain Toll/interleukin-1 receptor domains that recognize viral structures, our findings highlight a conserved mechanism of innate antiviral immunity....
More broadly, given that some mammalian immune pathways contain Toll/interleukin-1 receptor domains that recognize viral structures, our fin …
465 results