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Page 1
Proteome-Wide Multicenter Mendelian Randomization Analysis to Identify Novel Therapeutic Targets for Lung Cancer.
Wang K, Yi H, Wang Y, Jin D, Zhang G, Mao Y. Wang K, et al. Arch Bronconeumol. 2024 Sep;60(9):553-558. doi: 10.1016/j.arbres.2024.05.007. Epub 2024 May 16. Arch Bronconeumol. 2024. PMID: 38824092 English, Spanish.
RESULTS: Our analysis identified five proteins (TFPI, ICAM5, SFTPB, COL6A3, EPHB1) with significant associations to LC risk. External validation confirmed the potential therapeutic relevance of ICAM5 and SFTPB. ...The identified proteins, particularly ICAM5 and S …
RESULTS: Our analysis identified five proteins (TFPI, ICAM5, SFTPB, COL6A3, EPHB1) with significant associations to LC risk. External …
The Proteomic Profile of Interstitial Lung Abnormalities.
Axelsson GT, Gudmundsson G, Pratte KA, Aspelund T, Putman RK, Sanders JL, Gudmundsson EF, Hatabu H, Gudmundsdottir V, Gudjonsson A, Hino T, Hida T, Hobbs BD, Cho MH, Silverman EK, Bowler RP, Launer LJ, Jennings LL, Hunninghake GM, Emilsson V, Gudnason V. Axelsson GT, et al. Am J Respir Crit Care Med. 2022 Aug 1;206(3):337-346. doi: 10.1164/rccm.202110-2296OC. Am J Respir Crit Care Med. 2022. PMID: 35438610 Free PMC article.
Measurements and Main Results: Of 287 associations, SFTPB (surfactant protein B) (odds ratio [OR], 3.71 [95% confidence interval (CI), 3.20-4.30]; P = 4.28 10(-67)), SCGB3A1 (Secretoglobin family 3A member 1) (OR, 2.43 [95% CI, 2.13-2.77]; P = 8.01 10( …
Measurements and Main Results: Of 287 associations, SFTPB (surfactant protein B) (odds ratio [OR], 3.71 [95% con …
Surfactant protein disorders in childhood interstitial lung disease.
Singh J, Jaffe A, Schultz A, Selvadurai H. Singh J, et al. Eur J Pediatr. 2021 Sep;180(9):2711-2721. doi: 10.1007/s00431-021-04066-3. Epub 2021 Apr 11. Eur J Pediatr. 2021. PMID: 33839914 Review.
Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, …
Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the …
Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis.
Blumhagen RZ, Kurche JS, Cool CD, Walts AD, Heinz D, Fingerlin TE, Yang IV, Schwartz DA. Blumhagen RZ, et al. Respir Res. 2023 Nov 17;24(1):287. doi: 10.1186/s12931-023-02572-6. Respir Res. 2023. PMID: 37978501 Free PMC article.
Through cell deconvolution of transcriptome data and immunofluorescence staining, we confirmed loss of alveolar parenchymal signals (AGER, SFTPB, SFTPC), gain of secretory cell markers (SCGB3A2, MUC5B) as well as dysregulation of the upstream regulator ATF4, in histologica …
Through cell deconvolution of transcriptome data and immunofluorescence staining, we confirmed loss of alveolar parenchymal signals (AGER, …
Towards personalized therapies for genetic disorders of surfactant dysfunction.
Peers de Nieuwburgh M, Wambach JA, Griese M, Danhaive O. Peers de Nieuwburgh M, et al. Semin Fetal Neonatal Med. 2023 Dec;28(6):101500. doi: 10.1016/j.siny.2023.101500. Epub 2023 Nov 22. Semin Fetal Neonatal Med. 2023. PMID: 38036307 Free PMC article. Review.
This review explores genetic mechanisms underpinning surfactant dysfunction, highlighting specific surfactant-associated genes including SFTPB, SFTPC, ABCA3, and NKX2.1. Pathogenic variants in these genes contribute to a range of clinical presentations and courses, from ne …
This review explores genetic mechanisms underpinning surfactant dysfunction, highlighting specific surfactant-associated genes including …
Surfactant protein B deficiency: the RespiRare cohort.
