Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2025 58
2026 63

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

108 results

Results by year

Filters applied: . Clear all
Page 1
Human gut M cells resemble dendritic cells and present gluten antigen.
Wang D, Lim S, van de Wetering WJ, Lopez-Iglesias C, Okura Y, Teranishi-Ikawa Y, Mizoroki A, Spoelstra WK, Dayton T, van Son GJF, Pronk A, Smakman N, Gonera-de Jong GBC, Withoff S, Jonkers IH, van Zon JS, Tans SJ, Peters PJ, van Es JH, Clevers H. Wang D, et al. Nature. 2026 Feb;650(8100):251-260. doi: 10.1038/s41586-025-09829-8. Epub 2025 Dec 10. Nature. 2026. PMID: 41372409 Free PMC article.
Similar to dendritic cells, M cell development is induced by RANKL and CSF2 and requires the transcription factors SPIB and RUNX2. HLA-DQ2.5 M cells process and present gluten antigen as demonstrated in organoid-T cell co-culture assays. ...
Similar to dendritic cells, M cell development is induced by RANKL and CSF2 and requires the transcription factors SPIB and RUNX2. HL …
Multimodal spatial transcriptomic characterization of mouse kidney injury and repair.
Xuanyuan Q, Wu H, Sundaramoorthi H, Isnard P, Chen C, Rahmani W, Humphreys BD. Xuanyuan Q, et al. Nat Commun. 2025 Aug 14;16(1):7567. doi: 10.1038/s41467-025-62599-9. Nat Commun. 2025. PMID: 40813851 Free PMC article.
We further reveal a specific fibro-inflammatory niche enriched in failed-repair proximal tubule cells, fibroblasts, and immune cells, with conserved neighborhood gene signatures across mouse and human. Within this niche, we predict Runx2 as a key upstream regulator, along …
We further reveal a specific fibro-inflammatory niche enriched in failed-repair proximal tubule cells, fibroblasts, and immune cells, with c …
Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn's disease.
Arase M, Murakami M, Kihara T, Kuwahara R, Toyota H, Sumitani N, Kinoshita N, Chen KY, Yokoi T, Motooka D, Okuzaki D, Zhao Y, Miyazaki H, Ogino T, Hirota S, Ikeuchi H, Takeda K. Arase M, et al. J Exp Med. 2025 Nov 3;222(11):e20242106. doi: 10.1084/jem.20242106. Epub 2025 Sep 4. J Exp Med. 2025. PMID: 40906156 Free PMC article.
We identified two key transcription factors, RUNX2 and BHLHE40, as regulators of pathologically relevant CD4+ TRM. These transcriptional regulators work together to induce distinct cellular properties of disease-specific TRM, such as cytotoxicity, T helper 1-effector activ …
We identified two key transcription factors, RUNX2 and BHLHE40, as regulators of pathologically relevant CD4+ TRM. These transcriptio …
The evolution of hominin bipedalism in two steps.
Senevirathne G, Fernandopulle SC, Richard D, Baumgart SL, Christensen AL, Fabbri M, Höppner J, Jüppner H, Li P, Bothe V, Fröbisch N, Simcock I, Arthurs OJ, Calder A, Freilich N, Nowlan NC, Glass IA, Craft A, Capellini TD. Senevirathne G, et al. Nature. 2025 Sep;645(8082):952-963. doi: 10.1038/s41586-025-09399-9. Epub 2025 Aug 27. Nature. 2025. PMID: 40866708 Free PMC article.
Underlying these two shifts are regulatory changes in an integrated chondrocyte-perichondral-osteoblast pathway, involving complex hierarchical interactions between SOX9-ZNF521-PTH1R and RUNX2-FOXP1/2. These innovations facilitated further growth of the human pelvis and th …
Underlying these two shifts are regulatory changes in an integrated chondrocyte-perichondral-osteoblast pathway, involving complex hierarchi …
Transcriptional dynamics of CD8+ T-cell exhaustion in immune checkpoint inhibitor resistance at single-cell resolution.
Tseng TY, Hsieh CH, Huang HC, Wu YC, Hsu C, Hsu CL, Ou DL, Juan HF. Tseng TY, et al. Mol Cancer. 2025 Dec 11;24(1):306. doi: 10.1186/s12943-025-02468-7. Mol Cancer. 2025. PMID: 41382107 Free PMC article.
Runx2 was identified as a key transcription factor associated with CD8+ T-cell exhaustion in both models and correlated with immunotherapy response in clinical data. Additionally, functional marker expression and cytotoxicity assays demonstrated that inhibiting Runx2 …
