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SAR1B senses leucine levels to regulate mTORC1 signalling.
Chen J, Ou Y, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen PR, Liu Y. Chen J, et al. Nature. 2021 Aug;596(7871):281-284. doi: 10.1038/s41586-021-03768-w. Epub 2021 Jul 21. Nature. 2021. PMID: 34290409
SAR1B-GATOR2-mTORC1 signalling is conserved in nematodes and has a role in the regulation of lifespan. Bioinformatic analysis reveals that SAR1B deficiency correlates with the development of lung cancer. The silencing of SAR1B and its paralogue SAR1A promotes …
SAR1B-GATOR2-mTORC1 signalling is conserved in nematodes and has a role in the regulation of lifespan. Bioinformatic analysis reveals …
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
Wang X, Wang H, Xu B, Huang D, Nie C, Pu L, Zajac GJM, Yan H, Zhao J, Shi F, Emmer BT, Lu J, Wang R, Dong X, Dai J, Zhou W, Wang C, Gao G, Wang Y, Willer C, Lu X, Zhu Y, Chen XW. Wang X, et al. Cell Metab. 2021 Feb 2;33(2):350-366.e7. doi: 10.1016/j.cmet.2020.10.020. Epub 2020 Nov 12. Cell Metab. 2021. PMID: 33186557 Free article.
Here, we show that this process is quantitatively governed by the GTPase SAR1B and SURF4, a high-efficiency cargo receptor. While both genes are implicated in lipid regulation in humans, hepatic inactivation of either mouse Sar1b or Surf4 selectively depletes plasma …
Here, we show that this process is quantitatively governed by the GTPase SAR1B and SURF4, a high-efficiency cargo receptor. While bot …
Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
Tang VT, Xiang J, Chen Z, McCormick J, Abbineni PS, Chen XW, Hoenerhoff M, Emmer BT, Khoriaty R, Lin JD, Ginsburg D. Tang VT, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322164121. doi: 10.1073/pnas.2322164121. Epub 2024 Apr 30. Proc Natl Acad Sci U S A. 2024. PMID: 38687799 Free PMC article.
We also confirm previous reports that complete deficiency of murine Sar1b results in perinatal lethality. In contrast, we demonstrate that deletion of Sar1b restricted to hepatocytes is compatible with survival, though resulting in hypocholesterolemia that can be re …
We also confirm previous reports that complete deficiency of murine Sar1b results in perinatal lethality. In contrast, we demonstrate …
High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism.
Auclair N, Sané AT, Ahmarani L, Ould-Chikh NE, Patey N, Beaulieu JF, Delvin E, Spahis S, Levy E. Auclair N, et al. J Lipid Res. 2023 Sep;64(9):100423. doi: 10.1016/j.jlr.2023.100423. Epub 2023 Aug 7. J Lipid Res. 2023. PMID: 37558128 Free PMC article.
Biallelic pathogenic variants of the Sar1b gene cause chylomicron retention disease (CRD) whose central phenotype is the inability to secrete chylomicrons. ...Noteworthy, variations were observed between males and females, and between Sar1b deletion and mutation phe …
Biallelic pathogenic variants of the Sar1b gene cause chylomicron retention disease (CRD) whose central phenotype is the inability to …
Chylomicron retention disease: genetics, biochemistry, and clinical spectrum.
Levy E, Poinsot P, Spahis S. Levy E, et al. Curr Opin Lipidol. 2019 Apr;30(2):134-139. doi: 10.1097/MOL.0000000000000578. Curr Opin Lipidol. 2019. PMID: 30640893 Review.
The specific molecular defect was identified in 2003 and consists of mutations in the SAR1B or SARA2 gene encoding for intracellular SAR1B GTPase protein. The aim of this review is first to provide an update of the recent biochemical, genetic and clinical fin …
The specific molecular defect was identified in 2003 and consists of mutations in the SAR1B or SARA2 gene encoding for intrace …
Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Na(v)1.5.
