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2021 8
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69 results

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DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer.
Müller D, Győrffy B. Müller D, et al. Biochim Biophys Acta Rev Cancer. 2022 May;1877(3):188722. doi: 10.1016/j.bbcan.2022.188722. Epub 2022 Mar 17. Biochim Biophys Acta Rev Cancer. 2022. PMID: 35307512 Free article. Review.
First, we start with the two methylation-based diagnostic biomarkers already approved for colorectal cancer, SEPT9 and the combination of NDRG4 and BMP3. Then, we provide a list-based overview of new biomarker candidates depending on the sample source including plasma, sto …
First, we start with the two methylation-based diagnostic biomarkers already approved for colorectal cancer, SEPT9 and the combinatio …
Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase.
Darmasaputra GS, Geerlings CC, Chuva de Sousa Lopes SM, Clevers H, Galli M. Darmasaputra GS, et al. J Cell Biol. 2024 Aug 5;223(8):e202403020. doi: 10.1083/jcb.202403020. Epub 2024 May 10. J Cell Biol. 2024. PMID: 38727809 Free PMC article.
We find that cells in endomitosis M phase have normal mitotic timings, but lose membrane anchorage to the midbody during cytokinesis, which is associated with the loss of four cortical anchoring proteins, RacGAP1, Anillin, SEPT9, and citron kinase (CIT-K). Moreover, reduct …
We find that cells in endomitosis M phase have normal mitotic timings, but lose membrane anchorage to the midbody during cytokinesis, which …
A Role of Inflammation in Charcot-Marie-Tooth Disorders-In a Perspective of Treatment?
Kamińska J, Kochański A. Kamińska J, et al. Int J Mol Sci. 2024 Dec 24;26(1):15. doi: 10.3390/ijms26010015. Int J Mol Sci. 2024. PMID: 39795872 Free PMC article. Review.
We narrowed a group of more than 100 genes whose mutations were found in CMT-affected patients to the seven most common (MPZ, PMP22, GJB1, SEPT9, LITAF, FIG4, and GDAP1) as being linked to the coexistence of hereditary and inflammatory neuropathy. ...
We narrowed a group of more than 100 genes whose mutations were found in CMT-affected patients to the seven most common (MPZ, PMP22, GJB1, …
Detecting colorectal cancer using genetic and epigenetic biomarkers: screening and diagnosis.
Rezkitha YAA, Panenggak NSR, Lusida MI, Rianda RV, Mahmudah I, Pradana AD, Uchida T, Miftahussurur M. Rezkitha YAA, et al. J Med Life. 2024 Jan;17(1):4-14. doi: 10.25122/jml-2023-0269. J Med Life. 2024. PMID: 38737656 Free PMC article. Review.
Several markers show promising potential, including the methylation of vimentin (VIM), syndecan-2 (SDC2), and septin 9 (SEPT9). However, their application as screening and diagnostic tools, particularly for early-stage CRC, has not been fully optimized, and t …
Several markers show promising potential, including the methylation of vimentin (VIM), syndecan-2 (SDC2), and septin 9 (SEP …
Diagnostic efficacy of SEPT9 and PAX5 gene methylation in gastrointestinal cancer and precancerous lesions.
Yan Z, Liu H, Wang K. Yan Z, et al. Cell Mol Biol (Noisy-le-grand). 2024 Jul 28;70(7):128-133. doi: 10.14715/cmb/2024.70.7.18. Cell Mol Biol (Noisy-le-grand). 2024. PMID: 39097885
No significant difference was discovered in 3-year overall survival rate between GC patients with SEPT9 methylation and those without SEPT9 methylation. Combined detection could not improve the diagnostic value of GC, but could promote diagnosis sensitivity. In summ …
No significant difference was discovered in 3-year overall survival rate between GC patients with SEPT9 methylation and those without …
Combined SEPT9 and BMP3 methylation in plasma for colorectal cancer early detection and screening in a Brazilian population.
