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Revealing the location and dynamics of a concealed binding site in the dopamine transporter.
Zhu R, Sandtner W, Stockner T, Heilinger A, Holy M, Kudlacek O, Wildling L, Saha K, Fröhlich AS, Bindl M, Tziortzouda P, Haider A, Gobl J, Suh SH, Khan JA, Bicher J, Kastner N, Ebner A, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P. Zhu R, et al. Nat Commun. 2025 May 6;16(1):4197. doi: 10.1038/s41467-025-59511-w. Nat Commun. 2025. PMID: 40328781 Free PMC article.
Genotype-Phenotype Relations for the Dystonia-Parkinsonism Genes GLB1, SLC6A3, SLC30A10, SLC39A14, and PLA2G6: MDSGene Systematic Review.
Rodriguez-Antiguedad J, Rajalingam R, Krüger C, Teixeira-Dos-Santos D, Sun C, Fernandez-Toledo E, Duarte A, Saffie-Awad P, Barrett MJ, Flanigan JL, Emamikhah M, Patel N, San Luciano M, Cooper C, Bahr N, Oguh O, Buhrmann A, Vater M, Fuchshofen R, Vulinovic F, Parreidt MI, Weissbach A, Lohmann K, Klein C, Marras C, Camargos S. Rodriguez-Antiguedad J, et al. Int J Mol Sci. 2025 Apr 25;26(9):4074. doi: 10.3390/ijms26094074. Int J Mol Sci. 2025. PMID: 40362326 Free PMC article.
Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant.
Mayer FP, Stewart A, Varman DR, Moritz AE, Foster JD, Owens AW, Areal LB, Gowrishankar R, Velez M, Wickham K, Phelps H, Katamish R, Rabil M, Jayanthi LD, Vaughan RA, Daws LC, Blakely RD, Ramamoorthy S. Mayer FP, et al. Mol Psychiatry. 2025 Oct;30(10):4651-4664. doi: 10.1038/s41380-025-03055-4. Epub 2025 May 29. Mol Psychiatry. 2025. PMID: 40442453 Free PMC article.
78 results