Runx2 was identified as a key transcription factor associated with CD8+ T-cell exhaustion in both models and correlated with immunoth …
Smooth muscle-specific HuR knockout attenuates vascular calcification.
Chen A, Yuan P, Lu Y, Ma C, Xue F, Yang J, Zhang Y, Zhang W. Chen A, et al. J Mol Cell Cardiol. 2025 Aug;205:117-128. doi: 10.1016/j.yjmcc.2025.07.002. Epub 2025 Jul 5. J Mol Cell Cardiol. 2025. PMID: 40619120
Additionally, treatment with the HuR inhibitor CMLD-2 significantly attenuated calcification in mice. Mechanistically, HuR binds directly to Runt-related transcription factor 2 (Runx2) mRNA, increasing its stability and protein expression …
Additionally, treatment with the HuR inhibitor CMLD-2 significantly attenuated calcification in mice. Mechanistically, HuR binds directly to …
MAPK14 converges on key transcriptional machinery to promote vascular smooth muscle cell degeneration in abdominal aortic aneurysm.
Wu X, Wang C, Ishimwe N, Zhang W, Doja J, Shan S, Ge C, Sun Y, Zhao J, Castillo M, Sotonyi P, Gyurok G, Csanyi G, Bryant WB, Dong K, Chen Y, Vazquez-Padron R, Miano JM, Long X. Wu X, et al. Signal Transduct Target Ther. 2026 Jan 12;11(1):17. doi: 10.1038/s41392-025-02540-0. Signal Transduct Target Ther. 2026. PMID: 41526342 Free PMC article.
The VSMC differentiation gene program and upstream pathways were upregulated, whereas degeneration pathways, including extracellular matrix remodeling, inflammation, and apoptosis, were downregulated in KO VSMCs. snATAC-seq and validation revealed increased serum response factor …
The VSMC differentiation gene program and upstream pathways were upregulated, whereas degeneration pathways, including extracellular matrix …
Overexpression of RUNX2 promotes breast cancer multi-organ metastasis through stabilizing c-Myc.
Zhou TH, Fu H, Zhao S, Jiang WJ, Miao S, Tan H, Zhang R, Wang QS, Feng YM. Zhou TH, et al. Cell Death Dis. 2025 Oct 6;16(1):696. doi: 10.1038/s41419-025-08018-9. Cell Death Dis. 2025. PMID: 41053083 Free PMC article.
However, the underlying mechanism is still far from being fully understood. Runt-related transcription factor 2 (RUNX2), a master osteogenic transcription factor, is commonly considered a driver of bone-specific metastasis in breast cance …
However, the underlying mechanism is still far from being fully understood. Runt-related transcription factor …
RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness.
Vitale E, Gugnoni M, Manicardi V, Muccioli S, Torricelli F, Donati B, Piana S, Manzotti G, Salviato E, Reggiani F, Ascione C, Vezzani R, Ragazzi M, Forcato M, Romano O, Bicciato S, Goldman AR, Tigano M, Ciarrocchi A. Vitale E, et al. J Exp Clin Cancer Res. 2025 Oct 31;44(1):298. doi: 10.1186/s13046-025-03549-7. J Exp Clin Cancer Res. 2025. PMID: 41174748 Free PMC article.
By combining omics data with functional validation, we demonstrated that RUNX2 drives cancer cell metabolic rewiring by repressing mitochondrial respiration while promoting anabolic processes. We showed that RUNX2 upregulates key genes of lipid biosynthesis by regul …
By combining omics data with functional validation, we demonstrated that RUNX2 drives cancer cell metabolic rewiring by repressing mi …
The histone lysine methyltransferase NSD3 drives osteosarcomagenesis by inactivating ARID3A.
Lu J, Shao Y, Saw S, Fang H, Song G, Chen Y, Tang Q, Wood G, Wang J, Waterhouse P, Shen J, Khokha R. Lu J, et al. Cancer Lett. 2025 Nov 28;633:218045. doi: 10.1016/j.canlet.2025.218045. Epub 2025 Sep 17. Cancer Lett. 2025. PMID: 40967468
This culminates in altered expression of instructive genes RUNX2, MMP13, OCT4 and NANOG generating a shift in osteosarcoma cell differentiation to a primitive state. ...
This culminates in altered expression of instructive genes RUNX2, MMP13, OCT4 and NANOG generating a shift in osteosarcoma cell diffe …
108 results