Lima AB, Dos Reis MB, Matsushita M, Dos Reis MT, de Oliveira MA, Reis RM, Guimarães DP. Lima AB, et al. Cancer Med. 2023 Aug;12(15):15854-15867. doi: 10.1002/cam4.6224. Epub 2023 Jun 20. Cancer Med. 2023. PMID: 37338022 Free PMC article.
OBJECTIVE: This study aimed to evaluate the plasma methylation status of SEPT9 and BMP3 promoters as biomarkers for detection of CRC and its precursor lesions in a Brazilian population. ...CONCLUSION: The present study suggests that a combination of SEPT9 and BMP3 p …
OBJECTIVE: This study aimed to evaluate the plasma methylation status of SEPT9 and BMP3 promoters as biomarkers for detection of CRC …
BCAT1, IKZF1 and SEPT9: methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas.
Laven-Law G, Kichenadasse G, Young GP, Symonds EL, Winter JM. Laven-Law G, et al. Biomarkers. 2024 Jun;29(4):194-204. doi: 10.1080/1354750X.2024.2340663. Epub 2024 Apr 22. Biomarkers. 2024. PMID: 38644767 Free article.
Clinicodemographic predictors of BCAT1, IKZF1 and SEPT9 methylation, and the selectivity of hypermethylated BCAT1, IKZF1 and SEPT9 for colorectal adenocarcinomas in comparison to other cancers were each explored with beta regression. RESULTS: Hypermethylated BCAT1, …
Clinicodemographic predictors of BCAT1, IKZF1 and SEPT9 methylation, and the selectivity of hypermethylated BCAT1, IKZF1 and SEPT9 …
Diagnostic value of genetic and epigenetic biomarker panels for colorectal cancer detection: a systematic review.
Alampritis G, Thoukididou SN, Ramos M, Georgiou P, Kalofonou M, Simillis C. Alampritis G, et al. Int J Colorectal Dis. 2025 May 22;40(1):125. doi: 10.1007/s00384-025-04904-y. Int J Colorectal Dis. 2025. PMID: 40402271 Free PMC article.
Suboptimal APL sensitivities up to 57.0% were exhibited by Cologuard and variant panels (including KRAS, methylated BMP3, methylated NDRG4, FIT), and 47.8% for combinations including methylated SEPT9. CONCLUSIONS: High-performance, candidate ctDNA biomarker panels with exc …
Suboptimal APL sensitivities up to 57.0% were exhibited by Cologuard and variant panels (including KRAS, methylated BMP3, methylated NDRG4, …
PAX1 and SEPT9 methylation analyses in cervical exfoliated cells are highly efficient for detecting cervical (pre)cancer in hrHPV-positive women.
He L, Luo X, Bu Q, Jin J, Zhou S, He S, Zhang L, Lin Y, Hong X. He L, et al. J Obstet Gynaecol. 2023 Dec;43(1):2179916. doi: 10.1080/01443615.2023.2179916. J Obstet Gynaecol. 2023. PMID: 36799003 Free article.
This subject showed that PAX1 and SEPT9 methylation were closely associated with cervical cancer. The methylation rates and levels of PAX1 and SEPT9 increased with cervical lesion severity and reached a peak in cervical cancer exfoliated cells. We further assessed t …
This subject showed that PAX1 and SEPT9 methylation were closely associated with cervical cancer. The methylation rates and levels of …
SEPT9: From pan-cancer to lung squamous cell carcinoma.
Wang W, Zhang X, Gui P, Zou Q, Nie Y, Ma S, Zhang S. Wang W, et al. BMC Cancer. 2024 Sep 5;24(1):1105. doi: 10.1186/s12885-024-12877-4. BMC Cancer. 2024. PMID: 39237897 Free PMC article.
BACKGROUND: SEPT9 is a pivotal cytoskeletal GTPase that regulates diverse biological processes encompassing mitosis and cytokinesis. ...Additionally, clinical samples from 90 patients with lung squamous cell carcinoma (LUSC) were used to further experimentally validate the …
BACKGROUND: SEPT9 is a pivotal cytoskeletal GTPase that regulates diverse biological processes encompassing mitosis and cytokinesis. …
69 results