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Page 1
Genetic Disorders of Manganese Metabolism.
Anagianni S, Tuschl K. Anagianni S, et al. Curr Neurol Neurosci Rep. 2019 May 14;19(6):33. doi: 10.1007/s11910-019-0942-y. Curr Neurol Neurosci Rep. 2019. PMID: 31089831 Free PMC article. Review.
While the manganese efflux transporter SLC30A10 and the uptake transporter SLC39A14 work synergistically to reduce the manganese load, SLC39A8 has an opposing function facilitating manganese uptake into the organism. Bi-allelic mutations in any of these transporter protein …
While the manganese efflux transporter SLC30A10 and the uptake transporter SLC39A14 work synergistically to reduce the manganese load …
RELA-mediated upregulation of LINC03047 promotes ferroptosis in silica-induced pulmonary fibrosis via SLC39A14.
Zhang B, Wang E, Zhou S, Han R, Wu W, Sun G, Cao C, Wang R. Zhang B, et al. Free Radic Biol Med. 2024 Oct;223:250-262. doi: 10.1016/j.freeradbiomed.2024.08.002. Epub 2024 Aug 5. Free Radic Biol Med. 2024. PMID: 39111583
Moreover, knockdown of LINC03047 significantly decreased the expression of solute carrier family 39 member 14 (SLC39A14), a ferrous iron transporter, and inhibition of SLC39A14 alleviated the ferroptosis and EMT caused by LI …
Moreover, knockdown of LINC03047 significantly decreased the expression of solute carrier family 39 member …
The Functions of ZIP8, ZIP14, and ZnT10 in the Regulation of Systemic Manganese Homeostasis.
Winslow JWW, Limesand KH, Zhao N. Winslow JWW, et al. Int J Mol Sci. 2020 May 7;21(9):3304. doi: 10.3390/ijms21093304. Int J Mol Sci. 2020. PMID: 32392784 Free PMC article. Review.
In the past eight years, mutations of genes encoding metal transporters ZIP8 (SLC39A8), ZIP14 (SLC39A14), and ZnT10 (SLC30A10) have been identified to cause dysregulated manganese homeostasis in humans, highlighting the critical roles of these genes in manganese met …
In the past eight years, mutations of genes encoding metal transporters ZIP8 (SLC39A8), ZIP14 (SLC39A14), and ZnT10 (SLC30A10) …
Ferredoxin 1-like maintains iron homeostasis and hepatoma cell survival.
Zheng J, Zheng S, Zhou Q, Wu Y, Zhu C, Zheng Y, Li H, Li M, Zhong W, Yan D. Zheng J, et al. Free Radic Biol Med. 2025 Oct;238:52-63. doi: 10.1016/j.freeradbiomed.2025.06.018. Epub 2025 Jun 19. Free Radic Biol Med. 2025. PMID: 40543853
FDX1L deficiency induces inadequate maintenance of Fe-S clusters and strongly activates the iron-starvation response, leading to an upregulation of the metal transporter protein SLC39A14 and enhancement of iron influx. Consequently, FDX1L downregulation-induced iron overlo …
FDX1L deficiency induces inadequate maintenance of Fe-S clusters and strongly activates the iron-starvation response, leading to an upregula …
Dihydroartemisinin Sensitizes Lung Cancer Cells to Cisplatin Treatment by Upregulating ZIP14 Expression and Inducing Ferroptosis.
Yang Z, Zhou Z, Meng Q, Chen Z, Yun L, Jiang J, He Y, Dian M, Zhang R, Ge H, Yan T, Men B, Li Z, Wu X, He J, Rao S. Yang Z, et al. Cancer Med. 2024 Oct;13(19):e70271. doi: 10.1002/cam4.70271. Cancer Med. 2024. PMID: 39394878 Free PMC article.
Mechanistically, the combination of DHA and DDP synergistically enhances ZIP14 expression, modulating iron homeostasis and upregulating oxidative stress, leading to both in vitro and in vivo ferroptosis. Notably, our findings revealed that the sequential administration of …
Mechanistically, the combination of DHA and DDP synergistically enhances ZIP14 expression, modulating iron homeostasis and upregulati …
Familial manganese-induced neurotoxicity due to mutations in SLC30A10 or SLC39A14.
Mukhopadhyay S. Mukhopadhyay S. Neurotoxicology. 2018 Jan;64:278-283. doi: 10.1016/j.neuro.2017.07.030. Epub 2017 Aug 5. Neurotoxicology. 2018. PMID: 28789954 Free PMC article. Review.