Fleury M, Delestrain C, Roditis L, Perisson C, Renoux MC, Thumerelle C, Epaud R, Fletcher C, Jedidi N, Coulomb L'Hermine A, Corvol H, Ducou le Pointe H, Fanen P, Sileo C, Louvrier C, de Becdelievre A, Legendre M, Nathan N. Fleury M, et al. Thorax. 2025 Jan 17;80(2):109-112. doi: 10.1136/thorax-2024-221947. Thorax. 2025. PMID: 39632082
Gene Therapeutics for Surfactant Dysfunction Disorders: Targeting the Alveolar Type 2 Epithelial Cell.
Sitaraman S, Alysandratos KD, Wambach JA, Limberis MP. Sitaraman S, et al. Hum Gene Ther. 2022 Oct;33(19-20):1011-1022. doi: 10.1089/hum.2022.130. Hum Gene Ther. 2022. PMID: 36166236 Free PMC article. Review.
As such, the need for effective therapies remains. Pathogenic variants in the SFTPB, SFTPC, and ABCA3 genes, each of which encode proteins essential for proper pulmonary surfactant production and function, result in interstitial lung disease in infants, children, and adult …
As such, the need for effective therapies remains. Pathogenic variants in the SFTPB, SFTPC, and ABCA3 genes, each of which encode pro …
SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe COVID-19 pneumonia.
Fishchuk L, Rossokha Z, Pokhylko V, Cherniavska Y, Popova O, Vershyhora V, Kovtun S, Gorovenko N. Fishchuk L, et al. Respir Investig. 2023 Jan;61(1):103-109. doi: 10.1016/j.resinv.2022.10.008. Epub 2022 Nov 15. Respir Investig. 2023. PMID: 36460583 Free PMC article.
In this study, we decided to focus on two molecular markers that affect surfactant metabolism and lung development: the surfactant protein B (SFTPB) and the glucocorticoid receptor (NR3C1) genes. The aim of our study was to determine the effect of S …
In this study, we decided to focus on two molecular markers that affect surfactant metabolism and lung development: the surfactant …
Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients.
Qin N, Wang Z, Xu X, Xie Y, Chen Y, Luo W, Tang P, Wang X, Bi L, Gong L, Li Z, Chen C, Wang K, Guo S, Zhao Z, Xiang J, Zhu M, Jiang Y, He Y, Dai J, Yin R, Wang C, Hu Z, Ma H, Li W, Shen H. Qin N, et al. Cancer Res. 2025 Aug 1;85(15):2905-2920. doi: 10.1158/0008-5472.CAN-24-1799. Cancer Res. 2025. PMID: 40479597
The 3' untranslated region (UTR) was the most frequently altered noncoding element in LUAD, with recurrent disrupting mutations in the 3' UTR of SFTPB and SFTPA1. Unlike other cancer types, TERT promoter mutations were observed specifically among female patients with LUAD. …
The 3' untranslated region (UTR) was the most frequently altered noncoding element in LUAD, with recurrent disrupting mutations in the 3' UT …
The surfactant protein B polymorphisms (rs7316 and rs1130866) and their correlation with disease progression of COVID-19.
Behrouzi A, Sakhaee F, Ghazanfari Jajin M, Ahmadi I, Anvari E, Sotoodehnejadnematalahi F, Fateh A. Behrouzi A, et al. Cytokine. 2024 Dec;184:156775. doi: 10.1016/j.cyto.2024.156775. Epub 2024 Oct 4. Cytokine. 2024. PMID: 39368228
BACKGROUND: It is critical to examine the pathogenic pathways in coronavirus disease 2019 (COVID-19) that resulted in the development of severe lung injury. Surfactant protein B (SFTPB) is a vital component for sustaining life and serves pivotal functi …
BACKGROUND: It is critical to examine the pathogenic pathways in coronavirus disease 2019 (COVID-19) that resulted in the development of sev …
34 results