Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2022 1
2023 18
2024 37
2025 8

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

54 results

Results by year

Filters applied: . Clear all
Page 1
UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.
Tsai JM, Aguirre JD, Li YD, Brown J, Focht V, Kater L, Kempf G, Sandoval B, Schmitt S, Rutter JC, Galli P, Sandate CR, Cutler JA, Zou C, Donovan KA, Lumpkin RJ, Cavadini S, Park PMC, Sievers Q, Hatton C, Ener E, Regalado BD, Sperling MT, Słabicki M, Kim J, Zon R, Zhang Z, Miller PG, Belizaire R, Sperling AS, Fischer ES, Irizarry R, Armstrong SA, Thomä NH, Ebert BL. Tsai JM, et al. Mol Cell. 2023 Aug 3;83(15):2753-2767.e10. doi: 10.1016/j.molcel.2023.06.028. Epub 2023 Jul 20. Mol Cell. 2023. PMID: 37478846 Free PMC article.
Here, we demonstrate the ubiquitin ligase UBR5 drives degradation of multiple agonist-bound NRs, including the retinoic acid receptor alpha (RARA), retinoid x receptor alpha (RXRA), glucocorticoid, estrogen, liver-X, progesterone, and vitamin D …
Here, we demonstrate the ubiquitin ligase UBR5 drives degradation of multiple agonist-bound NRs, including the retinoic acid …
Phase separation of PML/RARα and BRD4 coassembled microspeckles governs transcriptional dysregulation in acute promyelocytic leukemia.
Zhang Y, Lou J, Liu Y, Jin P, Tan Y, Song H, Jin W, Wang D, Dong F, Wu S, Fang H, Chen S, Chen Z, Wang K. Zhang Y, et al. Proc Natl Acad Sci U S A. 2024 Aug 20;121(34):e2406519121. doi: 10.1073/pnas.2406519121. Epub 2024 Aug 13. Proc Natl Acad Sci U S A. 2024. PMID: 39136995 Free PMC article.
In acute promyelocytic leukemia (APL), the promyelocytic leukemia-retinoic acid receptor alpha (PML/RARalpha) fusion protein destroys PML nuclear bodies (NBs), leading to the formation of microspeckles. ...
In acute promyelocytic leukemia (APL), the promyelocytic leukemia-retinoic acid receptor alpha (PML/RARalpha) fu …
Approaches to the epidemiology of NOHL in the region of Madrid: Survey of neuro-ophthalmologists.
González-Martín-Moro J, Reche Sainz JA, Gracia T, Maroto Rodríguez B, Cabrejas Martínez L, Gutiérrez Ortiz C, Rojas P, Fraile Maya J, Blanco Calvo N, Muñoz Negrete F. González-Martín-Moro J, et al. Arch Soc Esp Oftalmol (Engl Ed). 2023 Dec;98(12):673-679. doi: 10.1016/j.oftale.2023.10.007. Epub 2023 Oct 20. Arch Soc Esp Oftalmol (Engl Ed). 2023. PMID: 37866435 Free article.
Retinoic acid receptor alpha inhibits ferroptosis by promoting thioredoxin and protein phosphatase 1F in lung adenocarcinoma.
Bian Y, Shan G, Liang J, Hu Z, Sui Q, Shi H, Wang Q, Bi G, Zhan C. Bian Y, et al. Commun Biol. 2024 Jun 20;7(1):751. doi: 10.1038/s42003-024-06452-7. Commun Biol. 2024. PMID: 38902322 Free PMC article.
However, evidence in the regulation of ferroptosis in lung adenocarcinoma (LUAD) remains elusive. Here, we show that retinoic acid receptor alpha (RARA) is upregulated with the treatment of ferroptosis inducers (FINs). Pharmacological activation …
However, evidence in the regulation of ferroptosis in lung adenocarcinoma (LUAD) remains elusive. Here, we show that retinoic acid …
De novo variants implicate chromatin modification, transcriptional regulation, and retinoic acid signaling in syndromic craniosynostosis.
