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Multifaceted roles of MAGOH Proteins.
Mitra R, Rehman A, Singh KK, Jaganathan BG. Mitra R, et al. Mol Biol Rep. 2023 Feb;50(2):1931-1941. doi: 10.1007/s11033-022-07904-1. Epub 2022 Nov 17. Mol Biol Rep. 2023. PMID: 36396768 Review.
The EJC is formed of core components EIF4A3, RBM8A, and MAGOH/MAGOHB. As a part of the EJC, MAGOH proteins are required for mRNA splicing, export, translation and nonsense-mediated mRNA decay (NMD). ...
The EJC is formed of core components EIF4A3, RBM8A, and MAGOH/MAGOHB. As a part of the EJC, MAGOH proteins are required for mRNA spli …
RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2.
Li F, Wang X, Zhang J, Zhang J, Jing X, Jiang Q, Zhou J, Cao L, Peng H, Tong D, Huang C. Li F, et al. J Transl Med. 2024 Sep 4;22(1):823. doi: 10.1186/s12967-024-05639-0. J Transl Med. 2024. PMID: 39232805 Free PMC article.
RESULTS: In this study, we showed that RBM8A is abnormally highly expressed in BC and knockdown of RBM8A inhibits BC cell proliferation and induces apoptosis in vitro. EIF4A3, which phenocopy RBM8A in BC, forms a complex with RBM8A in BC. Moreover, EIF …
RESULTS: In this study, we showed that RBM8A is abnormally highly expressed in BC and knockdown of RBM8A inhibits BC cell prol …
RNA-binding protein RBM8A (Y14) and MAGOH localize to centrosome in human A549 cells.
Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Iwabuchi K, Tomosugi N. Ishigaki Y, et al. Histochem Cell Biol. 2014 Jan;141(1):101-9. doi: 10.1007/s00418-013-1135-4. Epub 2013 Aug 15. Histochem Cell Biol. 2014. PMID: 23949737
RBM8A (Y14) is carrying RNA-binding motif and forms the tight heterodimer with MAGOH. ...Our experiments clearly showed that Myc-tagged RBM8A and Flag-tagged MAGOH formed a complex in centrosome. GFP-tagged PLK1 also co-localized with Myc-RBM8A. ...
RBM8A (Y14) is carrying RNA-binding motif and forms the tight heterodimer with MAGOH. ...Our experiments clearly showed that Myc-tagg …
Glycogen synthase kinase-3 and alternative splicing.
Liu X, Klein PS. Liu X, et al. Wiley Interdiscip Rev RNA. 2018 Nov;9(6):e1501. doi: 10.1002/wrna.1501. Epub 2018 Aug 17. Wiley Interdiscip Rev RNA. 2018. PMID: 30118183 Free PMC article. Review.
GSK-3-regulated phosphoproteins include SF3B1, SRSF2, PSF, RBM8A, nucleophosmin 1 (NPM1), and PHF6, many of which are mutated in leukemia and myelodysplasia. ...
GSK-3-regulated phosphoproteins include SF3B1, SRSF2, PSF, RBM8A, nucleophosmin 1 (NPM1), and PHF6, many of which are mutated in leuk …
Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets.
Gangras P, Gallagher TL, Parthun MA, Yi Z, Patton RD, Tietz KT, Deans NC, Bundschuh R, Amacher SL, Singh G. Gangras P, et al. PLoS Genet. 2020 Jun 5;16(6):e1008830. doi: 10.1371/journal.pgen.1008830. eCollection 2020 Jun. PLoS Genet. 2020. PMID: 32502192 Free PMC article.
We show that homozygous mutations in two zebrafish exon junction complex (EJC) core genes rbm8a and magoh leads to muscle disorganization, neural cell death, and motor neuron outgrowth defects, as well as dysregulation of mRNAs subjected to nonsense-mediated mRNA decay (NM …
We show that homozygous mutations in two zebrafish exon junction complex (EJC) core genes rbm8a and magoh leads to muscle disorganiza …
Expression and gene regulation network of RBM8A in hepatocellular carcinoma based on data mining.
Lin Y, Liang R, Qiu Y, Lv Y, Zhang J, Qin G, Yuan C, Liu Z, Li Y, Zou D, Mao Y. Lin Y, et al. Aging (Albany NY). 2019 Jan 22;11(2):423-447. doi: 10.18632/aging.101749. Aging (Albany NY). 2019. PMID: 30670676 Free PMC article.