Loss-of-function mutations in SLC30A10, a Mn efflux transporter, or SLC39A14, a Mn influx transporter, increase Mn levels in blood and brain, and induce severe neurotoxicity. ...
Loss-of-function mutations in SLC30A10, a Mn efflux transporter, or SLC39A14, a Mn influx transporter, increase Mn levels in blood an …
Genetic control of MRI contrast using the manganese transporter Zip14.
Rallapalli H, McCall EC, Koretsky AP. Rallapalli H, et al. Magn Reson Med. 2024 Aug;92(2):820-835. doi: 10.1002/mrm.29993. Epub 2024 Apr 4. Magn Reson Med. 2024. PMID: 38573932 Free PMC article.
Here, we demonstrate that the manganese ion transporter Zip14 is an in vivo MRI-visible, flexible, and robust gene-expression reporter to meet this need. ...Expression of Zip14 in astrocytes also enabled MRI of glia populations in the living mammalian brain. ...
Here, we demonstrate that the manganese ion transporter Zip14 is an in vivo MRI-visible, flexible, and robust gene-expression reporte …
Genotype-Phenotype Relations for the Dystonia-Parkinsonism Genes GLB1, SLC6A3, SLC30A10, SLC39A14, and PLA2G6: MDSGene Systematic Review.
Rodriguez-Antiguedad J, Rajalingam R, Krüger C, Teixeira-Dos-Santos D, Sun C, Fernandez-Toledo E, Duarte A, Saffie-Awad P, Barrett MJ, Flanigan JL, Emamikhah M, Patel N, San Luciano M, Cooper C, Bahr N, Oguh O, Buhrmann A, Vater M, Fuchshofen R, Vulinovic F, Parreidt MI, Weissbach A, Lohmann K, Klein C, Marras C, Camargos S. Rodriguez-Antiguedad J, et al. Int J Mol Sci. 2025 Apr 25;26(9):4074. doi: 10.3390/ijms26094074. Int J Mol Sci. 2025. PMID: 40362326 Free PMC article.
This systematic review explores the genotype-phenotype correlations of GLB1, SLC6A3, SLC30A10, PLA2G6, and SLC39A14-recently classified as DYT SLC39A14 and historically linked to dystonia-parkinsonism. ...Awareness of these phenotypes is essential for early diagnosi …
This systematic review explores the genotype-phenotype correlations of GLB1, SLC6A3, SLC30A10, PLA2G6, and SLC39A14-recently classifi …
Identification of endoplasmic reticulum stress-related genes as prognostic markers in colon cancer.
Xu W, Li W, Kuai D, Li Y, Sun W, Liu X, Xu B. Xu W, et al. Cancer Biol Ther. 2025 Dec;26(1):2458820. doi: 10.1080/15384047.2025.2458820. Epub 2025 Apr 1. Cancer Biol Ther. 2025. PMID: 40169935 Free PMC article.
Our study identified nine ERS related genes (ASNS, ATF4, ATF6B, BOK, CLU, DDIT3, MANF, SLC39A14, TRAF2) involved in critical pathways including IL-12, PI3K-AKT, IL-7, and IL-23 signaling, and linked to 1-, 3-, and 5-year survival of patients with colon cancer. ...
Our study identified nine ERS related genes (ASNS, ATF4, ATF6B, BOK, CLU, DDIT3, MANF, SLC39A14, TRAF2) involved in critical pathways …
Elucidating ferroptosis mechanisms in heart failure through transcriptomics, single-cell sequencing, and experimental validation.
Li K, Liu P, Han L, Tian J, Zheng Z, Sha M, Ye J, Zhu L. Li K, et al. Cell Signal. 2024 Dec;124:111416. doi: 10.1016/j.cellsig.2024.111416. Epub 2024 Sep 16. Cell Signal. 2024. PMID: 39293745 Free article.
RESULTS: A total of 127 DFRGs were identified, with 83 downregulated and 44 upregulated compared to controls. Seven key DFRGs (PTGS2, BECN1, SLC39A14, QSOX1, MLST8, TMSB4X, KDM4A) were identified, showing high diagnostic accuracy (AUC 0.988) in the GSE5406 dataset. ...The …
RESULTS: A total of 127 DFRGs were identified, with 83 downregulated and 44 upregulated compared to controls. Seven key DFRGs (PTGS2, BECN1, …
58 results