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Interstitial lung diseases in children.
Nathan N, Berdah L, Delestrain C, Sileo C, Clement A. Nathan N, et al. Presse Med. 2020 Jun;49(2):103909. doi: 10.1016/j.lpm.2019.06.007. Epub 2020 Jun 18. Presse Med. 2020. PMID: 32563946 Review.
Currently, the main genetic mutations associated with chILD are identified in the surfactant genes SFTPA1, SFTPA2, SFTPB, SFTPC, ABCA3 and NKX2-1. Other genetic contributors include mutations in MARS, CSF2RA and CSF2RB in pulmonary alveolar proteinosis, and mutations in TM …
Currently, the main genetic mutations associated with chILD are identified in the surfactant genes SFTPA1, SFTPA2, SFTPB, SFTPC, ABCA …
The Proteomic Profile of Interstitial Lung Abnormalities.
Axelsson GT, Gudmundsson G, Pratte KA, Aspelund T, Putman RK, Sanders JL, Gudmundsson EF, Hatabu H, Gudmundsdottir V, Gudjonsson A, Hino T, Hida T, Hobbs BD, Cho MH, Silverman EK, Bowler RP, Launer LJ, Jennings LL, Hunninghake GM, Emilsson V, Gudnason V. Axelsson GT, et al. Am J Respir Crit Care Med. 2022 Aug 1;206(3):337-346. doi: 10.1164/rccm.202110-2296OC. Am J Respir Crit Care Med. 2022. PMID: 35438610 Free PMC article.
Measurements and Main Results: Of 287 associations, SFTPB (surfactant protein B) (odds ratio [OR], 3.71 [95% confidence interval (CI), 3.20-4.30]; P = 4.28 10(-67)), SCGB3A1 (Secretoglobin family 3A member 1) (OR, 2.43 [95% CI, 2.13-2.77]; P = 8.01 10( …
Measurements and Main Results: Of 287 associations, SFTPB (surfactant protein B) (odds ratio [OR], 3.71 [95% con …
Surfactant protein disorders in childhood interstitial lung disease.
Singh J, Jaffe A, Schultz A, Selvadurai H. Singh J, et al. Eur J Pediatr. 2021 Sep;180(9):2711-2721. doi: 10.1007/s00431-021-04066-3. Epub 2021 Apr 11. Eur J Pediatr. 2021. PMID: 33839914 Review.
Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, …
Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the …
Persistent Respiratory Distress in the Term Neonate: Genetic Surfactant Deficiency Diseases.
Magnani JE, Donn SM. Magnani JE, et al. Curr Pediatr Rev. 2020;16(1):17-25. doi: 10.2174/1573396315666190723112916. Curr Pediatr Rev. 2020. PMID: 31544695 Review.
Genes that have been implicated in surfactant deficiency include SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD (which encode for surfactant proteins A, B, C, and D, respectively); ABCA3 (crucial for surfactant packaging and secretion); and NKX2 (a transcription factor that regul …
Genes that have been implicated in surfactant deficiency include SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD (which encode for surfactant …
Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS-mediated JNK/c-Jun signaling pathway.
Yang X, Yang P, Zhang J, Yang Y, Xiong M, Shi F, Li N, Jin Y. Yang X, et al. Environ Toxicol. 2022 Sep;37(9):2291-2301. doi: 10.1002/tox.23596. Epub 2022 Jun 11. Environ Toxicol. 2022. PMID: 35689653
Additionally, the JNK/c-Jun signaling pathway was activated, and the expression of surfactant protein A (SP-A) and surfactant protein B (SP-B) was decreased. After the cells being treated with N-acetyl-L-cysteine (NAC), we found that the ROS content was effec …
Additionally, the JNK/c-Jun signaling pathway was activated, and the expression of surfactant protein A (SP-A) and surfactant prot …
A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C.
Huang H, Pan J, Spielberg DR, Hanchard NA, Scott DA, Burrage LC, Dai H, Murdock D, Rosenfeld JA, Mohammad A, Huang T, Lindsey AG, Kim H, Chen J, Ramu A, Morrison SA, Dawson ZD, Hu AZ, Tycksen E, Silverman GA, Baldridge D, Wambach JA; Undiagnosed Diseases Network; Pak SC, Brody SL, Schedl T. Huang H, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2105228119. doi: 10.1073/pnas.2105228119. Proc Natl Acad Sci U S A. 2022. PMID: 35121658 Free PMC article.
Regulatory Roles of Human Surfactant Protein B Variants on Genetic Susceptibility to Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.
Yang F, Zhang J, Yang Y, Ruan F, Chen X, Guo J, Abdel-Razek O, Zuo YY, Wang G. Yang F, et al. Shock. 2020 Oct;54(4):507-519. doi: 10.1097/SHK.0000000000001494. Shock. 2020. PMID: 31851120 Free PMC article.
Surfactant protein B (SP-B) is essential for life and plays critical roles in host defense and lowering alveolar surface tension. ...
Surfactant protein B (SP-B) is essential for life and plays critical roles in host defense and lowering alveolar surfac …
Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis.
Abbasi A, Chen C, Gandhi CK, Wu R, Pardo A, Selman M, Floros J. Abbasi A, et al. Front Immunol. 2022 Jun 2;13:842745. doi: 10.3389/fimmu.2022.842745. eCollection 2022. Front Immunol. 2022. PMID: 35720392 Free PMC article.
We observed: 1) in terms of IPF, i) three single SFTPA1 SNPs to associate with decreased IPF risk, ii) three SFTPA1 haplotypes to associate with increased IPF risk, and iii) a number of three-SNP interactions to associate with IPF susceptibility. 2) Comparison of IPF and HP, i) t …
We observed: 1) in terms of IPF, i) three single SFTPA1 SNPs to associate with decreased IPF risk, ii) three SFTPA1 haplotypes to associate …
Construction and Validation of Prognostic Regulation Network Based on RNA-Binding Protein Genes in Lung Squamous Cell Carcinoma.
Zhao S, Liu Q, Li J, Hu C, Cao F, Ma W, Gao J. Zhao S, et al. DNA Cell Biol. 2021 Dec;40(12):1563-1583. doi: 10.1089/dna.2021.0145. DNA Cell Biol. 2021. PMID: 34931870
Moreover, we uncovered the regulatory networks of PHF5A-TOMM22-oxidative phosphorylation, TLR3-CTSO inflammation-related pathway, SECISBP2L-targeted RNA (ADGRF5, TGFBR2, CD302, AC096921.2, AHCYL2, RPS6KA2, SLC34A2, and SFTPB) angiogenesis, and SECISBP2L-AKAP13 signaling (D …
Moreover, we uncovered the regulatory networks of PHF5A-TOMM22-oxidative phosphorylation, TLR3-CTSO inflammation-related pathway, SECISBP2L- …
Biodistribution, inter-/intra-cellular localization and respiratory dysfunction induced by Ti3C2 nanosheets: Involvement of surfactant protein down-regulation in alveolar epithelial cells.
Sui B, Liu X, Sun J. Sui B, et al. J Hazard Mater. 2021 Jan 15;402:123562. doi: 10.1016/j.jhazmat.2020.123562. Epub 2020 Jul 28. J Hazard Mater. 2021. PMID: 32755797
In the lungs, they were retained in the cytoplasm of alveolar epithelial cells and endothelial cells, and inhibited pulmonary surfactant protein B (SP-B) expression on alveolar epithelial cell, causing increased airway resistance-induced respiratory disorder …
In the lungs, they were retained in the cytoplasm of alveolar epithelial cells and endothelial cells, and inhibited pulmonary surfactant …
20 results