RNA binding motif protein 8A (RBM8A) is an RNA binding protein in a core component of the exon junction complex. ...Our results demonstrate that data mining efficiently reveals information about RBM8A expression and potential regul …
RNA binding motif protein 8A (RBM8A) is an RNA binding protein in a core component of the exon jun …
Identification of molecular correlations of RBM8A with autophagy in Alzheimer's disease.
Zou D, Li R, Huang X, Chen G, Liu Y, Meng Y, Wang Y, Wu Y, Mao Y. Zou D, et al. Aging (Albany NY). 2019 Dec 9;11(23):11673-11685. doi: 10.18632/aging.102571. Epub 2019 Dec 9. Aging (Albany NY). 2019. PMID: 31816601 Free PMC article.
Our previous studies revealed RBM8A may play a role in various progressive neurological diseases. The present study aimed to explore the role of RBM8A in Alzheimer's disease (AD). RBM8A is significantly down-regulated in AD. Interestingly, 9186 differentially …
Our previous studies revealed RBM8A may play a role in various progressive neurological diseases. The present study aimed to explore …
Whole Exome Sequencing Identifies Epithelial and Immune Dysfunction-Related Biomarkers in Food Protein-Induced Enterocolitis Syndrome.
Camino-Mera A, Pardo-Seco J, Bello X, Argiz L, Boyle RJ, Custovic A, Herberg J, Kaforou M, Arasi S, Fiocchi A, Pecora V, Barni S, Mori F, Bracamonte T, Echeverria L, O'Valle-Aísa V, Hernández-Martínez NL, Carballeira I, García E, Garcia-Magan C, Moure-González JD, Gonzalez-Delgado P, Garriga-Baraut T, Infante S, Zambrano-Ibarra G, Tomás-Pérez M, Machinena A, Pascal M, Prieto A, Vázquez-Cortes S, Fernández-Rivas M, Vila L, Alsina L, Torres MJ, Mangone G, Quirce S, Martinón-Torres F, Vázquez-Ortiz M, Gómez-Carballa A, Salas A. Camino-Mera A, et al. Clin Exp Allergy. 2024 Nov;54(11):919-929. doi: 10.1111/cea.14564. Epub 2024 Sep 30. Clin Exp Allergy. 2024. PMID: 39348862
RESULTS: Notable genetic variants, including rs872786 (RBM8A), rs2241880 (ATG16L1) and rs2289477 (ATG16L1), were identified as significant findings in FPIES. ...Coexpression correlation analysis revealed a functional correlation between RBM8A and filaggrin gene (FLG …
RESULTS: Notable genetic variants, including rs872786 (RBM8A), rs2241880 (ATG16L1) and rs2289477 (ATG16L1), were identified as signif …
High expression of RBM8A predicts poor patient prognosis and promotes tumor progression in hepatocellular carcinoma.
Liang R, Lin Y, Ye JZ, Yan XX, Liu ZH, Li YQ, Luo XL, Ye HH. Liang R, et al. Oncol Rep. 2017 Apr;37(4):2167-2176. doi: 10.3892/or.2017.5457. Epub 2017 Feb 15. Oncol Rep. 2017. PMID: 28259942
Overexpression of RBM8A was associated with HbsAg and Edmondson pathological grading. Moreover, Kaplan-Meier survival analysis showed that high expression of RBM8A was related to the poor overall survival and progression-free survival of patients with HCC. ...It is …
Overexpression of RBM8A was associated with HbsAg and Edmondson pathological grading. Moreover, Kaplan-Meier survival analysis showed …
Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells.
Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Shimasaki T, Iwabuchi K, Tomosugi N. Ishigaki Y, et al. Exp Biol Med (Maywood). 2013 Aug 1;238(8):889-97. doi: 10.1177/1535370213494646. Exp Biol Med (Maywood). 2013. PMID: 23970407 Free article.
Recently, deficient cellular proliferation has been observed in RBM8A- or Magoh-depleted cells. These results prompted us to study the role of RBM8A in cell cycle progression of human tumour cells. The depletion of RBM8A in A549 cells resulted in poor cell su …
Recently, deficient cellular proliferation has been observed in RBM8A- or Magoh-depleted cells. These results prompted us to study th …
61 results