Wang Z, Yu G, Liu Y, Liu S, Aridor M, Huang Y, Hu Y, Wang L, Li S, Xiong H, Tang B, Li X, Cheng C, Chakrabarti S, Wang F, Wu Q, Karnik SS, Xu C, Chen Q, Wang QK. Wang Z, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3672-3684. doi: 10.1016/j.bbadis.2018.09.003. Epub 2018 Sep 6. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 30251687 Free PMC article.
Simultaneous knockdown of SAR1A and SAR1B expression by siRNAs significantly reduces the I(Na) density, whereas single knockdown of either SAR1A or SAR1B has minimal effect. ...Co-immunoprecipitation showed that SAR1A or SAR1B interacted with MOG1. Interestin …
Simultaneous knockdown of SAR1A and SAR1B expression by siRNAs significantly reduces the I(Na) density, whereas single knockdown of e …
Neighborhood Environment, DNA Methylation, and Presence of Crown-Like Structures of the Breast.
Harris AR, Hughes JD, Lawrence WR, Lenz P, Franklin J, Bhawsar PMS, Dorsey TH, Rossi EL, Pichardo CM, Pichardo MS, White AJ, Ramin C, Duggan MA, Abubakar M, Rozeboom AM, Almeida JS, Gierach GL, Ambs S, Jenkins BD. Harris AR, et al. JAMA Netw Open. 2025 Feb 3;8(2):e2461334. doi: 10.1001/jamanetworkopen.2024.61334. JAMA Netw Open. 2025. PMID: 39992653 Free PMC article.
The top 2 significant differentially methylated CpG sites by CLS-B status were SAR1B (beta = 0.01; 95% CI, 0.01-0.02; P < .001) and IL2RB (beta = -0.04; 95% CI, -0.05 to -0.02; P < .001). ...

The top 2 significant differentially methylated CpG sites by CLS-B status were SAR1B (beta = 0.01; 95% CI, 0.01-0.02; P < .001) an

…
Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.
Auclair N, Sané AT, Ahmarani L, Patey N, Beaulieu JF, Peretti N, Spahis S, Levy E. Auclair N, et al. J Lipid Res. 2021;62:100085. doi: 10.1016/j.jlr.2021.100085. Epub 2021 May 5. J Lipid Res. 2021. PMID: 33964306 Free PMC article.
To examine the physiological role and molecular mechanisms of Sar1b function, we generated mice expressing either a targeted deletion or mutation of human Sar1b using the CRISPR-Cas9 system. We found that deletion or mutation of Sar1b in mice resulted in late …
To examine the physiological role and molecular mechanisms of Sar1b function, we generated mice expressing either a targeted deletion …
The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Huang Q, Szebenyi DME. Huang Q, et al. Proteins. 2023 Apr;91(4):518-531. doi: 10.1002/prot.26445. Epub 2022 Nov 21. Proteins. 2023. PMID: 36369712 Free PMC article.
The overall structure of Sar1a ppGpp is more similar to Sar1b GDP than to Sar1b GTP. We also find that the Asp140-Arg138-water-ligand interaction net is important for the binding of ppGpp to Sar1a. This study provides further evidence showing that there are biochemi …
The overall structure of Sar1a ppGpp is more similar to Sar1b GDP than to Sar1b GTP. We also find that the Asp140-Arg138-water …
SAR1B GTPase is necessary to protect intestinal cells from disorders of lipid homeostasis, oxidative stress, and inflammation.
Sané A, Ahmarani L, Delvin E, Auclair N, Spahis S, Levy E. Sané A, et al. J Lipid Res. 2019 Oct;60(10):1755-1764. doi: 10.1194/jlr.RA119000119. Epub 2019 Aug 13. J Lipid Res. 2019. PMID: 31409740 Free PMC article.
The central aim of this study is to test the hypothesis that SAR1B deletion (SAR1B(-/-) ) disturbs enterocyte lipid homeostasis (e.g., FA beta-oxidation and lipogenesis) while promoting oxidative stress and inflammation. Another issue is to compare the impact of …
The central aim of this study is to test the hypothesis that SAR1B deletion (SAR1B(-/-) ) disturbs enterocyte lipid homeostasi …
29 results