Timberlake AT, McGee S, Allington G, Kiziltug E, Wolfe EM, Stiegler AL, Boggon TJ, Sanyoura M, Morrow M, Wenger TL, Fernandes EM, Caluseriu O, Persing JA, Jin SC, Lifton RP, Kahle KT, Kruszka P. Timberlake AT, et al. Am J Hum Genet. 2023 May 4;110(5):846-862. doi: 10.1016/j.ajhg.2023.03.017. Epub 2023 Apr 21. Am J Hum Genet. 2023. PMID: 37086723 Free PMC article.
A recurrent gain-of-function DNV in the retinoic acid receptor alpha (RARA; c.865G>A [p.Gly289Arg]) was identified in two probands with similar CS phenotypes. ...
A recurrent gain-of-function DNV in the retinoic acid receptor alpha (RARA; c.865G>A [p.Gly289Arg]) wa …
Function of PML-RARA in Acute Promyelocytic Leukemia.
Testa U, Pelosi E. Testa U, et al. Adv Exp Med Biol. 2024;1459:321-339. doi: 10.1007/978-3-031-62731-6_14. Adv Exp Med Biol. 2024. PMID: 39017850 Review.
APL is a paradigm for oncoprotein-targeted cure.APL is caused by a 15/17 chromosomal translocation which generates the PML-RARA fusion protein and can be cured by the chemotherapy-free approach based on the combination of two therapies targeting PML-RARA: retinoic a …
APL is a paradigm for oncoprotein-targeted cure.APL is caused by a 15/17 chromosomal translocation which generates the PML-RARA fusio …
WYC-209 inhibited GC malignant progression by down-regulating WNT4 through RARα.
Qian Z, Lin W, Cai X, Wu J, Ke K, Ye Z, Wu F. Qian Z, et al. Cancer Biol Ther. 2024 Dec 31;25(1):2299288. doi: 10.1080/15384047.2023.2299288. Epub 2024 Jan 4. Cancer Biol Ther. 2024. PMID: 38178596 Free PMC article.
Mechanically, WYC-209 significantly promoted the binding between retinoic acid receptor alpha (RARalpha) and WNT4 promoter. WYC-209 exerts anti-tumor effects in GC by down-regulating the expression of WNT4 via RARalpha....
Mechanically, WYC-209 significantly promoted the binding between retinoic acid receptor alpha (RARalpha) and WNT …
Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties.
Xiao P, Duan Z, Liu Z, Chen L, Zhang D, Liu L, Zhou C, Gan J, Dong Z, Yang CG. Xiao P, et al. J Med Chem. 2023 Jul 27;66(14):9731-9752. doi: 10.1021/acs.jmedchem.3c00543. Epub 2023 Jul 7. J Med Chem. 2023. PMID: 37418628
Moreover, 44/ZLD115 treatment noticeably increases m(6)A abundance on the AML cell RNA, upregulates RARA gene expression, and downregulates MYC gene expression in MOLM13 cells, which are consistent with FTO gene knockdown. ...
Moreover, 44/ZLD115 treatment noticeably increases m(6)A abundance on the AML cell RNA, upregulates RARA gene expression, and downreg …
Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein.
Day RB, Hickman JA, Xu Z, Katerndahl CD, Ferraro F, Ramakrishnan SM, Erdmann-Gilmore P, Sprung RW, Mi Y, Townsend RR, Miller CA, Ley TJ. Day RB, et al. J Clin Invest. 2023 Dec 7;134(4):e176311. doi: 10.1172/JCI176311. J Clin Invest. 2023. PMID: 38061017 Free PMC article.
To address this issue in an unbiased fashion, we fused a promiscuous biotin ligase (TurboID) in-frame with 3 favorable-risk AML oncofusion cDNAs (PML::RARA, RUNX1::RUNX1T1, and CBFB::MYH11) and identified their interacting proteins in primary murine hematopoietic cells. Th …
To address this issue in an unbiased fashion, we fused a promiscuous biotin ligase (TurboID) in-frame with 3 favorable-risk AML oncofusion c …
54 results